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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclizine
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Accession:CHEBI:3994 term browser browse the term
Definition:An N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group.
Synonyms:related_synonym: (N-Benzhydryl)(N'-methyl)diethylenediamine;   1-(Diphenylmethyl)-4-methylpiperazine;   1-Benzhydryl-4-methylpiperazin;   Formula=C18H22N2;   InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3;   InChIKey=UVKZSORBKUEBAZ-UHFFFAOYSA-N;   N-Benzhydryl-N'-methylpiperazine;   N-methyl-N'-benzhydrylpiperazine;   SMILES=CN1CCN(CC1)C(c1ccccc1)c1ccccc1;   ciclizina;   cyclizinum
 alt_id: CHEBI:127546
 xref: Beilstein:230441;   CAS:82-92-8;   DrugBank:DB01176;   Drug_Central:749;   HMDB:HMDB0015307;   KEGG:C06930;   KEGG:D03621;   LINCS:LSM-5857
 xref_mesh: MESH:D003501
 xref: PMID:22209223;   PMID:24215049;   PMID:24324230;   Patent:US2630435;   Reaxys:230441;   Wikipedia:Cyclizine


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cyclizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Cyclizine results in increased phosphorylation of AKT1 protein CTD PMID:37551787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Cyclizine results in increased expression of BAD protein CTD PMID:38314619 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Cyclizine results in decreased expression of BCL2 protein CTD PMID:38314619 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO Cyclizine results in increased activity of CASP3 protein CTD PMID:38314619 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Cyclizine results in increased activity of CASP8 protein CTD PMID:38314619 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Cyclizine results in increased activity of CASP9 protein CTD PMID:38314619 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Cyclizine results in increased expression of CD14 protein CTD PMID:37551787 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Cyclizine results in increased expression of FAS protein CTD PMID:38314619 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Cyclizine results in increased expression of ICAM1 protein CTD PMID:37551787 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO Cyclizine results in increased secretion of IL1B protein CTD PMID:37551787 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion ISO Cyclizine results in increased secretion of IL6 protein CTD PMID:37551787 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Cyclizine results in increased expression of ITGAM protein CTD PMID:37551787 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Cyclizine results in increased expression of NOS2 protein CTD PMID:37551787 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO Cyclizine results in increased expression of PTPRC protein CTD PMID:37551787 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Cyclizine results in increased phosphorylation of RELA protein CTD PMID:37551787 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO Cyclizine results in increased secretion of TNF protein CTD PMID:37551787 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            antiemetic 5369
              cyclizine 16
                cyclizine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            inorganic hydride 18191
                              pnictogen hydride 18181
                                nitrogen hydride 18092
                                  azane 17895
                                    ammonia 17894
                                      organic amino compound 17894
                                        tertiary amino compound 10156
                                          N-alkylpiperazine 3408
                                            cyclizine 16
                                              cyclizine hydrochloride 0
paths to the root