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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diflunisal
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Accession:CHEBI:39669 term browser browse the term
Definition:An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Synonyms:exact_synonym: 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
 related_synonym: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid;   2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid;   5-(2,4-difluorophenyl)salicylic acid;   Dolobid;   Formula=C13H8F2O3;   InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18);   InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
 alt_id: CHEBI:39656;   CHEBI:4538
 xref: CAS:22494-42-4;   DrugBank:DB00861;   Drug_Central:880;   HMDB:HMDB0014999;   KEGG:C01691;   KEGG:D00130;   LINCS:LSM-2490
 xref_mesh: MESH:D004061
 xref: PDBeChem:1FL;   PMID:23144359;   PMID:23416065;   PMID:28166217;   Reaxys:2654431;   Wikipedia:Diflunisal


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diflunisal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Diflunisal results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Diflunisal results in increased expression of IL1B mRNA CTD PMID:15135310 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression EXP Diflunisal results in increased expression of IL6 mRNA CTD PMID:15135310 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Diflunisal results in increased expression of NOS2 mRNA CTD PMID:15135310 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Slc6a8 solute carrier family 6 member 8 increases expression ISO Diflunisal results in increased expression of SLC6A8 mRNA CTD PMID:29901742 NCBI chr  X:157,129,987...157,139,321
Ensembl chr  X:157,129,987...157,139,291
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Diflunisal results in increased expression of TNF mRNA CTD PMID:15135310 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ttr transthyretin affects binding
multiple interactions
ISO Diflunisal binds to TTR protein mutant form
[Diflunisal binds to TTR protein mutant form] which results in decreased susceptibility to Urea; Diflunisal results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]
CTD PMID:17701470 PMID:27093678 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Diflunisal results in decreased activity of UGT1A1 protein CTD PMID:15593333 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Diflunisal CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Diflunisal CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Diflunisal; UGT2B7 protein results in increased glucuronidation of Diflunisal
CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        antimicrobial agent 17373
          antifungal agent 15050
            salicylic acid 768
              diflunisal 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        aromatic carboxylic acid 11266
                                          benzoic acids 11237
                                            benzoic acid 3865
                                              hydroxybenzoic acid 3254
                                                monohydroxybenzoic acid 1286
                                                  salicylic acid 768
                                                    diflunisal 11
paths to the root