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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allopurinol
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Accession:CHEBI:40279 term browser browse the term
Definition:A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Synonyms:related_synonym: 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one;   1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one;   1H-Pyrazolo(3,4-d)pyrimidin-4-ol;   4'-Hydroxypyrazolol(3,4-d)pyrimidine;   4-HPP;   4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine;   4-Hydroxy-3,4-pyrazolopyrimidine;   4-Hydroxypyrazolo(3,4-d)pyrimidine;   4-Hydroxypyrazolopyrimidine;   4-Hydroxypyrazolyl(3,4-d)pyrimidine;   4H-Pyrazolo(3,4-d)pyrimidin-4-one;   AL-100;   Allopurinolum;   Alopurinol;   Formula=C5H4N4O;   InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10);   InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N;   SMILES=Oc1ncnc2[nH]ncc12;   Zyloprim (TN)
 alt_id: CHEBI:2601;   CHEBI:40276
 xref: Beilstein:608611;   CAS:315-30-0;   DrugBank:DB00437;   Drug_Central:124;   KEGG:D00224;   LINCS:LSM-5919
 xref_mesh: MESH:D000493
 xref: PMID:11333159;   PMID:16650385;   PMID:24395556;   PMID:24590210;   PMID:24591375;   PMID:7602118;   Reaxys:608611;   Wikipedia:Allopurinol



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allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of ABCB11 mRNA CTD PMID:33749747 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ACADM mRNA]
Allopurinol results in increased expression of ACADM mRNA
CTD PMID:33749747 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ACOX1 mRNA]
Allopurinol results in increased expression of ACOX1 mRNA
CTD PMID:33749747 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] CTD PMID:21912612 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Agt angiotensinogen multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 PMID:19145780 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Allopurinol results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Allopurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Allopurinol results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression
multiple interactions
ISO Allopurinol results in decreased secretion of APOB protein
Allopurinol results in decreased expression of APOB mRNA
ursodoxicoltaurine inhibits the reaction [Allopurinol results in decreased secretion of APOB protein]
CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion
decreases expression
ISO Allopurinol results in decreased secretion of APOC3 protein
Allopurinol results in decreased expression of APOC3 mRNA
CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Allopurinol results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Allopurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]
CTD PMID:22426011 PMID:23647015 PMID:24491314 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cat catalase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of CAT protein] CTD PMID:12566098 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO
EXP
Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
Allopurinol inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]
CTD PMID:15689417 PMID:19158351 PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Cd36 CD36 molecule increases expression
decreases expression
EXP
ISO
Allopurinol results in increased expression of CD36 mRNA
Allopurinol results in decreased expression of CD36 mRNA
CTD PMID:28138970 PMID:32535746 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein] CTD PMID:22648416 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Ckm creatine kinase, M-type decreases secretion EXP Allopurinol results in decreased secretion of CKM protein CTD PMID:21912612 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CPT2 mRNA] CTD PMID:33749747 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of CYP7A1 mRNA CTD PMID:33749747 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of CYP8B1 mRNA CTD PMID:33749747 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Allopurinol results in increased expression of DDIT3 mRNA CTD PMID:32535746 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Allopurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Allopurinol results in increased expression of ERN1 mRNA CTD PMID:32535746 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN protein]
CTD PMID:23647015 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein] CTD PMID:22648416 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Allopurinol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein] CTD PMID:24491314 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GPX2 mRNA CTD PMID:33749747 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of GSR protein] CTD PMID:12566098 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTA1 mRNA CTD PMID:33749747 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTA1 mRNA CTD PMID:33749747 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTM3 mRNA CTD PMID:33749747 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of HADHA mRNA] CTD PMID:33749747 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Allopurinol results in increased expression of HMOX1 mRNA
CTD PMID:20888885 PMID:22659318 PMID:25091725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Allopurinol results in increased expression of HSPA5 mRNA CTD PMID:32535746 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein] CTD PMID:28949055 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein] CTD PMID:24491314 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011 PMID:23647015 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Allopurinol results in decreased expression of IL1B mRNA
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of IL1B mRNA
Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
CTD PMID:7695923 PMID:22426011 PMID:23647015 PMID:24491314 PMID:33749747 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]
Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
CTD PMID:15689417 PMID:21912612 PMID:22426011 PMID:23867654 PMID:33749747 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 PMID:24491314 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lep leptin multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Allopurinol results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK1 protein]
CTD PMID:26641773 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Allopurinol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Allopurinol results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK3 protein]
CTD PMID:26641773 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Allopurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:12566098 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Allopurinol results in decreased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Allopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]
Allopurinol inhibits the reaction [Oxonic Acid affects the localization of NFAT5 protein]
CTD PMID:23867654 PMID:30651350 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein] CTD PMID:24491314 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]
CTD PMID:22426011 PMID:23647015 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NOS2 mRNA CTD PMID:33749747 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Allopurinol inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]] CTD PMID:21912612 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NQO1 mRNA CTD PMID:33749747 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NR0B2 mRNA CTD PMID:33749747 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein] CTD PMID:23647015 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Allopurinol results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO
EXP
Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]
Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of PPARA protein]
Allopurinol results in increased expression of PPARA protein
Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]
CTD PMID:22426011 PMID:23647015 PMID:33749747 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein] CTD PMID:22426011 PMID:23647015 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]
CTD PMID:24491314 PMID:28949055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Allopurinol inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:33749747 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]
CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]
CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]
CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:21909718 PMID:22865646 NCBI chr10:38,133,333...38,179,932 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]
CTD PMID:21909718 PMID:22426011 PMID:22865646 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]
CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake
ISO SLC22A7 protein results in increased transport of Allopurinol
SLC22A7 protein results in increased uptake of Allopurinol
CTD PMID:12065749 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Allopurinol CTD PMID:15100168 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of SLC51B mRNA CTD PMID:33749747 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]] CTD PMID:23867654 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of SLCO1B2 mRNA CTD PMID:33749747 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]
CTD PMID:23647015 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]
CTD PMID:23647015 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] CTD PMID:18322232 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]] CTD PMID:21912612 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Allopurinol affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO Allopurinol results in decreased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor increases chemical synthesis
multiple interactions
increases expression
ISO
EXP
TNF protein results in increased chemical synthesis of Allopurinol
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF mRNA; [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF protein
Allopurinol results in increased expression of TNF mRNA
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of TNF mRNA]
Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]
CTD PMID:7695923 PMID:22426011 PMID:26641773 PMID:28949055 PMID:33749747 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO
EXP
Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]
CTD PMID:23647015 PMID:24491314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Umod uromodulin multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA] CTD PMID:21909718 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
G Xdh xanthine dehydrogenase decreases activity
multiple interactions
affects activity
ISO
EXP
Allopurinol results in decreased activity of XDH protein
Allopurinol inhibits the reaction [[Streptozocin affects the activity of XDH protein] which results in increased chemical synthesis of Hydrogen Peroxide]; Allopurinol inhibits the reaction [Indomethacin results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Streptozocin affects the activity of XDH protein]; Allopurinol inhibits the reaction [XDH protein results in increased oxidation of Quinoxalines]
Allopurinol affects the activity of XDH protein
[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of XDH mRNA; Allopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]
CTD PMID:1447108 PMID:3677084 PMID:8891675 PMID:12115777 PMID:12566098 More... NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          antimetabolite 8526
            allopurinol 95
              allopurinol riboside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organic heteropolycyclic compound 18067
                                    organic heterobicyclic compound 16872
                                      mancude organic heterobicyclic parent 5409
                                        1H-pyrazolo[4,3-d]pyrimidine 95
                                          allopurinol 95
                                            allopurinol riboside 0
paths to the root