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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amitrole
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Accession:CHEBI:40036 term browser browse the term
Definition:A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Synonyms:exact_synonym: 1H-1,2,4-triazol-3-amine
 related_synonym: 1H-1,2,4-triazol-3-ylamine;   3-AT;   3-Amino-1,2,4-triazole;   3-amino-s-triazole;   Aminotriazole;   Formula=C2H4N4;   InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6);   InChIKey=KLSJWNVTNUYHDU-UHFFFAOYSA-N;   SMILES=N1N=C(N=C1)N
 alt_id: CHEBI:1448;   CHEBI:40029
 xref: Beilstein:107687;   CAS:61-82-5;   Gmelin:200706;   KEGG:C11261;   LINCS:LSM-4595
 xref_mesh: MESH:D000640
 xref: MetaCyc:CPD0-1491;   PDBeChem:3TR;   PMID:11673067;   PMID:17549540;   PMID:25820916;   PMID:7546330;   PMID:7986209;   PPDB:31;   Patent:AU2012202062;   Patent:WO2007147209;   Pesticides:amitrole;   Reaxys:107687;   Wikipedia:Amitrole


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amitrole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein] CTD PMID:21266531 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of ACE protein] CTD PMID:25891026 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression		 EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein]
Amitrole results in decreased expression of AGT mRNA		 CTD PMID:10712386 PMID:34757178 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G App amyloid beta precursor protein affects activity EXP Amitrole affects the activity of APP protein CTD PMID:16204253 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Amitrole results in increased activity of CASP3 protein
Amitrole inhibits the reaction [Cadmium results in increased degradation of CASP3 protein]		 CTD PMID:12538343 PMID:20417273 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
affects binding
affects activity
decreases activity		 ISO
EXP		 [Amitrole results in decreased activity of CAT protein] which results in increased abundance of Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to Hydrogen Peroxide; [Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite; ABCB6 inhibits the reaction [[Amitrole results in decreased activity of CAT protein] which results in increased susceptibility to sodium arsenite]; Amitrole inhibits the reaction [ABCB6 protein results in increased activity of CAT protein]
Amitrole binds to CAT protein
Amitrole affects the activity of CAT protein
[Amitrole results in decreased activity of CAT protein] which results in decreased susceptibility to BMS 191095; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Amitrole affects the reaction [Ethanol affects the expression of CAT protein]; Amitrole inhibits the reaction [pirinixic acid results in increased activity of CAT protein]		 CTD PMID:8947833 PMID:9569045 PMID:9635878 PMID:10382262 PMID:10468195 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Amitrole results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] CTD PMID:25891026 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression
multiple interactions		 ISO Amitrole results in increased activity of CYP2A5 protein
Amitrole results in increased expression of CYP2A5 mRNA; Amitrole results in increased expression of CYP2A5 protein
heme arginate inhibits the reaction [Amitrole results in increased activity of CYP2A5 protein]		 CTD PMID:7543189 PMID:9698299 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Amitrole inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11353799 PMID:14722249 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Amitrole results in decreased activity of CYP2E1 protein CTD PMID:12464242 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Endog endonuclease G decreases activity EXP Amitrole results in decreased activity of ENDOG protein CTD PMID:16407272 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Epo erythropoietin multiple interactions ISO [Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein CTD PMID:7980410 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of GAD1 protein] CTD PMID:25891026 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gjb6 gap junction protein, beta 6 decreases expression EXP Amitrole results in decreased expression of GJB6 mRNA CTD PMID:34757178 NCBI chr15:31,284,562...31,295,010
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein] CTD PMID:25820916 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Amitrole results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Amitrole inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 protein] CTD PMID:25820916 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hopx HOP homeobox decreases expression EXP Amitrole results in decreased expression of HOPX mRNA CTD PMID:34757178 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor decreases expression EXP Amitrole results in decreased expression of HR mRNA CTD PMID:34757178 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Amitrole results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Amitrole results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in decreased expression of IL10 protein] CTD PMID:25891026 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of IL1B protein] CTD PMID:25891026 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amitrole inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein] CTD PMID:25820916 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb5 integrin subunit beta 5 decreases expression ISO Amitrole results in decreased expression of ITGB5 mRNA CTD PMID:23397585 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP Amitrole results in decreased expression of ITIH3 mRNA CTD PMID:34757178 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO
EXP		 Amitrole results in decreased expression of KLF9 mRNA CTD PMID:23397585 PMID:34757178 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO Amitrole inhibits the reaction [dihydrocapsaicin results in increased expression of MAP1LC3A protein] CTD PMID:18818525 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA] CTD PMID:24964743 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mog myelin oligodendrocyte glycoprotein decreases expression EXP Amitrole results in decreased expression of MOG mRNA CTD PMID:34757178 NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases expression ISO Amitrole results in decreased expression of MUC5AC mRNA CTD PMID:17512462 NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Amitrole promotes the reaction [AGT protein results in increased degradation of NFKBIA protein] CTD PMID:10712386 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor affects activity EXP Amitrole affects the activity of NGF protein CTD PMID:15935206 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of NOX4 protein] CTD PMID:25891026 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Pvalb parvalbumin decreases expression EXP Amitrole results in decreased expression of PVALB mRNA CTD PMID:34757178 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Amitrole co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tbx3 T-box transcription factor 3 decreases expression ISO Amitrole results in decreased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tg thyroglobulin increases expression
decreases secretion		 EXP Amitrole results in increased expression of TG mRNA
Amitrole results in decreased secretion of TG protein		 CTD PMID:20937625 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Amitrole promotes the reaction [Sodium Chloride, Dietary results in increased expression of TH protein] CTD PMID:25891026 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions		 EXP
ISO		 Amitrole results in decreased susceptibility to TNF protein
Amitrole inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]		 CTD PMID:12775721 PMID:25820916 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP
ISO		 Amitrole results in decreased activity of TPO protein CTD PMID:20937625 PMID:31629072 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression EXP Amitrole results in increased expression of TSHB protein CTD PMID:34757178 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Amitrole results in decreased activity of CAT protein] which results in increased expression of VEGFA mRNA CTD PMID:18930813 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      application 19770
        pesticide 17340
          herbicide 13323
            amitrole 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    main group molecular entity 19959
                      s-block molecular entity 19758
                        hydrogen molecular entity 19764
                          hydrides 19134
                            inorganic hydride 17935
                              pnictogen hydride 17901
                                nitrogen hydride 17789
                                  azane 17542
                                    ammonia 17541
                                      organic amino compound 17541
                                        aromatic amine 14924
                                          amitrole 47
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