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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyfluthrin
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Accession:CHEBI:4034 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation between 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid and (4-fluoro-3-phenoxyphenyl)(hydroxy)acetonitrile.
Synonyms:exact_synonym: cyano(4-fluoro-3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate
 related_synonym: (R,S)-alpha-Cyano-4-fluoro-3-phenoxybenzyl-(1R,S)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate;   Formula=C22H18Cl2FNO3;   InChI=1S/C22H18Cl2FNO3/c1-22(2)15(11-19(23)24)20(22)21(27)29-18(12-26)13-8-9-16(25)17(10-13)28-14-6-4-3-5-7-14/h3-11,15,18,20H,1-2H3;   InChIKey=QQODLKZGRKWIFG-UHFFFAOYSA-N;   SMILES=CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)c1ccc(F)c(Oc2ccccc2)c1
 xref: Beilstein:2788149;   CAS:68359-37-5;   Drug_Central:4407;   KEGG:C10982;   KEGG:D07761
 xref_mesh: MESH:C052570
 xref: PMID:17912691;   PMID:18383791;   PPDB:192;   Patent:DE2709264;   Patent:US4218469;   Patent:US4287208;   Reaxys:2788149


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cyfluthrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP cyfluthrin results in decreased activity of ACHE protein CTD PMID:26604153 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ar androgen receptor decreases activity
multiple interactions
ISO cyfluthrin results in decreased activity of AR protein
Dihydrotestosterone inhibits the reaction [cyfluthrin results in increased activity of AR protein]
CTD PMID:15064155, PMID:20410157 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cyfluthrin results in increased expression of BAX mRNA CTD PMID:32028016 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase increases expression ISO cyfluthrin results in increased expression of BCR protein CTD PMID:16790487 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP cyfluthrin results in increased expression of BDNF mRNA CTD PMID:16166269 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO cyfluthrin results in increased expression of CAMK2A mRNA CTD PMID:32028016 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO cyfluthrin results in increased expression of CAMK2B mRNA CTD PMID:32028016 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Cat catalase decreases activity
affects binding
decreases expression
multiple interactions
ISO
EXP
cyfluthrin results in decreased activity of CAT protein
cyfluthrin binds to CAT protein
cyfluthrin results in decreased expression of CAT protein
Selenium inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]; N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
CTD PMID:19961921, PMID:23595963, PMID:26604153, PMID:32278787 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ces2h carboxylesterase 2H increases metabolic processing ISO CES2 protein results in increased metabolism of cyfluthrin CTD PMID:19249324 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chat choline O-acetyltransferase decreases expression EXP cyfluthrin results in decreased expression of CHAT protein CTD PMID:26604153 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 increases expression ISO cyfluthrin results in increased expression of CLIP3 protein CTD PMID:16790487 NCBI chr 1:88,750,453...88,766,453
Ensembl chr 1:90,962,707...90,978,907
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP cyfluthrin results in increased activity of CYP2E1 protein CTD PMID:23639246 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Esr1 estrogen receptor 1 increases activity
decreases activity
ISO
EXP
cyfluthrin results in increased activity of ESR1 protein
cyfluthrin results in decreased activity of ESR1 protein
CTD PMID:15064155, PMID:20410157 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO cyfluthrin results in increased expression of GAP43 mRNA CTD PMID:32028016 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP Selenium inhibits the reaction [cyfluthrin results in decreased activity of GSR protein] CTD PMID:23595963 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hydin Hydin, axonemal central pair apparatus protein decreases expression ISO cyfluthrin results in decreased expression of HYDIN protein CTD PMID:16790487 NCBI chr19:41,036,507...41,379,634
Ensembl chr19:41,036,510...41,379,588
JBrowse link
G Ifng interferon gamma multiple interactions ISO cyfluthrin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IFNG protein] CTD PMID:12755381 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il4 interleukin 4 multiple interactions ISO cyfluthrin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL4 protein] CTD PMID:12755381 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression ISO cyfluthrin results in increased expression of IL6 protein CTD PMID:16790487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO cyfluthrin results in increased expression of MAPK1 protein CTD PMID:16790487 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO cyfluthrin results in increased expression of MAPK3 protein CTD PMID:16790487 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nefh neurofilament heavy increases expression ISO cyfluthrin results in increased expression of NEFH mRNA CTD PMID:32028016 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefl neurofilament light decreases expression ISO cyfluthrin results in decreased expression of NEFL mRNA CTD PMID:32028016 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO cyfluthrin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
EXP
ISO
cyfluthrin results in increased activity of NR1I2 protein
cyfluthrin results in increased activity of NR1I2 protein; cyfluthrin results in increased activity of NR1I2 protein polymorphism
cyfluthrin binds to and results in increased activity of NR1I2 protein
CTD PMID:19249324, PMID:21115097, PMID:22206814 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pgr progesterone receptor affects binding ISO cyfluthrin binds to PGR protein CTD PMID:32278787 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO cyfluthrin results in increased expression of PIK3C3 mRNA CTD PMID:32028016 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta increases expression ISO cyfluthrin results in increased expression of PPP2R3B protein CTD PMID:16790487 NCBI chr14:1,469,748...1,476,353
Ensembl chr14:1,469,748...1,476,355
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions
affects activity
EXP cyfluthrin affects the reaction [SCN10A protein results in increased transport of Sodium]
cyfluthrin affects the activity of SCN10A protein
CTD PMID:16051293, PMID:19766671 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 multiple interactions EXP cyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions EXP cyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions EXP cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 multiple interactions EXP cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Slc6a14 solute carrier family 6 member 14 decreases expression ISO cyfluthrin results in decreased expression of SLC6A14 protein CTD PMID:16790487 NCBI chr  X:120,624,522...120,647,964
Ensembl chr  X:120,624,518...120,649,111
JBrowse link
G Stat6 signal transducer and activator of transcription 6 decreases expression ISO cyfluthrin results in decreased expression of STAT6 protein CTD PMID:12755381 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Syn1 synapsin I decreases expression ISO cyfluthrin results in decreased expression of SYN1 mRNA CTD PMID:32028016 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Wnt3a Wnt family member 3A increases expression ISO cyfluthrin results in increased expression of WNT3A mRNA CTD PMID:32028016 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO cyfluthrin results in increased expression of WNT5A mRNA CTD PMID:32028016 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Wnt7a Wnt family member 7A increases expression ISO cyfluthrin results in increased expression of WNT7A mRNA CTD PMID:32028016 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        agrochemical 14436
          cyfluthrin 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          cyclopropanecarboxylic acid 738
                                            3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid 618
                                              cyfluthrin 39
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.