tocol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tocol	go back to main search page
Accession:	CHEBI:39437	browse the term
Definition:	A chromanol with a chroman-6-ol skeleton that is substituted at position 2 by a saturated or triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.
Synonyms:	related_synonym:	2-methyl-2-phytyl-6-chromanol; tocols
	alt_id:	CHEBI:27010; CHEBI:27011
	xref:	CAS:119-98-2; Reaxys:1436460

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Genes (266)

(R,R,R)-alpha-tocopherol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily D member 1

multiple interactions

alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA]

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

ATP binding cassette subfamily D member 3

multiple interactions

alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA]

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

acetyl-CoA acetyltransferase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [iron(II)-ascorbic acid complex results in decreased activity of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

acetylcholinesterase

multiple interactions

alpha-Tocopherol inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[alpha-Tocopherol co-treated with Paraoxon] results in decreased activity of ACHE protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]; alpha-Tocopherol binds to and results in decreased activity of ACHE protein; alpha-Tocopherol promotes the reaction [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of ACHE protein]

PMID:19464315 PMID:34506764

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

activin A receptor like type 1

increases expression

alpha-Tocopherol results in increased expression of ACVRL1 mRNA

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

angiotensinogen

multiple interactions

alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aldo-keto reductase family 1 member B1

increases expression

alpha-Tocopherol results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein]
alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of AKT1 protein]

PMID:19351882 PMID:22343715

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

5'-aminolevulinate synthase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein]

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

multiple interactions

alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]; sodium-4,5-dihydroxy-1,3-benzene disulfonate promotes the reaction [alpha-Tocopherol inhibits the reaction [beryllium nitrate results in decreased expression of ALB protein]]
[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of ALB protein; ALB protein inhibits the reaction [alpha-Tocopherol binds to and results in decreased activity of ACHE protein]

PMID:17429802 PMID:34506764 PMID:36372912

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

anoctamin 6

multiple interactions

alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of ANO6 mRNA]

NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589

G

apurinic/apyrimidinic endodeoxyribonuclease 2

multiple interactions
decreases expression

alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
alpha-Tocopherol results in decreased expression of APEX2 mRNA

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

apolipoprotein A1

decreases expression
decreases activity

alpha-Tocopherol results in decreased expression of APOA1 mRNA; alpha-Tocopherol results in decreased expression of APOA1 protein
alpha-Tocopherol results in decreased activity of APOA1 promoter

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

multiple interactions

alpha-Tocopherol promotes the reaction [APOB protein results in increased reduction of Copper]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

amyloid beta precursor protein

multiple interactions

alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activating transcription factor 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

beta-secretase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

increases expression

alpha-Tocopherol results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
alpha-Tocopherol results in increased expression of BAX mRNA

PMID:11805214 PMID:26332274 PMID:32134168 PMID:36058301

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]
alpha-Tocopherol analog results in decreased expression of BCL2 mRNA; alpha-Tocopherol analog results in decreased expression of BCL2 protein
[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of BCL2 protein]

PMID:11805214 PMID:16005924 PMID:16135673 PMID:20686688 PMID:29297235 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

alpha-Tocopherol results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions

[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BPI fold containing family B, member 1

multiple interactions

[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of BPIFB1 protein

NCBI chr 3:142,672,995...142,706,258
Ensembl chr 3:142,672,995...142,706,256

G

calnexin

affects localization
increases expression

alpha-Tocopherol affects the localization of CANX protein
alpha-Tocopherol results in increased expression of CANX mRNA; alpha-Tocopherol results in increased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

multiple interactions
decreases activity

[alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein; [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased cleavage of and results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP3 protein
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 protein]
alpha-Tocopherol results in decreased activity of CASP3 protein

PMID:12450566 PMID:14599462 PMID:14722101 PMID:15095415 PMID:17618090 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

alpha-Tocopherol inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]

PMID:23042730 PMID:29129777

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases cleavage

alpha-Tocopherol analog results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage
multiple interactions

alpha-Tocopherol analog results in increased cleavage of CASP9 protein
alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; alpha-Tocopherol results in increased cleavage of and results in increased activity of CASP9 protein

PMID:20686688 PMID:21869839 PMID:31712109 PMID:36058301

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases activity
increases expression

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; [Sodium Selenite co-treated with alpha-Tocopherol] inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [Copper Sulfate results in decreased activity of CAT protein]; alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]
alpha-Tocopherol results in increased activity of CAT protein
alpha-Tocopherol results in increased expression of CAT protein
alpha-Tocopherol results in increased expression of CAT mRNA; alpha-Tocopherol results in increased expression of CAT protein

PMID:9306888 PMID:16979807 PMID:18547560 PMID:19083475 PMID:19464315 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of CCL2 protein]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

PMID:19735175 PMID:24333275 PMID:26332274

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions

alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

CD36 molecule

affects expression
multiple interactions

alpha-Tocopherol affects the expression of CD36 mRNA
alpha-Tocopherol inhibits the reaction [[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein]

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression

alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]
alpha-Tocopherol results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CF transmembrane conductance regulator

multiple interactions

alpha-Tocopherol inhibits the reaction [Cadmium results in decreased expression of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

choline O-acetyltransferase

multiple interactions

[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

chloride voltage-gated channel 3

multiple interactions

alpha-Tocopherol inhibits the reaction [Ozone results in increased expression of CLCN3 mRNA]

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

claudin 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Potassium Dichromate affects the localization of CLDN2 protein]

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CPT1A mRNA]; alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA]
alpha-Tocopherol results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cellular retinoic acid binding protein 2

multiple interactions

[Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 mRNA; [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 protein

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cAMP responsive element binding protein 1

multiple interactions

[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

C-reactive protein

multiple interactions

[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

crystallin, alpha A

increases expression

alpha-Tocopherol results in increased expression of CRYAA mRNA

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

cathepsin D

increases expression

alpha-Tocopherol results in increased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

alpha-Tocopherol results in increased expression of CYP1A1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]; alpha-Tocopherol results in increased expression of and results in increased activity of CYP1A1 protein

PMID:15665910 PMID:22389237

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
multiple interactions

alpha-Tocopherol results in increased activity of CYP1A2 protein
alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA]

PMID:15665910 PMID:26102010

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

alpha-Tocopherol results in decreased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

alpha-Tocopherol inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
multiple interactions

alpha-Tocopherol results in increased expression of CYP2E1 mRNA
[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]

PMID:26332274 PMID:27919644 PMID:28062356

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]
alpha-Tocopherol results in increased expression of CYP3A4 mRNA
alpha-Tocopherol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA]; Galactosamine inhibits the reaction [alpha-Tocopherol results in increased expression of CYP3A4 mRNA]

PMID:17936189 PMID:27919644 PMID:31102695

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression
multiple interactions

alpha-Tocopherol results in increased expression of CYP3A13 mRNA; alpha-Tocopherol results in increased expression of CYP3A13 protein
alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]

PMID:26102010 PMID:31102695

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]
alpha-Tocopherol analog results in increased expression of DDIT3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]; DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein]

PMID:20459685 PMID:20686688

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

diablo, IAP-binding mitochondrial protein

affects localization

alpha-Tocopherol affects the localization of DIABLO protein

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

eukaryotic translation initiation factor 2A

increases phosphorylation
multiple interactions

alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein]

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

estrogen receptor 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas ligand

increases expression

alpha-Tocopherol results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibrillarin

decreases expression

alpha-Tocopherol deficiency results in decreased expression of FBL protein

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

flavin containing dimethylaniline monoxygenase 1

increases expression

alpha-Tocopherol results in increased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

fibronectin 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein]

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

growth arrest and DNA-damage-inducible, alpha

increases expression

alpha-Tocopherol results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]
[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNA

PMID:22389237 PMID:24530478

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glial fibrillary acidic protein

increases expression

alpha-Tocopherol results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

G protein subunit alpha i2

multiple interactions

alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha i3

multiple interactions

alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

glutamic--pyruvic transaminase

multiple interactions

alpha-Tocopherol inhibits the reaction [beryllium nitrate results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of GPX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 mRNA]
[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]]

PMID:26365763 PMID:29284473 PMID:36058301

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

multiple interactions

alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione-disulfide reductase

multiple interactions

alpha-Tocopherol inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase theta 1

increases expression

alpha-Tocopherol results in increased expression of GSTT1 protein

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glucuronidase, beta

multiple interactions

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

histidine ammonia lyase

increases expression

alpha-Tocopherol results in increased expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]

PMID:19595682 PMID:21535577

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

affects expression
multiple interactions

alpha-Tocopherol affects the expression of HMOX1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]
alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]

PMID:8743975 PMID:12180188 PMID:22053912 PMID:22389237 PMID:36058301

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

haptoglobin

affects activity
multiple interactions

alpha-Tocopherol affects the activity of HP protein polymorphism
Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism]

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD17B3 mRNA]

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of HSD3B2 mRNA]

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 1B

increases expression

alpha-Tocopherol results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

intercellular adhesion molecule 1

multiple interactions

[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]

PMID:22313677 PMID:25551565

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IFNG mRNA; alpha-Tocopherol results in decreased susceptibility to [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4]
alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]]

PMID:16307444 PMID:24333275 PMID:29284473

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 5

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
[alpha-Tocopherol co-treated with Lipopolysaccharides] results in increased expression of IL10 mRNA

PMID:24333275 PMID:25551565

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

multiple interactions

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

multiple interactions

alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 alpha

multiple interactions

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of IL1B mRNA]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]

PMID:19135433 PMID:19735175 PMID:26332274 PMID:31712109

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 5

multiple interactions

alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL5 mRNA]]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

alpha-Tocopherol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein]
alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of IL6 protein]
alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]]

PMID:15630180 PMID:24296301 PMID:29284473 PMID:32134168

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein]
alpha-Tocopherol results in increased expression of JUN mRNA; alpha-Tocopherol results in increased expression of JUN protein

PMID:14645110 PMID:19000923 PMID:20025956

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

Kelch-like ECH-associated protein 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lecithin cholesterol acyltransferase

multiple interactions

[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in decreased activity of LCAT protein]; [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]

PMID:19595682 PMID:21535577

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein]

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

lactate dehydrogenase A

multiple interactions

[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased secretion of LDHA protein]

PMID:21322096 PMID:26270818

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

multiple interactions

[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

galectin 3 binding protein

multiple interactions

[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of LGALS3BP protein

NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein]

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

mitogen activated protein kinase 1

multiple interactions
affects activity

alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein]
[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK1 protein]
[alpha-Tocopherol affects the activity of MAPK1 protein] which results in decreased susceptibility to Potassium Dichromate

PMID:17011908 PMID:19766176 PMID:30776390

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein]
alpha-Tocopherol inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]

PMID:12684028 PMID:14645110 PMID:29284473

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
affects activity

alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein]
[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of MAPK3 protein]
[alpha-Tocopherol affects the activity of MAPK3 protein] which results in decreased susceptibility to Potassium Dichromate

PMID:14645110 PMID:17011908 PMID:19766176 PMID:30776390

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein]

PMID:12684028 PMID:14645110 PMID:20686688

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation
multiple interactions

alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]; salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myoglobin

multiple interactions

alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

myelin basic protein

multiple interactions

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein]

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

increases expression

alpha-Tocopherol results in increased expression of MGAT3 mRNA

NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026

G

marker of proliferation Ki-67

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloperoxidase

multiple interactions

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mucin 4, cell surface associated

multiple interactions

[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of MUC4 protein

NCBI chr11:68,008,245...68,053,242

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

neurofilament heavy chain

increases expression

alpha-Tocopherol results in increased expression of NEFH protein modified form

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

NFE2 like bZIP transcription factor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]; [alpha-Tocopherol co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; alpha-Tocopherol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein]
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] promotes the reaction [[Ozone co-treated with Oxygen] results in increased localization of NFE2L2 protein]; alpha-Tocopherol promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]

PMID:22389237 PMID:26270818 PMID:29297235 PMID:31412289 PMID:32134168 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions
increases activity

alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]
alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]]
alpha-Tocopherol results in increased activity of NFKB1 protein

PMID:15025948 PMID:16135673 PMID:17936189 PMID:19083475

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

alpha-Tocopherol inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; alpha-Tocopherol inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
[Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased phosphorylation of NFKBIA protein]

PMID:16135673 PMID:17532611 PMID:25551565

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein]
alpha-Tocopherol inhibits the reaction [Galactosamine results in increased expression of NOS2 mRNA]

PMID:17936189 PMID:19135433

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression

alpha-Tocopherol results in increased expression of NOS3 mRNA; alpha-Tocopherol results in increased expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]
alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]

PMID:22389237 PMID:36058301

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

alpha-Tocopherol promotes the reaction [NR1I2 results in increased expression of CPT1A mRNA]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

oxoglutarate dehydrogenase

multiple interactions

alpha-Tocopherol inhibits the reaction [sodium arsenite results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

orosomucoid 1

increases expression

alpha-Tocopherol results in increased expression of ORM1 mRNA; alpha-Tocopherol results in increased expression of ORM1 protein

PMID:19000923 PMID:20025956

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

Parkinsonism associated deglycase

multiple interactions

alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein]
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]

PMID:14645110 PMID:24448832

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

multiple interactions

alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; alpha-Tocopherol inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein]

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

paired box 3

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA]
alpha-Tocopherol results in increased expression of PAX3 mRNA

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

phosphoenolpyruvate carboxykinase 1

decreases expression

alpha-Tocopherol results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

proliferating cell nuclear antigen

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet derived growth factor receptor beta

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

phosphoglycerate kinase 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

plasminogen

multiple interactions

alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]; alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein]

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

phospholipid transfer protein

decreases abundance

PLTP mutant form results in decreased abundance of alpha-Tocopherol

NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of PPARA mRNA]
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]
alpha-Tocopherol results in increased expression of PPARA mRNA

PMID:17936189 PMID:29065513

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions
increases activity

alpha-Tocopherol results in increased expression of PPARG mRNA; alpha-Tocopherol results in increased expression of PPARG protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]
alpha-Tocopherol results in increased activity of PPARG protein

PMID:11752099 PMID:14521714 PMID:19083475 PMID:22389237 PMID:28062356

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peptidylprolyl isomerase A

increases expression

alpha-Tocopherol results in increased expression of PPIA mRNA

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

proteasome 26S subunit, ATPase 6

multiple interactions

alpha-Tocopherol inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

prostaglandin-endoperoxide synthase 2

decreases activity
multiple interactions

alpha-Tocopherol metabolite results in decreased activity of PTGS2 protein; alpha-Tocopherol results in decreased activity of PTGS2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]

PMID:15225597 PMID:22389237

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions

alpha-Tocopherol affects the localization of RELA protein
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with ferulic acid] inhibits the reaction [[Ozone co-treated with Oxygen] results in increased localization of RELA protein]; alpha-Tocopherol affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]]
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:15025948 PMID:16135673 PMID:16882165 PMID:17936189 PMID:26270818 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6

multiple interactions

alpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein]

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

retinoid X receptor alpha

multiple interactions

[Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein; [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

selectin E

multiple interactions

[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of SELE protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]

PMID:12566129 PMID:25551565

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

solute carrier family 1 member 2

multiple interactions

alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 7 member 11

multiple interactions

[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

secretory leukocyte peptidase inhibitor

multiple interactions

[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in decreased secretion of SLPI protein

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SMAD family member 4

multiple interactions

SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

synuclein alpha

multiple interactions

alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

multiple interactions
increases expression

[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of SOD1 protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
alpha-Tocopherol inhibits the reaction [Hexachlorobenzene results in increased activity of SOD1 protein]
alpha-Tocopherol results in increased expression of SOD1 mRNA; alpha-Tocopherol results in increased expression of SOD1 protein

PMID:19083475 PMID:20194575 PMID:21344382 PMID:22732938 PMID:26365763

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression
increases expression
multiple interactions

alpha-Tocopherol results in decreased expression of SOD2 protein
alpha-Tocopherol results in increased expression of SOD2 mRNA; alpha-Tocopherol results in increased expression of SOD2 protein
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased expression of and results in increased activity of SOD2 protein]

PMID:16135673 PMID:18942769 PMID:20194575 PMID:22732938 PMID:23859036

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

serine and arginine rich splicing factor 2

decreases expression

alpha-Tocopherol deficiency results in decreased expression of SRSF2 protein

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

steroidogenic acute regulatory protein

multiple interactions

alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

increases expression

alpha-Tocopherol results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

telomerase reverse transcriptase

multiple interactions

alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein]

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

multiple interactions

[alpha-Tocopherol co-treated with hempseed oil co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor alpha

decreases response to substance

alpha-Tocopherol results in decreased susceptibility to TGFA protein

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions
decreases expression

alpha-Tocopherol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]
alpha-Tocopherol results in decreased expression of TGFB1 mRNA

PMID:9608545 PMID:14732287

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein; alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]

PMID:15790535 PMID:25891525

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
affects expression
decreases response to substance
decreases expression

[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; [Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]]; alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]]; alpha-Tocopherol promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Triiodothyronine, Reverse results in increased secretion of TNF protein]
alpha-Tocopherol affects the expression of TNF protein
alpha-Tocopherol results in decreased susceptibility to TNF protein
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; alpha-Tocopherol inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of TNF mRNA]]; alpha-Tocopherol inhibits the reaction [Vitamin E deficiency results in increased expression of TNF mRNA]
alpha-Tocopherol results in decreased expression of TNF protein

PMID:10588948 PMID:11805214 PMID:12195823 PMID:15025948 PMID:15630180 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 mRNA]; alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thioredoxin 1

multiple interactions

[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of TXN1 protein]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

multiple interactions

alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of VCAM1 protein]; alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein]

PMID:12566129 PMID:22313677

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

X-box binding protein 1

increases expression

alpha-Tocopherol analog results in increased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

X-ray repair cross complementing 6

multiple interactions

alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]

NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762

G

YY1 transcription factor

multiple interactions

alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

alpha-tocotrienol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

tocotrienol, alpha results in increased expression of ABCB1

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]
tocotrienol, alpha results in increased expression of CYP3A4

PMID:15269186 PMID:31102695

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects response to substance
multiple interactions

CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, alpha
tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

glutathione S-transferase mu 1

multiple interactions

GSTM1 gene polymorphism affects the susceptibility to [Ascorbic Acid co-treated with tocotrienol, alpha]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

nuclear receptor co-repressor 1

multiple interactions

tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

tocotrienol, alpha binds to and results in increased activity of NR1I2 protein; tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

UDP glucuronosyltransferase family 1 member A1

increases expression

tocotrienol, alpha results in increased expression of UGT1A1

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

beta-tocopherol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]
beta-Tocopherol affects the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]

PMID:12450566 PMID:22389237

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

estrogen receptor 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione S-transferase mu 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

heme oxygenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

NFE2 like bZIP transcription factor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

proliferating cell nuclear antigen

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

beta-tocotrienol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

tocotrienol, beta results in increased expression of ABCB1

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

tocotrienol, beta results in increased expression of CYP3A4

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

nuclear receptor co-repressor 1

multiple interactions

tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

tocotrienol, beta binds to and results in increased activity of NR1I2 protein; tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

UDP glucuronosyltransferase family 1 member A1

increases expression

tocotrienol, beta results in increased expression of UGT1A1

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

delta-tocopherol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cellular retinoic acid binding protein 2

multiple interactions

[Tretinoin co-treated with delta-tocopherol] results in increased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

estrogen receptor 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione S-transferase mu 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

heme oxygenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

NFE2 like bZIP transcription factor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

proliferating cell nuclear antigen

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

delta-tocotrienol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

tocotrienol, delta results in increased expression of ABCB1

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA]
tocotrienol, delta results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily D member 2

decreases expression

tocotrienol, delta results in decreased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

actin-like 6B

increases expression

tocotrienol, delta results in increased expression of ACTL6B mRNA

NCBI chr12:19,124,887...19,141,419
Ensembl chr12:19,124,916...19,141,376

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions
increases expression

tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of ATP2A2 mRNA]
tocotrienol, delta results in increased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

cyclin D1

decreases expression

tocotrienol, delta results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]
tocotrienol, delta results in increased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

CD40 molecule

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]
tocotrienol, delta results in increased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd69 molecule

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]
tocotrienol, delta results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

cytochrome c oxidase subunit 7B2

multiple interactions
decreases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]
tocotrienol, delta results in decreased expression of COX7B2 mRNA

NCBI chr14:36,693,120...36,805,323
Ensembl chr14:36,693,105...36,805,523

G

C-reactive protein

multiple interactions

[resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

catenin beta 1

decreases expression

tocotrienol, delta results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]
tocotrienol, delta results in increased expression of CYP3A4

PMID:15269186 PMID:31102695

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
affects response to substance

tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]
CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, delta

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

GTPase, IMAP family member 1

multiple interactions
decreases expression

tocotrienol, delta promotes the reaction [Lipopolysaccharides results in decreased expression of GIMAP1 mRNA]
tocotrienol, delta results in decreased expression of GIMAP1 mRNA

NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

tocotrienol, delta results in decreased expression of ICAM1 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon beta 1

multiple interactions

tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

decreases expression
multiple interactions

tocotrienol, delta results in decreased expression of IFNGR1 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interleukin 12B

decreases expression
multiple interactions

tocotrienol, delta results in decreased expression of IL12B mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 alpha

increases expression

tocotrienol, delta results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
tocotrienol, delta results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

increases expression
multiple interactions

tocotrienol, delta results in increased expression of IL1RN mRNA
tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

increases expression
multiple interactions

tocotrienol, delta results in increased expression of IL6 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

tocotrienol, delta results in decreased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

matrix metallopeptidase 7

decreases expression

tocotrienol, delta results in decreased expression of MMP7 protein

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

nuclear receptor co-repressor 1

multiple interactions

tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

nitric oxide synthase 2

multiple interactions

Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of NOS2]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

PMID:21356098 PMID:22185406

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

tocotrienol, delta binds to and results in increased activity of NR1I2 protein; tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

phosphorylase kinase regulatory subunit alpha 2

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PHKA2 mRNA]
tocotrienol, delta results in increased expression of PHKA2 mRNA

NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466

G

proteasome 20S subunit beta 2

decreases expression

tocotrienol, delta results in decreased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

polypyrimidine tract binding protein 2

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]
tocotrienol, delta results in increased expression of PTBP2 mRNA

NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506

G

RAS guanyl releasing protein 1

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of RASGRP1 mRNA]
tocotrienol, delta results in increased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

RAS guanyl releasing protein 3

decreases expression
multiple interactions

tocotrienol, delta results in decreased expression of RASGRP3 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]

NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578

G

suppressor of cytokine signaling 3

multiple interactions
decreases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]
tocotrienol, delta results in decreased expression of SOCS3 mRNA

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

tumor necrosis factor

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of TNF]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
tocotrienol, delta results in decreased expression of TNF mRNA

PMID:21356098 PMID:22185406

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transition protein 1

multiple interactions
decreases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of TNP1 mRNA]
tocotrienol, delta results in decreased expression of TNP1 mRNA

NCBI chr 9:74,594,463...74,595,072
Ensembl chr 9:74,594,466...74,595,274

G

TNF receptor-associated factor 1

multiple interactions
increases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]
tocotrienol, delta results in increased expression of TRAF1 mRNA

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

ubiquitin-conjugating enzyme E2D 2

multiple interactions
decreases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of UBE2D2A mRNA]
tocotrienol, delta results in decreased expression of UBE2D2A mRNA

NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181

G

UDP glucuronosyltransferase family 1 member A1

increases expression

tocotrienol, delta results in increased expression of UGT1A1

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
tocotrienol, delta results in decreased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

Wnt family member 1

decreases expression

tocotrienol, delta results in decreased expression of WNT1 protein

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

gamma-tocopherol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases activity
multiple interactions

Tocopherols results in decreased activity of ABCC1 protein
Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

albumin

multiple interactions

gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

amyloid beta precursor protein

decreases abundance
multiple interactions

APP protein modified form results in decreased abundance of Tocopherols
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

decreases expression
decreases activity

[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein
Tocopherols results in decreased activity of AR protein

PMID:12032296 PMID:16302272

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ADP-ribosylation factor 3

increases expression

Tocopherols results in increased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

assembly factor for spindle microtubules

increases expression

Tocopherols results in increased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Tocopherols results in increased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit beta 2

increases expression

Tocopherols results in increased expression of ATP1B2 mRNA

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

aurora kinase A

increases expression

Tocopherols results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

BCL2 associated X, apoptosis regulator

increases response to substance
multiple interactions
increases expression

BAX protein results in increased susceptibility to Tocopherols
[Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA
gamma-Tocopherol results in increased expression of BAX mRNA

PMID:16001965 PMID:31587439

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression
decreases response to substance

Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA
gamma-Tocopherol results in decreased expression of BCL2 mRNA
BCL2 protein results in decreased susceptibility to Tocopherols

PMID:8970189 PMID:16001965 PMID:31587439

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases response to substance

BCL2L1 protein results in decreased susceptibility to Tocopherols

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

increases expression

Tocopherols results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

calcium/calmodulin-dependent protein kinase II gamma

increases expression

Tocopherols results in increased expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

caspase 3

increases activity
multiple interactions

gamma-Tocopherol results in increased activity of CASP3 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]
thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein]

PMID:15596715 PMID:22389237

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

gamma-Tocopherol results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression

gamma-Tocopherol results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin B2

increases expression

Tocopherols results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression
multiple interactions

gamma-Tocopherol results in decreased expression of CCND1 mRNA; gamma-Tocopherol results in decreased expression of CCND1 protein; Tocopherols results in decreased expression of CCND1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA

PMID:12368234 PMID:12504091 PMID:31587439

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

Tocopherols results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression
multiple interactions

gamma-Tocopherol results in decreased expression of CCNE1 mRNA; gamma-Tocopherol results in decreased expression of CCNE1 protein; Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein
[Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA

PMID:12368234 PMID:12504091 PMID:31587439

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cell division cycle 6

increases expression

Tocopherols results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase 1

increases expression

Tocopherols results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression

Tocopherols results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Tocopherols results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

cyclin-dependent kinase inhibitor 1A

decreases expression

gamma-Tocopherol results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

gamma-Tocopherol results in decreased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

decreases expression

gamma-Tocopherol results in decreased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

C-type lectin domain family 4, member E

increases expression

Tocopherols results in increased expression of CLEC4E mRNA

NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767

G

complexin 1

increases expression

Tocopherols results in increased expression of CPLX1 mRNA

NCBI chr14:1,184,677...1,216,392

G

complexin 2

increases expression

Tocopherols results in increased expression of CPLX2 mRNA

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

cellular retinoic acid binding protein 2

multiple interactions

[Tretinoin co-treated with gamma-Tocopherol] results in increased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

C-reactive protein

multiple interactions

[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 1 receptor

increases expression

Tocopherols results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine-rich protein 2

increases expression

Tocopherols results in increased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DnaJ heat shock protein family (Hsp40) member C5

increases expression

Tocopherols results in increased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

E2F transcription factor 1

increases expression

Tocopherols results in increased expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

decreases activity

Tocopherols results in decreased activity of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

estrogen receptor 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fc epsilon receptor Ia

increases expression

Tocopherols results in increased expression of FCER1A mRNA

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

FES proto-oncogene, tyrosine kinase

increases expression

Tocopherols results in increased expression of FES mRNA

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor 1

decreases expression

Tocopherols results in decreased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

decreases expression

Tocopherols results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fibroblast growth factor receptor 1

decreases expression

Tocopherols results in decreased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FKBP prolyl isomerase 9

increases expression

Tocopherols results in increased expression of FKBP9 mRNA

NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutamate ionotropic receptor AMPA type subunit 2

increases expression

Tocopherols results in increased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

Tocopherols results in increased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutathione S-transferase mu 1

increases expression
multiple interactions

gamma-Tocopherol results in increased expression of GSTM1 mRNA; gamma-Tocopherol results in increased expression of GSTM1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]

PMID:19115203 PMID:22389237

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase omega 1

decreases activity

Tocopherols results in decreased activity of GSTO1 protein

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

histone H3 associated protein kinase

increases expression

Tocopherols results in increased expression of HASPIN mRNA

NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512

G

heme oxygenase 1

increases expression
multiple interactions

gamma-Tocopherol results in increased expression of HMOX1 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]

PMID:19115203 PMID:22389237

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 20A

increases expression

Tocopherols results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 4A

increases expression

Tocopherols results in increased expression of KIF4 mRNA

NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139

G

kallikrein 1-related peptidase C10

decreases expression
multiple interactions

[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of KLK3 mRNA; Tocopherols results in decreased expression of KLK3 protein
Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]; Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]

PMID:12032296 PMID:16302272

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

MCL1 apoptosis regulator, BCL2 family member

decreases response to substance

MCL1 protein results in decreased susceptibility to Tocopherols

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
decreases activity

Tocopherols results in decreased expression of MYC mRNA
Tocopherols results in decreased activity of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NSF attachment protein beta

increases expression

Tocopherols results in increased expression of NAPB mRNA

NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

gamma-Tocopherol results in increased expression of NFE2L2 mRNA; gamma-Tocopherol results in increased expression of NFE2L2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]

PMID:19115203 PMID:22389237

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

increases expression

Tocopherols results in increased expression of NSF mRNA

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

proliferating cell nuclear antigen

multiple interactions
decreases expression

[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]
Tocopherols results in decreased expression of PCNA

PMID:17927505 PMID:22389237

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

gamma-Tocopherol results in increased expression of PPARG mRNA; gamma-Tocopherol results in increased expression of PPARG protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]

PMID:14521714 PMID:22389237

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 3 catalytic subunit alpha

increases expression

Tocopherols results in increased expression of PPP3CA mRNA

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

proteinase 3

increases expression

Tocopherols results in increased expression of PRTN3 mRNA

NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944

G

prostaglandin-endoperoxide synthase 2

decreases activity
multiple interactions

gamma-Tocopherol results in decreased activity of PTGS2 protein
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]

PMID:15225597 PMID:22389237

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, O

increases expression

Tocopherols results in increased expression of PTPRO mRNA

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

RAB11B, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB11B mRNA

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

RAB3A, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB3A mRNA

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

RAB6B, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB6B mRNA

NCBI chr 8:103,695,328...103,764,023
Ensembl chr 8:103,695,631...103,805,732

G

RB transcriptional corepressor 1

decreases phosphorylation

Tocopherols results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

ribonucleotide reductase catalytic subunit M1

increases expression

Tocopherols results in increased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

increases expression

Tocopherols results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

synuclein alpha

increases expression

Tocopherols results in increased expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

synuclein, beta

increases expression

Tocopherols results in increased expression of SNCB mRNA

NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012

G

superoxide dismutase 1

increases expression

gamma-Tocopherol results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

syntaxin 1A

increases expression

Tocopherols results in increased expression of STX1A mRNA

NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930

G

syntaxin binding protein 1

increases expression

Tocopherols results in increased expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

synaptic vesicle glycoprotein 2a

increases expression

Tocopherols results in increased expression of SV2A mRNA

NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927

G

synapsin I

increases expression

Tocopherols results in increased expression of SYN1 mRNA

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

synapsin II

increases expression

Tocopherols results in increased expression of SYN2 mRNA

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

G

synaptogyrin 1

increases expression

Tocopherols results in increased expression of SYNGR1 mRNA

NCBI chr 7:111,635,911...111,659,341
Ensembl chr 7:111,635,918...111,659,341

G

synaptophysin

increases expression

Tocopherols results in increased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptotagmin 11

increases expression

Tocopherols results in increased expression of SYT11 mRNA

NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964

G

synaptotagmin 13

increases expression

Tocopherols results in increased expression of SYT13 mRNA

NCBI chr 3:78,877,114...78,917,527
Ensembl chr 3:78,877,114...78,917,392

G

tumor necrosis factor

multiple interactions

[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein
Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium]

PMID:17337591 PMID:18191645

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 2

increases expression

Tocopherols results in increased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

tumor protein p53

increases activity

Tocopherols results in increased activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tetratricopeptide repeat domain 3

increases expression

Tocopherols results in increased expression of TTC3 mRNA

NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

gamma-Tocopherol results in increased expression of UGT1A1 mRNA
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]

PMID:19115203 PMID:22389237

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vesicle-associated membrane protein 1

increases expression

Tocopherols results in increased expression of VAMP1 mRNA

NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349

G

vesicle-associated membrane protein 2

increases expression

Tocopherols results in increased expression of VAMP2 mRNA

NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809

G

vitamin D receptor

increases expression

Tocopherols results in increased expression of VDR mRNA

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

tocopherol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions
decreases activity

Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
Tocopherols results in decreased activity of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

amyloid beta precursor protein

multiple interactions
decreases abundance

resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

decreases activity
decreases expression

Tocopherols results in decreased activity of AR protein
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein

PMID:12032296 PMID:16302272

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ADP-ribosylation factor 3

increases expression

Tocopherols results in increased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

assembly factor for spindle microtubules

increases expression

Tocopherols results in increased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Tocopherols results in increased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit beta 2

increases expression

Tocopherols results in increased expression of ATP1B2 mRNA

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

aurora kinase A

increases expression

Tocopherols results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

BCL2 associated X, apoptosis regulator

increases response to substance

BAX protein results in increased susceptibility to Tocopherols

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases response to substance
increases expression

BCL2 protein results in decreased susceptibility to Tocopherols
Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein

PMID:8970189 PMID:16001965

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases response to substance

BCL2L1 protein results in decreased susceptibility to Tocopherols

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

increases expression

Tocopherols results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

calcium/calmodulin-dependent protein kinase II gamma

increases expression

Tocopherols results in increased expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

cyclin B2

increases expression

Tocopherols results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression

Tocopherols results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

Tocopherols results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression

Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cell division cycle 6

increases expression

Tocopherols results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase 1

increases expression

Tocopherols results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression

Tocopherols results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5 regulatory subunit 1

increases expression

Tocopherols results in increased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

C-type lectin domain family 4, member E

increases expression

Tocopherols results in increased expression of CLEC4E mRNA

NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767

G

complexin 1

increases expression

Tocopherols results in increased expression of CPLX1 mRNA

NCBI chr14:1,184,677...1,216,392

G

complexin 2

increases expression

Tocopherols results in increased expression of CPLX2 mRNA

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

colony stimulating factor 1 receptor

increases expression

Tocopherols results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine-rich protein 2

increases expression

Tocopherols results in increased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

DnaJ heat shock protein family (Hsp40) member C5

increases expression

Tocopherols results in increased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

E2F transcription factor 1

increases expression

Tocopherols results in increased expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

decreases activity

Tocopherols results in decreased activity of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

Fc epsilon receptor Ia

increases expression

Tocopherols results in increased expression of FCER1A mRNA

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

FES proto-oncogene, tyrosine kinase

increases expression

Tocopherols results in increased expression of FES mRNA

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor 1

decreases expression

Tocopherols results in decreased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

decreases expression

Tocopherols results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fibroblast growth factor receptor 1

decreases expression

Tocopherols results in decreased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FKBP prolyl isomerase 9

increases expression

Tocopherols results in increased expression of FKBP9 mRNA

NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamate ionotropic receptor AMPA type subunit 2

increases expression

Tocopherols results in increased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

Tocopherols results in increased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutathione S-transferase omega 1

decreases activity

Tocopherols results in decreased activity of GSTO1 protein

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

histone H3 associated protein kinase

increases expression

Tocopherols results in increased expression of HASPIN mRNA

NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 20A

increases expression

Tocopherols results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 4A

increases expression

Tocopherols results in increased expression of KIF4 mRNA

NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139

G

kallikrein 1-related peptidase C10

multiple interactions
decreases expression

Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]; Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of KLK3 mRNA; Tocopherols results in decreased expression of KLK3 protein

PMID:12032296 PMID:16302272

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

MCL1 apoptosis regulator, BCL2 family member

decreases response to substance

MCL1 protein results in decreased susceptibility to Tocopherols

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MYC proto-oncogene, bHLH transcription factor

decreases activity
decreases expression

Tocopherols results in decreased activity of MYC protein
Tocopherols results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NSF attachment protein beta

increases expression

Tocopherols results in increased expression of NAPB mRNA

NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

increases expression

Tocopherols results in increased expression of NSF mRNA

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

proliferating cell nuclear antigen

decreases expression

Tocopherols results in decreased expression of PCNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

protein phosphatase 3 catalytic subunit alpha

increases expression

Tocopherols results in increased expression of PPP3CA mRNA

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

proteinase 3

increases expression

Tocopherols results in increased expression of PRTN3 mRNA

NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944

G

protein tyrosine phosphatase, receptor type, O

increases expression

Tocopherols results in increased expression of PTPRO mRNA

NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771

G

RAB11B, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB11B mRNA

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

RAB3A, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB3A mRNA

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

RAB6B, member RAS oncogene family

increases expression

Tocopherols results in increased expression of RAB6B mRNA

NCBI chr 8:103,695,328...103,764,023
Ensembl chr 8:103,695,631...103,805,732

G

RB transcriptional corepressor 1

decreases phosphorylation

Tocopherols results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

ribonucleotide reductase catalytic subunit M1

increases expression

Tocopherols results in increased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

increases expression

Tocopherols results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

synuclein alpha

increases expression

Tocopherols results in increased expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

synuclein, beta

increases expression

Tocopherols results in increased expression of SNCB mRNA

NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012

G

syntaxin 1A

increases expression

Tocopherols results in increased expression of STX1A mRNA

NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930

G

syntaxin binding protein 1

increases expression

Tocopherols results in increased expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

synaptic vesicle glycoprotein 2a

increases expression

Tocopherols results in increased expression of SV2A mRNA

NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927

G

synapsin I

increases expression

Tocopherols results in increased expression of SYN1 mRNA

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

synapsin II

increases expression

Tocopherols results in increased expression of SYN2 mRNA

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

G

synaptogyrin 1

increases expression

Tocopherols results in increased expression of SYNGR1 mRNA

NCBI chr 7:111,635,911...111,659,341
Ensembl chr 7:111,635,918...111,659,341

G

synaptophysin

increases expression

Tocopherols results in increased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptotagmin 11

increases expression

Tocopherols results in increased expression of SYT11 mRNA

NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964

G

synaptotagmin 13

increases expression

Tocopherols results in increased expression of SYT13 mRNA

NCBI chr 3:78,877,114...78,917,527
Ensembl chr 3:78,877,114...78,917,392

G

tumor necrosis factor

multiple interactions

Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 2

increases expression

Tocopherols results in increased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

tumor protein p53

increases activity

Tocopherols results in increased activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tetratricopeptide repeat domain 3

increases expression

Tocopherols results in increased expression of TTC3 mRNA

NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975

G

vesicle-associated membrane protein 1

increases expression

Tocopherols results in increased expression of VAMP1 mRNA

NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349

G

vesicle-associated membrane protein 2

increases expression

Tocopherols results in increased expression of VAMP2 mRNA

NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809

G

vitamin D receptor

increases expression

Tocopherols results in increased expression of VDR mRNA

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

Tocophersolan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

[methoxy poly(ethylene glycol-co-epsilon-caprolactone) co-treated with tocophersolan co-treated with Resveratrol] results in decreased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
chemical role	19422
antioxidant	16120
tocol	266
DL-alpha-Tocopherol acetate	0
Tocopherol calcium succinate	0
Tocophersolan	1
Tocopheryl nicotinate	0
Tocoretinate	0
alpha-Tocopherol acetate	0
tocofibrate	0
tocopherol +	242
tocopherol succinate	0
tocotrienol +	43
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
p-block element atom	19759
carbon group element atom	19708
carbon atom	19734
organic molecular entity	19705
organic molecule	19658
organic cyclic compound	19471
organic heterocyclic compound	18862
oxacycle	17819
benzopyran	11950
1-benzopyran	11702
chromanes	4028
chromanol	1874
chroman-6-ol	1875
tocol	266
DL-alpha-Tocopherol acetate	0
Tocopherol calcium succinate	0
Tocophersolan	1
Tocopheryl nicotinate	0
Tocoretinate	0
alpha-Tocopherol acetate	0
tocofibrate	0
tocopherol +	242
tocopherol succinate	0
tocotrienol +	43

paths to the root