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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxyethane
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Accession:CHEBI:39832 term browser browse the term
Definition:An ether that is the methyl ether derivative of ethanol.
Synonyms:related_synonym: 1-methoxyethane;   Aethylmethylaether;   C2H5OCH3;   Formula=C3H8O;   InChI=1S/C3H8O/c1-3-4-2/h3H2,1-2H3;   InChIKey=XOBKSJJDNFUZPF-UHFFFAOYSA-N;   Methoxyethan;   Methylaethylaether;   SMILES=CCOC;   ethyl methyl ether
 xref: Beilstein:1730785;   CAS:540-67-0;   Gmelin:163978;   PDBeChem:2ME;   PMID:12662033;   Patent:KR20080019002;   Reaxys:1730785;   Wikipedia:Methoxyethane


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desflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of AVP protein CTD PMID:8017643 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Htt huntingtin multiple interactions ISO desflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15781515 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ren renin multiple interactions ISO [Propofol co-treated with desflurane] results in increased expression of REN protein CTD PMID:8017643 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sele selectin E multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15781515 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; desflurane inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; desflurane inhibits the reaction [TNF protein results in increased expression of SELE protein]; desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO desflurane inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15781515 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
enflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression
ISO Enflurane results in increased activity of ALAD protein
Enflurane results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Enflurane CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Enflurane results in increased expression of CXCL2 mRNA CTD PMID:10422944 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Enflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]] CTD PMID:10825391 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Enflurane inhibits the reaction [Trichloroethylene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]]; Enflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:10825391 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Enflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 PMID:10825391 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Enflurane results in increased activity of HMOX1 protein
Enflurane results in increased expression of HMOX1 mRNA
CTD PMID:16309571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma increases expression EXP Enflurane results in increased expression of IFNG mRNA CTD PMID:10422944 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Enflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Enflurane results in increased expression of TNF mRNA CTD PMID:10422944 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
isoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]; Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions
EXP Isoflurane results in increased phosphorylation of AKT1 protein
Isoflurane results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
CTD PMID:16249675 PMID:25597859 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase increases activity ISO Isoflurane results in increased activity of ALAD protein CTD PMID:16309571 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Isoflurane results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Isoflurane affects the expression of APP protein alternative form]; Isoflurane affects the metabolism of and affects the expression of and affects the secretion of APP protein alternative form CTD PMID:17287498 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Isoflurane results in decreased expression of ARC mRNA CTD PMID:16978161 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Labetalol co-treated with Isoflurane] results in increased expression of AVP protein CTD PMID:1897344 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO Isoflurane results in increased expression of BACE1 protein CTD PMID:17287498 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
affects expression
EXP Isoflurane results in decreased expression of BAD mRNA
Isoflurane affects the expression of BAD protein
CTD PMID:16978161 PMID:25597859 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 decreases expression EXP Isoflurane results in decreased expression of BAK1 mRNA CTD PMID:16978161 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression
EXP Isoflurane results in decreased expression of BAX mRNA
pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]
CTD PMID:16978161 PMID:29289695 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Isoflurane results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression
EXP Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Isoflurane promotes the reaction [Oxygen deficiency results in increased expression of BCL2 protein]
Isoflurane affects the expression of BCL2 protein
CTD PMID:16249675 PMID:20003127 PMID:29289695 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Isoflurane results in decreased expression of BCL2A1 mRNA CTD PMID:16978161 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression EXP Isoflurane affects the expression of BCL2L1 protein CTD PMID:25597859 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression EXP Isoflurane results in decreased expression of BCL2L11 mRNA CTD PMID:16978161 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Isoflurane results in decreased expression of BCL2L2 mRNA CTD PMID:16978161 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP Isoflurane results in decreased expression of BID mRNA CTD PMID:16978161 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression EXP Isoflurane results in decreased expression of BIRC3 mRNA CTD PMID:16978161 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression EXP Isoflurane results in decreased expression of BIRC5 mRNA CTD PMID:16978161 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases expression EXP Isoflurane results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Isoflurane results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Isoflurane CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO Isoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Isoflurane results in decreased expression of CAMP protein CTD PMID:18382663 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Capn1 calpain 1 increases expression
multiple interactions
EXP Isoflurane results in increased expression of CAPN1 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]
CTD PMID:29289695 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
EXP Isoflurane results in increased expression of CAPN2 protein
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein]
CTD PMID:29289695 PMID:31672664 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp12 caspase 12 decreases expression EXP Isoflurane results in decreased expression of CASP12 mRNA CTD PMID:16978161 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp14 caspase 14 decreases expression EXP Isoflurane results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Casp2 caspase 2 increases expression EXP Isoflurane results in increased expression of CASP2 mRNA CTD PMID:16978161 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
increases expression
ISO
EXP
APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein]; Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein
Isoflurane results in increased cleavage of CASP3 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP3 protein]
Isoflurane results in decreased expression of CASP3 mRNA
Isoflurane results in increased expression of CASP3 protein; Isoflurane results in increased expression of CASP3 protein modified form
Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]
CTD PMID:15915027 PMID:16249675 PMID:16978161 PMID:17287498 PMID:18349187 PMID:19352168 PMID:20003127 PMID:23922164 PMID:25597859 PMID:29289695 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 decreases expression EXP Isoflurane results in decreased expression of CASP4 mRNA CTD PMID:16978161 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
EXP Isoflurane inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP7 protein]
Isoflurane results in increased expression of CASP7 mRNA
CTD PMID:16249675 PMID:16978161 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP8 protein] CTD PMID:23922164 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression
increases activity
multiple interactions
EXP
ISO
Isoflurane results in decreased expression of CASP9 mRNA
Isoflurane results in increased activity of CASP9 protein
resveratrol inhibits the reaction [Isoflurane results in increased activity of CASP9 protein]
CTD PMID:16978161 PMID:23922164 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; Resveratrol inhibits the reaction [Isoflurane results in decreased activity of CAT protein]; trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein] CTD PMID:23922164 PMID:32663520 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Isoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd27 CD27 molecule decreases expression EXP Isoflurane results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd40 CD40 molecule decreases expression EXP Isoflurane results in decreased expression of CD40 mRNA CTD PMID:16978161 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand decreases expression EXP Isoflurane results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd70 Cd70 molecule decreases expression EXP Isoflurane results in decreased expression of CD70 mRNA CTD PMID:16978161 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cfl1 cofilin 1 decreases expression ISO Isoflurane results in decreased expression of CFL1 protein CTD PMID:18382663 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression EXP Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases expression EXP Isoflurane results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Isoflurane results in decreased expression of CIDEA mRNA CTD PMID:16978161 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Isoflurane results in decreased expression of CXCL1 mRNA CTD PMID:15564938 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Isoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
increases expression
EXP Isoflurane results in decreased expression of CXCL2 mRNA
Isoflurane results in increased expression of CXCL2 mRNA
CTD PMID:10422944 PMID:15564938 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Isoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:16508399 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression EXP Isoflurane results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
EXP Isoflurane results in decreased expression of DLG4 protein
IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]
CTD PMID:25597859 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 decreases expression
multiple interactions
EXP Isoflurane results in decreased expression of EPB41L1 protein
CAPN2 protein affects the reaction [Isoflurane results in decreased expression of EPB41L1 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein]
CTD PMID:31672664 NCBI chr 3:152,492,725...152,622,047
Ensembl chr 3:152,552,822...152,619,722
JBrowse link
G Fadd Fas associated via death domain decreases expression EXP Isoflurane results in decreased expression of FADD mRNA CTD PMID:16978161 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Faslg Fas ligand decreases expression EXP Isoflurane results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurane results in increased expression of FOS mRNA CTD PMID:10781476 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Isoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases activity ISO Isoflurane results in increased activity of GABRA1 protein CTD PMID:16807363 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 affects response to substance
multiple interactions
ISO GABRA4 affects the susceptibility to Isoflurane
[Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNA
CTD PMID:16733821 PMID:19923508 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Isoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Isoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression EXP Isoflurane results in increased expression of GRIN2B protein CTD PMID:31672664 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Hmgb1 high mobility group box 1 increases expression ISO Isoflurane results in increased expression of HMGB1 protein CTD PMID:24747151 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
ISO Isoflurane results in increased activity of HMOX1 protein
trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of HMOX1 protein]
Isoflurane results in increased expression of HMOX1 mRNA; Isoflurane results in increased expression of HMOX1 protein
CTD PMID:16309571 PMID:32663520 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrk harakiri, BCL2 interacting protein decreases expression EXP Isoflurane results in decreased expression of HRK mRNA CTD PMID:16978161 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Htt huntingtin multiple interactions ISO Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]; xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] CTD PMID:21059370 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO
EXP
Isoflurane results in decreased expression of ICAM1 mRNA
Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein]; Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
Isoflurane results in decreased expression of ICAM1 mRNA; Isoflurane results in decreased expression of ICAM1 protein
CTD PMID:15564938 PMID:17414419 PMID:28003439 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; [IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]; MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
Isoflurane results in decreased expression of IGF1 protein
CTD PMID:25597859 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases phosphorylation EXP Isoflurane results in decreased phosphorylation of IGF1R protein CTD PMID:25597859 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
ISO
EXP
Isoflurane results in decreased expression of IL1B mRNA
Isoflurane results in increased expression of IL1B mRNA
CTD PMID:10422944 PMID:17414419 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Isoflurane results in decreased expression of IL6 protein CTD PMID:17414419 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgae integrin subunit alpha E increases expression EXP Isoflurane results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Isoflurane inhibits the reaction [ITGAL protein binds to ICAM1 protein] CTD PMID:28003439 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M decreases expression
multiple interactions
ISO Isoflurane results in decreased expression of ITGAM protein
Isoflurane inhibits the reaction [ITGAM protein binds to ICAM1 protein]
CTD PMID:28003439 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurane results in increased expression of JUN mRNA CTD PMID:10781476 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression EXP Isoflurane results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr 4:157,822,838...157,829,291
Ensembl chr 4:157,822,840...157,829,241
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
EXP Isoflurane results in decreased phosphorylation of MAPK1 protein
[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]; Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:25597859 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Isoflurane results in decreased phosphorylation of MAPK3 protein CTD PMID:25597859 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Isoflurane results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression EXP Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mpo myeloperoxidase decreases activity EXP Isoflurane results in decreased activity of MPO protein CTD PMID:15564938 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression EXP Isoflurane results in decreased expression of NAIP2 mRNA CTD PMID:16978161 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Ncstn nicastrin increases expression ISO Isoflurane results in increased expression of NCSTN protein CTD PMID:17287498 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO Isoflurane results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [trilobatin inhibits the reaction [Isoflurane results in decreased activity of CAT protein]]; trilobatin promotes the reaction [Isoflurane results in increased expression of NFE2L2 protein]
CTD PMID:32663520 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Isoflurane results in increased expression of NOS2 protein] CTD PMID:18708911 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 mRNA]; trilobatin promotes the reaction [Isoflurane results in increased expression of NQO1 protein]
Isoflurane results in increased expression of NQO1 mRNA; Isoflurane results in increased expression of NQO1 protein
CTD PMID:32663520 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP Isoflurane results in increased expression of OBP3 mRNA CTD PMID:28717108 NCBI chr 5:77,313,357...77,316,875 JBrowse link
G Psen1 presenilin 1 affects response to substance EXP PSEN1 gene SNP affects the susceptibility to Isoflurane CTD PMID:18227305 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Isoflurane results in increased expression of PTGS2 mRNA
Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]
CTD PMID:21615343 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Isoflurane results in decreased expression of PYCARD mRNA CTD PMID:16978161 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin affects activity
multiple interactions
ISO Isoflurane affects the activity of REN protein
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein; [Labetalol co-treated with Isoflurane] results in increased expression of REN protein
CTD PMID:1897344 PMID:3281763 PMID:3284271 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
EXP IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein] CTD PMID:25597859 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Isoflurane results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Slc12a5 solute carrier family 12 member 5 multiple interactions
decreases expression
EXP CAPN2 protein affects the reaction [Isoflurane results in decreased expression of SLC12A5 protein]; ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein] CTD PMID:31672664 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Isoflurane results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases activity
EXP
ISO
5-hydroxydecanoic acid inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein; tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]
Isoflurane results in decreased activity of SOD2 protein
resveratrol inhibits the reaction [Isoflurane results in decreased activity of SOD2 protein]
CTD PMID:17693941 PMID:23922164 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tank TRAF family member-associated NFKB activator decreases expression EXP Isoflurane results in decreased expression of TANK mRNA CTD PMID:16978161 NCBI chr 3:47,439,007...47,515,706
Ensembl chr 3:47,439,076...47,515,700
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
ISO
EXP
Isoflurane results in decreased expression of TNF mRNA; Isoflurane results in decreased expression of TNF protein
Isoflurane results in increased expression of TNF mRNA
CTD PMID:10422944 PMID:15564938 PMID:16978161 PMID:17414419 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression EXP Isoflurane results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP Isoflurane results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Isoflurane results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 decreases expression EXP Isoflurane results in decreased expression of TNFRSF4 mRNA CTD PMID:16978161 NCBI chr 5:173,447,784...173,450,474
Ensembl chr 5:173,447,784...173,450,474
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression EXP Isoflurane results in decreased expression of TNFRSF8 mRNA CTD PMID:16978161 NCBI chr 5:163,186,349...163,231,578
Ensembl chr 5:163,186,349...163,231,578
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Isoflurane results in decreased expression of TNFSF10 mRNA CTD PMID:16978161 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression EXP Isoflurane results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr10:56,290,780...56,300,137
Ensembl chr10:56,290,780...56,300,077
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Isoflurane results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnfsf14 TNF superfamily member 14 decreases expression EXP Isoflurane results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr 9:9,761,363...9,765,461
Ensembl chr 9:9,761,536...9,765,186
JBrowse link
G Tnfsf4 TNF superfamily member 4 decreases expression EXP Isoflurane results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Tnfsf9 TNF superfamily member 9 decreases expression EXP Isoflurane results in decreased expression of TNFSF9 mRNA CTD PMID:16978161 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Isoflurane results in decreased expression of TP53 mRNA CTD PMID:16978161 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression EXP Isoflurane results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Traf3 Tnf receptor-associated factor 3 decreases expression EXP Isoflurane results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP Isoflurane results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      chemical role 19283
        donor 18416
          Lewis base 16963
            methoxyethane 118
              2-methoxyethyl group 0
              desflurane + 7
              enflurane 12
              isoflurane 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      chalcogen 19391
                        oxygen atom 19353
                          oxygen molecular entity 19353
                            hydroxides 19103
                              organic hydroxy compound 18658
                                alcohol 15007
                                  primary alcohol 13907
                                    ethanols 8136
                                      ethanol 8136
                                        methoxyethane 118
                                          2-methoxyethyl group 0
                                          desflurane + 7
                                          enflurane 12
                                          isoflurane 115
paths to the root