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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amitrole
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Accession:CHEBI:40036 term browser browse the term
Definition:A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Synonyms:exact_synonym: 1H-1,2,4-triazol-3-amine
 related_synonym: 1H-1,2,4-triazol-3-ylamine;   3-AT;   3-Amino-1,2,4-triazole;   3-amino-s-triazole;   Aminotriazole;   Formula=C2H4N4;   InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6);   InChIKey=KLSJWNVTNUYHDU-UHFFFAOYSA-N;   SMILES=N1N=C(N=C1)N
 alt_id: CHEBI:1448;   CHEBI:40029
 xref: Beilstein:107687;   CAS:61-82-5;   Gmelin:200706;   KEGG:C11261;   LINCS:LSM-4595
 xref_mesh: MESH:D000640
 xref: MetaCyc:CPD0-1491;   PDBeChem:3TR;   PMID:11673067;   PMID:17549540;   PMID:25820916;   PMID:7546330;   PMID:7986209;   PPDB:31;   Patent:AU2012202062;   Patent:WO2007147209;   Pesticides:amitrole;   Reaxys:107687;   Wikipedia:Amitrole


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amitrole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein] CTD PMID:21266531 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein] CTD PMID:25891026 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G App amyloid beta precursor protein affects activity EXP Amitrole affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Amitrole results in increased activity of CASP3 protein
Amitrole inhibits the reaction [Cadmium results in increased degradation of CASP3 protein]
CTD PMID:12538343 PMID:20417273 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
affects activity
affects binding
ISO
EXP
[Amitrole results in decreased activity of CAT protein] which results in increased abundance of Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite; ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein]
[Amitrole results in decreased activity of CAT protein] which results in decreased susceptibility to BMS 191095; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Amitrole affects the reaction [Ethanol affects the expression of CAT protein]; Amitrole inhibits the reaction [pirinixic acid results in increased activity of CAT protein]
Amitrole affects the activity of CAT protein
Amitrole binds to CAT protein
CTD PMID:8947833 PMID:9569045 PMID:9635878 PMID:10382262 PMID:10468195 PMID:10961904 PMID:12423650 PMID:12427601 PMID:12621067 PMID:15234257 PMID:15935206 PMID:16204253 PMID:16407272 PMID:17597214 PMID:18212794 PMID:18234233 PMID:18930813 PMID:21266531 PMID:24717679 PMID:31162603 PMID:31550440 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Amitrole results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] CTD PMID:25891026 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
multiple interactions
increases expression
ISO Amitrole results in increased activity of CYP2A5 protein
heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein]
Amitrole results in increased expression of CYP2A5 mRNA; Amitrole results in increased expression of CYP2A5 protein
CTD PMID:7543189 PMID:9698299 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Amitrole inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11353799 PMID:14722249 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Amitrole results in decreased activity of CYP2E1 protein CTD PMID:12464242 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Endog endonuclease G decreases activity EXP Amitrole results in decreased activity of ENDOG protein CTD PMID:16407272 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Epo erythropoietin multiple interactions ISO [Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein CTD PMID:7980410 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein] CTD PMID:25891026 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein] CTD PMID:25820916 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Amitrole results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein] CTD PMID:25820916 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Amitrole results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Amitrole results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of IL10 protein] CTD PMID:25891026 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of IL1B protein] CTD PMID:25891026 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amitrole inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein] CTD PMID:25820916 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb5 integrin subunit beta 5 decreases expression ISO Amitrole results in decreased expression of ITGB5 mRNA CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Amitrole results in decreased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Amitrole inhibits the reaction [dihydrocapsaicin results in increased expression of MAP1LC3A protein] CTD PMID:18818525 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA] CTD PMID:24964743 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO Amitrole results in decreased expression of MUC5AC mRNA CTD PMID:17512462 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor affects activity EXP Amitrole affects the activity of NGF protein CTD PMID:15935206 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of NOX4 protein] CTD PMID:25891026 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO Amitrole results in decreased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tg thyroglobulin increases expression
decreases secretion
EXP Amitrole results in increased expression of TG mRNA
Amitrole results in decreased secretion of TG protein
CTD PMID:20937625 NCBI chr 7:107,467,260...107,652,897
Ensembl chr 7:107,467,260...107,652,899
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein] CTD PMID:25891026 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
EXP
ISO
Amitrole results in decreased susceptibility to TNF protein
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]
CTD PMID:12775721 PMID:25820916 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP
ISO
Amitrole results in decreased activity of TPO protein CTD PMID:20937625 PMID:31629072 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA CTD PMID:18930813 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      application 19403
        pesticide 16582
          herbicide 11815
            amitrole 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        aromatic amine 13683
                                          amitrole 40
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