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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:8-hydroxy-2'-deoxyguanosine
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Accession:CHEBI:40304 term browser browse the term
Definition:Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.
Synonyms:exact_synonym: 2'-deoxy-8-oxoguanosine
 related_synonym: 2'-deoxy-8-hydroxyguanosine;   7,8-Dihydro-2'-deoxy-8-oxoguanosine;   8-Hydroxydeoxyguanosine;   8-OHdG;   8-Oxo-2'-deoxyguanine;   8-Oxo-7,8-dihydro-2'-deoxyguanosine;   8-Oxo-7-hydrodeoxyguanosine;   8-Oxo-dG;   8-Oxoguanosine;   8-oxo-2'-dG;   Formula=C10H13N5O5;   InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1;   InChIKey=HCAJQHYUCKICQH-VPENINKCSA-N;   SMILES=Nc1nc2n([C@H]3C[C@H](O)[C@@H](CO)O3)c(O)nc2c(=O)[nH]1
 alt_id: CHEBI:61068
 xref: Beilstein:5994628;   CAS:88847-89-6;   DrugBank:DB02502
 xref_mesh: MESH:C067134
 xref: PDBeChem:8HG;   PMID:11559029;   PMID:20081197;   PMID:9778313;   Reaxys:4882818;   Reaxys:5994628;   Wikipedia:8-Oxo-2'-deoxyguanosine



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8-hydroxy-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance ISO AGT protein modified form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:30354818 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects abundance ISO APEX1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:26629949 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15576237 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dnmt1 DNA methyltransferase 1 affects abundance
decreases activity
ISO DNMT1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine results in decreased activity of DNMT1 protein
CTD PMID:19896490 PMID:33052562 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects abundance ISO DNMT3B gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Glrx glutaredoxin affects abundance ISO GLRX gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases abundance
ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
increases cleavage
ISO thymidine glycol inhibits the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine]; thymidine glycol promotes the reaction [OGG1 protein results in increased cleavage of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:19193190 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15488632 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO PRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine] CTD PMID:27517622 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to 3,4-Methylenedioxyamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine] which results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:21163909 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects abundance ISO TXNRD1 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 affects abundance ISO TXNRD2 gene SNP affects the abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:19896490 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link

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  CHEBI ontology 19800
    role 19751
      application 19498
        indicator 8691
          biomarker 6473
            8-hydroxy-2'-deoxyguanosine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      carbohydrate derivative 11946
                                        glycosyl compound 10983
                                          N-glycosyl compound 5520
                                            nucleoside 5381
                                              ribonucleoside 684
                                                purine ribonucleoside 573
                                                  guanosines 36
                                                    8-hydroxy-2'-deoxyguanosine 15
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