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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tiratricol
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Accession:CHEBI:40021 term browser browse the term
Definition:A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.
Synonyms:exact_synonym: [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
 related_synonym: 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid;   3,3',5-triiodothyroacetic acid;   4-(4-hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid;   Emcitate;   Formula=C14H9I3O4;   InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20);   InChIKey=UOWZUVNAGUAEQC-UHFFFAOYSA-N;   Nidolin;   SMILES=OC(=O)CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1;   T3A;   TRIAC;   Teatrois;   Tiracana;   Triax;   [(4-hydroxy-3-iodo-4-phenoxy)-3,5-diiodophenyl]acetic acid;   tiratricolum;   triiodothyroacetic acid
 xref: CAS:51-24-1;   DrugBank:DB03604;   Drug_Central:3611;   KEGG:D07214;   LINCS:LSM-5706
 xref_mesh: MESH:C010642
 xref: PDBeChem:4HY;   PMID:12059130;   PMID:12660410;   PMID:15148977;   PMID:1517383;   PMID:18715309;   PMID:18844678;   PMID:21803722;   PMID:33171841;   PMID:34174920;   PMID:36565029;   PMID:36883873;   PMID:37088711;   PMID:3783484;   PMID:37879570;   PMID:3810549;   PMID:6232590;   PMID:9215287;   Wikipedia:Tiratricol


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tiratricol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein] CTD PMID:16324150 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of NR1I2 protein; [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO 3,3',5-triiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRA protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]		 CTD PMID:16324150 PMID:31566444 PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta increases activity
multiple interactions
affects binding		 ISO 3,3',5-triiodothyroacetic acid results in increased activity of THRB protein
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRB protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
3,3',5-triiodothyroacetic acid binds to THRB protein		 CTD PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO 3,3',5-triiodothyroacetic acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        antimicrobial agent 18104
          antiviral agent 11061
            tiratricol 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        tiratricol 10
paths to the root