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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-amino-1,8-naphthalimide
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Accession:CHEBI:40071 term browser browse the term
Definition:A benzoisoquinoline that has formula C12H8N2O2.
Synonyms:related_synonym: 4-aminonaphthalene-1,8-dicarboximide;   4-aminonaphthalimide;   6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE;   6-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione;   Formula=C12H8N2O2;   InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16);   InChIKey=SSMIFVHARFVINF-UHFFFAOYSA-N;   SMILES=Nc1ccc2C(=O)NC(=O)c3cccc1c23
 alt_id: CHEBI:36675;   CHEBI:40064
 xref: CAS:1742-95-6;   DrugBank:DB07096;   LINCS:LSM-3103
 xref_mesh: MESH:C086538
 xref: PDBeChem:4AN



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4-amino-1,8-naphthalimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase multiple interactions
affects response to substance
increases phosphorylation
ISO ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to 4-amino-1,8-naphthalimide
CTD PMID:16556909 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin affects the localization of BAX protein] CTD PMID:15456408 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:25972196 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 4-amino-1,8-naphthalimide promotes the reaction [arsenic trioxide results in increased expression of CASP3 protein]; 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
4-amino-1,8-naphthalimide results in increased activity of CASP3 protein
CTD PMID:15456408 PMID:18695944 PMID:25499136 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 mRNA]; 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 protein] CTD PMID:25499136 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO 4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein
PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]
CTD PMID:16556909 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of NOS2 protein] CTD PMID:25972196 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
decreases activity
ISO 4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein]
4-amino-1,8-naphthalimide results in decreased expression of PARP1 protein
ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]
CTD PMID:15456408 PMID:16556909 PMID:25499136 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit affects response to substance
multiple interactions
ISO PRKDC protein affects the susceptibility to 4-amino-1,8-naphthalimide
PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]
CTD PMID:16556909 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide affects the localization of RELA protein] CTD PMID:25972196 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 affects response to substance ISO XRCC5 protein affects the susceptibility to 4-amino-1,8-naphthalimide CTD PMID:16556909 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
lucifer yellow dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
increases uptake
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] CTD PMID:31348918 PMID:32305507 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  benzoisoquinoline 12
                    4-amino-1,8-naphthalimide 12
                      lucifer yellow anion + 1
                      lucifer yellow dye 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterotricyclic compound 14639
                                      benzoisoquinoline 12
                                        4-amino-1,8-naphthalimide 12
                                          lucifer yellow anion + 1
                                          lucifer yellow dye 1
paths to the root