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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbidopa (anhydrous)
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Accession:CHEBI:39585 term browser browse the term
Definition:3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Synonyms:exact_synonym: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
 related_synonym: (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid;   (S)-carbidopa;   (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid;   Formula=C10H14N2O4;   InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1;   InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N;   L-3-(3,4-dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid;   L-alpha-methyldopahydrazine;   SMILES=C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O;   carbidopum
 xref: Beilstein:4189448;   CAS:28860-95-9;   DrugBank:DB00190;   Drug_Central:496;   LINCS:LSM-5850;   PDBeChem:142;   Wikipedia:Carbidopa


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carbidopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO
EXP
COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            dopaminergic agent 5069
              carbidopa (anhydrous) 1
                carbidopa 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          carbidopa (anhydrous) 1
                                            carbidopa 1
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