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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxyethane
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Accession:CHEBI:39832 term browser browse the term
Definition:An ether that is the methyl ether derivative of ethanol.
Synonyms:related_synonym: 1-methoxyethane;   Aethylmethylaether;   C2H5OCH3;   Formula=C3H8O;   InChI=1S/C3H8O/c1-3-4-2/h3H2,1-2H3;   InChIKey=XOBKSJJDNFUZPF-UHFFFAOYSA-N;   Methoxyethan;   Methylaethylaether;   SMILES=CCOC;   ethyl methyl ether
 xref: Beilstein:1730785;   CAS:540-67-0;   Gmelin:163978;   PDBeChem:2ME;   PMID:12662033;   Patent:KR20080019002;   Reaxys:1730785;   Wikipedia:Methoxyethane


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desflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Htt huntingtin multiple interactions EXP desflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr 5:34,761,721...34,912,534
Ensembl chr 5:34,761,740...34,912,534
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15781515 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ren1 renin 1 structural multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15781515 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein]; desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate, delta-, dehydratase increases activity
increases expression
EXP Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit affects response to substance ISO CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr15:80,287,238...80,398,292
Ensembl chr15:80,287,238...80,398,279
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 increases expression ISO Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 multiple interactions ISO Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr17:37,045,966...37,074,305
Ensembl chr17:37,045,966...37,075,067
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930
JBrowse link
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 multiple interactions ISO Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 5:70,958,392...71,095,849
Ensembl chr 5:70,957,597...71,095,849
JBrowse link
G Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198, PMID:10825391 NCBI chr 5:71,657,921...72,149,572
Ensembl chr 5:71,658,113...72,149,037
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198, PMID:10825391 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
EXP Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA
CTD PMID:16309571 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma increases expression ISO Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
isoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]; Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Isoflurane results in increased phosphorylation of AKT1 protein
Isoflurane results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
CTD PMID:16249675, PMID:25597859 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alad aminolevulinate, delta-, dehydratase increases activity EXP Isoflurane results in increased activity of ALAD protein CTD PMID:16309571 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO Isoflurane results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Isoflurane affects the expression of APP protein alternative form]; Isoflurane affects the metabolism of and affects the expression of and affects the secretion of APP protein alternative form CTD PMID:17287498 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Arc activity regulated cytoskeletal-associated protein decreases expression ISO Isoflurane results in decreased expression of ARC mRNA CTD PMID:16978161 NCBI chr15:74,669,081...74,672,570
Ensembl chr15:74,669,083...74,672,570
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 increases expression ISO Isoflurane results in increased expression of BACE1 protein CTD PMID:17287498 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
affects expression
ISO Isoflurane results in decreased expression of BAD mRNA
Isoflurane affects the expression of BAD protein
CTD PMID:16978161, PMID:25597859 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression ISO Isoflurane results in decreased expression of BAK1 mRNA CTD PMID:16978161 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
multiple interactions
ISO Isoflurane results in decreased expression of BAX mRNA
Isoflurane results in increased expression of BAX protein
pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]
CTD PMID:16978161, PMID:29289695 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Isoflurane results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
affects expression
decreases expression
ISO Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Isoflurane promotes the reaction [Oxygen deficiency results in increased expression of BCL2 protein]
Isoflurane affects the expression of BCL2 protein
CTD PMID:16249675, PMID:20003127, PMID:29289695 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression ISO Isoflurane results in decreased expression of BCL2A1 mRNA CTD PMID:16978161 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bcl2l1 BCL2-like 1 affects expression ISO Isoflurane affects the expression of BCL2L1 protein CTD PMID:25597859 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) decreases expression ISO Isoflurane results in decreased expression of BCL2L11 mRNA CTD PMID:16978161 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bcl2l2 BCL2-like 2 decreases expression ISO Isoflurane results in decreased expression of BCL2L2 mRNA CTD PMID:16978161 NCBI chr14:54,883,366...54,890,858
Ensembl chr14:54,892,500...54,898,169
Ensembl chr14:54,892,500...54,898,169
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO Isoflurane results in decreased expression of BID mRNA CTD PMID:16978161 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO Isoflurane results in decreased expression of BIRC3 mRNA CTD PMID:16978161 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Isoflurane results in decreased expression of BIRC5 mRNA CTD PMID:16978161 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Blk B lymphoid kinase decreases expression ISO Isoflurane results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr14:63,372,837...63,417,187
Ensembl chr14:63,372,836...63,417,037
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression ISO Isoflurane results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit affects response to substance ISO CACNA1I protein affects the susceptibility to Isoflurane CTD PMID:15644869 NCBI chr15:80,287,238...80,398,292
Ensembl chr15:80,287,238...80,398,279
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Isoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression EXP Isoflurane results in decreased expression of CAMP protein CTD PMID:18382663 NCBI chr 9:109,847,377...109,849,456
Ensembl chr 9:109,847,379...109,849,617
JBrowse link
G Capn1 calpain 1 multiple interactions
increases expression
ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein] CTD PMID:29289695 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
ISO Isoflurane results in increased expression of CAPN2 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]
CTD PMID:29289695, PMID:31672664 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Casp12 caspase 12 decreases expression ISO Isoflurane results in decreased expression of CASP12 mRNA CTD PMID:16978161 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp14 caspase 14 decreases expression ISO Isoflurane results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr10:78,711,995...78,718,347
Ensembl chr10:78,711,991...78,718,294
JBrowse link
G Casp2 caspase 2 increases expression ISO Isoflurane results in increased expression of CASP2 mRNA CTD PMID:16978161 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
increases expression
ISO
EXP
APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein
Isoflurane results in increased cleavage of CASP3 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP3 protein]
Isoflurane results in decreased expression of CASP3 mRNA
Isoflurane results in increased expression of CASP3 protein; Isoflurane results in increased expression of CASP3 protein modified form
Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]
CTD PMID:15915027, PMID:16249675, PMID:16978161, PMID:17287498, PMID:18349187, PMID:19352168, PMID:20003127, PMID:23922164, PMID:25597859, PMID:29289695 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase decreases expression ISO Isoflurane results in decreased expression of CASP4 mRNA CTD PMID:16978161 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
ISO Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP7 protein]
Isoflurane results in increased expression of CASP7 mRNA
CTD PMID:16249675, PMID:16978161 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
EXP resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 decreases expression
increases activity
multiple interactions
ISO
EXP
Isoflurane results in decreased expression of CASP9 mRNA
Isoflurane results in increased activity of CASP9 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP9 protein]
CTD PMID:16978161, PMID:23922164 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP resveratrol inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:23922164 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO Isoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cd27 CD27 antigen decreases expression ISO Isoflurane results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr 6:125,232,620...125,237,136
Ensembl chr 6:125,232,622...125,237,010
JBrowse link
G Cd40 CD40 antigen decreases expression ISO Isoflurane results in decreased expression of CD40 mRNA CTD PMID:16978161 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Isoflurane results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Cd70 CD70 antigen decreases expression ISO Isoflurane results in decreased expression of CD70 mRNA CTD PMID:16978161 NCBI chr17:57,145,997...57,149,777
Ensembl chr17:57,145,997...57,149,777
JBrowse link
G Cfl1 cofilin 1, non-muscle decreases expression EXP Isoflurane results in decreased expression of CFL1 protein CTD PMID:18382663 NCBI chr19:5,490,455...5,494,031
Ensembl chr19:5,490,455...5,495,201
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Isoflurane results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A decreases expression ISO Isoflurane results in decreased expression of CIDEA mRNA CTD PMID:16978161 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 decreases expression ISO Isoflurane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 decreases expression ISO Isoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 decreases expression
increases expression
ISO Isoflurane results in decreased expression of CXCL2 mRNA
Isoflurane results in increased expression of CXCL2 mRNA
CTD PMID:10422944, PMID:15564938 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions EXP Isoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:16508399 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Dffa DNA fragmentation factor, alpha subunit decreases expression ISO Isoflurane results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 4:149,104,142...149,120,653
Ensembl chr 4:149,104,146...149,120,647
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
ISO Isoflurane results in decreased expression of DLG4 protein
IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]
CTD PMID:25597859 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1 like 1 multiple interactions
decreases expression
ISO CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein] CTD PMID:31672664 NCBI chr 2:156,417,595...156,543,214
Ensembl chr 2:156,420,909...156,543,214
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain decreases expression ISO Isoflurane results in decreased expression of FADD mRNA CTD PMID:16978161 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) decreases expression ISO Isoflurane results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Isoflurane results in increased expression of FOS mRNA CTD PMID:10781476 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 multiple interactions ISO Isoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr17:37,045,966...37,074,305
Ensembl chr17:37,045,966...37,075,067
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 increases activity EXP Isoflurane results in increased activity of GABRA1 protein CTD PMID:16807363 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930
JBrowse link
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 5:70,958,392...71,095,849
Ensembl chr 5:70,957,597...71,095,849
JBrowse link
G Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 affects response to substance
multiple interactions
EXP GABRA4 affects the susceptibility to Isoflurane
[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA
CTD PMID:16733821, PMID:19923508 NCBI chr 5:71,569,734...71,658,308
Ensembl chr 5:71,569,749...71,658,308
JBrowse link
G Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 5:71,657,921...72,149,572
Ensembl chr 5:71,658,113...72,149,037
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit multiple interactions ISO Isoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) increases expression ISO Isoflurane results in increased expression of GRIN2B protein CTD PMID:31672664 NCBI chr 6:135,713,221...136,173,615
Ensembl chr 6:135,713,233...136,173,511
JBrowse link
G Hmgb1 high mobility group box 1 increases expression EXP Isoflurane results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmox1 heme oxygenase 1 increases activity EXP Isoflurane results in increased activity of HMOX1 protein CTD PMID:16309571 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) decreases expression ISO Isoflurane results in decreased expression of HRK mRNA CTD PMID:16978161 NCBI chr 5:118,169,764...118,189,478
Ensembl chr 5:118,164,648...118,189,478
JBrowse link
G Htt huntingtin multiple interactions EXP Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]; xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr 5:34,761,721...34,912,534
Ensembl chr 5:34,761,740...34,912,534
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
Isoflurane results in decreased expression of ICAM1 mRNA
Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein]; Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
Isoflurane results in decreased expression of ICAM1 mRNA; Isoflurane results in decreased expression of ICAM1 protein
CTD PMID:15564938, PMID:17414419, PMID:28003439 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
Isoflurane results in decreased expression of IGF1 protein
CTD PMID:25597859 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases phosphorylation ISO Isoflurane results in decreased phosphorylation of IGF1R protein CTD PMID:25597859 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
EXP
ISO
Isoflurane results in decreased expression of IL1B mRNA
Isoflurane results in increased expression of IL1B mRNA
CTD PMID:10422944, PMID:17414419 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 decreases expression EXP Isoflurane results in decreased expression of IL6 protein CTD PMID:17414419 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itgae integrin alpha E, epithelial-associated increases expression ISO Isoflurane results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr11:73,090,505...73,147,449
Ensembl chr11:73,090,583...73,147,446
JBrowse link
G Itgal integrin alpha L multiple interactions EXP Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein] CTD PMID:28003439 NCBI chr 7:127,296,139...127,335,137
Ensembl chr 7:127,296,260...127,335,138
JBrowse link
G Itgam integrin alpha M decreases expression
multiple interactions
EXP Isoflurane results in decreased expression of ITGAM protein
Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
CTD PMID:28003439 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Jun jun proto-oncogene increases expression ISO Isoflurane results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Ltbr lymphotoxin B receptor decreases expression ISO Isoflurane results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr 6:125,306,571...125,313,885
Ensembl chr 6:125,306,571...125,313,885
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO Isoflurane results in decreased phosphorylation of MAPK1 protein
[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:25597859 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO Isoflurane results in decreased phosphorylation of MAPK3 protein CTD PMID:25597859 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO Isoflurane results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases expression ISO Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mpo myeloperoxidase decreases activity ISO Isoflurane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 decreases expression ISO Isoflurane results in decreased expression of NAIP2 mRNA CTD PMID:16978161 NCBI chr13:100,144,063...100,202,122
Ensembl chr13:100,144,063...100,202,092
JBrowse link
G Ncstn nicastrin increases expression ISO Isoflurane results in increased expression of NCSTN protein CTD PMID:17287498 NCBI chr 1:172,066,013...172,082,789
Ensembl chr 1:172,066,013...172,082,795
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
affects localization
ISO Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
ISO Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Isoflurane results in increased expression of NOS2 protein] CTD PMID:18708911 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Psen1 presenilin 1 affects response to substance ISO PSEN1 gene SNP affects the susceptibility to Isoflurane CTD PMID:18227305 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Isoflurane results in increased expression of PTGS2 mRNA
Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]
CTD PMID:21615343 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO Isoflurane results in decreased expression of PYCARD mRNA CTD PMID:16978161 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
affects localization
ISO Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Ren1 renin 1 structural affects activity
multiple interactions
ISO Isoflurane affects the activity of REN protein
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein; [Labetalol co-treated with Isoflurane] results in increased expression of REN protein
CTD PMID:1897344, PMID:3281763, PMID:3284271 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
ISO IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein] CTD PMID:25597859 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression EXP Isoflurane results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721
JBrowse link
G Slc12a5 solute carrier family 12, member 5 multiple interactions
decreases expression
ISO CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein] CTD PMID:31672664 NCBI chr 2:164,960,846...164,999,731
Ensembl chr 2:164,960,802...164,999,731
JBrowse link
G Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 increases expression ISO Isoflurane results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr 2:165,405,295...165,473,197
Ensembl chr 2:165,405,028...165,473,230
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
decreases activity
ISO
EXP
5-hydroxydecanoic acid inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein; tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]
Isoflurane results in decreased activity of SOD2 protein
resveratrol inhibits the reaction [Isoflurane results in decreased activity of SOD2 protein]
CTD PMID:17693941, PMID:23922164 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Tank TRAF family member-associated Nf-kappa B activator decreases expression ISO Isoflurane results in decreased expression of TANK mRNA CTD PMID:16978161 NCBI chr 2:61,578,557...61,654,171
Ensembl chr 2:61,578,585...61,654,171
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
EXP
ISO
Isoflurane results in decreased expression of TNF mRNA; Isoflurane results in decreased expression of TNF protein
Isoflurane results in increased expression of TNF mRNA
CTD PMID:10422944, PMID:15564938, PMID:16978161, PMID:17414419 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator decreases expression ISO Isoflurane results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr 1:105,780,673...105,849,444
Ensembl chr 1:105,780,718...105,847,981
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression ISO Isoflurane results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a decreases expression ISO Isoflurane results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484
JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 decreases expression ISO Isoflurane results in decreased expression of TNFRSF4 mRNA CTD PMID:16978161 NCBI chr 4:156,013,595...156,016,613
Ensembl chr 4:156,013,843...156,016,612
JBrowse link
G Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 decreases expression ISO Isoflurane results in decreased expression of TNFRSF8 mRNA CTD PMID:16978161 NCBI chr 4:145,267,132...145,315,164
Ensembl chr 4:145,267,137...145,315,164
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 decreases expression ISO Isoflurane results in decreased expression of TNFSF10 mRNA CTD PMID:16978161 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 decreases expression ISO Isoflurane results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr11:69,686,240...69,696,098
Ensembl chr11:69,686,250...69,695,849
JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 decreases expression ISO Isoflurane results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr11:69,682,577...69,685,554
Ensembl chr11:69,682,846...69,685,784
JBrowse link
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 decreases expression ISO Isoflurane results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr17:57,189,474...57,194,181
Ensembl chr17:57,189,492...57,194,177
JBrowse link
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 decreases expression ISO Isoflurane results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr 1:161,395,438...161,418,206
Ensembl chr 1:161,395,409...161,418,410
JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 decreases expression ISO Isoflurane results in decreased expression of TNFSF9 mRNA CTD PMID:16978161 NCBI chr17:57,105,287...57,107,758
Ensembl chr17:57,105,325...57,107,757
JBrowse link
G Traf2 TNF receptor-associated factor 2 decreases expression ISO Isoflurane results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 2:25,517,982...25,546,940
Ensembl chr 2:25,517,982...25,546,940
JBrowse link
G Traf3 TNF receptor-associated factor 3 decreases expression ISO Isoflurane results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr12:111,166,321...111,267,155
Ensembl chr12:111,166,370...111,267,153
JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Isoflurane results in decreased expression of TP53 mRNA CTD PMID:16978161 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Isoflurane results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21416
    role 21404
      chemical role 20723
        donor 19560
          Lewis base 17657
            methoxyethane 115
              2-methoxyethyl group 0
              desflurane + 7
              enflurane 12
              isoflurane 112
Path 2
Term Annotations click to browse term
  CHEBI ontology 21416
    subatomic particle 21412
      composite particle 21412
        hadron 21412
          baryon 21412
            nucleon 21412
              atomic nucleus 21412
                atom 21412
                  main group element atom 21307
                    p-block element atom 21307
                      chalcogen 20409
                        oxygen atom 20385
                          oxygen molecular entity 20385
                            hydroxides 20047
                              organic hydroxy compound 19069
                                alcohol 15241
                                  primary alcohol 14011
                                    ethanols 8313
                                      ethanol 8313
                                        methoxyethane 115
                                          2-methoxyethyl group 0
                                          desflurane + 7
                                          enflurane 12
                                          isoflurane 112
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.