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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxyethane
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Accession:CHEBI:39832 term browser browse the term
Definition:An ether that is the methyl ether derivative of ethanol.
Synonyms:related_synonym: 1-methoxyethane;   Aethylmethylaether;   C2H5OCH3;   Formula=C3H8O;   InChI=1S/C3H8O/c1-3-4-2/h3H2,1-2H3;   InChIKey=XOBKSJJDNFUZPF-UHFFFAOYSA-N;   Methoxyethan;   Methylaethylaether;   SMILES=CCOC;   ethyl methyl ether
 xref: Beilstein:1730785;   CAS:540-67-0;   Gmelin:163978;   PDBeChem:2ME;   PMID:12662033;   Patent:KR20080019002;   Reaxys:1730785;   Wikipedia:Methoxyethane



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desflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Htt huntingtin multiple interactions ISO desflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15781515 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Sele selectin E multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15781515 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein]; desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression
ISO Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:10825391 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 PMID:10825391 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA
CTD PMID:16309571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma increases expression EXP Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
isoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity
EXP rhodioloside inhibits the reaction [Isoflurane results in increased activity of ACHE protein] CTD PMID:28084090 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adam1a ADAM metallopeptidase domain 1a increases methylation ISO Isoflurane results in increased methylation of ADAM1A mRNA CTD PMID:35249202 NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
JBrowse link
G Ahcyl2 adenosylhomocysteinase-like 2 increases expression ISO Isoflurane results in increased expression of AHCYL2 protein CTD PMID:35249202 NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]; Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
EXP
ISO
Isoflurane results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]
CTD PMID:16249675 PMID:25597859 PMID:34553399 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase increases activity ISO Isoflurane results in increased activity of ALAD protein CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alg11 ALG11, alpha-1,2-mannosyltransferase decreases methylation ISO Isoflurane results in decreased methylation of ALG11 mRNA CTD PMID:35249202 NCBI chr16:69,940,540...69,951,617
Ensembl chr16:69,944,349...69,951,601
JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase decreases expression ISO Isoflurane results in decreased expression of ALKBH5 protein CTD PMID:35249202 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Isoflurane results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Isoflurane affects the expression of APP protein alternative form]; Isoflurane affects the metabolism of and affects the expression of and affects the secretion of APP protein alternative form CTD PMID:17287498 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Isoflurane results in decreased expression of ARC mRNA CTD PMID:16978161 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases methylation ISO Isoflurane results in increased methylation of ARFGAP3 mRNA CTD PMID:35249202 NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
JBrowse link
G Arhgap35 Rho GTPase activating protein 35 increases expression ISO Isoflurane results in increased expression of ARHGAP35 protein CTD PMID:35249202 NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO Isoflurane results in increased expression of BACE1 protein CTD PMID:17287498 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bach2 BTB domain and CNC homolog 2 decreases methylation ISO Isoflurane results in decreased methylation of BACH2 mRNA CTD PMID:35249202 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
affects expression
EXP Isoflurane results in decreased expression of BAD mRNA
Isoflurane affects the expression of BAD protein
CTD PMID:16978161 PMID:25597859 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression EXP Isoflurane results in decreased expression of BAK1 mRNA CTD PMID:16978161 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP Isoflurane results in decreased expression of BAX mRNA
Isoflurane results in increased expression of BAX protein
pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]
CTD PMID:16978161 PMID:29289695 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Isoflurane results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
affects expression
EXP [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Isoflurane promotes the reaction [Oxygen deficiency results in increased expression of BCL2 protein]
Isoflurane affects the expression of BCL2 protein
CTD PMID:16249675 PMID:20003127 PMID:29289695 PMID:32062618 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Isoflurane results in decreased expression of BCL2A1 mRNA CTD PMID:16978161 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression EXP Isoflurane affects the expression of BCL2L1 protein CTD PMID:25597859 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression EXP Isoflurane results in decreased expression of BCL2L11 mRNA CTD PMID:16978161 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Isoflurane results in decreased expression of BCL2L2 mRNA CTD PMID:16978161 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP Isoflurane results in decreased expression of BID mRNA CTD PMID:16978161 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression EXP Isoflurane results in decreased expression of BIRC3 mRNA CTD PMID:16978161 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression EXP Isoflurane results in decreased expression of BIRC5 mRNA CTD PMID:16978161 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases expression EXP Isoflurane results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Bmp7 bone morphogenetic protein 7 increases expression ISO Isoflurane results in increased expression of BMP7 protein CTD PMID:35249202 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Isoflurane results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G C4h2orf42 similar to human chromosome 2 open reading frame 42 decreases methylation ISO Isoflurane results in decreased methylation of C2ORF42 mRNA CTD PMID:35249202 NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936
JBrowse link
G C8h11orf65 similar to human chromosome 11 open reading frame 65 decreases methylation ISO Isoflurane results in decreased methylation of C11ORF65 mRNA CTD PMID:35249202 NCBI chr 8:53,796,033...53,825,277
Ensembl chr 8:53,796,366...53,824,748
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Isoflurane CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO Isoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Isoflurane results in decreased expression of CAMP protein CTD PMID:18382663 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Capn1 calpain 1 increases expression
multiple interactions
EXP Isoflurane results in increased expression of CAPN1 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]
CTD PMID:29289695 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
EXP Isoflurane results in increased expression of CAPN2 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]
CTD PMID:29289695 PMID:31672664 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
ISO Isoflurane results in increased cleavage of CASP1 protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased cleavage of CASP1 protein]; SETD7 protein affects the reaction [Isoflurane results in increased cleavage of CASP1 protein]
CTD PMID:35187972 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 decreases expression EXP Isoflurane results in decreased expression of CASP12 mRNA CTD PMID:16978161 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp14 caspase 14 decreases expression EXP Isoflurane results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Casp2 caspase 2 increases expression EXP Isoflurane results in increased expression of CASP2 mRNA CTD PMID:16978161 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
decreases expression
increases activity
ISO
EXP
APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein
Isoflurane results in increased cleavage of CASP3 protein
[Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]
Isoflurane results in increased expression of CASP3 protein; Isoflurane results in increased expression of CASP3 protein modified form
Isoflurane results in decreased expression of CASP3 mRNA
Isoflurane results in increased activity of CASP3 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP3 protein]
CTD PMID:15915027 PMID:16249675 PMID:16978161 PMID:17287498 PMID:18349187 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression EXP Isoflurane results in decreased expression of CASP4 mRNA CTD PMID:16978161 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
EXP Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP7 protein]
Isoflurane results in increased expression of CASP7 mRNA
CTD PMID:16249675 PMID:16978161 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity
EXP
ISO
Isoflurane results in decreased expression of CASP9 mRNA
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP9 protein]
CTD PMID:16978161 PMID:23922164 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; Resveratrol inhibits the reaction [Isoflurane results in decreased activity of CAT protein]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:23922164 PMID:32663520 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc8 coiled-coil domain containing 8 decreases methylation ISO Isoflurane results in decreased methylation of CCDC8 mRNA CTD PMID:35249202 NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Isoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd27 CD27 molecule decreases expression EXP Isoflurane results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
JBrowse link
G Cd40 CD40 molecule decreases expression EXP Isoflurane results in decreased expression of CD40 mRNA CTD PMID:16978161 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd40lg CD40 ligand decreases expression EXP Isoflurane results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd70 Cd70 molecule decreases expression EXP Isoflurane results in decreased expression of CD70 mRNA CTD PMID:16978161 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
JBrowse link
G Cd83 CD83 molecule increases methylation ISO Isoflurane results in increased methylation of CD83 mRNA CTD PMID:35249202 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cdadc1 cytidine and dCMP deaminase domain containing 1 decreases methylation ISO Isoflurane results in decreased methylation of CDADC1 mRNA CTD PMID:35249202 NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576
JBrowse link
G Cdhr2 cadherin-related family member 2 decreases expression ISO Isoflurane results in decreased expression of CDHR2 protein CTD PMID:35249202 NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575
JBrowse link
G Cfl1 cofilin 1 decreases expression ISO Isoflurane results in decreased expression of CFL1 protein CTD PMID:18382663 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
EXP Isoflurane results in decreased activity of CHAT protein
rhodioloside inhibits the reaction [Isoflurane results in decreased activity of CHAT protein]
CTD PMID:28084090 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression EXP Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases expression EXP Isoflurane results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Isoflurane results in decreased expression of CIDEA mRNA CTD PMID:16978161 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 decreases expression ISO Isoflurane results in decreased expression of CLASP1 protein CTD PMID:35249202 NCBI chr13:29,493,554...29,715,151
Ensembl chr13:29,493,596...29,715,146
JBrowse link
G Cnnm3 cyclin and CBS domain divalent metal cation transport mediator 3 decreases methylation ISO Isoflurane results in decreased methylation of CNNM3 mRNA CTD PMID:35249202 NCBI chr 9:38,755,374...38,770,740
Ensembl chr 9:38,755,390...38,770,740
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression ISO Isoflurane results in decreased expression of CNP protein CTD PMID:35249202 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cntnap5b contactin associated protein family member 5B decreases methylation ISO Isoflurane results in decreased methylation of CNTNAP5 mRNA CTD PMID:35249202 NCBI chr13:17,863,367...18,766,983
Ensembl chr13:18,093,420...18,761,014
JBrowse link
G Crb2 crumbs cell polarity complex component 2 decreases methylation ISO Isoflurane results in decreased methylation of CRB2 mRNA CTD PMID:35249202 NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294
JBrowse link
G Cstb cystatin B decreases expression ISO Isoflurane results in decreased expression of CSTB protein CTD PMID:35249202 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 increases methylation ISO Isoflurane results in increased methylation of CTDP1 mRNA CTD PMID:35249202 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Isoflurane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Isoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
increases expression
EXP Isoflurane results in decreased expression of CXCL2 mRNA
Isoflurane results in increased expression of CXCL2 mRNA
CTD PMID:10422944 PMID:15564938 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Isoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:16508399 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Dctn5 dynactin subunit 5 decreases expression ISO Isoflurane results in decreased expression of DCTN5 protein CTD PMID:35249202 NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression EXP Isoflurane results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
EXP Isoflurane results in decreased expression of DLG4 protein
IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]
CTD PMID:25597859 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dsel dermatan sulfate epimerase-like decreases methylation ISO Isoflurane results in decreased methylation of DSEL mRNA CTD PMID:35249202 NCBI chr13:186,413...192,592
Ensembl chr13:175,805...192,647
JBrowse link
G Dstn destrin, actin depolymerizing factor increases methylation ISO Isoflurane results in increased methylation of DSTN mRNA CTD PMID:35249202 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases methylation ISO Isoflurane results in decreased methylation of EEF1E1 mRNA CTD PMID:35249202 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 decreases expression
multiple interactions
EXP Isoflurane results in decreased expression of EPB41L1 protein
CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein]
CTD PMID:31672664 NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721
JBrowse link
G Fadd Fas associated via death domain decreases expression EXP Isoflurane results in decreased expression of FADD mRNA CTD PMID:16978161 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fam135b family with sequence similarity 135, member B decreases methylation ISO Isoflurane results in decreased methylation of FAM135B mRNA CTD PMID:35249202 NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708
JBrowse link
G Faslg Fas ligand decreases expression EXP Isoflurane results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn3krp fructosamine-3-kinase-related protein decreases expression ISO Isoflurane results in decreased expression of FN3KRP protein CTD PMID:35249202 NCBI chr10:106,688,413...106,697,137
Ensembl chr10:106,688,439...106,697,134
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurane results in increased expression of FOS mRNA CTD PMID:10781476 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxc1 forkhead box C1 decreases methylation ISO Isoflurane results in decreased methylation of FOXC1 mRNA CTD PMID:35249202 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803
JBrowse link
G Foxred2 FAD-dependent oxidoreductase domain containing 2 increases methylation ISO Isoflurane results in increased methylation of FOXRED2 mRNA CTD PMID:35249202 NCBI chr 7:109,521,761...109,538,300
Ensembl chr 7:109,521,761...109,540,874
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO Isoflurane results in decreased expression of FTO protein CTD PMID:35249202 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Isoflurane results in decreased methylation of FZD8 mRNA CTD PMID:35249202 NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Isoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases activity ISO Isoflurane results in increased activity of GABRA1 protein CTD PMID:16807363 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 affects response to substance
multiple interactions
ISO GABRA4 affects the susceptibility to Isoflurane
[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA
CTD PMID:16733821 PMID:19923508 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 increases methylation ISO Isoflurane results in increased methylation of GALNT7 mRNA CTD PMID:35249202 NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690
JBrowse link
G Gdf11 growth differentiation factor 11 decreases methylation ISO Isoflurane results in decreased methylation of GDF11 mRNA CTD PMID:35249202 NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
JBrowse link
G Gfod1 Gfo/Idh/MocA-like oxidoreductase domain containing 1 decreases methylation ISO Isoflurane results in decreased methylation of GFOD1 mRNA CTD PMID:35249202 NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938
JBrowse link
G Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 decreases methylation ISO Isoflurane results in decreased methylation of GGA2 mRNA CTD PMID:35249202 NCBI chr 1:176,552,046...176,585,332
Ensembl chr 1:176,552,046...176,585,361
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Isoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Gpr161 G protein-coupled receptor 161 increases methylation ISO Isoflurane results in increased methylation of GPR161 mRNA CTD PMID:35249202 NCBI chr13:77,578,257...77,623,661
Ensembl chr13:77,577,739...77,619,613
JBrowse link
G Gpr21 G protein-coupled receptor 21 decreases methylation ISO Isoflurane results in decreased methylation of GPR21 mRNA CTD PMID:35249202 NCBI chr 3:21,275,289...21,279,008
Ensembl chr 3:21,275,007...21,277,930
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression EXP Isoflurane results in increased expression of GRIN2B protein CTD PMID:31672664 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsdmd gasdermin D increases cleavage
multiple interactions
ISO Isoflurane results in increased cleavage of GSDMD protein
SETD7 protein affects the reaction [Isoflurane results in increased cleavage of GSDMD protein]
CTD PMID:35187972 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Gss glutathione synthetase decreases expression ISO Isoflurane results in decreased expression of GSS protein CTD PMID:35249202 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 decreases expression ISO Isoflurane results in decreased expression of HCN1 protein CTD PMID:35249202 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E increases methylation ISO Isoflurane results in increased methylation of H2BC11 mRNA CTD PMID:35249202 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Isoflurane results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
multiple interactions
decreases expression
ISO
EXP
Isoflurane results in increased activity of HMOX1 protein
Isoflurane results in increased expression of HMOX1 mRNA; Isoflurane results in increased expression of HMOX1 protein
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]
Isoflurane results in decreased expression of HMOX1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]; Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein
CTD PMID:16309571 PMID:32663520 PMID:36027947 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrk harakiri, BCL2 interacting protein decreases expression EXP Isoflurane results in decreased expression of HRK mRNA CTD PMID:16978161 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Htt huntingtin multiple interactions ISO Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]; xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
JBrowse link
G Hyal3 hyaluronidase 3 increases methylation ISO Isoflurane results in increased methylation of HYAL3 mRNA CTD PMID:35249202 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO
EXP
Isoflurane results in decreased expression of ICAM1 mRNA
Isoflurane results in decreased expression of ICAM1 mRNA; Isoflurane results in decreased expression of ICAM1 protein
Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein]; Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
CTD PMID:15564938 PMID:17414419 PMID:28003439 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ids iduronate 2-sulfatase decreases methylation ISO Isoflurane results in decreased methylation of IDS mRNA CTD PMID:35249202 NCBI chr  X:149,025,976...149,046,641
Ensembl chr  X:149,025,976...149,046,663
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases methylation ISO Isoflurane results in decreased methylation of IFIT3 mRNA CTD PMID:35249202 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
Isoflurane results in decreased expression of IGF1 protein
CTD PMID:25597859 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases phosphorylation EXP Isoflurane results in decreased phosphorylation of IGF1R protein CTD PMID:25597859 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
ISO N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of IL18 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL18 protein] CTD PMID:35187972 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
multiple interactions
ISO
EXP
Isoflurane results in decreased expression of IL1B mRNA
Isoflurane results in increased expression of IL1B mRNA; Isoflurane results in increased expression of IL1B protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; rhodioloside inhibits the reaction [Isoflurane results in increased expression of IL1B protein]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of IL1B protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL1B protein]
CTD PMID:10422944 PMID:17414419 PMID:28084090 PMID:35164634 PMID:35187972 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
increases expression
ISO
EXP
Isoflurane results in decreased expression of IL6 protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL6 protein]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]
CTD PMID:17414419 PMID:35164634 PMID:35187972 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Incenp inner centromere protein decreases methylation ISO Isoflurane results in decreased methylation of INCENP mRNA CTD PMID:35249202 NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265
JBrowse link
G Ino80 INO80 complex ATPase subunit increases methylation ISO Isoflurane results in increased methylation of INO80 mRNA CTD PMID:35249202 NCBI chr 3:106,368,455...106,465,716
Ensembl chr 3:106,368,455...106,467,911
JBrowse link
G Itgae integrin subunit alpha E increases expression EXP Isoflurane results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein] CTD PMID:28003439 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgam integrin subunit alpha M decreases expression
multiple interactions
ISO Isoflurane results in decreased expression of ITGAM protein
Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
CTD PMID:28003439 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurane results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kbtbd3 kelch repeat and BTB domain containing 3 decreases methylation ISO Isoflurane results in decreased methylation of KBTBD3 mRNA CTD PMID:35249202 NCBI chr 8:1,464,162...1,491,144
Ensembl chr 8:1,473,247...1,487,943
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 increases methylation ISO Isoflurane results in increased methylation of KCNJ6 mRNA CTD PMID:35249202 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Lamp5 lysosomal-associated membrane protein family, member 5 decreases expression ISO Isoflurane results in decreased expression of LAMP5 protein CTD PMID:35249202 NCBI chr 3:123,372,462...123,384,973
Ensembl chr 3:123,372,462...123,384,952
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 decreases methylation ISO Isoflurane results in decreased methylation of LDLRAP1 mRNA CTD PMID:35249202 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601
JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression EXP Isoflurane results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
JBrowse link
G Mag myelin-associated glycoprotein decreases expression ISO Isoflurane results in decreased expression of MAG protein CTD PMID:35249202 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
EXP Isoflurane results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:25597859 PMID:36027947 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Isoflurane results in decreased phosphorylation of MAPK3 protein CTD PMID:25597859 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Isoflurane results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein increases methylation ISO Isoflurane results in increased methylation of MCM3AP mRNA CTD PMID:35249202 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression EXP Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Meg3 maternally expressed 3 increases expression
multiple interactions
ISO
EXP
Isoflurane results in increased expression of MEG3 mRNA
MEG3 mRNA affects the reaction [Isoflurane results in decreased expression of MIR7-1 mRNA]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]; MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]]
CTD PMID:35164634 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Megf10 multiple EGF-like domains 10 decreases methylation ISO Isoflurane results in decreased methylation of MEGF10 mRNA CTD PMID:35249202 NCBI chr18:50,605,231...50,755,441
Ensembl chr18:50,605,656...50,754,456
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO Isoflurane results in decreased expression of METTL3 protein CTD PMID:35249202 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041
JBrowse link
G Mir140 microRNA 140 increases expression
multiple interactions
EXP Isoflurane results in increased expression of MIR140 mRNA
[Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; [Antagomirs results in decreased expression of MIR140 mRNA] inhibits the reaction [Isoflurane results in increased expression of MIR140 mRNA]
CTD PMID:32062618 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir191 microRNA 191 increases expression EXP Isoflurane results in increased expression of MIR191 mRNA CTD PMID:33586613 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir7-1 microRNA 7-1 multiple interactions
decreases expression
EXP MEG3 mRNA affects the reaction [Isoflurane results in decreased expression of MIR7-1 mRNA]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL1B protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of IL6 protein]]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]] CTD PMID:35164634 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
JBrowse link
G Mpo myeloperoxidase decreases activity EXP Isoflurane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases methylation ISO Isoflurane results in decreased methylation of MSMO1 mRNA CTD PMID:35249202 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases methylation ISO Isoflurane results in decreased methylation of MX1 mRNA CTD PMID:35249202 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression EXP Isoflurane results in decreased expression of NAIP2 mRNA CTD PMID:16978161 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Ncstn nicastrin increases expression ISO Isoflurane results in increased expression of NCSTN protein CTD PMID:17287498 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
Isoflurane results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]
Isoflurane results in decreased expression of NFE2L2 mRNA; Isoflurane results in decreased expression of NFE2L2 protein
CTD PMID:32663520 PMID:36027947 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nkx1-1 NK1 homeobox 1 increases methylation ISO Isoflurane results in increased methylation of NKX1-1 mRNA CTD PMID:35249202 NCBI chr14:77,296,676...77,300,575
Ensembl chr14:77,296,796...77,300,036
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO Isoflurane results in increased expression of NLRP3 protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of NLRP3 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of NLRP3 protein]
CTD PMID:35187972 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Isoflurane results in increased expression of NOS2 protein] CTD PMID:18708911 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
Isoflurane results in increased expression of NQO1 mRNA; Isoflurane results in increased expression of NQO1 protein
CTD PMID:32663520 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 increases methylation ISO Isoflurane results in increased methylation of NR2F6 mRNA CTD PMID:35249202 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
JBrowse link
G Nrk Nik related kinase increases methylation ISO Isoflurane results in increased methylation of NRK mRNA CTD PMID:35249202 NCBI chr  X:102,365,765...102,462,957
Ensembl chr  X:102,365,765...102,459,657
JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP Isoflurane results in increased expression of OBP3 mRNA CTD PMID:28717108 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
JBrowse link
G Pabpn1l PABPN1 like increases methylation ISO Isoflurane results in increased methylation of PABPN1L mRNA CTD PMID:35249202 NCBI chr19:50,669,965...50,673,409
Ensembl chr19:50,669,967...50,673,366
JBrowse link
G Pcdhga2 protocadherin gamma subfamily A, 2 decreases methylation ISO Isoflurane results in decreased methylation of PCDHGA2 mRNA CTD PMID:35249202 NCBI chr18:29,493,954...29,667,865
Ensembl chr18:29,493,954...29,667,868
JBrowse link
G Pcdhga9 protocadherin gamma subfamily A, 9 increases methylation ISO Isoflurane results in increased methylation of PCDHGA9 mRNA CTD PMID:35249202 NCBI chr18:29,564,614...29,667,865 JBrowse link
G Pdcd4 programmed cell death 4 decreases methylation ISO Isoflurane results in decreased methylation of PDCD4 mRNA CTD PMID:35249202 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pgf placental growth factor increases methylation ISO Isoflurane results in increased methylation of PGF mRNA CTD PMID:35249202 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pianp PILR alpha associated neural protein decreases methylation ISO Isoflurane results in decreased methylation of PIANP mRNA CTD PMID:35249202 NCBI chr 4:157,796,425...157,804,842
Ensembl chr 4:157,798,808...157,804,842
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha decreases expression ISO Isoflurane results in decreased expression of PIP4K2A protein CTD PMID:35249202 NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029
JBrowse link
G Pipox pipecolic acid and sarcosine oxidase decreases methylation ISO Isoflurane results in decreased methylation of PIPOX mRNA CTD PMID:35249202 NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
JBrowse link
G Pkig cAMP-dependent protein kinase inhibitor gamma decreases methylation ISO Isoflurane results in decreased methylation of PKIG mRNA CTD PMID:35249202 NCBI chr 3:152,330,477...152,398,085
Ensembl chr 3:152,366,041...152,398,082
JBrowse link
G Polr3k RNA polymerase III subunit K increases methylation ISO Isoflurane results in increased methylation of POLR3K mRNA CTD PMID:35249202 NCBI chr 3:168,982,846...168,987,043
Ensembl chr 3:168,982,812...168,987,040
JBrowse link
G Prickle2 prickle planar cell polarity protein 2 increases expression ISO Isoflurane results in increased expression of PRICKLE2 protein CTD PMID:35249202 NCBI chr 4:124,869,655...125,214,862
Ensembl chr 4:124,869,552...125,214,824
JBrowse link
G Psen1 presenilin 1 affects response to substance EXP PSEN1 gene SNP affects the susceptibility to Isoflurane CTD PMID:18227305 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Isoflurane results in increased expression of PTGS2 mRNA
Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]
CTD PMID:21615343 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Puf60 poly-U binding splicing factor 60 increases expression ISO Isoflurane results in increased expression of PUF60 protein CTD PMID:35249202 NCBI chr 7:107,782,799...107,793,759
Ensembl chr 7:107,782,770...107,794,531
JBrowse link
G Pycard PYD and CARD domain containing decreases expression
multiple interactions
increases expression
EXP
ISO
Isoflurane results in decreased expression of PYCARD mRNA
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Isoflurane results in increased expression of PYCARD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of PYCARD protein]
CTD PMID:16978161 PMID:35187972 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Ralb RAS like proto-oncogene B increases expression ISO Isoflurane results in increased expression of RALB protein CTD PMID:35249202 NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin affects activity
multiple interactions
ISO Isoflurane affects the activity of REN protein
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein; [Labetalol co-treated with Isoflurane] results in increased expression of REN protein
CTD PMID:1897344 PMID:3281763 PMID:3284271 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rnf34 ring finger protein 34 decreases methylation ISO Isoflurane results in decreased methylation of RNF34 mRNA CTD PMID:35249202 NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586
JBrowse link
G Rps27 ribosomal protein S27 decreases methylation ISO Isoflurane results in decreased methylation of RPS27 mRNA CTD PMID:35249202 NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
EXP IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein] CTD PMID:25597859 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Isoflurane results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sar1a secretion associated, Ras related GTPase 1A decreases expression ISO Isoflurane results in decreased expression of SAR1A protein CTD PMID:35249202 NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935
JBrowse link
G Sdf2 stromal cell derived factor 2 decreases expression ISO Isoflurane results in decreased expression of SDF2 protein CTD PMID:35249202 NCBI chr10:63,140,563...63,151,038
Ensembl chr10:63,140,563...63,201,109
JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase decreases expression ISO Isoflurane results in decreased expression of SEL1L protein CTD PMID:35249202 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Isoflurane results in increased expression of SERPINE2 protein CTD PMID:35249202 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase multiple interactions ISO SETD7 protein affects the reaction [Isoflurane results in increased cleavage of CASP1 protein]; SETD7 protein affects the reaction [Isoflurane results in increased cleavage of GSDMD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL18 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL1B protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of IL6 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of NLRP3 protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of PYCARD protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of TNF protein] CTD PMID:35187972 NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468
JBrowse link
G Sf3b4 splicing factor 3B subunit 4 increases expression ISO Isoflurane results in increased expression of SF3B4 protein CTD PMID:35249202 NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 decreases methylation ISO Isoflurane results in decreased methylation of SH3KBP1 mRNA CTD PMID:35249202 NCBI chr  X:34,877,862...35,223,013
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases methylation ISO Isoflurane results in decreased methylation of SIPA1L2 mRNA CTD PMID:35249202 NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428
JBrowse link
G Slc12a5 solute carrier family 12 member 5 multiple interactions
decreases expression
EXP CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein] CTD PMID:31672664 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Isoflurane results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
JBrowse link
G Slc66a1 solute carrier family 66 member 1 decreases methylation ISO Isoflurane results in decreased methylation of SLC66A1 mRNA CTD PMID:35249202 NCBI chr 5:151,537,870...151,552,259
Ensembl chr 5:151,542,376...151,552,259
JBrowse link
G Snx12 sorting nexin 12 multiple interactions EXP Isoflurane promotes the reaction [Streptozocin results in decreased expression of SNX12 protein] CTD PMID:32062618 NCBI chr  X:66,226,995...66,356,945
Ensembl chr  X:66,227,053...66,356,950
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein] CTD PMID:36027947 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases activity
EXP
ISO
5-hydroxydecanoic acid inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein; tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]
resveratrol inhibits the reaction [Isoflurane results in decreased activity of SOD2 protein]
CTD PMID:17693941 PMID:23922164 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spryd4 SPRY domain containing 4 decreases expression ISO Isoflurane results in decreased expression of SPRYD4 protein CTD PMID:35249202 NCBI chr 7:633,400...637,564
Ensembl chr 7:633,394...637,557
JBrowse link
G Srpk1 SRSF protein kinase 1 decreases methylation ISO Isoflurane results in decreased methylation of SRPK1 mRNA CTD PMID:35249202 NCBI chr20:6,645,809...6,682,448
Ensembl chr20:6,645,809...6,682,134
JBrowse link
G Stard6 StAR-related lipid transfer domain containing 6 increases methylation ISO Isoflurane results in increased methylation of STARD6 mRNA CTD PMID:35249202 NCBI chr18:64,089,618...64,118,528
Ensembl chr18:64,089,471...64,107,099
JBrowse link
G Strn3 striatin 3 increases expression ISO Isoflurane results in increased expression of STRN3 protein CTD PMID:35249202 NCBI chr 6:69,047,776...69,134,102
Ensembl chr 6:69,047,776...69,134,102
JBrowse link
G Surf4 surfeit 4 decreases methylation ISO Isoflurane results in decreased methylation of SURF4 mRNA CTD PMID:35249202 NCBI chr 3:10,248,360...10,261,537
Ensembl chr 3:10,241,837...10,263,315
JBrowse link
G Tank TRAF family member-associated NFKB activator decreases expression EXP Isoflurane results in decreased expression of TANK mRNA CTD PMID:16978161 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264
JBrowse link
G Tmem9b TMEM9 domain family, member B increases expression ISO Isoflurane results in increased expression of TMEM9B protein CTD PMID:35249202 NCBI chr 1:163,755,307...163,783,880
Ensembl chr 1:163,764,433...163,783,278
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions
ISO
EXP
Isoflurane results in decreased expression of TNF mRNA; Isoflurane results in decreased expression of TNF protein
Isoflurane results in increased expression of TNF mRNA; Isoflurane results in increased expression of TNF protein
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; MIR7-1 mRNA affects the reaction [MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]]; rhodioloside inhibits the reaction [Isoflurane results in increased expression of TNF protein]
MEG3 mRNA affects the reaction [Isoflurane results in increased expression of TNF protein]; SETD7 protein affects the reaction [Isoflurane results in increased expression of TNF protein]
CTD PMID:10422944 PMID:15564938 PMID:16978161 PMID:17414419 PMID:28084090 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression EXP Isoflurane results in decreased expression of TNFRSF10B mRNA CTD PMID:16978161 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression EXP Isoflurane results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP Isoflurane results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Isoflurane results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 decreases expression EXP Isoflurane results in decreased expression of TNFRSF4 mRNA CTD PMID:16978161 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression EXP Isoflurane results in decreased expression of TNFRSF8 mRNA CTD PMID:16978161 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Isoflurane results in decreased expression of TNFSF10 mRNA CTD PMID:16978161 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression EXP Isoflurane results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Isoflurane results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
JBrowse link
G Tnfsf14 TNF superfamily member 14 decreases expression EXP Isoflurane results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216
JBrowse link
G Tnfsf4 TNF superfamily member 4 decreases expression EXP Isoflurane results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Tnfsf9 TNF superfamily member 9 decreases expression EXP Isoflurane results in decreased expression of TNFSF9 mRNA CTD PMID:16978161 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
JBrowse link
G Tnks1bp1 tankyrase 1 binding protein 1 increases expression ISO Isoflurane results in increased expression of TNKS1BP1 protein CTD PMID:35249202 NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Isoflurane results in decreased expression of TP53 mRNA CTD PMID:16978161 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO Isoflurane results in increased expression of TPM4 protein CTD PMID:35249202 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Tprg1l tumor protein p63 regulated 1-like increases expression ISO Isoflurane results in increased expression of TPRG1L protein CTD PMID:35249202 NCBI chr 5:164,722,151...164,725,358
Ensembl chr 5:164,710,285...164,725,425
JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression EXP Isoflurane results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Traf3 Tnf receptor-associated factor 3 decreases expression EXP Isoflurane results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
JBrowse link
G Trappc2l trafficking protein particle complex subunit 2L increases expression ISO Isoflurane results in increased expression of TRAPPC2L protein CTD PMID:35249202 NCBI chr19:50,662,507...50,666,193
Ensembl chr19:50,662,507...50,666,192
JBrowse link
G Tsfm Ts translation elongation factor, mitochondrial decreases expression ISO Isoflurane results in decreased expression of TSFM protein CTD PMID:35249202 NCBI chr 7:62,828,997...62,864,784
Ensembl chr 7:62,845,488...62,864,769
JBrowse link
G Uba3 ubiquitin-like modifier activating enzyme 3 increases expression ISO Isoflurane results in increased expression of UBA3 protein CTD PMID:35249202 NCBI chr 4:129,789,526...129,810,707
Ensembl chr 4:129,789,204...129,810,606
JBrowse link
G Ung uracil-DNA glycosylase increases methylation ISO Isoflurane results in increased methylation of UNG mRNA CTD PMID:35249202 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Usp54 ubiquitin specific peptidase 54 increases methylation ISO Isoflurane results in increased methylation of USP54 mRNA CTD PMID:35249202 NCBI chr15:3,659,345...3,757,703
Ensembl chr15:3,659,240...3,757,711
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases methylation ISO Isoflurane results in increased methylation of VPS45 mRNA CTD PMID:35249202 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP Isoflurane results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zbtb8os zinc finger and BTB domain containing 8 opposite strand decreases methylation ISO Isoflurane results in decreased methylation of ZBTB8OS mRNA CTD PMID:35249202 NCBI chr 5:141,675,595...141,687,148
Ensembl chr 5:141,675,857...141,688,660
JBrowse link
G Zfp354a zinc finger protein 354A increases methylation ISO Isoflurane results in increased methylation of ZNF354A mRNA CTD PMID:35249202 NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
JBrowse link
G Zfp420 zinc finger protein 420 decreases methylation ISO Isoflurane results in decreased methylation of ZNF420 mRNA CTD PMID:35249202 NCBI chr 1:85,092,810...85,143,682
Ensembl chr 1:85,093,085...85,106,693
Ensembl chr 1:85,093,085...85,106,693
JBrowse link
G Zfp655 zinc finger protein 655 decreases methylation ISO Isoflurane results in decreased methylation of ZNF655 mRNA CTD PMID:35249202 NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      chemical role 19512
        donor 18935
          Lewis base 17850
            methoxyethane 232
              2-methoxyethyl group 0
              desflurane + 7
              enflurane 12
              isoflurane 229
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              organic hydroxy compound 19003
                                alcohol 15559
                                  primary alcohol 14468
                                    ethanols 8809
                                      ethanol 8809
                                        methoxyethane 232
                                          2-methoxyethyl group 0
                                          desflurane + 7
                                          enflurane 12
                                          isoflurane 229
paths to the root