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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-amino-1,8-naphthalimide
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Accession:CHEBI:40071 term browser browse the term
Definition:A benzoisoquinoline that has formula C12H8N2O2.
Synonyms:related_synonym: 4-aminonaphthalene-1,8-dicarboximide;   4-aminonaphthalimide;   6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE;   6-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione;   Formula=C12H8N2O2;   InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16);   InChIKey=SSMIFVHARFVINF-UHFFFAOYSA-N;   SMILES=Nc1ccc2C(=O)NC(=O)c3cccc1c23
 alt_id: CHEBI:36675;   CHEBI:40064
 xref: CAS:1742-95-6;   DrugBank:DB07096;   LINCS:LSM-3103
 xref_mesh: MESH:C086538
 xref: PDBeChem:4AN


show annotations for term's descendants           Sort by:
4-amino-1,8-naphthalimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
affects response to substance		 ISO ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to 4-amino-1,8-naphthalimide		 CTD PMID:16556909 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin affects the localization of BAX protein] CTD PMID:15456408 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:25972196 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO 4-amino-1,8-naphthalimide promotes the reaction [arsenic trioxide results in increased expression of CASP3 protein]; 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
4-amino-1,8-naphthalimide results in increased activity of CASP3 protein		 CTD PMID:15456408 PMID:18695944 PMID:25499136 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 mRNA]; 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 protein] CTD PMID:25499136 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions		 ISO 4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein
PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]		 CTD PMID:16556909 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of NOS2 protein] CTD PMID:25972196 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases activity
decreases expression		 ISO 4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein]
4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein
ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]
4-amino-1,8-naphthalimide results in decreased expression of PARP1 protein		 CTD PMID:15456408 PMID:16556909 PMID:25499136 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit affects response to substance
multiple interactions		 ISO PRKDC protein affects the susceptibility to 4-amino-1,8-naphthalimide
PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]		 CTD PMID:16556909 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide affects the localization of RELA protein] CTD PMID:25972196 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 affects response to substance ISO XRCC5 protein affects the susceptibility to 4-amino-1,8-naphthalimide CTD PMID:16556909 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
lucifer yellow dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
increases uptake		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] CTD PMID:31348918 PMID:32305507 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      atom 19919
        nonmetal atom 19848
          nitrogen atom 19027
            nitrogen molecular entity 19027
              organonitrogen compound 18877
                organonitrogen heterocyclic compound 18184
                  benzoisoquinoline 12
                    4-amino-1,8-naphthalimide 12
                      lucifer yellow anion + 1
                      lucifer yellow dye 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organic heteropolycyclic compound 18316
                                    organic heterotricyclic compound 15655
                                      benzoisoquinoline 12
                                        4-amino-1,8-naphthalimide 12
                                          lucifer yellow anion + 1
                                          lucifer yellow dye 1
paths to the root