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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID
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Accession:CHEBI:40021 term browser browse the term
Definition:An aromatic ether that has formula C14H9I3O4.
Synonyms:xref_mesh: MESH:C010642


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[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein] CTD PMID:16324150 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of NR1I2 protein; [3,3',5-triiodothyroacetic acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 3,3',5-triiodothyroacetic acid binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO 3,3',5-triiodothyroacetic acid binds to RXRA protein CTD PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO MED1 protein promotes the reaction [3,3',5-triiodothyroacetic acid results in increased activity of THRA protein]
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRA protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRA protein binds to NCOA2 protein]
CTD PMID:16324150 PMID:31566444 PMID:33049310 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity
affects binding
multiple interactions
ISO 3,3',5-triiodothyroacetic acid results in increased activity of THRB protein
3,3',5-triiodothyroacetic acid binds to THRB protein
3,3',5-triiodothyroacetic acid binds to and results in increased activity of THRB protein; 3,3',5-triiodothyroacetic acid promotes the reaction [THRB protein binds to NCOA2 protein]
CTD PMID:31077750 PMID:31566444 PMID:33049310 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    chemical entity 19781
      group 19699
        polyatomic entity 19698
          molecule 19540
            organic molecule 19510
              organic cyclic compound 19337
                organic aromatic compound 19162
                  aromatic ether 16193
                    [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    main group molecular entity 19669
                      p-block molecular entity 19669
                        carbon group molecular entity 19588
                          organic molecular entity 19578
                            heteroorganic entity 19216
                              organochalcogen compound 18966
                                organooxygen compound 18893
                                  ether 16897
                                    aromatic ether 16193
                                      [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID 8
paths to the root