The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
cucurbitacin E results in decreased expression of ACTA2 mRNA; cucurbitacin E results in decreased expression of ACTA2 protein cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]
Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein] cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein] cucurbitacin E results in decreased phosphorylation of RPS6KB1 protein
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein] cucurbitacin E results in decreased expression of TIMP1 mRNA; cucurbitacin E results in decreased expression of TIMP1 protein
Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein