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ONTOLOGY REPORT - ANNOTATIONS


Term:allopurinol
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Accession:CHEBI:40279 term browser browse the term
Definition:A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Synonyms:related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one;   1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one;   1H-Pyrazolo(3,4-d)pyrimidin-4-ol;   4'-Hydroxypyrazolol(3,4-d)pyrimidine;   4-HPP;   4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine;   4-Hydroxy-3,4-pyrazolopyrimidine;   4-Hydroxypyrazolo(3,4-d)pyrimidine;   4-Hydroxypyrazolopyrimidine;   4-Hydroxypyrazolyl(3,4-d)pyrimidine;   4H-Pyrazolo(3,4-d)pyrimidin-4-one;   AL-100;   Allopurinolum;   Alopurinol;   Formula=C5H4N4O;   InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10);   InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N;   SMILES=Oc1ncnc2[nH]ncc12;   Zyloprim (TN)
 alt_id: CHEBI:2601;   CHEBI:40276
 xref: Beilstein:608611 "Beilstein";   CAS:315-30-0 "ChemIDplus";   CAS:315-30-0 "KEGG DRUG";   CAS:315-30-0 "NIST Chemistry WebBook";   DrugBank:DB00437;   Drug_Central:124 "DrugCentral";   KEGG:D00224;   LINCS:LSM-5919
 xref_mesh: MESH:D000493
 xref: PMID:11333159 "Europe PMC";   PMID:16650385 "Europe PMC";   PMID:24395556 "Europe PMC";   PMID:24590210 "Europe PMC";   PMID:24591375 "Europe PMC";   PMID:7602118 "Europe PMC";   Reaxys:608611 "Reaxys";   Wikipedia:Allopurinol


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allopurinol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Adipor2 adiponectin receptor 2 JBrowse link 4 151,412,135 151,480,108 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Ckm creatine kinase, M-type JBrowse link 1 80,321,507 80,331,841 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Glul glutamate-ammonia ligase JBrowse link 13 71,331,052 71,340,207 RGD:6480464
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:6480464
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 JBrowse link 3 80,004,130 80,014,197 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slc22a12 solute carrier family 22 member 12 JBrowse link 1 221,910,787 221,919,277 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a4 solute carrier family 22 member 4 JBrowse link 10 39,334,972 39,373,508 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc2a9 solute carrier family 2 member 9 JBrowse link 14 77,067,537 77,192,702 RGD:6480464
G Slc5a3 solute carrier family 5 member 3 JBrowse link 11 32,229,366 32,231,812 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Umod uromodulin JBrowse link 1 189,186,027 189,199,939 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19596
    role 19539
      biological role 19537
        biochemical role 19055
          antimetabolite 8452
            allopurinol 65
              allopurinol riboside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19596
    subatomic particle 19592
      composite particle 19592
        hadron 19592
          baryon 19592
            nucleon 19592
              atomic nucleus 19592
                atom 19592
                  main group element atom 19471
                    p-block element atom 19471
                      carbon group element atom 19345
                        carbon atom 19337
                          organic molecular entity 19337
                            organic molecule 19254
                              organic cyclic compound 19041
                                organic heterocyclic compound 18111
                                  organic heteropolycyclic compound 17349
                                    organic heterobicyclic compound 15875
                                      mancude organic heterobicyclic parent 5038
                                        1H-pyrazolo[4,3-d]pyrimidine 65
                                          allopurinol 65
                                            allopurinol riboside 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.