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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrimidine ribonucleosides
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Accession:CHEBI:39446 term browser browse the term
Synonyms:alt_id: CHEBI:13784;   CHEBI:26445;   CHEBI:7263

show annotations for term's descendants           Sort by:
 
5-fluorocytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cda cytidine deaminase increases metabolic processing ISO CDA protein results in increased metabolism of 5-fluorocytidine CTD PMID:21804305 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541 		JBrowse link
5-fluorouridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 increases export ISO ABCC5 protein results in increased export of 5-fluorouridine CTD PMID:15897250 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Sod1 superoxide dismutase 1 affects binding ISO 5-fluorouridine binds to SOD1 protein; 5-fluorouridine binds to SOD1 protein mutant form CTD PMID:23612299 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
capecitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 decreases response to substance ISO ABCB7 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases response to substance ISO AGPAT2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G Canx calnexin multiple interactions ISO CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Capecitabine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of Capecitabine CTD PMID:15687373 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases response to substance		 ISO CES2 protein results in increased hydrolysis of and results in increased activity of Capecitabine
CES2 gene polymorphism results in increased susceptibility to Capecitabine		 CTD PMID:15687373 PMID:18473752 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525 		JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases expression
decreases response to substance
affects response to substance		 ISO Capecitabine results in increased expression of DPYD mRNA
DPYD protein results in decreased susceptibility to Capecitabine
DPYD protein affects the susceptibility to Capecitabine		 CTD PMID:16734730 PMID:17611699 PMID:18846242 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586 		JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350 		JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524 		JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:46,955,460...46,969,468
Ensembl chr10:46,955,487...46,969,406 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 5:154,269,296...154,286,545
Ensembl chr 5:154,269,118...154,286,544 		JBrowse link
G Hdgfl3 HDGF like 3 decreases response to substance ISO HDGFL3 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:143,702,864...143,752,060
Ensembl chr 1:143,702,853...143,751,789 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance ISO HIF1A protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases response to substance ISO IL1R2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO JUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:87,019,598...87,027,720
Ensembl chr 1:87,019,975...87,027,691 		JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO MDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO MMP2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817 		JBrowse link
G Myrf myelin regulatory factor increases response to substance ISO MYRF protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:226,260,558...226,292,650
Ensembl chr 1:226,260,558...226,292,480 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257 		JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064 		JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases response to substance ISO PPA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:31,265,519...31,292,451
Ensembl chr20:31,265,483...31,310,674 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Capecitabine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664 		JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535 		JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:110,557,798...110,585,424
Ensembl chr10:110,557,729...110,585,376 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO RB1 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO RBBP4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240 		JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512 		JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:178,940,515...179,010,257
Ensembl chr 1:178,940,516...179,010,257 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514 		JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061 		JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Trim15 tripartite motif containing 15 increases response to substance ISO TRIM15 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:2,194,293...2,203,636
Ensembl chr20:2,194,709...2,201,668 		JBrowse link
G Tyms thymidylate synthetase affects expression
decreases response to substance
multiple interactions		 ISO Capecitabine affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to Capecitabine
[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]		 CTD PMID:16438929 PMID:16734730 PMID:21048041 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin] CTD PMID:21048041 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Zfp706 zinc finger protein 706 increases response to substance ISO ZNF706 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:75,803,310...75,809,853
Ensembl chr 7:75,801,735...75,809,836 		JBrowse link
cytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor increases activity EXP Cytidine results in increased activity of ADORA1 protein CTD PMID:18313046 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adora2a adenosine A2a receptor increases activity EXP Cytidine results in increased activity of ADORA2A protein CTD PMID:18313046 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Chlorine binds to Cytidine] which results in decreased expression of CCL5 mRNA CTD PMID:31066272 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Gypa glycophorin A multiple interactions ISO Cytidine inhibits the reaction [A 771726 results in increased expression of GYPA protein] CTD PMID:12181422 NCBI chr19:31,115,545...31,131,079 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Cytidine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cytidine]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Chlorine binds to Cytidine] which results in increased expression of IL1B mRNA; [Chlorine binds to Cytidine] which results in increased expression of IL1B protein CTD PMID:31066272 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions
increases transport		 ISO Cytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
SLC28A1 protein results in increased transport of Cytidine		 CTD PMID:9124315 PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Cytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Cytidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189 		JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Cytidine CTD PMID:15772079 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276 		JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777 		JBrowse link
UDP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]; Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein] CTD PMID:18523137 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; [Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein; montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein; zafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein] CTD PMID:20083671 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269 		JBrowse link
G Gpr17 G protein-coupled receptor 17 multiple interactions ISO cangrelor inhibits the reaction [Uridine Diphosphate results in increased activity of GPR17 protein] CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Uridine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Uridine Diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO MRS 2211 inhibits the reaction [Uridine Diphosphate results in increased expression of IL6 protein]; P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:18523137 PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Uridine Diphosphate results in increased phosphorylation of MAPK1 protein
P2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15034929 PMID:18523137 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Uridine Diphosphate results in increased phosphorylation of MAPK3 protein
P2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15034929 PMID:18523137 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G P2ry6 pyrimidinergic receptor P2Y6 multiple interactions
affects response to substance		 ISO P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]; P2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; P2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK1 protein]; P2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK3 protein]
P2RY6 gene affects the susceptibility to Uridine Diphosphate		 CTD PMID:18523137 NCBI chr 1:165,972,439...166,008,348
Ensembl chr 1:165,972,440...165,997,751 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Uridine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
UDP-alpha-D-galactose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Galactose binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Uridine Diphosphate Galactose results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Galactose co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790 		JBrowse link
UDP-alpha-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucose binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Uridine Diphosphate Glucose results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucose co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790 		JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions		 ISO B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]		 CTD PMID:11986319 NCBI chr 1:225,120,061...225,126,579
Ensembl chr 1:225,120,061...225,126,579 		JBrowse link
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790 		JBrowse link
UDP-D-galactose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Galactose binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Uridine Diphosphate Galactose results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Galactose co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790 		JBrowse link
UDP-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate Glucose binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases activity ISO Uridine Diphosphate Glucose results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucose co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790 		JBrowse link
UDP-N-acetyl-alpha-D-galactosamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO Uridine Diphosphate N-Acetylgalactosamine binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
UDP-N-acetyl-alpha-D-glucosamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
uridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor increases activity EXP Uridine results in increased activity of ADORA1 protein CTD PMID:18313046 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Uridine inhibits the reaction [tripterine results in increased expression of BAX protein] CTD PMID:27374097 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Uridine inhibits the reaction [tripterine results in increased cleavage of CASP3 protein] CTD PMID:27374097 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Uridine inhibits the reaction [tripterine results in increased cleavage of CASP9 protein] CTD PMID:27374097 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Faslg Fas ligand increases expression ISO Uridine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Gypa glycophorin A multiple interactions ISO Uridine inhibits the reaction [A 771726 results in increased expression of GYPA protein] CTD PMID:12181422 NCBI chr19:31,115,545...31,131,079 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein] CTD PMID:17187420 PMID:18163507 PMID:20032772 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein] CTD PMID:9808420 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions
increases uptake
increases export
increases transport		 ISO
EXP		 Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Cytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Cytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]; Sodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
SLC28A1 protein results in increased export of Uridine
Cytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]; Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]		 CTD PMID:8700147 PMID:8713072 PMID:9124315 PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615 		JBrowse link
G Slc28a2 solute carrier family 28 member 2 increases transport ISO SLC28A2 protein results in increased transport of Uridine CTD PMID:10087507 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions
increases uptake		 ISO
EXP		 4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; [SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine; Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]; Lidoflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Adenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Uridine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; 4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]		 CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 PMID:18381442 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions
increases uptake		 ISO
EXP		 4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]; [SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
SLC29A2 protein results in increased uptake of Uridine
2'-deoxyadenosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Adenine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Cytidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]; Thymidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]		 CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Uridine inhibits the reaction [tripterine results in increased expression of TP53 protein] CTD PMID:27374097 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Upp1 uridine phosphorylase 1 affects abundance
multiple interactions
increases metabolic processing		 ISO UPP1 protein affects the abundance of Uridine
[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Fluorouracil; [UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital		 CTD PMID:15772079 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276 		JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP Uridine Triphosphate affects the folding of [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:1848756 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Uridine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein] CTD PMID:12044622 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation EXP Uridine Triphosphate results in increased phosphorylation of EGFR protein CTD PMID:14676212 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] CTD PMID:14676212 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Uridine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO [Nicotinic Acids results in increased activity of HCAR2 protein] promotes the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased abundance of Arachidonic Acids]; [Nicotinic Acids results in increased activity of HCAR2 protein] promotes the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased abundance of Arachidonic Acids] CTD PMID:16674924 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO NF157 compound inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]
MRS 2211 inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]		 CTD PMID:24793913 PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased abundance of Arachidonic Acids]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Nicotinic Acids results in increased activity of HCAR2 protein] promotes the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased abundance of Arachidonic Acids]; [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased abundance of Arachidonic Acids; Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein
RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Uridine Triphosphate results in increased phosphorylation of MAPK1 protein		 CTD PMID:14676212 PMID:15034929 PMID:16674924 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased abundance of Arachidonic Acids]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Nicotinic Acids results in increased activity of HCAR2 protein] promotes the reaction [[Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased abundance of Arachidonic Acids]; [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased abundance of Arachidonic Acids; Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein
RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Uridine Triphosphate results in increased phosphorylation of MAPK3 protein		 CTD PMID:14676212 PMID:15034929 PMID:16674924 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Myl2 myosin light chain 2 multiple interactions EXP Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYOCD protein results in increased expression of MYL2 protein] CTD PMID:14676212 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239 		JBrowse link
G Myocd myocardin multiple interactions EXP Uridine Triphosphate inhibits the reaction [MYOCD protein results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYOCD protein results in increased expression of NPPA protein] CTD PMID:14676212 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYOCD protein results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Uridine Triphosphate results in increased expression of NPPA mRNA		 CTD PMID:14676212 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions EXP
ISO		 Uridine Triphosphate binds to and results in increased activity of P2RY2 protein
Endocannabinoids inhibits the reaction [Uridine Triphosphate binds to and results in increased activity of P2RY2 protein]; Uridine Triphosphate binds to and results in increased activity of P2RY2 protein		 CTD PMID:15654852 PMID:30102254 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424 		JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 multiple interactions EXP Uridine Triphosphate binds to and results in increased activity of P2RY4 protein CTD PMID:15654852 NCBI chr  X:70,421,599...70,447,109
Ensembl chr  X:70,426,951...70,428,364 		JBrowse link
G Panx1 Pannexin 1 decreases activity ISO Uridine Triphosphate results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040 		JBrowse link
G Sftpb surfactant protein B increases secretion ISO Uridine Triphosphate results in increased secretion of SFTPB protein CTD PMID:14565945 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938 		JBrowse link
G Sftpc surfactant protein C increases secretion ISO Uridine Triphosphate results in increased secretion of SFTPC protein CTD PMID:14565945 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Uridine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
zebularine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP pyrimidin-2-one beta-ribofuranoside affects the reaction [Folic Acid affects the methylation of AKT3 gene] CTD PMID:24629913 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913 		JBrowse link
G Ankrd6 ankyrin repeat domain 6 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of ANKRD6 mRNA CTD PMID:19194470 NCBI chr 5:48,052,610...48,167,568
Ensembl chr 5:48,052,401...48,194,294 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO pyrimidin-2-one beta-ribofuranoside affects the expression of APAF1 mRNA CTD PMID:17133271 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Apobec3 apolipoprotein B mRNA editing enzyme catalytic subunit 3 multiple interactions ISO [pyrimidin-2-one beta-ribofuranoside results in decreased activity of APOBEC3B protein] which results in increased susceptibility to Decitabine; pyrimidin-2-one beta-ribofuranoside inhibits the reaction [APOBEC3B protein results in decreased amination of Decitabine] CTD PMID:18398609 NCBI chr 7:121,108,108...121,128,346
Ensembl chr 7:121,109,241...121,128,542 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO pyrimidin-2-one beta-ribofuranoside inhibits the reaction [Folic Acid results in decreased expression of APP protein] CTD PMID:26492244 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects cleavage ISO pyrimidin-2-one beta-ribofuranoside affects the cleavage of BAX protein CTD PMID:19459041 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects cleavage
decreases expression		 ISO pyrimidin-2-one beta-ribofuranoside affects the cleavage of BCL2 protein
pyrimidin-2-one beta-ribofuranoside results in decreased expression of BCL2 protein		 CTD PMID:19459041 PMID:23320119 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO pyrimidin-2-one beta-ribofuranoside results in increased cleavage of CASP3 protein CTD PMID:19459041 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO pyrimidin-2-one beta-ribofuranoside results in increased activity of CASP8 protein CTD PMID:23320119 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity ISO pyrimidin-2-one beta-ribofuranoside results in increased activity of CASP9 protein CTD PMID:23320119 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of CCND1 protein CTD PMID:19459041 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of CDK2 protein CTD PMID:23320119 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of CDKN1A protein
pyrimidin-2-one beta-ribofuranoside results in increased expression of CDKN1A protein		 CTD PMID:19459041 PMID:23320119 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation ISO pyrimidin-2-one beta-ribofuranoside results in increased phosphorylation of CREB1 protein CTD PMID:18830594 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of CSGALNACT2 mRNA CTD PMID:19194470 NCBI chr 4:150,148,626...150,185,062
Ensembl chr 4:150,153,844...150,185,044 		JBrowse link
G Cux1 cut-like homeobox 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of CUX1 mRNA CTD PMID:19194470 NCBI chr12:23,150,886...23,470,095
Ensembl chr12:23,151,180...23,445,074 		JBrowse link
G Derl1 derlin 1 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of DERL1 mRNA CTD PMID:19194470 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases response to substance
decreases expression		 ISO EIF2AK2 protein results in decreased susceptibility to pyrimidin-2-one beta-ribofuranoside
pyrimidin-2-one beta-ribofuranoside results in decreased expression of EIF2AK2 protein modified form		 CTD PMID:23320119 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of ESR1 mRNA CTD PMID:19459041 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of H2AX protein CTD PMID:17991895 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of HSP90AA1 protein CTD PMID:18830594 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO pyrimidin-2-one beta-ribofuranoside affects the expression of IGFBP3 mRNA CTD PMID:16505122 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit affects expression ISO pyrimidin-2-one beta-ribofuranoside affects the expression of JUNB mRNA CTD PMID:16505122 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Larp7 La ribonucleoprotein 7, transcriptional regulator increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of LARP7 mRNA CTD PMID:19194470 NCBI chr 2:231,866,888...231,882,002
Ensembl chr 2:231,867,135...231,881,939 		JBrowse link
G Map1a microtubule-associated protein 1A increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of MAP1A mRNA CTD PMID:19194470 NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of MAPK1 protein modified form CTD PMID:23320119 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of MAPK3 protein modified form CTD PMID:23320119 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of MAPK8IP3 mRNA CTD PMID:19194470 NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of MBD2 protein CTD PMID:19459041 NCBI chr18:65,814,026...65,885,115
Ensembl chr18:65,814,026...65,885,114 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of MBD3 protein CTD PMID:19459041 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656 		JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of MECP2 protein CTD PMID:19459041 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233 		JBrowse link
G Mtrf1l mitochondrial translation release factor 1 like increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of MTRF1L mRNA CTD PMID:19194470 NCBI chr 1:42,475,791...42,485,999
Ensembl chr 1:42,475,792...42,486,035 		JBrowse link
G Nfatc2ip nuclear factor of activated T-cells 2 interacting protein increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of NFATC2IP mRNA CTD PMID:19194470 NCBI chr 1:197,785,966...197,800,943
Ensembl chr 1:197,785,968...197,801,634 		JBrowse link
G Nfic nuclear factor I/C increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of NFIC mRNA CTD PMID:19194470 NCBI chr 7:11,151,941...11,179,544
Ensembl chr 7:11,152,038...11,177,664 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pyrimidin-2-one beta-ribofuranoside results in increased cleavage of PARP1 protein CTD PMID:19459041 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of PHLDB1 mRNA CTD PMID:19194470 NCBI chr 8:48,997,189...49,045,176
Ensembl chr 8:48,997,184...49,045,154 		JBrowse link
G Pml PML nuclear body scaffold decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of PML mRNA CTD PMID:19194470 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226 		JBrowse link
G Rabgap1l RAB GTPase activating protein 1-like decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of RABGAP1L mRNA CTD PMID:19194470 NCBI chr13:77,975,392...78,609,009
Ensembl chr13:78,011,047...78,609,045 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of RB1 protein modified form CTD PMID:23320119 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbm34 RNA binding motif protein 34 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of RBM34 mRNA CTD PMID:19194470 NCBI chr19:59,874,745...59,894,981
Ensembl chr19:59,874,752...59,894,937 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of RRM2B mRNA CTD PMID:19010910 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817 		JBrowse link
G RT1-Bb RT1 class II, locus Bb increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of HLA-DQB1 mRNA CTD PMID:19194470 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711 		JBrowse link
G Sla src-like adaptor increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of SLA mRNA CTD PMID:19194470 NCBI chr 7:107,585,055...107,604,950
Ensembl chr 7:107,584,118...107,634,335 		JBrowse link
G Snip1 Smad nuclear interacting protein 1 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of SNIP1 mRNA CTD PMID:19194470 NCBI chr15:19,275,273...19,282,753
Ensembl chr 5:143,063,099...143,070,884 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases methylation		 ISO [pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 gene] which results in increased expression of SOD2 protein; [pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 promoter] which results in increased expression of SOD2 mRNA; [pyrimidin-2-one beta-ribofuranoside results in decreased methylation of SOD2 promoter] which results in increased expression of SOD2 protein CTD PMID:15908783 PMID:17895890 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of ST3GAL6 mRNA CTD PMID:19194470 NCBI chr11:44,176,518...44,237,119
Ensembl chr11:44,192,940...44,237,100 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of TFE3 mRNA CTD PMID:19194470 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO pyrimidin-2-one beta-ribofuranoside results in increased expression of TP53 protein CTD PMID:23320119 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Wdr47 WD repeat domain 47 decreases expression ISO pyrimidin-2-one beta-ribofuranoside results in decreased expression of WDR47 mRNA CTD PMID:19194470 NCBI chr 2:211,380,894...211,441,817
Ensembl chr 2:211,381,036...211,441,815 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          nitrogen atom 18572
            nitrogen molecular entity 18572
              nucleobase-containing molecular entity 5345
                nucleoside 5345
                  ribonucleoside 667
                    pyrimidine ribonucleosides 148
                      3,4-dihydrozebularine 0
                      cytidines + 67
                      isocytidines 0
                      pyrimidine ribonucleoside 0
                      uridines + 48
                      zebularine + 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            heteroorganic entity 19195
                              organochalcogen compound 18941
                                organooxygen compound 18868
                                  carbohydrates and carbohydrate derivatives 12260
                                    carbohydrate 12260
                                      carbohydrate derivative 11888
                                        glycosyl compound 10962
                                          N-glycosyl compound 5484
                                            nucleoside 5345
                                              ribonucleoside 667
                                                pyrimidine ribonucleosides 148
                                                  3,4-dihydrozebularine 0
                                                  cytidines + 67
                                                  isocytidines 0
                                                  pyrimidine ribonucleoside 0
                                                  uridines + 48
                                                  zebularine + 49
paths to the root