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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tiratricol
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Accession:CHEBI:40021 term browser browse the term
Definition:A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome.
Synonyms:exact_synonym: [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
 related_synonym: 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid;   3,3',5-triiodothyroacetic acid;   4-(4-hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid;   Emcitate;   Formula=C14H9I3O4;   InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20);   InChIKey=UOWZUVNAGUAEQC-UHFFFAOYSA-N;   Nidolin;   SMILES=OC(=O)CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1;   T3A;   TRIAC;   Teatrois;   Tiracana;   Triax;   [(4-hydroxy-3-iodo-4-phenoxy)-3,5-diiodophenyl]acetic acid;   tiratricolum;   triiodothyroacetic acid
 xref: CAS:51-24-1;   DrugBank:DB03604;   Drug_Central:3611;   KEGG:D07214;   LINCS:LSM-5706
 xref_mesh: MESH:C010642
 xref: PDBeChem:4HY;   PMID:12059130;   PMID:12660410;   PMID:15148977;   PMID:1517383;   PMID:18715309;   PMID:18844678;   PMID:21803722;   PMID:33171841;   PMID:34174920;   PMID:36565029;   PMID:36883873;   PMID:37088711;   PMID:3783484;   PMID:37879570;   PMID:3810549;   PMID:6232590;   PMID:9215287;   Wikipedia:Tiratricol


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tiratricol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions EXP MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein] CTD PMID:16324150 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of NR1I2 protein; [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 PMID:33049310 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP
ISO		 3,3',5-triiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO 3,3',5-triiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions EXP
ISO		 MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRA protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]		 CTD PMID:16324150 PMID:31566444 PMID:33049310 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta increases activity
affects binding
multiple interactions		 ISO 3,3',5-triiodothyroacetic acid results in increased activity of THRB protein
3,3',5-triiodothyroacetic acid binds to THRB protein
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRB protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]		 CTD PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO 3,3',5-triiodothyroacetic acid affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        antimicrobial agent 19567
          antiviral agent 11407
            tiratricol 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      monocarboxylic acid 18969
                                        tiratricol 9
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