CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amprenavir
Accession: CHEBI:40050
browse the term
Definition: A tetrahydrofuryl ester that has formula C25H35N3O6S.
Synonyms: related_synonym: (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate; (3S)-tetrahydrofuran-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-hydroxypropyl]carbamate; Agenerase; Formula=C25H35N3O6S; InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1; InChIKey=YMARZQAQMVYCKC-OEMFJLHTSA-N; SMILES=CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
alt_id: CHEBI:2684; CHEBI:40043
xref: Beilstein:10126027; CAS:161814-49-9; DrugBank:DB00701; Drug_Central:200; KEGG:C08086; KEGG:D00894
xref_mesh: MESH:C095108
xref: Wikipedia:Amprenavir
G
Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
amprenavir results in decreased activity of ABCB11 protein
CTD
PMID:20829430
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
increases transport affects binding multiple interactions
ISO
ABCB1 protein results in increased transport of amprenavir amprenavir binds to ABCB1 protein [Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of amprenavir
CTD
PMID:23976943
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
amprenavir results in increased expression of CCL2 protein
CTD
PMID:17668557
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3
C-C motif chemokine ligand 3
increases expression
ISO
amprenavir results in increased expression of CCL3 protein
CTD
PMID:17668557
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
amprenavir results in decreased activity of CYP3A4 protein
CTD
PMID:15523003
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of amprenavir]
CTD
PMID:18799805
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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