CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amitrole
Accession: CHEBI:40036
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Definition: A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Synonyms: exact_synonym: 1H-1,2,4-triazol-3-amine
related_synonym: 1H-1,2,4-triazol-3-ylamine; 3-AT; 3-Amino-1,2,4-triazole; 3-amino-s-triazole; Aminotriazole; Formula=C2H4N4; InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6); InChIKey=KLSJWNVTNUYHDU-UHFFFAOYSA-N; SMILES=N1N=C(N=C1)N
alt_id: CHEBI:1448; CHEBI:40029
xref: Beilstein:107687; CAS:61-82-5; Gmelin:200706; KEGG:C11261; LINCS:LSM-4595
xref_mesh: MESH:D000640
xref: MetaCyc:CPD0-1491; PDBeChem:3TR; PMID:11673067; PMID:17549540; PMID:25820916; PMID:7546330; PMID:7986209; PPDB:31; Patent:AU2012202062; Patent:WO2007147209; Pesticides:amitrole; Reaxys:107687; Wikipedia:Amitrole
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Abcb6
ATP binding cassette subfamily B member 6
multiple interactions
ISO
ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein]
CTD
PMID:21266531
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Ace
angiotensin I converting enzyme
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein]
CTD
PMID:25891026
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Agt
angiotensinogen
multiple interactions decreases expression
EXP
Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] Amitrole results in decreased expression of AGT mRNA
CTD
PMID:10712386 PMID:34757178
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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App
amyloid beta precursor protein
affects activity
EXP
Amitrole affects the activity of APP protein
CTD
PMID:16204253
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Casp3
caspase 3
increases activity multiple interactions
ISO
Amitrole results in increased activity of CASP3 protein Amitrole inhibits the reaction [Cadmium results in increased degradation of CASP3 protein]
CTD
PMID:12538343 PMID:20417273
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions affects binding affects activity decreases activity
ISO EXP
[Amitrole results in decreased activity of CAT protein] which results in increased abundance of Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite; ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein] Amitrole binds to CAT protein Amitrole affects the activity of CAT protein [Amitrole results in decreased activity of CAT protein] which results in decreased susceptibility to BMS 191095; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Amitrole affects the reaction [Ethanol affects the expression of CAT protein]; Amitrole inhibits the reaction [pirinixic acid results in increased activity of CAT protein]
CTD
PMID:8947833 PMID:9569045 PMID:9635878 PMID:10382262 PMID:10468195 PMID:10961904 PMID:12423650 PMID:12427601 PMID:12621067 PMID:15234257 PMID:15935206 PMID:16204253 PMID:16407272 PMID:17597214 PMID:18212794 PMID:18234233 PMID:18930813 PMID:21266531 PMID:24717679 PMID:31162603 PMID:31550440 More...
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Amitrole results in decreased expression of CCL2 mRNA
CTD
PMID:23397585
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cybb
cytochrome b-245 beta chain
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein]
CTD
PMID:25891026
NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586
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Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
increases activity increases expression multiple interactions
ISO
Amitrole results in increased activity of CYP2A5 protein Amitrole results in increased expression of CYP2A5 mRNA; Amitrole results in increased expression of CYP2A5 protein heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein]
CTD
PMID:7543189 PMID:9698299
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions
EXP
Amitrole inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]
CTD
PMID:11353799 PMID:14722249
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Amitrole results in decreased activity of CYP2E1 protein
CTD
PMID:12464242
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Endog
endonuclease G
decreases activity
EXP
Amitrole results in decreased activity of ENDOG protein
CTD
PMID:16407272
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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Epo
erythropoietin
multiple interactions
ISO
[Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein
CTD
PMID:7980410
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Gad1
glutamate decarboxylase 1
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein]
CTD
PMID:25891026
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gjb6
gap junction protein, beta 6
decreases expression
EXP
Amitrole results in decreased expression of GJB6 mRNA
CTD
PMID:34757178
NCBI chr15:31,284,562...31,295,010
Ensembl chr15:31,284,419...31,294,582
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Gsta1
glutathione S-transferase alpha 1
multiple interactions
EXP
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein]
CTD
PMID:25820916
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Gulp1
GULP PTB domain containing engulfment adaptor 1
increases expression
ISO
Amitrole results in increased expression of GULP1 mRNA
CTD
PMID:23397585
NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005
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Hmox1
heme oxygenase 1
multiple interactions
EXP
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein]
CTD
PMID:25820916
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hopx
HOP homeobox
decreases expression
EXP
Amitrole results in decreased expression of HOPX mRNA
CTD
PMID:34757178
NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
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Hr
HR, lysine demethylase and nuclear receptor corepressor
decreases expression
EXP
Amitrole results in decreased expression of HR mRNA
CTD
PMID:34757178
NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
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Id2
inhibitor of DNA binding 2
decreases expression
ISO
Amitrole results in decreased expression of ID2 mRNA
CTD
PMID:23397585
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Id3
inhibitor of DNA binding 3, HLH protein
decreases expression
ISO
Amitrole results in decreased expression of ID3 mRNA
CTD
PMID:23397585
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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Il10
interleukin 10
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of IL10 protein]
CTD
PMID:25891026
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of IL1B protein]
CTD
PMID:25891026
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]
CTD
PMID:25820916
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb5
integrin subunit beta 5
decreases expression
ISO
Amitrole results in decreased expression of ITGB5 mRNA
CTD
PMID:23397585
NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
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Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
EXP
Amitrole results in decreased expression of ITIH3 mRNA
CTD
PMID:34757178
NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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Klf9
Kruppel-like factor 9
decreases expression
ISO EXP
Amitrole results in decreased expression of KLF9 mRNA
CTD
PMID:23397585 PMID:34757178
NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
multiple interactions
ISO
Amitrole inhibits the reaction [dihydrocapsaicin results in increased expression of MAP1LC3A protein]
CTD
PMID:18818525
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
CTD
PMID:10464329
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA]
CTD
PMID:24964743
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA]
CTD
PMID:24964743
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mog
myelin oligodendrocyte glycoprotein
decreases expression
EXP
Amitrole results in decreased expression of MOG mRNA
CTD
PMID:34757178
NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
decreases expression
ISO
Amitrole results in decreased expression of MUC5AC mRNA
CTD
PMID:17512462
NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein]
CTD
PMID:10712386
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngf
nerve growth factor
affects activity
EXP
Amitrole affects the activity of NGF protein
CTD
PMID:15935206
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nox4
NADPH oxidase 4
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of NOX4 protein]
CTD
PMID:25891026
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Pvalb
parvalbumin
decreases expression
EXP
Amitrole results in decreased expression of PVALB mRNA
CTD
PMID:34757178
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Sod2
superoxide dismutase 2
multiple interactions
ISO
[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
CTD
PMID:10464329
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Tbx3
T-box transcription factor 3
decreases expression
ISO
Amitrole results in decreased expression of TBX3 mRNA
CTD
PMID:23397585
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
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Tfrc
transferrin receptor
multiple interactions
ISO
Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]
CTD
PMID:24964743
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tg
thyroglobulin
increases expression decreases secretion
EXP
Amitrole results in increased expression of TG mRNA Amitrole results in decreased secretion of TG protein
CTD
PMID:20937625
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Th
tyrosine hydroxylase
multiple interactions
EXP
Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein]
CTD
PMID:25891026
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
decreases response to substance multiple interactions
EXP ISO
Amitrole results in decreased susceptibility to TNF protein Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]
CTD
PMID:12775721 PMID:25820916
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tpo
thyroid peroxidase
decreases activity
EXP ISO
Amitrole results in decreased activity of TPO protein
CTD
PMID:20937625 PMID:31629072
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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Tshb
thyroid stimulating hormone subunit beta
increases expression
EXP
Amitrole results in increased expression of TSHB protein
CTD
PMID:34757178
NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
[Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA
CTD
PMID:18930813
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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