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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:12-hydroxylauric acid
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Accession:CHEBI:39567 term browser browse the term
Definition:A medium-chain fatty acid that is the 12-hydroxylated derivative of lauric acid.
Synonyms:related_synonym: 12-Hydroxydodecanoic acid;   12-hydroxy lauric acid;   2-hydroxy-dodecanoic acid;   Formula=C12H24O3;   InChI=1S/C12H24O3/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h13H,1-11H2,(H,14,15);   InChIKey=ZDHCZVWCTKTBRY-UHFFFAOYSA-N;   SMILES=OCCCCCCCCCCCC(O)=O;   omega-OH dodecanoic acid;   omega-OH lauric acid;   omega-hydroxy lauric acid;   omega-hydroxydodecanoic acid
 alt_id: CHEBI:10616;   CHEBI:39557
 xref: Beilstein:1238370;   CAS:505-95-3;   DrugBank:DB03704;   HMDB:HMDB0002059;   KEGG:C08317;   KNApSAcK:C00001219;   LIPID_MAPS_instance:LMFA01050039
 xref_mesh: MESH:C031263
 xref: PDBeChem:12H;   PMID:113393;   PMID:16719385;   PMID:2155662;   PMID:7872779;   Reaxys:1238370
 cyclic_relationship: is_conjugate_acid_of CHEBI:36204



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12-hydroxylauric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide affects binding
increases oxidation
ISO 12-hydroxydodecanoic acid binds to ADH5 protein
ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid
CTD PMID:12196016 PMID:12604204 PMID:19428350 NCBI chr 2:226,975,184...226,987,591 JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 multiple interactions
increases chemical synthesis
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid] CTD PMID:28729181 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          antibacterial agent 13972
            dodecanoic acid 176
              12-hydroxylauric acid 2
                (3R)-3,12-dihydroxylauric acid + 0
                oscr#20 + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        monocarboxylic acid 17618
                                          fatty acid 16009
                                            saturated fatty acid 15984
                                              straight-chain saturated fatty acid 15439
                                                dodecanoic acid 176
                                                  12-hydroxylauric acid 2
                                                    (3R)-3,12-dihydroxylauric acid + 0
                                                    oscr#20 + 0
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