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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Cyclopamine
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Accession:CHEBI:4021 term browser browse the term
Definition:A piperidine that has formula C27H41NO2.
Synonyms:related_synonym: Formula=C27H41NO2;   InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1;   InChIKey=QASFUMOKHFSJGL-LAFRSMQTSA-N;   SMILES=C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
 xref: CAS:4449-51-8;   KEGG:C10798;   KNApSAcK:C00002245
 xref_mesh: MESH:C000541



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Cyclopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase increases expression ISO cyclopamine results in increased expression of ABHD12 mRNA CTD PMID:33168583 NCBI chr 3:139,659,315...139,719,529
Ensembl chr 3:139,659,317...139,719,564
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO cyclopamine results in increased expression of ABHD4 mRNA CTD PMID:33168583 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase increases expression ISO cyclopamine results in increased expression of ABHD6 mRNA CTD PMID:33168583 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of AR] CTD PMID:26710974 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 increases expression ISO cyclopamine results in increased expression of ARG1 mRNA CTD PMID:30578886 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP cyclopamine results in decreased expression of ASCL1 mRNA CTD PMID:21703336 NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]] CTD PMID:27481074 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO
EXP
cyclopamine inhibits the reaction [polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; cyclopamine promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]
cyclopamine inhibits the reaction [hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]
CTD PMID:27481074 PMID:31326407 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]] CTD PMID:27481074 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]] CTD PMID:27481074 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 decreases expression
increases response to substance
ISO cyclopamine results in decreased expression of CCNE1 protein
CCNE1 protein results in increased susceptibility to cyclopamine
CTD PMID:22923130 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd86 CD86 molecule decreases expression ISO cyclopamine results in decreased expression of CD86 mRNA CTD PMID:30578886 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO cyclopamine results in increased expression of CNR1 mRNA; cyclopamine results in increased expression of CNR1 protein CTD PMID:33168583 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Dagla diacylglycerol lipase, alpha increases expression ISO cyclopamine results in increased expression of DAGLA mRNA CTD PMID:33168583 NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases expression ISO cyclopamine results in decreased expression of DIO3 mRNA CTD PMID:26825960 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dlx1 distal-less homeobox 1 decreases expression ISO cyclopamine results in decreased expression of DLX1 mRNA CTD PMID:20865013 NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO cyclopamine results in increased expression of FAAH mRNA CTD PMID:33168583 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression ISO cyclopamine results in decreased expression of GAD2 mRNA CTD PMID:20865013 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
affects expression
multiple interactions
ISO
EXP
cyclopamine results in decreased expression of GLI1 mRNA; cyclopamine results in decreased expression of GLI1 protein
cyclopamine affects the expression of GLI1 protein
cyclopamine inhibits the reaction [Resveratrol results in increased expression of GLI1 protein]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 protein]
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SAG compound results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
CTD PMID:20032413 PMID:20179202 PMID:20395211 PMID:20434536 PMID:21110116 More... NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression EXP cyclopamine results in decreased expression of GLI2 mRNA CTD PMID:21703336 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Hes5 hes family bHLH transcription factor 5 decreases expression EXP cyclopamine results in decreased expression of HES5 mRNA CTD PMID:21703336 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression EXP cyclopamine results in decreased expression of ID3 mRNA CTD PMID:21703336 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases response to substance ISO IGFBP6 mutant form results in increased susceptibility to cyclopamine CTD PMID:22923130 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
JBrowse link
G Il10 interleukin 10 increases expression ISO cyclopamine results in increased expression of IL10 mRNA CTD PMID:30578886 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO cyclopamine results in decreased expression of IL1B mRNA CTD PMID:30578886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO cyclopamine results in increased expression of IL6 mRNA CTD PMID:30578886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP cyclopamine inhibits the reaction [resveratrol results in increased expression of MAP2 protein] CTD PMID:24464877 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO cyclopamine results in decreased expression of MKI67 protein CTD PMID:22923130 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression ISO cyclopamine results in increased expression of MRC1 mRNA CTD PMID:30578886 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression ISO cyclopamine results in decreased expression of NKX2-1 mRNA CTD PMID:20865013 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO cyclopamine results in decreased expression of NOS2 mRNA CTD PMID:30578886 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 multiple interactions
decreases cleavage
ISO [2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with cyclopamine] results in decreased expression of and results in decreased cleavage of NOTCH1 protein; [cyclopamine co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein; cyclopamine results in decreased expression of and results in decreased cleavage of NOTCH1 protein
cyclopamine results in decreased cleavage of NOTCH1 protein
CTD PMID:21498710 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO cyclopamine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ptch1 patched 1 multiple interactions
decreases expression
EXP
ISO
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]
cyclopamine results in decreased expression of PTCH1 mRNA
mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in decreased expression of PTCH1 mRNA]
CTD PMID:21110116 PMID:26710974 PMID:27481074 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Retnlb resistin like beta increases expression ISO cyclopamine results in increased expression of RETNLB mRNA CTD PMID:30578886 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions
decreases expression
EXP
ISO
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH protein]
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
cyclopamine results in decreased expression of SHH mRNA
CTD PMID:20395211 PMID:20434536 PMID:20865013 PMID:21110116 PMID:24388991 More... NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Smo smoothened, frizzled class receptor increases expression
multiple interactions
ISO
EXP
cyclopamine results in increased expression of SMO mRNA
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein]
cyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO protein]
mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA]
CTD PMID:24388991 PMID:24464877 PMID:26710974 PMID:27481074 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO cyclopamine inhibits the reaction [N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA]; cyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA] CTD PMID:25487280 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      biological role 19989
        inhibitor 18758
          glioma-associated oncogene inhibitor 3309
            Cyclopamine 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic molecule 19798
                              organic cyclic compound 19560
                                organic heterocyclic compound 18776
                                  organic heteromonocyclic compound 17161
                                    piperidines 7678
                                      Cyclopamine 38
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