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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cucurbitacin E
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Accession:CHEBI:3944 term browser browse the term
Definition:A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
Synonyms:exact_synonym: (4R,23E)-2,16alpha,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate
 related_synonym: (23E)-25-acetyloxy-2,16alpha,20-trihydroxy-9beta-methyl-19-nor-10alpha-lanosta-1,5,23-triene-3,11,22-trione;   2,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-1,5,23-triene-3,11,22-trione 25-acetate;   Formula=C32H44O8;   InChI=1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1;   InChIKey=NDYMQXYDSVBNLL-MUYMLXPFSA-N;   SMILES=[H][C@@]12CC=C3[C@@]([H])(C=C(O)C(=O)C3(C)C)[C@]1(C)C(=O)C[C@]1(C)[C@]([H])([C@H](O)C[C@@]21C)[C@@](C)(O)C(=O)\\C=C\\C(C)(C)OC(C)=O;   alpha-Elaterin;   alpha-Elaterine
 xref: Beilstein:2343323;   CAS:18444-66-1;   KEGG:C08797;   KNApSAcK:C00003686;   LIPID_MAPS_instance:LMST01010107
 xref_mesh: MESH:C102326
 xref: PMID:13611647;   PMID:15908139;   PMID:19177898;   PMID:19816711;   PMID:20110807;   PMID:20347305;   PMID:4384331;   Reaxys:2343323


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cucurbitacin E term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
cucurbitacin E results in decreased expression of ACTA2 mRNA; cucurbitacin E results in decreased expression of ACTA2 protein
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
CTD PMID:27363783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
ISO Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein] CTD PMID:27106530 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
cucurbitacin E results in increased expression of BAX protein CTD PMID:27106530 PMID:27363783 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP
cucurbitacin E results in decreased expression of BCL2 protein CTD PMID:27106530 PMID:27363783 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cucurbitacin E results in decreased expression of BCL2L1 protein CTD PMID:27106530 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein CTD PMID:27106530 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein] CTD PMID:27106530 PMID:27363783 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
ISO acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein] CTD PMID:27106530 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases cleavage ISO cucurbitacin E results in increased cleavage of CASP9 protein CTD PMID:27106530 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP cucurbitacin E results in decreased expression of COL1A1 mRNA CTD PMID:27363783 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP cucurbitacin E results in decreased phosphorylation of MAPK1 protein CTD PMID:27363783 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP cucurbitacin E results in decreased phosphorylation of MAPK3 protein CTD PMID:27363783 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO
EXP
Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
CTD PMID:27106530 PMID:27363783 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO
EXP
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein] CTD PMID:27106530 PMID:27363783 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:27106530 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO
EXP
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
cucurbitacin E results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:27363783 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of SQSTM1 protein] CTD PMID:27106530 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO
EXP
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]
cucurbitacin E results in decreased expression of TIMP1 mRNA; cucurbitacin E results in decreased expression of TIMP1 protein
CTD PMID:27363783 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein CTD PMID:27106530 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            allelochemical 1383
              cucurbitacin 45
                cucurbitacin E 19
                  cucurbitacin E 2-O-beta-D-glucopyranoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              tertiary alpha-hydroxy ketone 8374
                                                cucurbitacin E 19
                                                  cucurbitacin E 2-O-beta-D-glucopyranoside 0
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