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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:limonoid
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Accession:CHEBI:39434 term browser browse the term
Definition:Any triterpenoid that is highly oxygenated and has a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. The term 'limonoid' comes from limonin, the first tetranortriterpenoid obtained from citrus bitter principles.
Synonyms:related_synonym: limonoids
 xref: PMID:16462017;   Wikipedia:Limonoid


show annotations for term's descendants           Sort by:
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
azadirachtin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant decreases expression
multiple interactions		 ISO azadirachtin results in decreased expression of ACP5 mRNA
azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of ACP5 mRNA]		 CTD PMID:31225646 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO azadirachtin results in increased expression of BAD mRNA CTD PMID:20429769 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO azadirachtin results in increased expression of BAX mRNA CTD PMID:20429769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO azadirachtin results in decreased expression of BCL2 mRNA; azadirachtin results in decreased expression of BCL2 protein CTD PMID:20429769 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO azadirachtin results in decreased expression of BCL2L1 mRNA CTD PMID:20429769 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of BGLAP protein] CTD PMID:31225646 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO azadirachtin results in increased expression of BID mRNA CTD PMID:20429769 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO azadirachtin results in decreased expression of BIRC5 protein CTD PMID:20429769 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO azadirachtin results in increased expression of BMP2 mRNA; azadirachtin results in increased expression of BMP2 protein CTD PMID:31225646 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 increases expression ISO azadirachtin results in increased expression of CASP3 mRNA; azadirachtin results in increased expression of CASP3 protein CTD PMID:20429769 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases expression ISO azadirachtin results in increased expression of CASP6 protein CTD PMID:20429769 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 increases expression ISO azadirachtin results in increased expression of CASP8 protein CTD PMID:20429769 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression ISO azadirachtin results in increased expression of CASP9 mRNA; azadirachtin results in increased expression of CASP9 protein CTD PMID:20429769 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO azadirachtin results in decreased expression of CCND1 mRNA CTD PMID:20429769 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO azadirachtin results in increased expression of CDKN1A mRNA; azadirachtin results in increased expression of CDKN1A protein CTD PMID:20429769 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic increases expression
affects localization		 ISO azadirachtin results in increased expression of CYCS mRNA
azadirachtin affects the localization of CYCS protein		 CTD PMID:20429769 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
affects binding		 ISO azadirachtin results in increased expression of ESR1 mRNA; azadirachtin results in increased expression of ESR1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [azadirachtin results in increased expression of ESR1 protein]; azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR1 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]
azadirachtin binds to ESR1 protein		 CTD PMID:31225646 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases expression		 ISO azadirachtin inhibits the reaction [Estrogens deficiency results in decreased expression of ESR2 mRNA]
azadirachtin binds to ESR2 protein
azadirachtin results in increased expression of ESR2 mRNA; azadirachtin results in increased expression of ESR2 protein		 CTD PMID:31225646 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO azadirachtin results in decreased expression of IKBKB protein CTD PMID:20429769 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK1 protein CTD PMID:31225646 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO azadirachtin results in increased phosphorylation of MAPK3 protein CTD PMID:31225646 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO azadirachtin results in decreased expression of NFKB1 protein CTD PMID:20429769 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO azadirachtin results in decreased expression of NFKBIA protein modified form CTD PMID:20429769 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO azadirachtin results in decreased expression of PCNA mRNA; azadirachtin results in decreased expression of PCNA protein CTD PMID:20429769 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO azadirachtin results in decreased expression of RELA protein CTD PMID:20429769 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 ISO azadirachtin results in increased expression of RUNX2 mRNA; azadirachtin results in increased expression of RUNX2 protein
ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 mRNA]; ESR1 protein promotes the reaction [azadirachtin results in increased expression of RUNX2 protein]		 CTD PMID:31225646 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Smad1 SMAD family member 1 increases expression ISO azadirachtin results in increased expression of SMAD1 protein modified form CTD PMID:31225646 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO azadirachtin results in decreased expression of TNF mRNA CTD PMID:31225646 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions
decreases expression		 ISO azadirachtin inhibits the reaction [Estrogens deficiency results in increased expression of TNFRSF11A mRNA]
azadirachtin results in decreased expression of TNFRSF11A mRNA		 CTD PMID:31225646 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO azadirachtin results in increased expression of TP53 mRNA; azadirachtin results in increased expression of TP53 protein CTD PMID:20429769 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
CEDRELONE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO cedrelone analog results in decreased phosphorylation of AKT1 protein CTD PMID:31857088 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cedrelone analog results in increased expression of BAX protein CTD PMID:31857088 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO cedrelone analog results in decreased expression of BCL2 protein CTD PMID:31857088 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 affects cleavage ISO cedrelone analog affects the cleavage of CASP3 protein CTD PMID:31857088 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO cedrelone analog results in decreased expression of EGFR protein CTD PMID:31857088 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO cedrelone analog results in decreased expression of ITGB1 protein CTD PMID:31857088 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO cedrelone analog results in decreased activity of MMP9 protein CTD PMID:31857088 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO cedrelone analog results in decreased expression of NFKB1 protein CTD PMID:31857088 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
gedunin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO gedunin results in increased expression of AHSA1 mRNA CTD PMID:17010675 NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO gedunin results in increased expression of AKR1C1 mRNA CTD PMID:17010675 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO gedunin results in increased expression of AKR1C2 mRNA CTD PMID:17010675 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Ar androgen receptor decreases expression ISO gedunin results in decreased expression of AR protein CTD PMID:17010675 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO gedunin results in decreased expression of ARID5B mRNA CTD PMID:17010675 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gedunin results in increased expression of ATF3 mRNA CTD PMID:17010675 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO gedunin results in increased expression of BAG3 mRNA CTD PMID:17010675 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO gedunin results in decreased expression of BIRC5 mRNA CTD PMID:17010675 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO gedunin results in decreased expression of BTG1 mRNA CTD PMID:17010675 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Cacybp calcyclin binding protein increases expression ISO gedunin results in increased expression of CACYBP mRNA CTD PMID:17010675 NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177 		JBrowse link
G Casp3 caspase 3 increases activity ISO gedunin results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO gedunin results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO gedunin results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO gedunin results in increased expression of CBR3 mRNA CTD PMID:17010675 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO gedunin results in decreased expression of CDC7 mRNA CTD PMID:17010675 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO gedunin results in decreased expression of CDK2 mRNA CTD PMID:17010675 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO gedunin results in increased expression of CHORDC1 mRNA CTD PMID:17010675 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO gedunin results in decreased expression of CITED2 mRNA CTD PMID:17010675 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO gedunin results in decreased expression of CYP1A1 mRNA CTD PMID:17010675 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO gedunin results in increased expression of DDIT3 mRNA CTD PMID:17010675 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO gedunin results in increased expression of DDIT4 mRNA CTD PMID:17010675 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO gedunin results in increased expression of DNAJA1 mRNA CTD PMID:17010675 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO gedunin results in increased expression of DNAJB4 mRNA CTD PMID:17010675 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Efnb2 ephrin B2 decreases expression ISO gedunin results in decreased expression of EFNB2 mRNA CTD PMID:17010675 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO gedunin results in decreased expression of EGFR protein CTD PMID:17010675 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression ISO gedunin results in increased expression of FICD mRNA CTD PMID:17010675 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO gedunin results in decreased expression of FLT3 protein CTD PMID:17010675 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO gedunin results in decreased expression of GATD3 mRNA CTD PMID:17010675 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO gedunin results in increased expression of GCLM mRNA CTD PMID:17010675 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO gedunin results in increased expression of GDF15 mRNA CTD PMID:17010675 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gtpbp2 GTP binding protein 2 increases expression ISO gedunin results in increased expression of GTPBP2 mRNA CTD PMID:17010675 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO gedunin results in decreased expression of HILPDA mRNA CTD PMID:17010675 NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO gedunin results in increased expression of HMGCS1 mRNA CTD PMID:17010675 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO gedunin results in increased expression of HMOX1 mRNA CTD PMID:17010675 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases activity ISO gedunin results in decreased activity of HSP90AA1 protein CTD PMID:17010675 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 increases expression ISO gedunin results in increased expression of HSPA13 mRNA CTD PMID:17010675 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO gedunin results in increased expression of HSPA1A mRNA CTD PMID:17010675 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO gedunin results in increased expression of HSPA1B mRNA CTD PMID:17010675 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gedunin results in increased expression of HSPA5 mRNA CTD PMID:17010675 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO gedunin results in increased expression of HSPH1 mRNA CTD PMID:17010675 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO gedunin results in decreased expression of IL1RN mRNA CTD PMID:17010675 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gedunin results in increased expression of INSIG1 mRNA CTD PMID:17010675 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO gedunin results in decreased expression of JAG1 mRNA CTD PMID:17010675 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression ISO gedunin results in decreased expression of KCNN2 mRNA CTD PMID:17010675 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO gedunin results in increased expression of LDLR mRNA CTD PMID:17010675 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lpin1 lipin 1 increases expression ISO gedunin results in increased expression of LPIN1 mRNA CTD PMID:17010675 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO gedunin results in decreased expression of LTN1 mRNA CTD PMID:17010675 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886 		JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO gedunin results in decreased expression of MAFB mRNA CTD PMID:17010675 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO gedunin results in decreased expression of MDH2 mRNA CTD PMID:17010675 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO gedunin results in increased expression of ME1 mRNA CTD PMID:17010675 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mnt MAX network transcriptional repressor increases expression ISO gedunin results in increased expression of MNT mRNA CTD PMID:17010675 NCBI chr10:59,699,208...59,714,848
Ensembl chr10:59,699,585...59,714,835 		JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO gedunin results in increased expression of MRPL18 mRNA CTD PMID:17010675 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO gedunin results in decreased expression of MSH6 mRNA CTD PMID:17010675 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO gedunin results in increased expression of MSMO1 mRNA CTD PMID:17010675 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mycbp2 MYC binding protein 2 decreases expression ISO gedunin results in decreased expression of MYCBP2 mRNA CTD PMID:17010675 NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498 		JBrowse link
G Mynn myoneurin decreases expression ISO gedunin results in decreased expression of MYNN mRNA CTD PMID:17010675 NCBI chr 2:112,779,654...112,797,188
Ensembl chr 2:112,779,657...112,796,397 		JBrowse link
G Nbn nibrin decreases expression ISO gedunin results in decreased expression of NBN mRNA CTD PMID:17010675 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO gedunin results in decreased expression of NKX3-1 mRNA CTD PMID:17010675 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO gedunin results in decreased expression of NREP mRNA CTD PMID:17010675 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO gedunin results in decreased expression of OPRK1 mRNA CTD PMID:17010675 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression ISO gedunin results in increased expression of OSER1 mRNA CTD PMID:17010675 NCBI chr 3:152,066,975...152,085,180
Ensembl chr 3:152,066,975...152,085,149 		JBrowse link
G Pde9a phosphodiesterase 9A decreases expression ISO gedunin results in decreased expression of PDE9A mRNA CTD PMID:17010675 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO gedunin results in decreased expression of PIK3CD mRNA CTD PMID:17010675 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases expression ISO gedunin results in decreased expression of PIK3R1 mRNA CTD PMID:17010675 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [gedunin co-treated with Glucose] binds to PPARA protein; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO gedunin results in decreased expression of PPIF mRNA CTD PMID:17010675 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Pura purine rich element binding protein A decreases expression ISO gedunin results in decreased expression of PURA mRNA CTD PMID:17010675 NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO gedunin results in decreased expression of RRM2 mRNA CTD PMID:17010675 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO gedunin results in increased expression of SERP1 mRNA CTD PMID:17010675 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Sesn1 sestrin 1 decreases expression ISO gedunin results in decreased expression of SESN1 mRNA CTD PMID:17010675 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO gedunin results in increased expression of SLC3A2 mRNA CTD PMID:17010675 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO gedunin results in increased expression of SLC7A11 mRNA CTD PMID:17010675 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO gedunin results in decreased expression of SLTM mRNA CTD PMID:17010675 NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825 		JBrowse link
G Sox4 SRY-box transcription factor 4 decreases expression ISO gedunin results in decreased expression of SOX4 mRNA CTD PMID:17010675 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO gedunin results in increased expression of STIP1 mRNA CTD PMID:17010675 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO gedunin results in decreased expression of TAOK3 mRNA CTD PMID:17010675 NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO gedunin results in decreased expression of TXNIP mRNA CTD PMID:17010675 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO gedunin results in increased expression of TXNRD1 mRNA CTD PMID:17010675 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression ISO gedunin results in increased expression of UBE2B mRNA CTD PMID:17010675 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO gedunin results in increased expression of UGDH mRNA CTD PMID:17010675 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Wdr77 WD repeat domain 77 decreases expression ISO gedunin results in decreased expression of WDR77 mRNA CTD PMID:17010675 NCBI chr 2:193,435,465...193,445,534
Ensembl chr 2:193,435,468...193,445,520 		JBrowse link
G Zbtb43 zinc finger and BTB domain containing 43 decreases expression ISO gedunin results in decreased expression of ZBTB43 mRNA CTD PMID:17010675 NCBI chr 3:16,744,535...16,763,854
Ensembl chr 3:16,744,535...16,763,909 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO gedunin results in decreased expression of ZC3H12A mRNA CTD PMID:17010675 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
limonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions		 ISO limonin results in decreased expression of ALDH1A1 mRNA
limonin results in decreased expression of and results in decreased activity of ALDH1A1 protein		 CTD PMID:30738134 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of BCL2 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein] CTD PMID:34423886 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO limonin results in increased activity of CASP3 protein CTD PMID:31702096 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO limonin results in increased activity of CASP9 protein CTD PMID:31702096 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] CTD PMID:31702096 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of CCL2 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein] CTD PMID:34423886 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO limonin results in decreased expression of CCN2 mRNA CTD PMID:30738134 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Arginine results in increased expression of CCND1 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein] CTD PMID:34423886 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO limonin results in increased expression of CDH1 mRNA; limonin results in increased expression of CDH1 protein CTD PMID:30738134 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO limonin results in decreased activity of CYP3A4 protein CTD PMID:22001672 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO limonin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO limonin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein] CTD PMID:31702096 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Arginine results in increased expression of HMOX1 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein] CTD PMID:34423886 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL1B protein]; limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein] CTD PMID:31702096 PMID:34423886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; limonin inhibits the reaction [Arginine results in increased secretion of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein] CTD PMID:34423886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Arginine results in increased expression of JAK2 protein]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein] CTD PMID:34423886 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO limonin results in decreased expression of NANOG mRNA; limonin results in decreased expression of NANOG protein CTD PMID:30738134 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Arginine results in increased phosphorylation of STAT3 protein]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein] CTD PMID:34423886 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]]; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; limonin inhibits the reaction [Arginine results in increased secretion of TNF protein]; limonin inhibits the reaction [Benzo(a)pyrene results in increased activity of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein] CTD PMID:31702096 PMID:34423886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression ISO limonin results in decreased expression of VIM mRNA; limonin results in decreased expression of VIM protein CTD PMID:30738134 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization ISO limonin affects the localization of YAP1 protein CTD PMID:30738134 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
nomilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 multiple interactions ISO nomilin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
Obacunone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions		 ISO obacunone results in decreased expression of AKT1 protein modified form
obacunone results in decreased expression of and results in decreased phosphorylation of AKT1 protein		 CTD PMID:25592883 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor affects expression ISO obacunone affects the expression of AR protein CTD PMID:25592883 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO obacunone results in increased expression of BAD protein CTD PMID:25592883 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO obacunone results in increased expression of BAX mRNA; obacunone results in increased expression of BAX protein CTD PMID:21333732 PMID:25592883 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO obacunone results in decreased expression of BCL2 mRNA; obacunone results in decreased expression of BCL2 protein CTD PMID:21333732 PMID:25592883 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
decreases expression
multiple interactions		 ISO obacunone results in increased activity of CASP3 protein
obacunone results in decreased expression of CASP3 protein
obacunone results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression
increases cleavage		 ISO obacunone results in decreased expression of CASP8 protein
obacunone results in increased cleavage of CASP8 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO obacunone results in increased activity of CASP9 protein
obacunone results in increased cleavage of CASP9 protein		 CTD PMID:21333732 PMID:25592883 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO obacunone results in increased expression of CDKN1A protein CTD PMID:25592883 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Il6 interleukin 6 decreases expression ISO obacunone results in decreased expression of IL6 protein CTD PMID:25592883 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression ISO obacunone results in decreased expression of KLK3 protein CTD PMID:25592883 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO obacunone results in decreased expression of PTGS2 protein CTD PMID:21333732 PMID:25592883 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO obacunone results in decreased expression of RELA protein CTD PMID:21333732 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO obacunone results in increased expression of TP53 protein CTD PMID:21333732 PMID:25592883 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
toosendanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO toosendanin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO toosendanin results in increased expression of ATF3 protein
toosendanin results in increased expression of ATF3 mRNA; toosendanin results in increased expression of ATF3 protein		 CTD PMID:36801351 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO toosendanin results in increased expression of ATF4 protein
toosendanin results in increased expression of ATF4 mRNA; toosendanin results in increased expression of ATF4 protein		 CTD PMID:36801351 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO toosendanin results in increased expression of BAX protein CTD PMID:23111283 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO toosendanin results in decreased expression of BCL2 protein CTD PMID:23111283 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO toosendanin analog results in decreased expression of BCL2L1 protein; toosendanin results in decreased expression of BCL2L1 protein CTD PMID:34742683 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 increases expression ISO toosendanin analog results in increased expression of BECN1 protein; toosendanin results in increased expression of BECN1 protein CTD PMID:34742683 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression		 ISO toosendanin analog results in increased cleavage of CASP3 protein; toosendanin results in increased cleavage of CASP3 protein
toosendanin results in increased expression of CASP3 protein modified form		 CTD PMID:23111283 PMID:34742683 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO toosendanin analog results in increased cleavage of CASP9 protein; toosendanin results in increased cleavage of CASP9 protein CTD PMID:34742683 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO toosendanin results in decreased expression of CDC42 protein CTD PMID:23111283 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
affects expression		 ISO toosendanin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
toosendanin affects the expression of EIF2AK3 mRNA		 CTD PMID:36801351 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
affects expression		 ISO toosendanin results in increased phosphorylation of EIF2S1 protein
toosendanin affects the expression of EIF2S1 mRNA		 CTD PMID:36801351 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eno1 enolase 1 increases activity
affects binding		 EXP toosendanin results in increased activity of ENO1 protein
toosendanin metabolite binds to ENO1 protein		 CTD PMID:30848893 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO toosendanin results in decreased expression of FTH1 mRNA; toosendanin results in decreased expression of FTH1 protein CTD PMID:36801351 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO toosendanin results in increased expression of ALT protein CTD PMID:36801351 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO toosendanin results in decreased expression of GPX4 mRNA; toosendanin results in decreased expression of GPX4 protein CTD PMID:36801351 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation ISO toosendanin analog results in increased lipidation of MAP1LC3B protein; toosendanin results in increased lipidation of MAP1LC3B protein CTD PMID:34742683 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO toosendanin results in decreased expression of MAP2K1 protein modified form CTD PMID:23111283 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mir194-1 microRNA 194-1 increases expression ISO toosendanin results in increased expression of MIR194-1 mRNA CTD PMID:28844483 NCBI chr13:96,851,166...96,851,248
Ensembl chr13:96,851,166...96,851,248 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 affects expression
increases expression		 ISO toosendanin affects the expression of NCOA4 mRNA
toosendanin results in increased expression of NCOA4 protein		 CTD PMID:36801351 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO toosendanin results in increased expression of PARP1 protein modified form CTD PMID:23111283 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO toosendanin results in decreased expression of SLC40A1 mRNA; toosendanin results in decreased expression of SLC40A1 protein CTD PMID:36801351 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO toosendanin results in decreased expression of SQSTM1 protein CTD PMID:34742683 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO toosendanin results in decreased phosphorylation of STAT3 protein CTD PMID:37946196 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tfrc transferrin receptor increases expression
affects expression		 ISO toosendanin results in increased expression of TFRC protein
toosendanin affects the expression of TFRC mRNA		 CTD PMID:36801351 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tpi1 triosephosphate isomerase 1 decreases activity
affects binding		 EXP toosendanin results in decreased activity of TPI1 protein
toosendanin metabolite binds to TPI1 protein		 CTD PMID:30848893 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          carbon atom 19724
            organic molecular entity 19724
              isoprenoid 14029
                terpenoid 13728
                  triterpenoid 871
                    limonoid 149
                      (6R,6As,6bR,7aS,10R,10aS,12bR)-10-(furan-3-yl)-4,4,6a,10a,12b-pentamethyl-3,8-dioxo-3,4,4a,5,6,6a,7a,8,10,10a,11,12,12a,12b-tetradecahydronaphtho[2,1-f]oxireno[d]isochromen-6-yl acetate 0
                      1,2-diacetyltrichagmalin C 0
                      1,3-diacetylvilasinin 0
                      1,30-diacetyltrichagmalin F 0
                      12-O-deacetyltrichilin H 0
                      12alpha-Hydroxyamoorstatin 0
                      14-deoxyxyloccensin K 0
                      15-acetyltrichagmalin C 0
                      15-acetyltrichagmalin E 0
                      15-hydroxyazadiradione 0
                      17-defurano-17-oxosalannin 0
                      17-epi-17-hydroxyazadiradione 0
                      17-epiazadiradione + 0
                      17-hydroxyazadiradione 0
                      2',3'-dihydrosalannin 0
                      2-acetyloxy-3-methylpentanoic acid [(3S,3aR,4R,5R)-6-[(2S,4R,5S)-5-acetyloxy-2-(acetyloxymethyl)-3-(2-methoxy-2-oxoethyl)-2,4-dimethyl-7-oxo-4-oxepanyl]-5-formyloxy-3-(3-furanyl)-7a-hydroxy-3a-methyl-7-methylene-1-oxo-3,4,5,6-tetrahydro-2H-inden-4-yl] ester 0
                      20,21,22,23-tetrahydro-23-oxoazadirone 0
                      23-epivepaol 0
                      28-deoxonimbolide 3
                      3-acetyl-11-methoxy-1-tigloylazadirachtinin 0
                      3-acetyl-7-tigloylvilasinin lactone 0
                      3-deacetylsalannin 0
                      30-acetyltrichagmalin F 0
                      6-acetylnimbandiol 0
                      6-deacetylnimbin 0
                      7-acetyl-16,17-dehydro-16-hydroxyneotrichilenone 0
                      7-benzoylnimbocinol 0
                      7-deacetyl-17-epinimolicinol 0
                      7-deacetyl-7-benzoylepoxyazadiradione 0
                      7-deacetyl-7-benzoylgedunin 0
                      7-deacetylgedunin 0
                      7alpha-Obacunyl acetate 0
                      CEDRELONE 8
                      Chisomicine B 0
                      DIHYDROGEDUNIN 0
                      Deacetylnomilin 0
                      FISSINOLIDE 0
                      HAVANENSIN TRIACETATE 0
                      HEUDELOTTIN C 0
                      Harrisonin 0
                      Humilin B 0
                      KHAYASIN 0
                      Khivorin 0
                      Khivorine 0
                      LSM-4386 0
                      Limonexic acid 0
                      Limonoate A-ring-lactone 0
                      Methyl 2-[13-(furan-3-yl)-6,6,8,12-tetramethyl-17-methylidene-5,15-dioxo-2,14-dioxatetracyclo[7.7.1.01,12.03,8]heptadecan-7-yl]-2-hydroxyacetate 0
                      Methyl 2-[6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7,18-dioxapentacyclo[11.3.1.111,14.02,11.05,10]octadec-9-en-16-yl]acetate 0
                      Methyl 6-hydroxyangolensate 0
                      Obacunone 14
                      Protoxylocarpin A 0
                      Protoxylocarpin B 0
                      Protoxylocarpin C 0
                      Protoxylocarpin D 0
                      Protoxylocarpin E 0
                      Trichilin A 0
                      XYLOCARPUS A 0
                      Zapoterin 0
                      [(1R,2S,4R,6R,9R,10S,11R,12S,14R,15R,18R)-14-Acetyloxy-6-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadec-7-en-12-yl] (E)-2-methylbut-2-enoate 0
                      [(1S,6S,7R,10R,15S,16R,18S,19R,20R)-6-(3-Furyl)-8,9,18,19,20-pentahydroxy-3-(1-hydroxy-2-methylpropylidene)-7,12,15,17-tetramethyl-4-oxo-5,11,13,21-tetraoxaheptacyclo[10.8.1.114,17.01,10.02,7.010,15.014,19]docos-16-yl]acetic acid 0
                      [12-acetyloxy-6-(furan-3-yl)-14-hydroxy-1,7,11,15,15-pentamethyl-5-oxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-18-yl] acetate 0
                      [13-Acetyloxy-7-(furan-3-yl)-19-hydroxy-1,8,12,16,16-pentamethyl-5-oxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadecan-15-yl] acetate 0
                      [14-acetyloxy-6-(furan-3-yl)-12-hydroxy-1,7,11,15,15-pentamethyl-5-oxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-18-yl] acetate 0
                      [3-acetyloxy-16-(furan-3-yl)-2,7,7,11,17-pentamethyl-18-(2-methylpropanoyloxy)-5-oxo-6,13-dioxapentacyclo[9.8.0.02,8.012,14.012,17]nonadecan-10-yl] (E)-2-methylbut-2-enoate 0
                      [6-(furan-3-yl)-6,8,12,16,21-pentahydroxy-7,15-dimethyl-9-oxo-3,17,19-trioxaheptacyclo[9.9.3.01,10.02,4.02,7.011,18.015,23]tricosan-14-yl] 2-methylbutanoate 0
                      alpha-nimolactone 0
                      azadirachtin + 31
                      azadiradione + 4
                      azadiradionolide 0
                      azadirone + 0
                      beta-nimolactone 0
                      delta(8,14)-2-hydroxy-6-deoxyswietenine 0
                      deoxylimonoic acid 0
                      deoxylimonoic acid D-ring-lactone 0
                      desfuranoazadiradione 0
                      epoxyazadiradione + 0
                      gedunin + 83
                      limonin + 21
                      limonoic acid 0
                      nimbin + 0
                      nimbocinol + 0
                      nimolicinol 0
                      nomilin 1
                      ohchinin acetate 0
                      proceranolide 0
                      ruageanin B 0
                      salannin + 0
                      skimmiarepin A 0
                      skimmiarepin C 0
                      toosendanin 26
                      trichagmalin A 0
                      trichagmalin B 0
                      trichagmalin C + 0
                      trichagmalin D 0
                      trichagmalin E + 0
                      trichagmalin F + 0
                      trichanolide 0
                      vepaol 0
                      xylocarpin J 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            organic hydride 18674
                              organic fundamental parent 18674
                                hydrocarbon 18410
                                  terpene 14029
                                    triterpene 875
                                      triterpenoid 871
                                        limonoid 149
                                          (6R,6As,6bR,7aS,10R,10aS,12bR)-10-(furan-3-yl)-4,4,6a,10a,12b-pentamethyl-3,8-dioxo-3,4,4a,5,6,6a,7a,8,10,10a,11,12,12a,12b-tetradecahydronaphtho[2,1-f]oxireno[d]isochromen-6-yl acetate 0
                                          1,2-diacetyltrichagmalin C 0
                                          1,3-diacetylvilasinin 0
                                          1,30-diacetyltrichagmalin F 0
                                          12-O-deacetyltrichilin H 0
                                          12alpha-Hydroxyamoorstatin 0
                                          14-deoxyxyloccensin K 0
                                          15-acetyltrichagmalin C 0
                                          15-acetyltrichagmalin E 0
                                          15-hydroxyazadiradione 0
                                          17-defurano-17-oxosalannin 0
                                          17-epi-17-hydroxyazadiradione 0
                                          17-epiazadiradione + 0
                                          17-hydroxyazadiradione 0
                                          2',3'-dihydrosalannin 0
                                          2-acetyloxy-3-methylpentanoic acid [(3S,3aR,4R,5R)-6-[(2S,4R,5S)-5-acetyloxy-2-(acetyloxymethyl)-3-(2-methoxy-2-oxoethyl)-2,4-dimethyl-7-oxo-4-oxepanyl]-5-formyloxy-3-(3-furanyl)-7a-hydroxy-3a-methyl-7-methylene-1-oxo-3,4,5,6-tetrahydro-2H-inden-4-yl] ester 0
                                          20,21,22,23-tetrahydro-23-oxoazadirone 0
                                          23-epivepaol 0
                                          28-deoxonimbolide 3
                                          3-acetyl-11-methoxy-1-tigloylazadirachtinin 0
                                          3-acetyl-7-tigloylvilasinin lactone 0
                                          3-deacetylsalannin 0
                                          30-acetyltrichagmalin F 0
                                          6-acetylnimbandiol 0
                                          6-deacetylnimbin 0
                                          7-acetyl-16,17-dehydro-16-hydroxyneotrichilenone 0
                                          7-benzoylnimbocinol 0
                                          7-deacetyl-17-epinimolicinol 0
                                          7-deacetyl-7-benzoylepoxyazadiradione 0
                                          7-deacetyl-7-benzoylgedunin 0
                                          7-deacetylgedunin 0
                                          7alpha-Obacunyl acetate 0
                                          CEDRELONE 8
                                          Chisomicine B 0
                                          DIHYDROGEDUNIN 0
                                          Deacetylnomilin 0
                                          FISSINOLIDE 0
                                          HAVANENSIN TRIACETATE 0
                                          HEUDELOTTIN C 0
                                          Harrisonin 0
                                          Humilin B 0
                                          KHAYASIN 0
                                          Khivorin 0
                                          Khivorine 0
                                          LSM-4386 0
                                          Limonexic acid 0
                                          Limonoate A-ring-lactone 0
                                          Methyl 2-[13-(furan-3-yl)-6,6,8,12-tetramethyl-17-methylidene-5,15-dioxo-2,14-dioxatetracyclo[7.7.1.01,12.03,8]heptadecan-7-yl]-2-hydroxyacetate 0
                                          Methyl 2-[6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7,18-dioxapentacyclo[11.3.1.111,14.02,11.05,10]octadec-9-en-16-yl]acetate 0
                                          Methyl 6-hydroxyangolensate 0
                                          Obacunone 14
                                          Protoxylocarpin A 0
                                          Protoxylocarpin B 0
                                          Protoxylocarpin C 0
                                          Protoxylocarpin D 0
                                          Protoxylocarpin E 0
                                          Trichilin A 0
                                          XYLOCARPUS A 0
                                          Zapoterin 0
                                          [(1R,2S,4R,6R,9R,10S,11R,12S,14R,15R,18R)-14-Acetyloxy-6-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-7,9,11,15-tetramethyl-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadec-7-en-12-yl] (E)-2-methylbut-2-enoate 0
                                          [(1S,6S,7R,10R,15S,16R,18S,19R,20R)-6-(3-Furyl)-8,9,18,19,20-pentahydroxy-3-(1-hydroxy-2-methylpropylidene)-7,12,15,17-tetramethyl-4-oxo-5,11,13,21-tetraoxaheptacyclo[10.8.1.114,17.01,10.02,7.010,15.014,19]docos-16-yl]acetic acid 0
                                          [12-acetyloxy-6-(furan-3-yl)-14-hydroxy-1,7,11,15,15-pentamethyl-5-oxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-18-yl] acetate 0
                                          [13-Acetyloxy-7-(furan-3-yl)-19-hydroxy-1,8,12,16,16-pentamethyl-5-oxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadecan-15-yl] acetate 0
                                          [14-acetyloxy-6-(furan-3-yl)-12-hydroxy-1,7,11,15,15-pentamethyl-5-oxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-18-yl] acetate 0
                                          [3-acetyloxy-16-(furan-3-yl)-2,7,7,11,17-pentamethyl-18-(2-methylpropanoyloxy)-5-oxo-6,13-dioxapentacyclo[9.8.0.02,8.012,14.012,17]nonadecan-10-yl] (E)-2-methylbut-2-enoate 0
                                          [6-(furan-3-yl)-6,8,12,16,21-pentahydroxy-7,15-dimethyl-9-oxo-3,17,19-trioxaheptacyclo[9.9.3.01,10.02,4.02,7.011,18.015,23]tricosan-14-yl] 2-methylbutanoate 0
                                          alpha-nimolactone 0
                                          azadirachtin + 31
                                          azadiradione + 4
                                          azadiradionolide 0
                                          azadirone + 0
                                          beta-nimolactone 0
                                          delta(8,14)-2-hydroxy-6-deoxyswietenine 0
                                          deoxylimonoic acid 0
                                          deoxylimonoic acid D-ring-lactone 0
                                          desfuranoazadiradione 0
                                          epoxyazadiradione + 0
                                          gedunin + 83
                                          limonin + 21
                                          limonoic acid 0
                                          nimbin + 0
                                          nimbocinol + 0
                                          nimolicinol 0
                                          nomilin 1
                                          ohchinin acetate 0
                                          proceranolide 0
                                          ruageanin B 0
                                          salannin + 0
                                          skimmiarepin A 0
                                          skimmiarepin C 0
                                          toosendanin 26
                                          trichagmalin A 0
                                          trichagmalin B 0
                                          trichagmalin C + 0
                                          trichagmalin D 0
                                          trichagmalin E + 0
                                          trichagmalin F + 0
                                          trichanolide 0
                                          vepaol 0
                                          xylocarpin J 0
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