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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Cyclopamine
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Accession:CHEBI:4021 term browser browse the term
Definition:A piperidine that has formula C27H41NO2.
Synonyms:related_synonym: Formula=C27H41NO2;   InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1;   InChIKey=QASFUMOKHFSJGL-LAFRSMQTSA-N;   SMILES=C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
 xref: CAS:4449-51-8;   KEGG:C10798;   KNApSAcK:C00002245
 xref_mesh: MESH:C000541


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Cyclopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
increases expression
ISO mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of AR] CTD PMID:26710974 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 increases expression ISO cyclopamine results in increased expression of ARG1 mRNA CTD PMID:30578886 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP cyclopamine results in decreased expression of ASCL1 mRNA CTD PMID:21703336 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]] CTD PMID:27481074 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO
EXP
cyclopamine inhibits the reaction [polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; cyclopamine promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]
cyclopamine inhibits the reaction [hyperoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]]
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]
CTD PMID:27481074 PMID:31326407 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]] CTD PMID:27481074 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]] CTD PMID:27481074 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 decreases expression
increases response to substance
ISO cyclopamine results in decreased expression of CCNE1 protein
CCNE1 protein results in increased susceptibility to cyclopamine
CTD PMID:22923130 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd86 CD86 molecule decreases expression ISO cyclopamine results in decreased expression of CD86 mRNA CTD PMID:30578886 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases expression ISO cyclopamine results in decreased expression of DIO3 mRNA CTD PMID:26825960 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dlx1 distal-less homeobox 1 decreases expression ISO cyclopamine results in decreased expression of DLX1 mRNA CTD PMID:20865013 NCBI chr 3:58,164,931...58,169,521
Ensembl chr 3:58,164,931...58,169,521
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression ISO cyclopamine results in decreased expression of GAD2 mRNA CTD PMID:20865013 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression
affects expression
multiple interactions
ISO
EXP
cyclopamine results in decreased expression of GLI1 mRNA; cyclopamine results in decreased expression of GLI1 protein
cyclopamine affects the expression of GLI1 protein
cyclopamine inhibits the reaction [Resveratrol results in increased expression of GLI1 protein]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of GLI1 protein]
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SAG compound results in increased expression of GLI1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
CTD PMID:20032413 PMID:20179202 PMID:20395211 PMID:20434536 PMID:21110116 PMID:21703336 PMID:22923130 PMID:24388991 PMID:24464877 PMID:27481074 PMID:31642701 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression EXP cyclopamine results in decreased expression of GLI2 mRNA CTD PMID:21703336 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Hes5 hes family bHLH transcription factor 5 decreases expression EXP cyclopamine results in decreased expression of HES5 mRNA CTD PMID:21703336 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression EXP cyclopamine results in decreased expression of ID3 mRNA CTD PMID:21703336 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases response to substance ISO IGFBP6 mutant form results in increased susceptibility to cyclopamine CTD PMID:22923130 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Il10 interleukin 10 increases expression ISO cyclopamine results in increased expression of IL10 mRNA CTD PMID:30578886 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO cyclopamine results in decreased expression of IL1B mRNA CTD PMID:30578886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO cyclopamine results in increased expression of IL6 mRNA CTD PMID:30578886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP cyclopamine inhibits the reaction [resveratrol results in increased expression of MAP2 protein] CTD PMID:24464877 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO cyclopamine results in decreased expression of MKI67 protein CTD PMID:22923130 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression ISO cyclopamine results in increased expression of MRC1 mRNA CTD PMID:30578886 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression ISO cyclopamine results in decreased expression of NKX2-1 mRNA CTD PMID:20865013 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO cyclopamine results in decreased expression of NOS2 mRNA CTD PMID:30578886 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 multiple interactions
decreases cleavage
ISO [2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide co-treated with cyclopamine] results in decreased expression of and results in decreased cleavage of NOTCH1 protein; [cyclopamine co-treated with 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide] results in decreased cleavage of NOTCH1 protein; cyclopamine results in decreased expression of and results in decreased cleavage of NOTCH1 protein
cyclopamine results in decreased cleavage of NOTCH1 protein
CTD PMID:21498710 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO cyclopamine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ptch1 patched 1 multiple interactions
decreases expression
EXP
ISO
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PTCH1 protein]
cyclopamine results in decreased expression of PTCH1 mRNA
mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in decreased expression of PTCH1 mRNA]
CTD PMID:21110116 PMID:26710974 PMID:27481074 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Retnlb resistin like beta increases expression ISO cyclopamine results in increased expression of RETNLB mRNA CTD PMID:30578886 NCBI chr11:54,565,471...54,567,578
Ensembl chr11:54,565,472...54,567,357
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions
decreases expression
EXP
ISO
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH protein]
cyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]
cyclopamine results in decreased expression of SHH mRNA
CTD PMID:20395211 PMID:20434536 PMID:20865013 PMID:21110116 PMID:24388991 PMID:27481074 PMID:31642701 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Smo smoothened, frizzled class receptor increases expression
multiple interactions
ISO
EXP
cyclopamine results in increased expression of SMO mRNA
cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein]
cyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO protein]
mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA]
CTD PMID:24388991 PMID:24464877 PMID:26710974 PMID:27481074 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO cyclopamine inhibits the reaction [N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of UCP1 mRNA]; cyclopamine inhibits the reaction [tofacitinib results in increased expression of UCP1 mRNA] CTD PMID:25487280 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link

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  CHEBI ontology 19875
    role 19825
      biological role 19825
        inhibitor 18304
          glioma-associated oncogene inhibitor 3262
            Cyclopamine 32
Path 2
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteromonocyclic compound 16621
                                    piperidines 7567
                                      Cyclopamine 32
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