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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorescent probe
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Accession:CHEBI:39442 term browser browse the term
Definition:A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy.



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1-nitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCE1 mRNA CTD PMID:19041380 NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO 1-nitropyrene results in increased expression of ADAMTS1 mRNA CTD PMID:19041380 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 increases expression ISO 1-nitropyrene results in increased expression of ADGRG6 mRNA CTD PMID:19041380 NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein] CTD PMID:24904980 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO 1-nitropyrene results in increased expression of AFF4 mRNA CTD PMID:19041380 NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751
JBrowse link
G Aftph aftiphilin increases expression ISO 1-nitropyrene results in increased expression of AFTPH mRNA CTD PMID:19041380 NCBI chr14:94,871,429...94,925,625
Ensembl chr14:94,871,429...94,925,376
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
ISO 1-nitropyrene binds to and results in increased activity of AHR protein; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]
AHR affects the susceptibility to 1-nitropyrene
CTD PMID:12117779 PMID:22044530 PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1-nitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO 1-nitropyrene results in increased expression of ALCAM mRNA CTD PMID:19041380 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Ang angiogenin decreases expression ISO 1-nitropyrene results in decreased expression of ANG mRNA CTD PMID:19041380 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO 1-nitropyrene results in increased expression of ANTXR2 mRNA CTD PMID:19041380 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094
JBrowse link
G Apcdd1 APC down-regulated 1 decreases expression ISO 1-nitropyrene results in decreased expression of APCDD1 mRNA CTD PMID:19041380 NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070
JBrowse link
G Ar androgen receptor multiple interactions ISO 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO 1-nitropyrene results in increased expression of ARFIP1 mRNA CTD PMID:19041380 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO 1-nitropyrene results in increased expression of ASNS mRNA CTD PMID:19041380 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atg7 autophagy related 7 multiple interactions
affects response to substance
increases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
ATG7 protein affects the susceptibility to 1-nitropyrene
1-nitropyrene results in increased expression of ATG7 mRNA; 1-nitropyrene results in increased expression of ATG7 protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:29078374 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of ATP5H mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5H mRNA]
CTD PMID:29078374 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO 1-nitropyrene results in increased expression of ATP8B1 mRNA CTD PMID:19041380 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of BAD protein CTD PMID:17240030 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of BAX mRNA
TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]
CTD PMID:10837373 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 1-nitropyrene results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 1-nitropyrene results in decreased expression of BCL2L1 protein CTD PMID:17240030 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 1-nitropyrene results in increased expression of BID protein CTD PMID:17240030 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO 1-nitropyrene results in increased expression of BIRC3 mRNA CTD PMID:21540303 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO 1-nitropyrene results in increased expression of BMP2 mRNA CTD PMID:21540303 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 1-nitropyrene results in increased expression of BMPER mRNA CTD PMID:19041380 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO 1-nitropyrene results in decreased expression of BRCA1 mRNA CTD PMID:21540303 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G C1qtnf2 C1q and TNF related 2 decreases expression ISO 1-nitropyrene results in decreased expression of C1QTNF2 mRNA CTD PMID:19041380 NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185
JBrowse link
G C1rl complement C1r subcomponent like decreases expression ISO 1-nitropyrene results in decreased expression of C1RL mRNA CTD PMID:19041380 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134
JBrowse link
G Ca6 carbonic anhydrase 6 decreases expression ISO 1-nitropyrene results in decreased expression of CA6 mRNA CTD PMID:19041380 NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Casp2 caspase 2 increases activity ISO 1-nitropyrene results in increased activity of CASP2 protein CTD PMID:21872649 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP3 protein; methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein] CTD PMID:17240030 PMID:21872649 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cbs cystathionine beta synthase increases expression ISO 1-nitropyrene results in increased expression of CBS mRNA CTD PMID:19041380 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccdc18 coiled-coil domain containing 18 increases expression ISO 1-nitropyrene results in increased expression of CCDC18 mRNA CTD PMID:19041380 NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO 1-nitropyrene results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO 1-nitropyrene results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO 1-nitropyrene results in increased expression of CCL20 mRNA CTD PMID:19428942 PMID:19879285 PMID:21540303 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO 1-nitropyrene results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO 1-nitropyrene results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 decreases expression ISO 1-nitropyrene results in decreased expression of CCL26 mRNA CTD PMID:19428942 NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 1-nitropyrene results in increased expression of CCL5 mRNA CTD PMID:19879285 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCL15 mRNA CTD PMID:19428942 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO 1-nitropyrene results in increased expression of CCN2 mRNA CTD PMID:19041380 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 1-nitropyrene results in increased expression of CCND1 mRNA CTD PMID:19041380 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO 1-nitropyrene results in increased expression of CCR4 mRNA CTD PMID:19428942 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO 1-nitropyrene results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO 1-nitropyrene results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629
JBrowse link
G Cd14 CD14 molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD14 mRNA CTD PMID:19041380 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd8b CD8b molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD8B1 mRNA CTD PMID:19041380 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 1-nitropyrene results in decreased expression of CDH1 mRNA CTD PMID:19041380 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh13 cadherin 13 increases expression ISO 1-nitropyrene results in increased expression of CDH13 mRNA CTD PMID:19041380 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 1-nitropyrene results in decreased expression of CDH3 mRNA CTD PMID:19041380 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdk17 cyclin-dependent kinase 17 increases expression ISO 1-nitropyrene results in increased expression of CDK17 mRNA CTD PMID:19041380 NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
1-nitropyrene results in increased expression of CDKN1A mRNA; 1-nitropyrene results in increased expression of CDKN1A protein
CTD PMID:21540303 PMID:22044530 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
ISO [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein] CTD PMID:29078374 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO 1-nitropyrene results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO 1-nitropyrene results in decreased expression of CEBPD mRNA CTD PMID:19041380 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO 1-nitropyrene results in increased expression of CEBPG mRNA CTD PMID:19041380 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Cenpb centromere protein B decreases expression ISO 1-nitropyrene results in decreased expression of CENPB mRNA CTD PMID:19041380 NCBI chr 3:118,396,987...118,399,788
Ensembl chr 3:118,388,546...118,400,470
JBrowse link
G Clu clusterin decreases expression ISO 1-nitropyrene results in decreased expression of CLU mRNA CTD PMID:19041380 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of COMMD3 mRNA CTD PMID:19041380 NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
JBrowse link
G Coro1c coronin 1C increases expression ISO 1-nitropyrene results in increased expression of CORO1C mRNA CTD PMID:19041380 NCBI chr12:42,712,960...42,785,179
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 1-nitropyrene results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 1-nitropyrene results in increased expression of CTH mRNA CTD PMID:19041380 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380 PMID:19428942 PMID:19879285 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 1-nitropyrene results in increased expression of CXCL10 mRNA CTD PMID:19428942 PMID:19879285 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 1-nitropyrene results in increased expression of CXCL11 mRNA CTD PMID:19428942 PMID:19879285 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 1-nitropyrene results in increased expression of CXCL2 mRNA CTD PMID:19041380 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380 PMID:19428942 PMID:19879285 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL6 mRNA CTD PMID:19428942 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO 1-nitropyrene results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases degradation
multiple interactions
increases stability
increases expression
ISO
EXP
1-nitropyrene results in increased degradation of CYP1A1 protein
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]
1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein
1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]
CTD PMID:12117779 PMID:16280210 PMID:17240030 PMID:18493746 PMID:19961161 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
ISO
EXP
CYP1A2 affects the susceptibility to 1-nitropyrene
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]
CTD PMID:10727902 PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
ISO 1-nitropyrene results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of 1-nitropyrene
CTD PMID:11525925 PMID:12117779 PMID:21887816 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 1-nitropyrene results in increased expression of DDIT3 mRNA CTD PMID:19041380 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO 1-nitropyrene results in increased expression of DKK1 mRNA CTD PMID:19041380 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO 1-nitropyrene results in increased expression of DLC1 mRNA CTD PMID:19041380 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 increases expression ISO 1-nitropyrene results in increased expression of DMTF1 mRNA CTD PMID:19041380 NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO 1-nitropyrene results in increased expression of DNER mRNA CTD PMID:19041380 NCBI chr 9:85,586,985...85,902,820
Ensembl chr 9:85,586,987...85,902,637
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 1-nitropyrene results in increased expression of DUSP10 mRNA CTD PMID:19041380 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO 1-nitropyrene results in increased expression of DUSP6 mRNA CTD PMID:19041380 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1-nitropyrene results in increased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO 1-nitropyrene results in increased expression of EHHADH mRNA CTD PMID:19041380 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of EIF4EBP1 mRNA CTD PMID:19041380 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ereg epiregulin increases expression ISO 1-nitropyrene results in increased expression of EREG mRNA CTD PMID:21887816 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ESM1 mRNA CTD PMID:19041380 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
JBrowse link
G Etv5 ETS variant transcription factor 5 increases expression ISO 1-nitropyrene results in increased expression of ETV5 mRNA CTD PMID:19041380 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO 1-nitropyrene results in increased expression of EVI2A mRNA CTD PMID:19041380 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G Exoc5 exocyst complex component 5 increases expression ISO 1-nitropyrene results in increased expression of EXOC5 mRNA CTD PMID:19041380 NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-nitropyrene results in increased expression of F3 mRNA CTD PMID:19041380 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO 1-nitropyrene results in increased expression of FGF5 mRNA CTD PMID:19041380 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of FOS mRNA CTD PMID:21540303 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO 1-nitropyrene results in increased expression of G0S2 mRNA CTD PMID:19041380 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of GARS1 mRNA CTD PMID:19041380 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO 1-nitropyrene results in decreased expression of GAS1 mRNA CTD PMID:19041380 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of GBP2 mRNA CTD PMID:19041380 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 increases expression ISO 1-nitropyrene results in increased expression of GDAP1 mRNA CTD PMID:19041380 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO 1-nitropyrene results in increased expression of GLIPR1 mRNA CTD PMID:19041380 NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
JBrowse link
G Golga4 golgin A4 increases expression ISO 1-nitropyrene results in increased expression of GOLGA4 mRNA CTD PMID:19041380 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO 1-nitropyrene results in increased expression of GPT2 mRNA CTD PMID:19041380 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 1-nitropyrene results in increased expression of GREM1 mRNA CTD PMID:19041380 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Gsdmc gasdermin C decreases expression ISO 1-nitropyrene results in decreased expression of GSDMC mRNA CTD PMID:19041380 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344
JBrowse link
G Habp2 hyaluronan binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of HABP2 mRNA CTD PMID:19041380 NCBI chr 1:255,315,870...255,350,161
Ensembl chr 1:255,315,915...255,350,160
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1-nitropyrene results in increased expression of HBEGF mRNA CTD PMID:19041380 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 1-nitropyrene results in increased expression of HIF1A mRNA CTD PMID:19041380 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 1-nitropyrene results in increased expression of HMGA2 mRNA CTD PMID:19041380 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1-nitropyrene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:10727902 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression
increases expression
EXP
ISO
1-nitropyrene affects the expression of HRAS mRNA
1-nitropyrene results in increased expression of HRAS mRNA
CTD PMID:9891514 PMID:11201684 PMID:11911274 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of HSPA5 protein
Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]
CTD PMID:19460413 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of IARS1 mRNA CTD PMID:19041380 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ICAM1 mRNA CTD PMID:21540303 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of IFITM1 mRNA CTD PMID:19041380 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO 1-nitropyrene results in increased expression of IFRD1 mRNA CTD PMID:19041380 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO 1-nitropyrene results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-nitropyrene results in increased expression of IL1A mRNA CTD PMID:19428942 PMID:21540303 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1-nitropyrene results in increased secretion of IL1B protein CTD PMID:19041380 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO 1-nitropyrene results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO 1-nitropyrene results in increased expression of IL6 mRNA
1-nitropyrene results in increased secretion of IL6 protein
3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:19041380 PMID:19879285 PMID:29078374 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha increases expression ISO 1-nitropyrene results in increased expression of INA mRNA CTD PMID:19041380 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO 1-nitropyrene results in increased expression of INHBB mRNA CTD PMID:19041380 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B increases expression ISO 1-nitropyrene results in increased expression of INPP4B mRNA CTD PMID:19041380 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634
JBrowse link
G Ipo7 importin 7 increases expression ISO 1-nitropyrene results in increased expression of IPO7 mRNA CTD PMID:19041380 NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO 1-nitropyrene results in increased expression of IRF1 mRNA CTD PMID:21540303 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO 1-nitropyrene results in decreased expression of ITGB4 mRNA CTD PMID:19041380 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kctd15 potassium channel tetramerization domain containing 15 increases expression ISO 1-nitropyrene results in increased expression of KCTD15 mRNA CTD PMID:19041380 NCBI chr 1:87,258,658...87,271,979
Ensembl chr 1:87,258,658...87,273,497
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases mutagenesis
ISO [1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene
1-nitropyrene results in increased mutagenesis of KRAS gene
CTD PMID:9726818 PMID:10396879 PMID:11746253 PMID:12616606 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt34 keratin 34 increases expression ISO 1-nitropyrene results in increased expression of KRT34 mRNA CTD PMID:19041380 NCBI chr10:84,970,351...84,974,040
Ensembl chr10:84,970,017...84,974,040
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor increases expression ISO 1-nitropyrene results in increased expression of LCOR mRNA CTD PMID:19041380 NCBI chr 1:240,298,565...240,405,627
Ensembl chr 1:240,298,563...240,402,448
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO 1-nitropyrene results in increased expression of LIG4 mRNA CTD PMID:19041380 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO 1-nitropyrene results in increased expression of LMAN1 mRNA CTD PMID:19041380 NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
JBrowse link
G Lrrc17 leucine rich repeat containing 17 decreases expression ISO 1-nitropyrene results in decreased expression of LRRC17 mRNA CTD PMID:19041380 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
JBrowse link
G Lta lymphotoxin alpha decreases expression ISO 1-nitropyrene results in decreased expression of LTA mRNA CTD PMID:19428942 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltb lymphotoxin beta increases expression ISO 1-nitropyrene results in increased expression of LTB mRNA CTD PMID:19428942 PMID:19879285 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression ISO 1-nitropyrene results in increased expression of LURAP1L mRNA CTD PMID:19041380 NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
JBrowse link
G Mak16 MAK16 homolog increases expression ISO 1-nitropyrene results in increased expression of MAK16 mRNA CTD PMID:19041380 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MAP1LC3B mRNA; 1-nitropyrene results in increased expression of MAP1LC3B protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]
CTD PMID:29078374 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK1 protein CTD PMID:17240030 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK3 protein CTD PMID:17240030 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO 1-nitropyrene results in increased expression of MAPK6 mRNA CTD PMID:19041380 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK8 protein CTD PMID:17240030 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of MARS1 mRNA CTD PMID:19041380 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 protein; 1-nitropyrene results in increased expression of MDM2 protein modified form
nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373 PMID:22044530 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO 1-nitropyrene results in decreased expression of METTL7A mRNA CTD PMID:19041380 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
JBrowse link
G Mlph melanophilin increases expression ISO 1-nitropyrene results in increased expression of MLPH mRNA CTD PMID:19041380 NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983
JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO 1-nitropyrene results in increased expression of MOB4 mRNA CTD PMID:19041380 NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329
JBrowse link
G Mocos molybdenum cofactor sulfurase increases expression ISO 1-nitropyrene results in increased expression of MOCOS mRNA CTD PMID:19041380 NCBI chr18:15,931,654...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mospd1 motile sperm domain containing 1 increases expression ISO 1-nitropyrene results in increased expression of MOSPD1 mRNA CTD PMID:19041380 NCBI chr  X:133,100,200...133,127,960
Ensembl chr  X:133,100,422...133,127,908
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO 1-nitropyrene results in increased expression of MTHFD1L mRNA CTD PMID:19041380 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtmr2 myotubularin related protein 2 increases expression ISO 1-nitropyrene results in increased expression of MTMR2 mRNA CTD PMID:19041380 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1-nitropyrene results in increased expression of MYC mRNA CTD PMID:10928071 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFA1 mRNA
1-nitropyrene results in decreased expression of NDUFA1 mRNA; 1-nitropyrene results in decreased expression of NDUFA1 protein
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
CTD PMID:29078374 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions
decreases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
1-nitropyrene results in decreased expression of NDUFA2 mRNA; 1-nitropyrene results in decreased expression of NDUFA2 protein
CTD PMID:29078374 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions
decreases expression
ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA] CTD PMID:29078374 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFS4 mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]
CTD PMID:29078374 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 1-nitropyrene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
ISO 1-nitropyrene results in increased expression of NFKB1 mRNA
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]
CTD PMID:12393170 PMID:21540303 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased expression of CXCL8 mRNA] CTD PMID:12393170 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Noc3l NOC3-like DNA replication regulator increases expression ISO 1-nitropyrene results in increased expression of NOC3L mRNA CTD PMID:19041380 NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO 1-nitropyrene results in increased expression of NRG1 mRNA CTD PMID:19041380 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO 1-nitropyrene results in increased expression of NT5E mRNA CTD PMID:19041380 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Ntn3 netrin 3 decreases expression ISO 1-nitropyrene results in decreased expression of NTN3 mRNA CTD PMID:19041380 NCBI chr10:13,236,905...13,240,001
Ensembl chr10:13,236,905...13,240,001
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 1-nitropyrene results in decreased expression of OAS1 mRNA CTD PMID:19041380 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression ISO 1-nitropyrene results in increased expression of OASL mRNA CTD PMID:19041380 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Osbpl6 oxysterol binding protein-like 6 increases expression ISO 1-nitropyrene results in increased expression of OSBPL6 mRNA CTD PMID:19041380 NCBI chr 3:61,343,776...61,541,170
Ensembl chr 3:61,343,809...61,537,102
JBrowse link
G Oxr1 oxidation resistance 1 increases expression ISO 1-nitropyrene results in increased expression of OXR1 mRNA CTD PMID:19041380 NCBI chr 7:72,528,782...72,965,666
Ensembl chr 7:72,528,786...72,965,666
JBrowse link
G Pcdhb8 protocadherin beta 8 decreases expression ISO 1-nitropyrene results in decreased expression of PCDHB5 mRNA CTD PMID:19041380 NCBI chr18:29,065,466...29,067,805
Ensembl chr18:29,065,466...29,067,805
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO 1-nitropyrene results in increased expression of PCK2 mRNA CTD PMID:19041380 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRB mRNA CTD PMID:19041380 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdgfrl platelet-derived growth factor receptor-like decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRL mRNA CTD PMID:19041380 NCBI chr16:51,347,929...51,407,850
Ensembl chr16:51,347,948...51,407,850
JBrowse link
G Pdpn podoplanin decreases expression ISO 1-nitropyrene results in decreased expression of PDPN mRNA CTD PMID:19041380 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO 1-nitropyrene results in increased expression of PICALM mRNA CTD PMID:19041380 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO 1-nitropyrene results in increased expression of PIK3C2A mRNA CTD PMID:19041380 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pir pirin decreases expression ISO 1-nitropyrene results in decreased expression of PIR mRNA CTD PMID:19041380 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 decreases expression ISO 1-nitropyrene results in decreased expression of PLEKHB1 mRNA CTD PMID:19041380 NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of POLA1 mRNA CTD PMID:19041380 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Polr2e RNA polymerase II, I and III subunit E decreases expression ISO 1-nitropyrene results in decreased expression of POLR2E mRNA CTD PMID:19041380 NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO 1-nitropyrene results in increased expression of PRKAA1 mRNA CTD PMID:19041380 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha increases expression ISO 1-nitropyrene results in increased expression of PRKAR1A mRNA CTD PMID:19041380 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkch protein kinase C, eta increases expression ISO 1-nitropyrene results in increased expression of PRKCH mRNA CTD PMID:19041380 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression ISO 1-nitropyrene results in increased expression of PRMT3 mRNA CTD PMID:19041380 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO 1-nitropyrene results in increased expression of PSAT1 mRNA CTD PMID:19041380 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO 1-nitropyrene results in decreased expression of PSMB9 mRNA CTD PMID:19041380 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO 1-nitropyrene results in increased expression of PSMD5 mRNA CTD PMID:19041380 NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO 1-nitropyrene results in increased expression of PSME4 mRNA CTD PMID:19041380 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Ptcd2 pentatricopeptide repeat domain 2 increases expression ISO 1-nitropyrene results in increased expression of PTCD2 mRNA CTD PMID:19041380 NCBI chr 2:30,712,276...30,739,968
Ensembl chr 2:30,712,280...30,739,942
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 1-nitropyrene results in increased expression of PTHLH mRNA CTD PMID:19041380 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptn pleiotrophin decreases expression ISO 1-nitropyrene results in decreased expression of PTN mRNA CTD PMID:19041380 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B increases expression ISO 1-nitropyrene results in increased expression of PTPRB mRNA CTD PMID:19041380 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748
JBrowse link
G Rab20 RAB20, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB20 mRNA CTD PMID:19041380 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529
JBrowse link
G Rab26 RAB26, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB26 mRNA CTD PMID:19041380 NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB34 mRNA CTD PMID:19041380 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538
JBrowse link
G Ramp1 receptor activity modifying protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of RAMP1 mRNA CTD PMID:19041380 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression ISO 1-nitropyrene results in increased expression of RANBP6 mRNA CTD PMID:19041380 NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942
JBrowse link
G Rasa2 RAS p21 protein activator 2 increases expression ISO 1-nitropyrene results in increased expression of RASA2 mRNA CTD PMID:19041380 NCBI chr 8:97,119,983...97,236,687
Ensembl chr 8:97,118,802...97,236,671
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO 1-nitropyrene results in increased activity of RELA protein
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]
CTD PMID:12393170 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1306227 similar to 4833420G17Rik protein increases expression ISO 1-nitropyrene results in increased expression of C5ORF34 mRNA CTD PMID:19041380 NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085
JBrowse link
G Riox2 ribosomal oxygenase 2 increases expression ISO 1-nitropyrene results in increased expression of RIOX2 mRNA CTD PMID:19041380 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO 1-nitropyrene results in increased expression of RND3 mRNA CTD PMID:19041380 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Sacs sacsin molecular chaperone increases expression ISO 1-nitropyrene results in increased expression of SACS mRNA CTD PMID:19041380 NCBI chr15:35,285,783...35,370,335
Ensembl chr15:35,285,782...35,370,335
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
decreases response to substance
ISO 1-nitropyrene results in decreased expression of SCD1 mRNA; 1-nitropyrene results in decreased expression of SCD1 protein
SCD1 protein results in decreased susceptibility to 1-nitropyrene
CTD PMID:21872649 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression ISO 1-nitropyrene results in decreased expression of SCNN1A mRNA CTD PMID:19041380 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Sectm1b secreted and transmembrane 1B decreases expression ISO 1-nitropyrene results in decreased expression of SECTM1 mRNA CTD PMID:19041380 NCBI chr10:106,325,202...106,333,769
Ensembl chr10:106,325,203...106,333,769
JBrowse link
G Sele selectin E increases expression ISO 1-nitropyrene results in increased expression of SELE mRNA CTD PMID:21540303 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO 1-nitropyrene results in increased expression of SERPINB8 mRNA CTD PMID:19041380 NCBI chr13:23,626,945...23,650,270
Ensembl chr13:23,626,945...23,650,835
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1-nitropyrene results in increased expression of SERPINE1 mRNA CTD PMID:19041380 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of SH3KBP1 mRNA CTD PMID:19041380 NCBI chr  X:34,877,862...35,223,013
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 increases expression ISO 1-nitropyrene results in increased expression of SH3RF1 mRNA CTD PMID:19041380 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Slmap sarcolemma associated protein increases expression ISO 1-nitropyrene results in increased expression of SLMAP mRNA CTD PMID:19041380 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 increases expression ISO 1-nitropyrene results in increased expression of SMURF2 mRNA CTD PMID:19041380 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Snca synuclein alpha decreases expression ISO 1-nitropyrene results in decreased expression of SNCA mRNA CTD PMID:19041380 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Snx14 sorting nexin 14 increases expression ISO 1-nitropyrene results in increased expression of SNX14 mRNA CTD PMID:19041380 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580
JBrowse link
G Sox21 SRY-box transcription factor 21 decreases expression ISO 1-nitropyrene results in decreased expression of SOX21 mRNA CTD PMID:19041380 NCBI chr15:95,292,272...95,295,316 JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 1-nitropyrene results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO 1-nitropyrene results in increased expression of STC2 mRNA CTD PMID:19041380 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO 1-nitropyrene results in decreased expression of TACSTD2 mRNA CTD PMID:19041380 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
G Tagln transgelin increases expression ISO 1-nitropyrene results in increased expression of TAGLN mRNA CTD PMID:19041380 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of TARS1 mRNA CTD PMID:19041380 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of TAX1BP1 mRNA CTD PMID:19041380 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100
JBrowse link
G Thbd thrombomodulin increases expression ISO 1-nitropyrene results in increased expression of THBD mRNA CTD PMID:19041380 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene CTD PMID:23458896 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tmpo thymopoietin increases expression ISO 1-nitropyrene results in increased expression of TMPO mRNA CTD PMID:19041380 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO 1-nitropyrene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]
1-nitropyrene results in increased secretion of TNF protein
CTD PMID:19041380 PMID:19428942 PMID:19879285 PMID:21540303 PMID:28633978 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnpo1 transportin 1 increases expression ISO 1-nitropyrene results in increased expression of TNPO1 mRNA CTD PMID:19041380 NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO 1-nitropyrene results in increased expression of TOP1 mRNA CTD PMID:19041380 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2b DNA topoisomerase II beta increases expression ISO 1-nitropyrene results in increased expression of TOP2B mRNA CTD PMID:19041380 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
decreases expression
affects localization
affects response to substance
affects expression
multiple interactions
ISO
EXP
1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form
1-nitropyrene results in increased phosphorylation of TRP53 protein
1-nitropyrene results in decreased expression of TRP53 mRNA
1-nitropyrene results in increased expression of TRP53 mRNA
1-nitropyrene affects the localization of TRP53 protein
TP53 affects the susceptibility to 1-nitropyrene
1-nitropyrene affects the expression of TP53 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373 PMID:10928071 PMID:11201684 PMID:11911274 PMID:17240030 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 1-nitropyrene results in increased expression of TRIB3 mRNA CTD PMID:19041380 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim23 tripartite motif-containing 23 increases expression ISO 1-nitropyrene results in increased expression of TRIM23 mRNA CTD PMID:19041380 NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO 1-nitropyrene results in increased expression of TRPM7 mRNA CTD PMID:19041380 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
G Trub1 TruB pseudouridine synthase family member 1 increases expression ISO 1-nitropyrene results in increased expression of TRUB1 mRNA CTD PMID:19041380 NCBI chr 1:256,513,418...256,554,549
Ensembl chr 1:256,515,562...256,552,814
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B increases expression ISO 1-nitropyrene results in increased expression of UBASH3B mRNA CTD PMID:19041380 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201
JBrowse link
G Usp15 ubiquitin specific peptidase 15 increases expression ISO 1-nitropyrene results in increased expression of USP15 mRNA CTD PMID:19041380 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
JBrowse link
G Vcan versican increases expression ISO 1-nitropyrene results in increased expression of VCAN mRNA CTD PMID:19041380 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Virma vir like m6A methyltransferase associated increases expression ISO 1-nitropyrene results in increased expression of VIRMA mRNA CTD PMID:19041380 NCBI chr 5:24,961,208...25,024,660
Ensembl chr 5:24,960,778...25,023,341
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of WARS1 mRNA CTD PMID:19041380 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of WDFY3 mRNA CTD PMID:19041380 NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO 1-nitropyrene results in increased expression of WNT2 mRNA CTD PMID:21540303 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO 1-nitropyrene results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:123,479,454...123,516,168
Ensembl chr 8:123,479,590...123,487,226
JBrowse link
G Xpot exportin for tRNA increases expression ISO 1-nitropyrene results in increased expression of XPOT mRNA CTD PMID:19041380 NCBI chr 7:57,111,536...57,151,847
Ensembl chr 7:57,111,536...57,152,099
JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 increases expression ISO 1-nitropyrene results in increased expression of ZDHHC11 mRNA CTD PMID:19041380 NCBI chr 1:29,296,216...29,327,227
Ensembl chr 1:29,296,334...29,326,898
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 1-nitropyrene results in increased expression of ZEB1 mRNA CTD PMID:19041380 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp62 zinc finger protein 62 increases expression ISO 1-nitropyrene results in increased expression of ZFP62 mRNA CTD PMID:19041380 NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013
JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Cat catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation
ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases activity
increases metabolic processing
multiple interactions
increases glucuronidation
ISO Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
increases activity
multiple interactions
increases glucuronidation
EXP
ISO
UGT1A6 gene polymorphism affects the metabolism of Hymecromone
UGT1A6 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 More... NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions
increases activity
increases glucuronidation
increases metabolic processing
ISO
EXP
[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]; Phenylbutazone inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Phenylbutazone inhibits the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558 PMID:15502008 PMID:15802387 PMID:26875642 PMID:31812603 More... NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions
ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Hymecromone CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation
increases activity
increases metabolic processing
multiple interactions
EXP
ISO
UGT2B1 protein results in increased glucuronidation of Hymecromone
UGT2B17 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]
CTD PMID:8302279 PMID:8798464 PMID:26875642 PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases glucuronidation
increases metabolic processing
multiple interactions
ISO Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased glucuronidation of Hymecromone
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:26875642 PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions ISO [UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Phenylbutazone inhibits the reaction [[UGT1A8 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO [UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide CTD PMID:33290829 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 PMID:33290829 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa alpha glucosidase multiple interactions
increases metabolic processing
ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
7-hydroxycoumarin O(7)-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases abundance EXP UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
8-anilinonaphthalene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor affects binding ISO 1-anilino-8-naphthalenesulfonate binds to AMBP protein CTD PMID:16461020 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G Apod apolipoprotein D affects binding ISO 1-anilino-8-naphthalenesulfonate binds to APOD protein CTD PMID:16461020 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G C8g complement C8 gamma chain affects binding ISO 1-anilino-8-naphthalenesulfonate binds to C8G protein CTD PMID:16461020 NCBI chr 3:8,320,495...8,323,495
Ensembl chr 3:8,305,920...8,323,495
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to GSTA1 protein CTD PMID:14690442 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Lcn2 lipocalin 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN2 protein CTD PMID:16461020 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Obp2a odorant binding protein 2A affects binding ISO 1-anilino-8-naphthalenesulfonate binds to OBP2A protein CTD PMID:16461020 NCBI chr 3:8,505,990...8,509,269
Ensembl chr 3:8,505,990...8,509,269
JBrowse link
G Orm1 orosomucoid 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to ORM1 protein CTD PMID:16461020 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Paep progestagen associated endometrial protein affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PAEP protein CTD PMID:16461020 NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ttr transthyretin affects binding
multiple interactions
ISO 1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]
CTD PMID:23584369 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Vegp2 von Ebners gland protein 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN1 protein CTD PMID:16461020 NCBI chr 3:9,516,457...9,542,088 JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,680,489...16,683,276 JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Chlortetracycline results in decreased activity of CAT protein CTD PMID:30768968 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Coumaphos binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Coumaphos binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Coumaphos binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Coumaphos binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
filipin III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Filipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]
CTD PMID:12614848 PMID:17172471 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein] CTD PMID:20036696 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:29724254 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA] CTD PMID:29724254 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Des desmin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein] CTD PMID:19632255 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein] CTD PMID:17172471 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein] CTD PMID:20036696 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Prnp prion protein increases secretion
decreases expression
multiple interactions
ISO Filipin results in increased secretion of PRNP protein
Filipin results in decreased expression of PRNP protein alternative form
[Copper co-treated with Filipin] results in increased cleavage of PRNP protein; Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]
CTD PMID:11994310 PMID:19597535 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein] CTD PMID:19632255 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:24,953,464...25,490,003
Ensembl chr  X:24,953,464...25,488,663
JBrowse link
G Azi2 5-azacytidine induced 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
JBrowse link
G Cd109 CD109 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194
JBrowse link
G Cd180 CD180 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr 2:33,855,940...33,870,046
Ensembl chr 2:33,855,991...33,899,936
JBrowse link
G Cd86 CD86 molecule increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cd93 CD93 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378
JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Copa COPI coat complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982
JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr 7:8,917,786...8,959,474
Ensembl chr 7:8,917,786...8,956,475
JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
CTD PMID:27871981 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206
JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:29198882 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:27129696 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:27129696 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein
CTD PMID:27129696 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mybpc1 myosin binding protein C1 affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]
CTD PMID:20491607 PMID:27871981 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
JBrowse link
G Postn periostin affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Pprc1 PPARG related coactivator 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 8:63,599,153...63,609,727
Ensembl chr 8:63,599,165...63,607,756
JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]] CTD PMID:27871981 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]
CTD PMID:27871981 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]
CTD PMID:27871981 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
JBrowse link
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal affects expression
multiple interactions
ISO pyrene affects the expression of ACP2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein
CTD PMID:28803881 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
affects response to substance
increases activity
EXP
ISO
pyrene binds to and results in increased activity of AHR protein; pyrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
pyrene binds to AHR protein
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA; [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA; AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]
pyrene results in increased activity of AHR protein
[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [pyrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; fluoranthene promotes the reaction [pyrene results in increased activity of AHR protein]; pyrene promotes the reaction [fluoranthene results in increased activity of AHR protein]
CTD PMID:3024361 PMID:12850102 PMID:17618724 PMID:17665671 PMID:28710019 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019 PMID:30980910 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases expression ISO pyrene results in decreased expression of ALDH3A1 mRNA CTD PMID:32890658 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Ar androgen receptor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; pyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; pyrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:26022396 PMID:30980910 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
pyrene affects the expression of BAX protein
CTD PMID:28803881 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
EXP
ISO
pyrene results in increased expression of CASP3 mRNA
pyrene results in increased activity of CASP3 protein
pyrene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein
CTD PMID:19815060 PMID:28803881 PMID:31368503 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity EXP pyrene results in increased activity of CASP7 protein CTD PMID:31368503 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
pyrene results in decreased expression of CCNA2 protein
CTD PMID:28803881 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
pyrene results in increased expression of CCND1 protein
CTD PMID:28803881 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd63 Cd63 molecule decreases expression EXP pyrene results in decreased expression of CD63 protein CTD PMID:31368503 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cd81 Cd81 molecule decreases expression EXP pyrene results in decreased expression of CD81 protein CTD PMID:31368503 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
pyrene results in increased expression of CDK2 protein
CTD PMID:28803881 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
pyrene affects the expression of CYP19A1 protein
CTD PMID:28803881 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
increases activity
increases hydroxylation
ISO
EXP
[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of CYP1A1 mRNA; [fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
pyrene results in decreased expression of CYP1A1 mRNA
pyrene results in increased expression of CYP1A1 mRNA; pyrene results in increased expression of CYP1A1 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA
pyrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of pyrene
CTD PMID:7750161 PMID:15016593 PMID:15566942 PMID:16906435 PMID:25956473 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases expression
multiple interactions
ISO
EXP
CYP1A2 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1A2 mRNA
pyrene results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of CYP1A2 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:7750161 PMID:15016593 PMID:17618724 PMID:26160115 PMID:30240548 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
decreases expression
increases expression
multiple interactions
ISO CYP1B1 protein results in increased hydroxylation of pyrene
pyrene results in decreased expression of CYP1B1 mRNA
pyrene results in increased expression of CYP1B1 protein
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD PMID:15016593 PMID:15566942 PMID:19365803 PMID:19563207 PMID:30248327 More... NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]
pyrene results in increased expression of CYP2B1 mRNA
CTD PMID:17618724 PMID:26160115 PMID:30240548 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pyrene results in increased expression of CYP2B2 mRNA CTD PMID:30240548 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO pyrene results in increased expression of CYP2B6 mRNA
[fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with fluoranthene] results in increased expression of CYP2B6 mRNA; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]
CTD PMID:26160115 PMID:33249052 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP pyrene affects the expression of CYP2C11 mRNA CTD PMID:30240548 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects expression EXP pyrene affects the expression of CYP2C6V1 mRNA CTD PMID:30240548 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP pyrene results in decreased expression of CYP2E1 mRNA CTD PMID:30240548 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP pyrene results in increased expression of CYP3A23-3A1 mRNA CTD PMID:30240548 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; pyrene binds to and results in increased activity of ESR1 protein CTD PMID:30980910 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO pyrene binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP pyrene results in decreased expression of GJB1 protein CTD PMID:25268939 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression ISO pyrene results in decreased expression of GSTA1 mRNA CTD PMID:32890658 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO [Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of GSTM1 protein
pyrene results in increased expression of GSTM1 mRNA
CTD PMID:25956473 PMID:26160115 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO pyrene results in increased expression of GSTM3 mRNA CTD PMID:26160115 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrene results in increased expression of HSPA1A mRNA CTD PMID:22367790
G Icam1 intercellular adhesion molecule 1 increases expression ISO pyrene results in increased expression of ICAM1 protein CTD PMID:22313677 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma affects activity ISO pyrene affects the activity of IFNG protein CTD PMID:9258441 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il4 interleukin 4 increases expression ISO pyrene results in increased expression of IL4 mRNA; pyrene results in increased expression of IL4 protein CTD PMID:10756232 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP pyrene results in increased activity of NQO1 protein CTD PMID:16906435 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases expression
decreases expression
increases activity
increases response to substance
ISO
EXP
AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]; NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione]; NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]; pyrene affects the localization of and results in increased activity of NR1I3 protein
pyrene results in decreased expression of NR1I3 mRNA
pyrene results in increased activity of NR1I3 protein
NR1I3 results in increased susceptibility to pyrene
[Benzo(a)pyrene co-treated with fluoranthene] inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; [Benzo(a)pyrene co-treated with pyrene] inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA]; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; fluoranthene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; pyrene inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA]
CTD PMID:17618724 PMID:26160115 PMID:28927721 PMID:30240548 PMID:33249052 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression EXP pyrene results in increased expression of PDCD6IP protein CTD PMID:31368503 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP pyrene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pyrene binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Docosahexaenoic Acids co-treated with pyrene] results in increased expression of PTGS2 mRNA CTD PMID:25956473 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene CTD PMID:23458896 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [pyrene results in increased expression of CXCL8 mRNA] CTD PMID:18434080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein] CTD PMID:22120587 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tsg101 tumor susceptibility 101 increases expression EXP pyrene results in increased expression of TSG101 protein CTD PMID:31368503 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA CTD PMID:17618724 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression
multiple interactions
ISO pyrene results in decreased expression of UGT1A6 mRNA
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA
CTD PMID:15566942 PMID:26160115 NCBI chr 9:88,747,229...88,808,465 JBrowse link
scopoletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] CTD PMID:26115886 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] CTD PMID:26115886 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:26115886 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] CTD PMID:26115886 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] CTD PMID:26115886 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression
EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats
CTD
RGD
PMID:26115886 PMID:26115886 RGD:25330099 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions EXP Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] CTD PMID:26115886 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:26115886 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:26115886 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26115886 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:26115886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] CTD PMID:26115886 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26115886 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] CTD PMID:26115886 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:26115886 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:26115886 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] CTD PMID:26115886 NCBI chr 9:1,102,559...1,115,573 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26115886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Scopoletin CTD PMID:15044611 PMID:15802387 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Scopoletin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to Scopoletin CTD PMID:22280988 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
scopolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO scopolin binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO scopolin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
JBrowse link
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases expression
ISO 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein
CTD PMID:22964423 PMID:28263721 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions
increases expression
ISO 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein
CTD PMID:22964423 PMID:28263721 PMID:30849339 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression ISO 7-hydroxycoumarin results in increased expression of AKR7A3 mRNA CTD PMID:28263721 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 7-hydroxycoumarin results in increased expression of BAX protein CTD PMID:15964220 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 7-hydroxycoumarin results in decreased expression of BCL2 protein CTD PMID:15964220 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 7-hydroxycoumarin results in decreased expression of CCND1 protein CTD PMID:11679177 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
EXP 7-hydroxycoumarin results in increased expression of CREB1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CREB1 mRNA]
CTD PMID:33522649 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cygb cytoglobin multiple interactions
increases expression
EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CYGB protein]
7-hydroxycoumarin results in increased expression of CYGB protein
CTD PMID:33522649 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] CTD PMID:33522649 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IKBKB protein] CTD PMID:33522649 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33522649 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation
ISO [4-aminobenzhydrazide results in decreased activity of MPO protein] which affects the susceptibility to 7-hydroxycoumarin
MPO protein results in increased oxidation of 7-hydroxycoumarin
CTD PMID:23994743 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO
EXP
7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 protein
7-hydroxycoumarin results in increased expression of NFE2L2 mRNA; 7-hydroxycoumarin results in increased expression of NFE2L2 protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]
CTD PMID:28263721 PMID:33522649 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
EXP 7-hydroxycoumarin results in decreased expression of NFKBIA protein
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]
CTD PMID:33522649 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of PPARG mRNA]
7-hydroxycoumarin results in increased expression of PPARG mRNA
CTD PMID:33522649 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:33522649 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP 7-hydroxycoumarin results in increased expression of SIRT1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]
CTD PMID:33522649 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:33522649 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
EXP UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin
CTD PMID:9429234 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15044611 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 7-hydroxycoumarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        probe 501
          fluorescent probe 432
            1-hexadecanoyl-2-\{12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoyl\}-sn-glycero-3-phosphocholine 0
            1-hexadecanoyl-2-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phosphocholine 0
            1-oleoyl-2-\{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl\}-sn-glycero-3-phospho-L-serine 0
            2'-MANT-GDP + 0
            2'-MANT-GTP + 0
            3'-MANT-GDP + 0
            3'-MANT-GTP + 0
            4-chloro-7-nitrobenzofurazan 0
            5-[(2-acetamidoethyl)amino]naphthalene-1-sulfonic acid 0
            5-\{[2-(iodoacetamido)ethyl]amino\}naphthalene-1-sulfonic acid 0
            6-O-(carboxymethyl)fluorescein ethyl ester 0
            7-glycidyloxy-9-(2-glycidyloxycarbonylphenyl)-2-xanthone 0
            8-anilinonaphthalene-1-sulfonic acid 11
            MANT-GDP 0
            MANT-GTP 0
            N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine 1
            N-\{6-[(7-nitrobenzo-2,1,3-oxadiazol-4-yl)amino]hexanoyl\}sphingosylphosphocholine 0
            beta-Ala-Lys-N(epsilon)-AMCA 0
            chlortetracycline 2
            filipin III 20
            fluorescein isothiocyanate + 56
            lissamine rhodamine 0
            pyrene + 290
            rac-1,2-di-O-dodecanylglycero-3-glutaric acid 6'-methylresorufin ester 0
            rhodamine B 0
            sapintoxin D 0
            sodium 8-methoxypyrene-1,3,6-trisulfonate 0
            tetrasulfocyanine 0
            umbelliferone + 96
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