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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methoxyethane
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Accession:CHEBI:39832 term browser browse the term
Definition:An ether that is the methyl ether derivative of ethanol.
Synonyms:related_synonym: 1-methoxyethane;   Aethylmethylaether;   C2H5OCH3;   Formula=C3H8O;   InChI=1S/C3H8O/c1-3-4-2/h3H2,1-2H3;   InChIKey=XOBKSJJDNFUZPF-UHFFFAOYSA-N;   Methoxyethan;   Methylaethylaether;   SMILES=CCOC;   ethyl methyl ether
 xref: Beilstein:1730785;   CAS:540-67-0;   Gmelin:163978;   PDBeChem:2ME;   PMID:12662033;   Patent:KR20080019002;   Reaxys:1730785;   Wikipedia:Methoxyethane


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desflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin multiple interactions EXP [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G HTT huntingtin multiple interactions ISO desflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr 4:3,074,681...3,243,960
Ensembl chr 4:3,041,363...3,243,957 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15781515 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G REN renin multiple interactions EXP [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G SELE selectin E multiple interactions EXP desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15781515 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein]; desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase increases activity
increases expression		 ISO Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA		 CTD PMID:16309571 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I affects response to substance ISO CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr22:39,570,753...39,689,735
Ensembl chr22:39,570,753...39,689,735 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions EXP Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions EXP Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 multiple interactions EXP Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:10825391 NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 PMID:10825391 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851 		JBrowse link
G HMOX1 heme oxygenase 1 increases activity
increases expression		 ISO Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA		 CTD PMID:16309571 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma increases expression ISO Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta increases expression ISO Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G TNF tumor necrosis factor increases expression ISO Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
isoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions
increases activity		 ISO rhodioloside inhibits the reaction [Isoflurane results in increased activity of ACHE protein] CTD PMID:28084090 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ADAM1A ADAM metallopeptidase domain 1A (pseudogene) increases methylation ISO Isoflurane results in increased methylation of ADAM1A mRNA CTD PMID:35249202 NCBI chr12:111,899,063...111,901,902
Ensembl chr12:111,899,263...111,901,391 		JBrowse link
G AHCYL2 adenosylhomocysteinase like 2 increases expression ISO Isoflurane results in increased expression of AHCYL2 protein CTD PMID:35249202 NCBI chr 7:129,225,030...129,430,211
Ensembl chr 7:129,225,030...129,430,211 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]; Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO Isoflurane results in increased phosphorylation of AKT1 protein
Isoflurane results in decreased phosphorylation of AKT1 protein
fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]		 CTD PMID:16249675 PMID:25597859 PMID:34553399 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALAD aminolevulinate dehydratase increases activity ISO Isoflurane results in increased activity of ALAD protein CTD PMID:16309571 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALG11 ALG11 alpha-1,2-mannosyltransferase decreases methylation ISO Isoflurane results in decreased methylation of ALG11 mRNA CTD PMID:35249202 NCBI chr13:52,012,398...52,033,600
Ensembl chr13:52,012,391...52,079,232 		JBrowse link
G ALKBH5 alkB homolog 5, RNA demethylase decreases expression ISO Isoflurane results in decreased expression of ALKBH5 protein CTD PMID:35249202 NCBI chr17:18,183,828...18,209,954
Ensembl chr17:18,183,078...18,209,954 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 decreases expression ISO Isoflurane results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Isoflurane affects the expression of APP protein alternative form]; Isoflurane affects the metabolism of and affects the expression of and affects the secretion of APP protein alternative form CTD PMID:17287498 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ARC activity regulated cytoskeleton associated protein decreases expression ISO Isoflurane results in decreased expression of ARC mRNA CTD PMID:16978161 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G ARFGAP3 ADP ribosylation factor GTPase activating protein 3 increases methylation ISO Isoflurane results in increased methylation of ARFGAP3 mRNA CTD PMID:35249202 NCBI chr22:42,796,502...42,857,273
Ensembl chr22:42,796,502...42,858,106 		JBrowse link
G ARHGAP35 Rho GTPase activating protein 35 increases expression ISO Isoflurane results in increased expression of ARHGAP35 protein CTD PMID:35249202 NCBI chr19:46,860,997...47,005,077
Ensembl chr19:46,860,997...47,005,077 		JBrowse link
G AVP arginine vasopressin multiple interactions EXP [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G BACE1 beta-secretase 1 increases expression EXP Isoflurane results in increased expression of BACE1 protein CTD PMID:17287498 NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259 		JBrowse link
G BACH2 BTB domain and CNC homolog 2 decreases methylation ISO Isoflurane results in decreased methylation of BACH2 mRNA CTD PMID:35249202 NCBI chr 6:89,926,528...90,296,843
Ensembl chr 6:89,926,528...90,296,843 		JBrowse link
G BAD BCL2 associated agonist of cell death decreases expression
affects expression		 ISO Isoflurane results in decreased expression of BAD mRNA
Isoflurane affects the expression of BAD protein		 CTD PMID:16978161 PMID:25597859 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 decreases expression ISO Isoflurane results in decreased expression of BAK1 mRNA CTD PMID:16978161 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions		 ISO Isoflurane results in decreased expression of BAX mRNA
Isoflurane results in increased expression of BAX protein
pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]		 CTD PMID:16978161 PMID:29289695 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCHE butyrylcholinesterase decreases activity ISO Isoflurane results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
affects expression
decreases expression		 ISO [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Isoflurane promotes the reaction [Oxygen deficiency results in increased expression of BCL2 protein]
Isoflurane affects the expression of BCL2 protein		 CTD PMID:16249675 PMID:20003127 PMID:29289695 PMID:32062618 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 decreases expression ISO Isoflurane results in decreased expression of BCL2A1 mRNA CTD PMID:16978161 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL2L1 BCL2 like 1 affects expression ISO Isoflurane affects the expression of BCL2L1 protein CTD PMID:25597859 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BCL2L11 BCL2 like 11 decreases expression ISO Isoflurane results in decreased expression of BCL2L11 mRNA CTD PMID:16978161 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BCL2L2 BCL2 like 2 decreases expression ISO Isoflurane results in decreased expression of BCL2L2 mRNA CTD PMID:16978161 NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,751 		JBrowse link
G BID BH3 interacting domain death agonist decreases expression ISO Isoflurane results in decreased expression of BID mRNA CTD PMID:16978161 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression ISO Isoflurane results in decreased expression of BIRC3 mRNA CTD PMID:16978161 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression ISO Isoflurane results in decreased expression of BIRC5 mRNA CTD PMID:16978161 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G BLK BLK proto-oncogene, Src family tyrosine kinase decreases expression ISO Isoflurane results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr 8:11,494,387...11,564,599
Ensembl chr 8:11,486,894...11,564,599 		JBrowse link
G BMP7 bone morphogenetic protein 7 increases expression ISO Isoflurane results in increased expression of BMP7 protein CTD PMID:35249202 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G BNIP3 BCL2 interacting protein 3 increases expression ISO Isoflurane results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967 		JBrowse link
G C11orf65 chromosome 11 open reading frame 65 decreases methylation ISO Isoflurane results in decreased methylation of C11ORF65 mRNA CTD PMID:35249202 NCBI chr11:108,308,519...108,469,881
Ensembl chr11:108,308,519...108,467,531 		JBrowse link
G C2orf42 chromosome 2 open reading frame 42 decreases methylation ISO Isoflurane results in decreased methylation of C2ORF42 mRNA CTD PMID:35249202 NCBI chr 2:70,149,885...70,191,019
Ensembl chr 2:70,149,885...70,248,615 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I affects response to substance ISO CACNA1I protein affects the susceptibility to Isoflurane CTD PMID:15644869 NCBI chr22:39,570,753...39,689,735
Ensembl chr22:39,570,753...39,689,735 		JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions EXP Isoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CAMP cathelicidin antimicrobial peptide decreases expression ISO Isoflurane results in decreased expression of CAMP protein CTD PMID:18382663 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491 		JBrowse link
G CAPN1 calpain 1 increases expression
multiple interactions		 ISO Isoflurane results in increased expression of CAPN1 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]		 CTD PMID:29289695 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006 		JBrowse link
G CAPN2 calpain 2 multiple interactions
increases expression		 ISO calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 PMID:31672664 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018 		JBrowse link
G CASP1 caspase 1 increases cleavage
multiple interactions		 ISO Isoflurane results in increased cleavage of CASP1 protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased cleavage of CASP1 protein]; SETD7 protein affects the reaction [Isoflurane results in increased cleavage of CASP1 protein]		 CTD PMID:35187972 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) decreases expression ISO Isoflurane results in decreased expression of CASP12 mRNA CTD PMID:16978161 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP14 caspase 14 decreases expression ISO Isoflurane results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr19:15,049,480...15,058,293
Ensembl chr19:15,049,480...15,058,293 		JBrowse link
G CASP2 caspase 2 increases expression ISO Isoflurane results in increased expression of CASP2 mRNA CTD PMID:16978161 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
increases expression		 EXP
ISO		 APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein
Isoflurane results in increased cleavage of CASP3 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP3 protein]
Isoflurane results in decreased expression of CASP3 mRNA
Isoflurane results in increased expression of CASP3 protein; Isoflurane results in increased expression of CASP3 protein modified form
[Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]		 CTD PMID:15915027 PMID:16249675 PMID:16978161 PMID:17287498 PMID:18349187 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP4 caspase 4 decreases expression ISO Isoflurane results in decreased expression of CASP4 mRNA CTD PMID:16978161 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP7 caspase 7 multiple interactions
increases expression		 ISO Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP7 protein]
Isoflurane results in increased expression of CASP7 mRNA		 CTD PMID:16249675 PMID:16978161 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases activity		 ISO resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 decreases expression
increases activity
multiple interactions		 ISO Isoflurane results in decreased expression of CASP9 mRNA
Isoflurane results in increased activity of CASP9 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP9 protein]		 CTD PMID:16978161 PMID:23922164 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
decreases activity		 ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; Resveratrol inhibits the reaction [Isoflurane results in decreased activity of CAT protein]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:23922164 PMID:32663520 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCDC8 coiled-coil domain containing 8 decreases methylation ISO Isoflurane results in decreased methylation of CCDC8 mRNA CTD PMID:35249202 NCBI chr19:46,410,329...46,413,564
Ensembl chr19:46,410,329...46,413,564 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression ISO Isoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CD27 CD27 molecule decreases expression ISO Isoflurane results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr12:6,443,892...6,451,713
Ensembl chr12:6,444,955...6,451,718 		JBrowse link
G CD40 CD40 molecule decreases expression ISO Isoflurane results in decreased expression of CD40 mRNA CTD PMID:16978161 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD40LG CD40 ligand decreases expression ISO Isoflurane results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CD70 CD70 molecule decreases expression ISO Isoflurane results in decreased expression of CD70 mRNA CTD PMID:16978161 NCBI chr19:6,581,648...6,591,150
Ensembl chr19:6,583,183...6,604,103 		JBrowse link
G CD83 CD83 molecule increases methylation ISO Isoflurane results in increased methylation of CD83 mRNA CTD PMID:35249202 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918 		JBrowse link
G CDADC1 cytidine and dCMP deaminase domain containing 1 decreases methylation ISO Isoflurane results in decreased methylation of CDADC1 mRNA CTD PMID:35249202 NCBI chr13:49,247,925...49,293,485
Ensembl chr13:49,247,925...49,293,485 		JBrowse link
G CDHR2 cadherin related family member 2 decreases expression ISO Isoflurane results in decreased expression of CDHR2 protein CTD PMID:35249202 NCBI chr 5:176,542,511...176,595,974
Ensembl chr 5:176,542,511...176,595,974 		JBrowse link
G CFL1 cofilin 1 decreases expression ISO Isoflurane results in decreased expression of CFL1 protein CTD PMID:18382663 NCBI chr11:65,854,673...65,858,180
Ensembl chr11:65,823,022...65,862,026 		JBrowse link
G CHAT choline O-acetyltransferase decreases activity
multiple interactions		 ISO Isoflurane results in decreased activity of CHAT protein
rhodioloside inhibits the reaction [Isoflurane results in decreased activity of CHAT protein]		 CTD PMID:28084090 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942 		JBrowse link
G CHEK1 checkpoint kinase 1 decreases expression ISO Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 increases expression ISO Isoflurane results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CIDEA cell death inducing DFFA like effector a decreases expression ISO Isoflurane results in decreased expression of CIDEA mRNA CTD PMID:16978161 NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595 		JBrowse link
G CLASP1 cytoplasmic linker associated protein 1 decreases expression ISO Isoflurane results in decreased expression of CLASP1 protein CTD PMID:35249202 NCBI chr 2:121,337,776...121,649,462
Ensembl chr 2:121,337,776...121,649,476 		JBrowse link
G CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 decreases methylation ISO Isoflurane results in decreased methylation of CNNM3 mRNA CTD PMID:35249202 NCBI chr 2:96,816,268...96,837,466
Ensembl chr 2:96,816,245...96,835,382 		JBrowse link
G CNP 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression ISO Isoflurane results in decreased expression of CNP protein CTD PMID:35249202 NCBI chr17:41,966,795...41,977,740
Ensembl chr17:41,966,763...41,977,740 		JBrowse link
G CNTNAP5 contactin associated protein family member 5 decreases methylation ISO Isoflurane results in decreased methylation of CNTNAP5 mRNA CTD PMID:35249202 NCBI chr 2:124,025,287...124,921,219
Ensembl chr 2:124,025,287...124,921,219 		JBrowse link
G CRB2 crumbs cell polarity complex component 2 decreases methylation ISO Isoflurane results in decreased methylation of CRB2 mRNA CTD PMID:35249202 NCBI chr 9:123,354,065...123,380,326
Ensembl chr 9:123,356,170...123,380,324 		JBrowse link
G CSTB cystatin B decreases expression ISO Isoflurane results in decreased expression of CSTB protein CTD PMID:35249202 NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330 		JBrowse link
G CTDP1 CTD phosphatase subunit 1 increases methylation ISO Isoflurane results in increased methylation of CTDP1 mRNA CTD PMID:35249202 NCBI chr18:79,676,768...79,756,625
Ensembl chr18:79,679,803...79,754,503 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of CXCL1 mRNA
Isoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]		 CTD PMID:15564938 PMID:16508399 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression ISO Isoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression
increases expression		 ISO Isoflurane results in decreased expression of CXCL2 mRNA
Isoflurane results in increased expression of CXCL2 mRNA		 CTD PMID:10422944 PMID:15564938 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G DCTN5 dynactin subunit 5 decreases expression ISO Isoflurane results in decreased expression of DCTN5 protein CTD PMID:35249202 NCBI chr16:23,641,466...23,677,472
Ensembl chr16:23,641,466...23,677,472 		JBrowse link
G DFFA DNA fragmentation factor subunit alpha decreases expression ISO Isoflurane results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 1:10,456,522...10,472,529
Ensembl chr 1:10,456,522...10,472,529 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of DLG4 protein
IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]		 CTD PMID:25597859 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841 		JBrowse link
G DSEL dermatan sulfate epimerase like decreases methylation ISO Isoflurane results in decreased methylation of DSEL mRNA CTD PMID:35249202 NCBI chr18:67,506,587...67,516,720
Ensembl chr18:67,506,587...67,516,720 		JBrowse link
G DSTN destrin, actin depolymerizing factor increases methylation ISO Isoflurane results in increased methylation of DSTN mRNA CTD PMID:35249202 NCBI chr20:17,570,075...17,609,919
Ensembl chr20:17,570,075...17,609,919 		JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 decreases methylation ISO Isoflurane results in decreased methylation of EEF1E1 mRNA CTD PMID:35249202 NCBI chr 6:8,073,360...8,102,548
Ensembl chr 6:8,073,360...8,102,559 		JBrowse link
G EPB41L1 erythrocyte membrane protein band 4.1 like 1 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of EPB41L1 protein
CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein]		 CTD PMID:31672664 NCBI chr20:36,091,414...36,232,799
Ensembl chr20:36,091,504...36,232,799 		JBrowse link
G FADD Fas associated via death domain decreases expression ISO Isoflurane results in decreased expression of FADD mRNA CTD PMID:16978161 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAM135B family with sequence similarity 135 member B decreases methylation ISO Isoflurane results in decreased methylation of FAM135B mRNA CTD PMID:35249202 NCBI chr 8:138,130,023...138,497,730
Ensembl chr 8:138,130,023...138,497,261 		JBrowse link
G FASLG Fas ligand decreases expression ISO Isoflurane results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FN3KRP fructosamine 3 kinase related protein decreases expression ISO Isoflurane results in decreased expression of FN3KRP protein CTD PMID:35249202 NCBI chr17:82,716,706...82,728,013
Ensembl chr17:82,716,706...82,730,328 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Isoflurane results in increased expression of FOS mRNA CTD PMID:10781476 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXC1 forkhead box C1 decreases methylation ISO Isoflurane results in decreased methylation of FOXC1 mRNA CTD PMID:35249202 NCBI chr 6:1,609,915...1,613,897
Ensembl chr 6:1,609,915...1,613,897 		JBrowse link
G FOXRED2 FAD dependent oxidoreductase domain containing 2 increases methylation ISO Isoflurane results in increased methylation of FOXRED2 mRNA CTD PMID:35249202 NCBI chr22:36,487,190...36,507,040
Ensembl chr22:36,487,190...36,507,221 		JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase decreases expression ISO Isoflurane results in decreased expression of FTO protein CTD PMID:35249202 NCBI chr16:53,703,963...54,121,941
Ensembl chr16:53,701,692...54,158,512 		JBrowse link
G FZD8 frizzled class receptor 8 decreases methylation ISO Isoflurane results in decreased methylation of FZD8 mRNA CTD PMID:35249202 NCBI chr10:35,638,247...35,642,296
Ensembl chr10:35,638,247...35,642,296 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions EXP Isoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 increases activity ISO Isoflurane results in increased activity of GABRA1 protein CTD PMID:16807363 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 multiple interactions EXP Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 affects response to substance
multiple interactions		 ISO GABRA4 affects the susceptibility to Isoflurane
[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA		 CTD PMID:16733821 PMID:19923508 NCBI chr 4:46,918,900...46,993,581
Ensembl chr 4:46,918,900...46,993,581 		JBrowse link
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447 		JBrowse link
G GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 increases methylation ISO Isoflurane results in increased methylation of GALNT7 mRNA CTD PMID:35249202 NCBI chr 4:173,168,811...173,323,967
Ensembl chr 4:173,168,811...173,323,967 		JBrowse link
G GDF11 growth differentiation factor 11 decreases methylation ISO Isoflurane results in decreased methylation of GDF11 mRNA CTD PMID:35249202 NCBI chr12:55,743,122...55,757,264
Ensembl chr12:55,743,122...55,757,264 		JBrowse link
G GFOD1 Gfo/Idh/MocA-like oxidoreductase domain containing 1 decreases methylation ISO Isoflurane results in decreased methylation of GFOD1 mRNA CTD PMID:35249202 NCBI chr 6:13,357,830...13,487,600
Ensembl chr 6:13,357,830...13,487,662 		JBrowse link
G GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 decreases methylation ISO Isoflurane results in decreased methylation of GGA2 mRNA CTD PMID:35249202 NCBI chr16:23,463,542...23,524,359
Ensembl chr16:23,463,542...23,521,995 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP Isoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr 5:151,822,513...151,924,851
Ensembl chr 5:151,822,513...151,924,851 		JBrowse link
G GPR161 G protein-coupled receptor 161 increases methylation ISO Isoflurane results in increased methylation of GPR161 mRNA CTD PMID:35249202 NCBI chr 1:168,079,542...168,137,667
Ensembl chr 1:168,079,542...168,137,667 		JBrowse link
G GPR21 G protein-coupled receptor 21 decreases methylation ISO Isoflurane results in decreased methylation of GPR21 mRNA CTD PMID:35249202 NCBI chr 9:123,033,667...123,049,103
Ensembl chr 9:123,033,667...123,035,665 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B increases expression ISO Isoflurane results in increased expression of GRIN2B protein CTD PMID:31672664 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G GSDMD gasdermin D multiple interactions
increases cleavage		 ISO SETD7 protein affects the reaction [Isoflurane results in increased cleavage of GSDMD protein] CTD PMID:35187972 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G GSS glutathione synthetase decreases expression ISO Isoflurane results in decreased expression of GSS protein CTD PMID:35249202 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G H2BC11 H2B clustered histone 11 increases methylation ISO Isoflurane results in increased methylation of H2BC11 mRNA CTD PMID:35249202 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,795 		JBrowse link
G H2BC17 H2B clustered histone 17 decreases expression ISO Isoflurane results in decreased expression of H2BC17 protein CTD PMID:35249202 NCBI chr 6:27,893,425...27,893,891
Ensembl chr 6:27,893,425...27,893,891 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 decreases expression ISO Isoflurane results in decreased expression of HCN1 protein CTD PMID:35249202 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498 		JBrowse link
G HMGB1 high mobility group box 1 increases expression ISO Isoflurane results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 increases activity
multiple interactions
decreases expression
increases expression		 ISO Isoflurane results in increased activity of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]; Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein
Isoflurane results in increased expression of HMOX1 mRNA; Isoflurane results in increased expression of HMOX1 protein
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]		 CTD PMID:16309571 PMID:32663520 PMID:36027947 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HRK harakiri, BCL2 interacting protein decreases expression ISO Isoflurane results in decreased expression of HRK mRNA CTD PMID:16978161 NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441 		JBrowse link
G HTT huntingtin multiple interactions ISO Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]; xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr 4:3,074,681...3,243,960
Ensembl chr 4:3,041,363...3,243,957 		JBrowse link
G HYAL3 hyaluronidase 3 increases methylation ISO Isoflurane results in increased methylation of HYAL3 mRNA CTD PMID:35249202 NCBI chr 3:50,292,832...50,299,405
Ensembl chr 3:50,292,831...50,299,405 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of ICAM1 mRNA
Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein]; Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
Isoflurane results in decreased expression of ICAM1 mRNA; Isoflurane results in decreased expression of ICAM1 protein		 CTD PMID:15564938 PMID:17414419 PMID:28003439 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IDS iduronate 2-sulfatase decreases methylation ISO Isoflurane results in decreased methylation of IDS mRNA CTD PMID:35249202 NCBI chr  X:149,476,988...149,505,306
Ensembl chr  X:149,476,988...149,521,096 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 decreases methylation ISO Isoflurane results in decreased methylation of IFIT3 mRNA CTD PMID:35249202 NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
Isoflurane results in decreased expression of IGF1 protein		 CTD PMID:25597859 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases phosphorylation ISO Isoflurane results in decreased phosphorylation of IGF1R protein CTD PMID:25597859 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression		 ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of IL18 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL18 protein] CTD PMID:35187972 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta decreases expression
increases expression
multiple interactions		 ISO Isoflurane results in decreased expression of IL1B mRNA
Isoflurane results in increased expression of IL1B protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of IL1B protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL1B protein]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; rhodioloside inhibits the reaction [Isoflurane results in increased expression of IL1B protein]
Isoflurane results in increased expression of IL1B mRNA; Isoflurane results in increased expression of IL1B protein		 CTD PMID:10422944 PMID:17414419 PMID:28084090 PMID:35164634 PMID:35187972 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 decreases expression
increases expression
multiple interactions		 ISO Isoflurane results in decreased expression of IL6 protein
Isoflurane results in increased expression of IL6 protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL6 protein]		 CTD PMID:17414419 PMID:35164634 PMID:35187972 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INCENP inner centromere protein decreases methylation ISO Isoflurane results in decreased methylation of INCENP mRNA CTD PMID:35249202 NCBI chr11:62,124,011...62,153,169
Ensembl chr11:62,123,998...62,153,169 		JBrowse link
G INO80 INO80 complex ATPase subunit increases methylation ISO Isoflurane results in increased methylation of INO80 mRNA CTD PMID:35249202 NCBI chr15:40,978,880...41,116,280
Ensembl chr15:40,978,880...41,116,280 		JBrowse link
G ITGAE integrin subunit alpha E increases expression ISO Isoflurane results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr17:3,714,628...3,801,188
Ensembl chr17:3,714,628...3,801,188 		JBrowse link
G ITGAL integrin subunit alpha L multiple interactions ISO Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein] CTD PMID:28003439 NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567 		JBrowse link
G ITGAM integrin subunit alpha M decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of ITGAM protein
Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]		 CTD PMID:28003439 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Isoflurane results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KBTBD3 kelch repeat and BTB domain containing 3 decreases methylation ISO Isoflurane results in decreased methylation of KBTBD3 mRNA CTD PMID:35249202 NCBI chr11:106,051,098...106,077,347
Ensembl chr11:106,051,098...106,077,459 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 increases methylation ISO Isoflurane results in increased methylation of KCNJ6 mRNA CTD PMID:35249202 NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345 		JBrowse link
G LAMP5 lysosomal associated membrane protein family member 5 decreases expression ISO Isoflurane results in decreased expression of LAMP5 protein CTD PMID:35249202 NCBI chr20:9,514,590...9,530,524
Ensembl chr20:9,514,358...9,530,524 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 decreases methylation ISO Isoflurane results in decreased methylation of LDLRAP1 mRNA CTD PMID:35249202 NCBI chr 1:25,543,606...25,590,400
Ensembl chr 1:25,543,606...25,568,886 		JBrowse link
G LTBR lymphotoxin beta receptor decreases expression ISO Isoflurane results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571 		JBrowse link
G MAG myelin associated glycoprotein decreases expression ISO Isoflurane results in decreased expression of MAG protein CTD PMID:35249202 NCBI chr19:35,292,161...35,313,807
Ensembl chr19:35,292,125...35,313,807 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO Isoflurane results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]		 CTD PMID:25597859 PMID:36027947 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation ISO Isoflurane results in decreased phosphorylation of MAPK3 protein CTD PMID:25597859 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Isoflurane results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MCM3AP minichromosome maintenance complex component 3 associated protein increases methylation ISO Isoflurane results in increased methylation of MCM3AP mRNA CTD PMID:35249202 NCBI chr21:46,235,133...46,286,265
Ensembl chr21:46,235,133...46,286,297 		JBrowse link
G MDM2 MDM2 proto-oncogene decreases expression ISO Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G MEG3 maternally expressed 3 increases expression
multiple interactions		 ISO Isoflurane results in increased expression of MEG3 mRNA
MEG3 mRNA affects the reaction [Isoflurane results in decreased expression of MIR7-1 mRNA]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]]		 CTD PMID:35164634 NCBI chr14:100,826,108...100,861,026
Ensembl chr14:100,779,410...100,861,031 		JBrowse link
G MEGF10 multiple EGF like domains 10 decreases methylation ISO Isoflurane results in decreased methylation of MEGF10 mRNA CTD PMID:35249202 NCBI chr 5:127,229,300...127,461,222
Ensembl chr 5:127,290,796...127,465,737 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Isoflurane results in decreased expression of METTL3 protein CTD PMID:35249202 NCBI chr14:21,498,138...21,511,340
Ensembl chr14:21,498,133...21,511,342 		JBrowse link
G MIR140 microRNA 140 multiple interactions
increases expression		 ISO [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of MIR140 mRNA] CTD PMID:32062618 NCBI chr16:69,933,081...69,933,180
Ensembl chr16:69,933,081...69,933,180 		JBrowse link
G MIR191 microRNA 191 increases expression ISO Isoflurane results in increased expression of MIR191 mRNA CTD PMID:33586613 NCBI chr 3:49,020,618...49,020,709
Ensembl chr 3:49,020,618...49,020,709 		JBrowse link
G MIR7-1 microRNA 7-1 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of MIR7-1 mRNA
MEG3 mRNA affects the reaction [Isoflurane results in decreased expression of MIR7-1 mRNA]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]]		 CTD PMID:35164634 NCBI chr 9:83,969,748...83,969,857
Ensembl chr 9:83,969,748...83,969,857 		JBrowse link
G MPO myeloperoxidase decreases activity ISO Isoflurane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 decreases methylation ISO Isoflurane results in decreased methylation of MSMO1 mRNA CTD PMID:35249202 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164 		JBrowse link
G MX1 MX dynamin like GTPase 1 decreases methylation ISO Isoflurane results in decreased methylation of MX1 mRNA CTD PMID:35249202 NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071 		JBrowse link
G NAIP NLR family apoptosis inhibitory protein decreases expression ISO Isoflurane results in decreased expression of NAIP2 mRNA CTD PMID:16978161 NCBI chr 5:70,968,166...71,025,339
Ensembl chr 5:70,968,166...71,025,339 		JBrowse link
G NCSTN nicastrin increases expression EXP Isoflurane results in increased expression of NCSTN protein CTD PMID:17287498 NCBI chr 1:160,343,383...160,358,949
Ensembl chr 1:160,343,294...160,358,952 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases phosphorylation
decreases expression
increases expression		 ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]
Isoflurane results in decreased expression of NFE2L2 mRNA; Isoflurane results in decreased expression of NFE2L2 protein		 CTD PMID:32663520 PMID:36027947 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 ISO Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NKX1-1 NK1 homeobox 1 increases methylation ISO Isoflurane results in increased methylation of NKX1-1 mRNA CTD PMID:35249202 NCBI chr 4:1,402,932...1,406,442
Ensembl chr 4:1,402,932...1,406,442 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression		 ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of NLRP3 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of NLRP3 protein] CTD PMID:35187972 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Isoflurane results in increased expression of NOS2 protein] CTD PMID:18708911 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO Isoflurane results in increased expression of NQO1 mRNA; Isoflurane results in increased expression of NQO1 protein
trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]		 CTD PMID:32663520 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR2F6 nuclear receptor subfamily 2 group F member 6 increases methylation ISO Isoflurane results in increased methylation of NR2F6 mRNA CTD PMID:35249202 NCBI chr19:17,231,883...17,245,919
Ensembl chr19:17,231,883...17,245,919 		JBrowse link
G NRK Nik related kinase increases methylation ISO Isoflurane results in increased methylation of NRK mRNA CTD PMID:35249202 NCBI chr  X:105,821,786...105,958,610
Ensembl chr  X:105,822,539...105,958,610 		JBrowse link
G OVGP1 oviductal glycoprotein 1 increases methylation ISO Isoflurane results in increased methylation of OVGP1 mRNA CTD PMID:35249202 NCBI chr 1:111,414,319...111,427,735
Ensembl chr 1:111,414,319...111,427,735 		JBrowse link
G PABPN1L PABPN1 like, cytoplasmic increases methylation ISO Isoflurane results in increased methylation of PABPN1L mRNA CTD PMID:35249202 NCBI chr16:88,863,333...88,870,135
Ensembl chr16:88,863,333...88,866,660 		JBrowse link
G PCDHGA2 protocadherin gamma subfamily A, 2 decreases methylation ISO Isoflurane results in decreased methylation of PCDHGA2 mRNA CTD PMID:35249202 NCBI chr 5:141,338,760...141,512,975
Ensembl chr 5:141,338,760...141,512,975 		JBrowse link
G PCDHGA9 protocadherin gamma subfamily A, 9 increases methylation ISO Isoflurane results in increased methylation of PCDHGA9 mRNA CTD PMID:35249202 NCBI chr 5:141,402,778...141,512,975
Ensembl chr 5:141,402,778...141,512,975 		JBrowse link
G PDCD4 programmed cell death 4 decreases methylation ISO Isoflurane results in decreased methylation of PDCD4 mRNA CTD PMID:35249202 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006 		JBrowse link
G PGF placental growth factor increases methylation ISO Isoflurane results in increased methylation of PGF mRNA CTD PMID:35249202 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626 		JBrowse link
G PIANP PILR alpha associated neural protein decreases methylation ISO Isoflurane results in decreased methylation of PIANP mRNA CTD PMID:35249202 NCBI chr12:6,692,178...6,700,815
Ensembl chr12:6,693,791...6,700,815 		JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha decreases expression ISO Isoflurane results in decreased expression of PIP4K2A protein CTD PMID:35249202 NCBI chr10:22,534,854...22,714,578
Ensembl chr10:22,534,854...22,714,578 		JBrowse link
G PIPOX pipecolic acid and sarcosine oxidase decreases methylation ISO Isoflurane results in decreased methylation of PIPOX mRNA CTD PMID:35249202 NCBI chr17:29,043,141...29,057,216
Ensembl chr17:28,950,513...29,057,216 		JBrowse link
G PKIG cAMP-dependent protein kinase inhibitor gamma decreases methylation ISO Isoflurane results in decreased methylation of PKIG mRNA CTD PMID:35249202 NCBI chr20:44,531,875...44,619,037
Ensembl chr20:44,531,785...44,624,247 		JBrowse link
G POLR3K RNA polymerase III subunit K increases methylation ISO Isoflurane results in increased methylation of POLR3K mRNA CTD PMID:35249202 NCBI chr16:46,407...53,608
Ensembl chr16:46,407...53,608 		JBrowse link
G PRICKLE2 prickle planar cell polarity protein 2 increases expression ISO Isoflurane results in increased expression of PRICKLE2 protein CTD PMID:35249202 NCBI chr 3:64,092,236...64,268,173
Ensembl chr 3:64,092,236...64,445,476 		JBrowse link
G PSEN1 presenilin 1 affects response to substance ISO PSEN1 gene SNP affects the susceptibility to Isoflurane CTD PMID:18227305 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Isoflurane results in increased expression of PTGS2 mRNA
Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]		 CTD PMID:21615343 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PUF60 poly(U) binding splicing factor 60 increases expression ISO Isoflurane results in increased expression of PUF60 protein CTD PMID:35249202 NCBI chr 8:143,816,344...143,829,315
Ensembl chr 8:143,816,344...143,830,709 		JBrowse link
G PYCARD PYD and CARD domain containing decreases expression
increases expression
multiple interactions		 ISO Isoflurane results in decreased expression of PYCARD mRNA
Isoflurane results in increased expression of PYCARD protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of PYCARD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of PYCARD protein]		 CTD PMID:16978161 PMID:35187972 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RALB RAS like proto-oncogene B increases expression ISO Isoflurane results in increased expression of RALB protein CTD PMID:35249202 NCBI chr 2:120,240,070...120,294,710
Ensembl chr 2:120,240,064...120,294,710 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G REN renin affects activity
multiple interactions		 EXP Isoflurane affects the activity of REN protein
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein; [Labetalol co-treated with Isoflurane] results in increased expression of REN protein		 CTD PMID:1897344 PMID:3281763 PMID:3284271 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RNF34 ring finger protein 34 decreases methylation ISO Isoflurane results in decreased methylation of RNF34 mRNA CTD PMID:35249202 NCBI chr12:121,400,118...121,424,348
Ensembl chr12:121,400,083...121,430,623 		JBrowse link
G RPS27 ribosomal protein S27 decreases methylation ISO Isoflurane results in decreased methylation of RPS27 mRNA CTD PMID:35249202 NCBI chr 1:153,990,762...153,992,155
Ensembl chr 1:153,990,762...153,992,155 		JBrowse link
G RPS6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein] CTD PMID:25597859 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236 		JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression ISO Isoflurane results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023 		JBrowse link
G SAR1A secretion associated Ras related GTPase 1A decreases expression ISO Isoflurane results in decreased expression of SAR1A protein CTD PMID:35249202 NCBI chr10:70,147,289...70,170,514
Ensembl chr10:70,147,289...70,170,523 		JBrowse link
G SDF2 stromal cell derived factor 2 decreases expression ISO Isoflurane results in decreased expression of SDF2 protein CTD PMID:35249202 NCBI chr17:28,648,346...28,662,194
Ensembl chr17:28,648,346...28,662,189 		JBrowse link
G SEL1L SEL1L adaptor subunit of SYVN1 ubiquitin ligase decreases expression ISO Isoflurane results in decreased expression of SEL1L protein CTD PMID:35249202 NCBI chr14:81,471,547...81,533,853
Ensembl chr14:81,471,547...81,533,853 		JBrowse link
G SERPINE2 serpin family E member 2 increases expression ISO Isoflurane results in increased expression of SERPINE2 protein CTD PMID:35249202 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase multiple interactions ISO SETD7 protein affects the reaction [Isoflurane results in increased cleavage of CASP1 protein]; SETD7 protein affects the reaction [Isoflurane results in increased cleavage of GSDMD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL18 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL1B protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL6 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of NLRP3 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of PYCARD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of TNF protein] CTD PMID:35187972 NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699 		JBrowse link
G SF3B4 splicing factor 3b subunit 4 increases expression ISO Isoflurane results in increased expression of SF3B4 protein CTD PMID:35249202 NCBI chr 1:149,923,317...149,927,803
Ensembl chr 1:149,923,317...149,927,803 		JBrowse link
G SH3KBP1 SH3 domain containing kinase binding protein 1 decreases methylation ISO Isoflurane results in decreased methylation of SH3KBP1 mRNA CTD PMID:35249202 NCBI chr  X:19,533,977...19,887,600
Ensembl chr  X:19,533,977...19,887,600 		JBrowse link
G SIPA1L2 signal induced proliferation associated 1 like 2 decreases methylation ISO Isoflurane results in decreased methylation of SIPA1L2 mRNA CTD PMID:35249202 NCBI chr 1:232,397,965...232,630,496
Ensembl chr 1:232,397,965...232,630,571 		JBrowse link
G SLC12A5 solute carrier family 12 member 5 decreases expression
multiple interactions		 ISO Isoflurane results in decreased expression of SLC12A5 protein
CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein]		 CTD PMID:31672664 NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150 		JBrowse link
G SLC13A3 solute carrier family 13 member 3 increases expression ISO Isoflurane results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr20:46,557,828...46,684,485
Ensembl chr20:46,557,823...46,684,467 		JBrowse link
G SLC66A1 solute carrier family 66 member 1 decreases methylation ISO Isoflurane results in decreased methylation of SLC66A1 mRNA CTD PMID:35249202 NCBI chr 1:19,312,326...19,334,463
Ensembl chr 1:19,312,326...19,329,300 		JBrowse link
G SNX12 sorting nexin 12 multiple interactions ISO Isoflurane promotes the reaction [Streptozocin results in decreased expression of SNX12 protein] CTD PMID:32062618 NCBI chr  X:71,059,247...71,073,426
Ensembl chr  X:71,056,332...71,073,426 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein] CTD PMID:36027947 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 ISO 5-hydroxydecanoic acid inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein; tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]
Isoflurane results in decreased activity of SOD2 protein
resveratrol inhibits the reaction [Isoflurane results in decreased activity of SOD2 protein]		 CTD PMID:17693941 PMID:23922164 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SPRYD4 SPRY domain containing 4 decreases expression ISO Isoflurane results in decreased expression of SPRYD4 protein CTD PMID:35249202 NCBI chr12:56,468,578...56,479,708
Ensembl chr12:56,468,578...56,479,708 		JBrowse link
G SRPK1 SRSF protein kinase 1 decreases methylation ISO Isoflurane results in decreased methylation of SRPK1 mRNA CTD PMID:35249202 NCBI chr 6:35,832,966...35,921,098
Ensembl chr 6:35,832,966...35,921,342 		JBrowse link
G STARD6 StAR related lipid transfer domain containing 6 increases methylation ISO Isoflurane results in increased methylation of STARD6 mRNA CTD PMID:35249202 NCBI chr18:54,324,492...54,357,858
Ensembl chr18:54,324,358...54,357,964 		JBrowse link
G STRN3 striatin 3 increases expression ISO Isoflurane results in increased expression of STRN3 protein CTD PMID:35249202 NCBI chr14:30,893,804...31,026,379
Ensembl chr14:30,893,799...31,026,401 		JBrowse link
G SURF4 surfeit 4 decreases methylation ISO Isoflurane results in decreased methylation of SURF4 mRNA CTD PMID:35249202 NCBI chr 9:133,361,464...133,377,949
Ensembl chr 9:133,361,450...133,376,166 		JBrowse link
G TANK TRAF family member associated NFKB activator decreases expression ISO Isoflurane results in decreased expression of TANK mRNA CTD PMID:16978161 NCBI chr 2:161,136,963...161,236,230
Ensembl chr 2:161,136,908...161,236,230 		JBrowse link
G TMEM9B TMEM9 domain family member B increases expression ISO Isoflurane results in increased expression of TMEM9B protein CTD PMID:35249202 NCBI chr11:8,947,202...8,964,947
Ensembl chr11:8,947,202...8,965,011 		JBrowse link
G TNF tumor necrosis factor decreases expression
increases expression
multiple interactions		 ISO Isoflurane results in decreased expression of TNF mRNA; Isoflurane results in decreased expression of TNF protein
Isoflurane results in increased expression of TNF protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of TNF protein]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]]; rhodioloside inhibits the reaction [Isoflurane results in increased expression of TNF protein]
Isoflurane results in increased expression of TNF mRNA; Isoflurane results in increased expression of TNF protein		 CTD PMID:10422944 PMID:15564938 PMID:16978161 PMID:17414419 PMID:28084090 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c decreases expression ISO Isoflurane results in decreased expression of TNFRSF10B mRNA CTD PMID:16978161 NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a decreases expression ISO Isoflurane results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression ISO Isoflurane results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A decreases expression ISO Isoflurane results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFRSF4 TNF receptor superfamily member 4 decreases expression ISO Isoflurane results in decreased expression of TNFRSF4 mRNA CTD PMID:16978161 NCBI chr 1:1,211,340...1,214,153
Ensembl chr 1:1,211,326...1,214,153 		JBrowse link
G TNFRSF8 TNF receptor superfamily member 8 decreases expression ISO Isoflurane results in decreased expression of TNFRSF8 mRNA CTD PMID:16978161 NCBI chr 1:12,063,303...12,144,207
Ensembl chr 1:12,063,303...12,144,207 		JBrowse link
G TNFSF10 TNF superfamily member 10 decreases expression ISO Isoflurane results in decreased expression of TNFSF10 mRNA CTD PMID:16978161 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TNFSF12 TNF superfamily member 12 decreases expression ISO Isoflurane results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr17:7,549,058...7,557,881
Ensembl chr17:7,548,508...7,557,890 		JBrowse link
G TNFSF13 TNF superfamily member 13 decreases expression ISO Isoflurane results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr17:7,558,282...7,561,601
Ensembl chr17:7,558,292...7,561,608 		JBrowse link
G TNFSF14 TNF superfamily member 14 decreases expression ISO Isoflurane results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr19:6,661,253...6,670,588
Ensembl chr19:6,661,253...6,670,588 		JBrowse link
G TNFSF4 TNF superfamily member 4 decreases expression ISO Isoflurane results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,183,731...173,207,331 		JBrowse link
G TNFSF9 TNF superfamily member 9 decreases expression ISO Isoflurane results in decreased expression of TNFSF9 mRNA CTD PMID:16978161 NCBI chr19:6,531,026...6,535,924
Ensembl chr19:6,531,026...6,535,924 		JBrowse link
G TNKS1BP1 tankyrase 1 binding protein 1 increases expression ISO Isoflurane results in increased expression of TNKS1BP1 protein CTD PMID:35249202 NCBI chr11:57,299,642...57,324,952
Ensembl chr11:57,299,638...57,324,952 		JBrowse link
G TP53 tumor protein p53 decreases expression ISO Isoflurane results in decreased expression of TP53 mRNA CTD PMID:16978161 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TPM4 tropomyosin 4 increases expression ISO Isoflurane results in increased expression of TPM4 protein CTD PMID:35249202 NCBI chr19:16,067,538...16,103,002
Ensembl chr19:16,067,021...16,103,002 		JBrowse link
G TPRG1L tumor protein p63 regulated 1 like increases expression ISO Isoflurane results in increased expression of TPRG1L protein CTD PMID:35249202 NCBI chr 1:3,625,015...3,630,127
Ensembl chr 1:3,625,015...3,630,127 		JBrowse link
G TRAF2 TNF receptor associated factor 2 decreases expression ISO Isoflurane results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607 		JBrowse link
G TRAF3 TNF receptor associated factor 3 decreases expression ISO Isoflurane results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr14:102,777,449...102,911,500
Ensembl chr14:102,777,449...102,911,500 		JBrowse link
G TRAPPC2L trafficking protein particle complex subunit 2L increases expression ISO Isoflurane results in increased expression of TRAPPC2L protein CTD PMID:35249202 NCBI chr16:88,856,220...88,862,678
Ensembl chr16:88,856,220...88,862,686 		JBrowse link
G TSFM Ts translation elongation factor, mitochondrial decreases expression ISO Isoflurane results in decreased expression of TSFM protein CTD PMID:35249202 NCBI chr12:57,782,787...57,802,856
Ensembl chr12:57,782,761...57,808,071 		JBrowse link
G UBA3 ubiquitin like modifier activating enzyme 3 increases expression ISO Isoflurane results in increased expression of UBA3 protein CTD PMID:35249202 NCBI chr 3:69,054,730...69,080,373
Ensembl chr 3:69,054,730...69,080,408 		JBrowse link
G UNG uracil DNA glycosylase increases methylation ISO Isoflurane results in increased methylation of UNG mRNA CTD PMID:35249202 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725 		JBrowse link
G USP54 ubiquitin specific peptidase 54 increases methylation ISO Isoflurane results in increased methylation of USP54 mRNA CTD PMID:35249202 NCBI chr10:73,497,538...73,625,981
Ensembl chr10:73,497,538...73,626,117 		JBrowse link
G VPS45 vacuolar protein sorting 45 homolog increases methylation ISO Isoflurane results in increased methylation of VPS45 mRNA CTD PMID:35249202 NCBI chr 1:150,067,382...150,145,329
Ensembl chr 1:150,067,279...150,145,329 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression ISO Isoflurane results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZBTB8OS zinc finger and BTB domain containing 8 opposite strand decreases methylation ISO Isoflurane results in decreased methylation of ZBTB8OS mRNA CTD PMID:35249202 NCBI chr 1:32,620,820...32,650,932
Ensembl chr 1:32,600,172...32,650,903 		JBrowse link
G ZNF354A zinc finger protein 354A increases methylation ISO Isoflurane results in increased methylation of ZNF354A mRNA CTD PMID:35249202 NCBI chr 5:178,711,512...178,730,659
Ensembl chr 5:178,711,512...178,730,659 		JBrowse link
G ZNF420 zinc finger protein 420 decreases methylation ISO Isoflurane results in decreased methylation of ZNF420 mRNA CTD PMID:35249202 NCBI chr19:37,007,902...37,130,368
Ensembl chr19:37,007,857...37,130,368 		JBrowse link
G ZNF655 zinc finger protein 655 decreases methylation ISO Isoflurane results in decreased methylation of ZNF655 mRNA CTD PMID:35249202 NCBI chr 7:99,558,642...99,576,453
Ensembl chr 7:99,558,406...99,576,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        donor 23222
          Lewis base 19943
            methoxyethane 231
              2-methoxyethyl group 0
              desflurane + 7
              enflurane 12
              isoflurane 228
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              organic hydroxy compound 22060
                                alcohol 16612
                                  primary alcohol 15330
                                    ethanols 9063
                                      ethanol 9073
                                        methoxyethane 231
                                          2-methoxyethyl group 0
                                          desflurane + 7
                                          enflurane 12
                                          isoflurane 228
paths to the root