2,2,2-tetramine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2,2,2-tetramine	go back to main search page
Accession:	CHEBI:39501	browse the term
Definition:	A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens.
Synonyms:	exact_synonym:	N,N'-bis(2-aminoethyl)ethane-1,2-diamine
	related_synonym:	Formula=C6H18N4; InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2; InChIKey=VILCJCGEZXAXTO-UHFFFAOYSA-N; N,N'-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE; SMILES=NCCNCCNCCN; TETA; Trientine; Triethylenetetramine; trien; triethylenetetraamine
	alt_id:	CHEBI:39496; CHEBI:9705
	xref:	Beilstein:605448; CAS:112-24-3; Drug_Central:2738; Gmelin:27008; KEGG:C07166
	xref_mesh:	MESH:D014266
	xref:	PDBeChem:104; PMID:23024204; PMID:24162190; Reaxys:605448; Wikipedia:Trientine

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Genes (122)

2,2,2-tetramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase medium chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACADM protein]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acetyl-CoA acetyltransferase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

aconitase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACO2 protein]

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

actin, alpha, cardiac muscle 1

decreases expression

Trientine results in decreased expression of ACTC1 protein

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

actinin alpha 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein]

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

aminoacylase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ACY1 protein]

NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682

G

advanced glycosylation end product-specific receptor

decreases expression
multiple interactions

Trientine results in decreased expression of AGER protein
Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]
Trientine results in decreased expression of AGER mRNA; Trientine results in decreased expression of AGER protein

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

alanine-glyoxylate aminotransferase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein]

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

adenylate kinase 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein]

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1 member A1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein]

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldolase, fructose-bisphosphate B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ALDOB protein]

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

alanyl aminopeptidase, membrane

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein]

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein]

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ANXA5 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA5 protein]

PMID:19634143 PMID:21136691

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apolipoprotein A1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of APOA1 protein]

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

amyloid beta precursor protein

multiple interactions
increases metabolic processing
decreases expression
decreases cleavage

Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Trientine results in increased metabolism of APP protein
Trientine results in decreased expression of APP protein modified form
Trientine results in decreased cleavage of APP protein
Trientine results in decreased expression of and affects the localization of APP protein modified form

PMID:10940226 PMID:12963085 PMID:17964426 PMID:23541064

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of AQP1 protein]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

argininosuccinate synthase 1

decreases expression

Trientine results in decreased expression of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATP synthase F1 subunit alpha

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1A protein]

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1B protein]

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase membrane subunit f

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5MF protein]

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase peripheral stalk subunit OSCP

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5PO protein]

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit A

decreases expression

Trientine results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B2

decreases expression

Trientine results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase copper transporting alpha

increases expression

Trientine results in increased expression of ATP7A mRNA; Trientine results in increased expression of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 1

multiple interactions
decreases expression

Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]
Trientine results in decreased expression of BACE1 protein

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
increases expression

Trientine results in decreased expression of BCL2 protein
Copper Sulfate inhibits the reaction [Trientine results in increased expression of BCL2 protein]

PMID:11369509 PMID:14513838

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calmodulin 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CALM3 protein]

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calreticulin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CALR protein]

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

multiple interactions
increases activity

Paraquat promotes the reaction [Trientine results in increased activity of CASP3 protein]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]

PMID:11369509 PMID:12963085 PMID:14513838 PMID:22362149

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Trientine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

copper chaperone for superoxide dismutase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

CDGSH iron sulfur domain 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CISD1 protein]

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

clusterin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CLU protein]

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type VI alpha 1 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A1 protein]

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 2 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A2 protein]

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VI alpha 3 chain

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein]

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

ceruloplasmin

decreases expression

Trientine results in decreased expression of CP protein

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CPT2 protein]

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

crystallin zeta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of CRYZ protein]

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

citrate synthase

increases expression

Trientine results in increased expression of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cytochrome c-1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of CYC1 protein]

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome P450, family 4, subfamily a, polypeptide 2

multiple interactions

Trientine promotes the reaction [Streptozocin results in decreased expression of CYP4A2 protein]

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

G

D-amino-acid oxidase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DAO protein]

NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741

G

dihydrolipoamide S-acetyltransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLAT protein]

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

dihydrolipoamide dehydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein]

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dihydrolipoamide S-succinyltransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of DLST protein]

PMID:19634143 PMID:21136691

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

enolase 1, pseudogene 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ENO1-PS1 protein]

NCBI chr 3:57,576,643...57,578,321
Ensembl chr 3:57,576,709...57,578,013

G

epoxide hydrolase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein]

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

electron transfer flavoprotein subunit alpha

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFA protein]

NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969

G

electron transfer flavoprotein subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFB protein]

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

fibronectin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FXYD domain-containing ion transport regulator 2

increases expression

Trientine results in increased expression of FXYD2 protein

NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of G6PC1 protein]

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glycine amidinotransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GATM protein]

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

gamma-glutamyltransferase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

G protein subunit gamma 12

increases expression

Trientine results in increased expression of GNG12 protein

NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712

G

glutamic-oxaloacetic transaminase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GOT2 protein]

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glutathione peroxidase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein]

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione S-transferase alpha 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of GSTA2 protein]

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of GSTA3 protein]

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase pi 1

decreases expression

Trientine results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hydroxyacid oxidase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HAO2 protein]

NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425

G

hemoglobin subunit beta

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HBB-B1 protein]

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heme oxygenase 1

multiple interactions

Trientine inhibits the reaction [Dimethyldithiocarbamate results in increased expression of HMOX1 protein]; Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSD17B10 protein]

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA9 protein]

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family D (Hsp60) member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPD1 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of HSPD1 protein]

PMID:19634143 PMID:21136691

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPE1 protein]

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heparan sulfate proteoglycan 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of HSPG2 protein]

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

insulin 2

multiple interactions

Trientine inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of and affects the folding of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

lactate dehydrogenase B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of LDHB protein]

PMID:19634143 PMID:21136691

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

malate dehydrogenase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein]

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

malate dehydrogenase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of MDH2 protein]

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

membrane metallo-endopeptidase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of MME protein]

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

NADH:ubiquinone oxidoreductase subunit A10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFA10 protein]

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

NADH:ubiquinone oxidoreductase subunit AB1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFAB1 protein]

NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase core subunit S2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS2 protein]

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

NADH:ubiquinone oxidoreductase subunit S4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS4 protein]

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase core subunit V2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFV2 protein]

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

nicotinamide nucleotide transhydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of NNT protein]

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

ornithine aminotransferase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of OAT protein]

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

oxoglutarate dehydrogenase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

pyruvate carboxylase

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PC protein]

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PCK1 protein]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

prohibitin 1

decreases expression

Trientine results in decreased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

podocalyxin-like

increases expression

Trientine results in increased expression of PODXL protein

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

peptidylprolyl isomerase A

multiple interactions

Trientine inhibits the reaction [Copper results in decreased secretion of PPIA protein]

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

prion protein

increases expression
affects response to substance

Trientine results in increased expression of PRNP mRNA; Trientine results in increased expression of PRNP protein
PRNP protein affects the susceptibility to Trientine

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

pyridine nucleotide-disulphide oxidoreductase domain 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of PYROXD2 protein]

NCBI chr 1:241,523,278...241,549,083
Ensembl chr 1:241,523,377...241,548,761

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Trientine results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6

multiple interactions
increases phosphorylation

Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Trientine results in increased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

S100 calcium binding protein B

multiple interactions

Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SDHA protein]

PMID:19634143 PMID:21136691

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein]

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

G

serpin family E member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SFXN1 protein]

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

solute carrier family 22 member 6

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC22A6 protein]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 25 member 10

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A10 protein]

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 25 member 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A3 protein]

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25 member 5

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A5 protein]

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 31 member 1

increases expression
multiple interactions

Trientine results in increased expression of SLC31A1 mRNA
[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Trientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]
Trientine results in increased expression of SLC31A1 mRNA; Trientine results in increased expression of SLC31A1 protein

PMID:22362149 PMID:22491798 PMID:22914438

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 31 member 2

multiple interactions

Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 mRNA]; Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 protein]

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542

G

solute carrier family 3 member 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC3A1 protein]

NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907

G

SMAD family member 4

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

synaptosome associated protein 25

increases expression

Trientine results in increased expression of SNAP25 protein

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

superoxide dismutase 1

decreases expression
multiple interactions
decreases activity
increases activity

Trientine results in decreased expression of SOD1 protein
[Trientine results in decreased abundance of Copper] which results in decreased activity of SOD1 protein; Copper Sulfate inhibits the reaction [Trientine results in decreased activity of SOD1 protein]
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]; Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Trientine inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of SOD1 protein]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD1 protein]
Trientine results in increased activity of SOD1 protein

PMID:11369509 PMID:14513838 PMID:19634143 PMID:21140194 PMID:22362149 More...

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]
Trientine results in increased expression of and results in increased activity of SOD2 protein

PMID:14513838 PMID:19634143

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein]

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

synaptophysin

increases expression

Trientine results in increased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

transforming growth factor, beta 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tubulointerstitial nephritis antigen

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of TINAG protein]

NCBI chr 8:77,800,031...77,885,077
Ensembl chr 8:77,800,032...77,885,077

G

tumor protein p53

multiple interactions
increases phosphorylation

Paraquat promotes the reaction [Trientine results in increased phosphorylation of TP53 protein]; Trientine results in increased expression of and results in increased activity of TP53 protein

PMID:11369509 PMID:14513838

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transthyretin

multiple interactions

Trientine inhibits the reaction [Streptozocin results in decreased expression of TTR protein]

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

Trientine inhibits the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein]

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein]

PMID:19634143 PMID:21136691

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

voltage-dependent anion channel 1

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC1 protein]

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

voltage-dependent anion channel 2

multiple interactions

Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC2 protein]

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
chemical role	19422
ligand	6727
chelator	6714
copper chelator	664
2,2,2-tetramine	122
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
main group molecular entity	19759
s-block molecular entity	19628
hydrogen molecular entity	19614
hydrides	19087
inorganic hydride	18091
pnictogen hydride	18080
nitrogen hydride	17987
azane	17796
ammonia	17795
organic amino compound	17795
polyamine	9019
tetramine	188
2,2,2-tetramine	122

paths to the root