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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:8-hydroxy-2'-deoxyguanosine
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Accession:CHEBI:40304 term browser browse the term
Definition:Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.
Synonyms:exact_synonym: 2'-deoxy-8-oxoguanosine
 related_synonym: 2'-deoxy-8-hydroxyguanosine;   7,8-Dihydro-2'-deoxy-8-oxoguanosine;   8-Hydroxydeoxyguanosine;   8-OHdG;   8-Oxo-2'-deoxyguanine;   8-Oxo-7,8-dihydro-2'-deoxyguanosine;   8-Oxo-7-hydrodeoxyguanosine;   8-Oxo-dG;   8-Oxoguanosine;   8-oxo-2'-dG;   Formula=C10H13N5O5;   InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1;   InChIKey=HCAJQHYUCKICQH-VPENINKCSA-N;   SMILES=Nc1nc2n([C@H]3C[C@H](O)[C@@H](CO)O3)c(O)nc2c(=O)[nH]1
 alt_id: CHEBI:61068
 xref: Beilstein:5994628;   CAS:88847-89-6;   DrugBank:DB02502
 xref_mesh: MESH:C067134
 xref: PDBeChem:8HG;   PMID:11559029;   PMID:20081197;   PMID:9778313;   Reaxys:4882818;   Reaxys:5994628;   Wikipedia:8-Oxo-2'-deoxyguanosine


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8-hydroxy-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance ISO AGT protein modified form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:30354818 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects abundance ISO APEX1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:26629949 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15576237 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects abundance ISO DNMT1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects abundance ISO DNMT3B gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Glrx glutaredoxin affects abundance ISO GLRX gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases abundance
ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
increases cleavage
ISO thymidine glycol inhibits the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine]; thymidine glycol promotes the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:19193190 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15488632 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects abundance ISO TXNRD1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 affects abundance ISO TXNRD2 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        indicator 8675
          biomarker 6446
            8-hydroxy-2'-deoxyguanosine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            heteroorganic entity 19257
                              organochalcogen compound 18964
                                organooxygen compound 18886
                                  carbohydrates and carbohydrate derivatives 12267
                                    carbohydrate 12267
                                      carbohydrate derivative 11894
                                        glycosyl compound 10944
                                          N-glycosyl compound 5483
                                            nucleoside 5345
                                              ribonucleoside 709
                                                purine ribonucleoside 603
                                                  guanosines 98
                                                    8-hydroxy-2'-deoxyguanosine 15
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