dioxolane - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dioxolane	go back to main search page
Accession:	CHEBI:39430	browse the term
Synonyms:	related_synonym:	dioxolanes

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Rat (894) Mouse (905) Human (897) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (894)

Chloralose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Chloralose results in increased expression of FOS protein
[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of FOS protein

PMID:7970238 PMID:12088752

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type B receptor subunit 1

multiple interactions

Chloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type A receptor subunit alpha 2

multiple interactions

Chloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]; Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein mutant form]; Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]; Chloralose results in increased activity of [GABRA2 protein mutant form binds to GABRB1 protein]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]

NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944

G

gamma-aminobutyric acid type A receptor subunit beta1

multiple interactions

Chloralose promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]; Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein mutant form]; Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]; Chloralose results in increased activity of [GABRA2 protein mutant form binds to GABRB1 protein]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]]

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

myeloperoxidase

multiple interactions

[Urethane co-treated with Chloralose] inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

tyrosine hydroxylase

multiple interactions

[Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH protein

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

difenoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression

difenoconazole results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily G member 8

increases expression

difenoconazole results in increased expression of ABCG8 mRNA

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetylcholinesterase

multiple interactions

[dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA oxidase 1

multiple interactions

[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase 2

multiple interactions

[difenoconazole co-treated with fludioxonil] results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acyl-CoA synthetase long-chain family member 3

decreases expression

difenoconazole results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

difenoconazole results in increased activity of ALPL protein
Quercetin inhibits the reaction [difenoconazole results in increased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

annexin A10

increases expression

difenoconazole results in increased expression of ANXA10 mRNA

NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648

G

androgen receptor

affects expression

difenoconazole affects the expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

decreases expression

difenoconazole results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

arrestin domain containing 4

decreases expression

difenoconazole results in decreased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

difenoconazole results in increased expression of BAX mRNA
ginger extract inhibits the reaction [difenoconazole results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

multiple interactions
increases expression

ginger extract inhibits the reaction [difenoconazole results in increased expression of CASP3 mRNA]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

affects binding
decreases activity
multiple interactions

difenoconazole binds to CAT protein
difenoconazole results in decreased activity of CAT protein
Quercetin inhibits the reaction [difenoconazole results in decreased activity of CAT protein]

PMID:28679351 PMID:32278787 PMID:34519103

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CDC42 effector protein 3

increases expression

difenoconazole results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

carnitine palmitoyltransferase 1A

increases expression

difenoconazole results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

difenoconazole results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

difenoconazole results in increased expression of CYP1A1 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A1 mRNA

PMID:32194361 PMID:33575850

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

[difenoconazole co-treated with fludioxonil] results in increased expression of CYP1A2 mRNA
difenoconazole results in increased expression of CYP1A2 mRNA

PMID:33575850 PMID:34425431

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

difenoconazole results in increased expression of CYP2B6 mRNA
difenoconazole results in increased expression of CYP2B10 mRNA
[difenoconazole co-treated with fludioxonil] results in increased expression of CYP2B6 mRNA

PMID:33575850 PMID:34425431

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

difenoconazole results in increased expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression
increases expression

difenoconazole results in decreased expression of CYP2C19 protein
difenoconazole results in increased expression of CYP2C29 mRNA

PMID:32194361 PMID:34425431

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases expression

difenoconazole results in decreased expression of CYP2J9 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

difenoconazole results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

increases expression

difenoconazole results in increased expression of CYP51 mRNA

PMID:28263823 PMID:29337257

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

difenoconazole results in decreased expression of CYP7A1 mRNA; difenoconazole results in decreased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

diazepam binding inhibitor

decreases expression

difenoconazole results in decreased expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

diacylglycerol O-acyltransferase 1

increases expression

difenoconazole results in increased expression of DGAT1 mRNA

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

diacylglycerol O-acyltransferase 2

increases expression

difenoconazole results in increased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

7-dehydrocholesterol reductase

increases expression

difenoconazole results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

fatty acid binding protein 1

decreases expression

difenoconazole results in decreased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 2

decreases expression

difenoconazole results in decreased expression of FABP2 mRNA

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

G

fatty acid binding protein 5

decreases expression

difenoconazole results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

farnesyl diphosphate farnesyl transferase 1

increases expression

difenoconazole results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

folate hydrolase 1

increases expression

difenoconazole results in increased expression of FOLH1 mRNA

NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379

G

follicle stimulating hormone subunit beta

decreases expression

difenoconazole results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

difenoconazole results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glycerol kinase

decreases expression

difenoconazole results in decreased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

glutamic-oxaloacetic transaminase 1

increases activity
multiple interactions

difenoconazole results in increased activity of GOT1 protein
Quercetin inhibits the reaction [difenoconazole results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

Quercetin inhibits the reaction [difenoconazole results in increased activity of GPT protein]

PMID:28679351 PMID:34425431

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

decreases activity
multiple interactions

difenoconazole results in decreased activity of GPX1 protein
Quercetin inhibits the reaction [difenoconazole results in decreased activity of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

difenoconazole results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

difenoconazole results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hydroxysteroid (17-beta) dehydrogenase 7

increases expression

difenoconazole results in increased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases activity

difenoconazole results in decreased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases activity

difenoconazole results in decreased activity of HSD3B2 protein

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

isopentenyl-diphosphate delta isomerase 1

increases expression

difenoconazole results in increased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

potassium calcium-activated channel subfamily N member 2

decreases expression

difenoconazole results in decreased expression of KCNN2 mRNA

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

kallikrein 1-related peptidase C10

decreases expression

difenoconazole results in decreased expression of KLK3 mRNA

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

lactate dehydrogenase A

increases activity
multiple interactions

difenoconazole results in increased activity of LDHA protein
Quercetin inhibits the reaction [difenoconazole results in increased activity of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone subunit beta

decreases expression

difenoconazole results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIM homeobox 1

increases expression

difenoconazole results in increased expression of LHX1 mRNA

NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617

G

marker of proliferation Ki-67

multiple interactions
increases expression

ginger extract inhibits the reaction [difenoconazole results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MLX interacting protein-like

multiple interactions
decreases expression

[difenoconazole co-treated with fludioxonil] results in decreased expression of MLXIPL mRNA
difenoconazole results in decreased expression of MLXIPL mRNA

PMID:33575850 PMID:34425431

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

G

methylsterol monooxygenase 1

increases expression

difenoconazole results in increased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

NK3 homeobox 1

decreases expression

difenoconazole results in decreased expression of NKX3-1 mRNA

NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I2 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[difenoconazole co-treated with fludioxonil] results in decreased expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

NAD(P) dependent steroid dehydrogenase-like

increases expression

difenoconazole results in increased expression of NSDHL mRNA

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

progesterone receptor

affects binding

difenoconazole binds to PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phospholipase A2, group XIIA

increases expression

difenoconazole results in increased expression of PLA2G12A mRNA

NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740

G

perilipin 4

decreases expression

difenoconazole results in decreased expression of PLIN4 mRNA

NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056

G

prostate transmembrane protein, androgen induced 1

decreases expression

difenoconazole results in decreased expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

peroxisome proliferator activated receptor alpha

decreases expression

difenoconazole results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

difenoconazole results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

retinoic acid receptor, beta

increases expression

difenoconazole results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAR-related orphan receptor A

affects binding

difenoconazole binds to RORA protein

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

sterol-C5-desaturase

increases expression

difenoconazole results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

stearoyl-CoA desaturase

decreases expression

difenoconazole results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

SEC61 translocon subunit alpha 2

increases expression

difenoconazole results in increased expression of SEC61A2 mRNA

NCBI chr17:72,407,574...72,445,630
Ensembl chr17:72,407,671...72,434,494

G

solute carrier organic anion transporter family, member 1a4

increases expression

difenoconazole results in increased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

superoxide dismutase 1

multiple interactions
decreases activity

Quercetin inhibits the reaction [difenoconazole results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

squalene epoxidase

increases expression

difenoconazole results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 1

decreases expression

difenoconazole results in decreased expression of SREBF1 mRNA; difenoconazole results in decreased expression of SREBF1 protein

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

steroidogenic acute regulatory protein

decreases activity

difenoconazole results in decreased activity of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

StAR-related lipid transfer domain containing 4

increases expression

difenoconazole results in increased expression of STARD4 mRNA

NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024

G

sulfotransferase family 1E member 1

increases expression

difenoconazole results in increased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

thioredoxin interacting protein

decreases expression

difenoconazole results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

UDP glucuronosyltransferase family 1 member A9

increases expression

difenoconazole results in increased expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

itraconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

Itraconazole results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects activity
decreases activity
multiple interactions
affects transport

Itraconazole affects the activity of ABCB1 protein
Itraconazole results in decreased activity of ABCB1 protein
Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]
ABCB1 protein affects the transport of Itraconazole

PMID:15905803 PMID:15964336 PMID:15969931 PMID:16084853

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

activin A receptor type 1C

increases expression

Itraconazole results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

aryl hydrocarbon receptor

multiple interactions

AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

amidohydrolase domain containing 1

decreases expression

Itraconazole results in decreased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

androgen receptor

multiple interactions

Itraconazole binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BicC family RNA binding protein 1

decreases expression

Itraconazole results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

C-C motif chemokine ligand 5

multiple interactions

Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

carboxypeptidase N subunit 2

decreases expression

Itraconazole results in decreased expression of CPN2 mRNA

NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472

G

C-X-C motif chemokine ligand 10

multiple interactions

Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

increases expression

Itraconazole results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

Itraconazole binds to and results in decreased activity of CYP11B1 protein

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Itraconazole binds to and results in decreased activity of CYP11B2 protein

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases activity

Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 protein
Itraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 protein
Itraconazole results in decreased activity of CYP1A1 protein

PMID:17283379 PMID:28390928

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

decreases activity

Itraconazole results in decreased activity of CYP24A1 protein

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases hydroxylation
affects activity
decreases activity
affects metabolic processing
increases metabolic processing
decreases expression

Itraconazole binds to and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Itraconazole
Itraconazole affects the activity of CYP3A4 protein
Itraconazole results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Itraconazole
CYP3A4 protein results in increased metabolism of Itraconazole
Itraconazole results in decreased expression of CYP3A4 mRNA; Itraconazole results in decreased expression of CYP3A4 protein

PMID:15328084 PMID:15383492 PMID:15447735 PMID:15684493 PMID:15784650 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases activity
decreases response to substance
multiple interactions

Itraconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Itraconazole
CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]

PMID:16989930 PMID:18694951

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

DNA cross-link repair 1C

increases expression

Itraconazole results in increased expression of DCLRE1C mRNA

NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186

G

DNA-damage inducible transcript 3

increases expression

Itraconazole results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dystrobrevin, alpha

decreases expression

Itraconazole results in decreased expression of DTNA mRNA

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

Itraconazole results in decreased expression of ENPP3 mRNA

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Itraconazole results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen related receptor, alpha

decreases expression

Itraconazole results in decreased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

fatty acid binding protein 5

increases expression

Itraconazole results in increased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Itraconazole results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glutamine fructose-6-phosphate transaminase 1

decreases expression

Itraconazole results in decreased expression of GFPT1 mRNA

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

gap junction protein, beta 1

decreases expression

Itraconazole results in decreased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

GLI family zinc finger 1

decreases expression

Itraconazole analog results in decreased expression of GLI1 mRNA; Itraconazole results in decreased expression of GLI1 mRNA

PMID:21936514 PMID:33905526

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glutamic-oxaloacetic transaminase 1

increases expression

Itraconazole results in increased expression of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

G protein-coupled receptor 6

decreases expression

Itraconazole results in decreased expression of GPR6 mRNA

NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624

G

glutamic--pyruvic transaminase

increases expression

Itraconazole results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione S-transferase pi 1

multiple interactions

Itraconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

GULP PTB domain containing engulfment adaptor 1

decreases expression

Itraconazole results in decreased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

G

high mobility group AT-hook 2

increases expression

Itraconazole results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Itraconazole results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Itraconazole results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Itraconazole results in decreased activity of HSD11B2 protein

PMID:28131847 PMID:29385285 PMID:33387577

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

Indian hedgehog signaling molecule

decreases expression

Itraconazole results in decreased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 12B

increases expression

Itraconazole results in increased expression of IL12B mRNA

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 4

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]

PMID:11886533 PMID:15284827 PMID:23688403

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

G

methyl-CpG binding domain protein 1

increases expression

Itraconazole results in increased expression of MBD1 mRNA

NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554

G

myelin transcription factor 1

increases expression

Itraconazole results in increased expression of MYT1 mRNA

NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341

G

nuclear receptor coactivator 1

multiple interactions

Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NFKB inhibitor alpha

multiple interactions

Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]
Itraconazole results in increased expression of NQO1 mRNA; Itraconazole results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases expression

Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]
Itraconazole results in increased expression of NR1I2 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

ornithine decarboxylase antizyme 3

decreases expression

Itraconazole results in decreased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

PNMA family member 2

increases expression

Itraconazole results in increased expression of PNMA2 mRNA

NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427

G

patched 1

decreases expression

Itraconazole results in decreased expression of PTCH1 mRNA

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

Rap guanine nucleotide exchange factor 4

decreases expression

Itraconazole results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

regulator of G-protein signaling 16

decreases expression

Itraconazole results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

ribonuclease P and MRP subunit p25

increases expression

Itraconazole results in increased expression of RPP25 mRNA

NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732

G

semaphorin 3E

increases expression

Itraconazole results in increased expression of SEMA3E mRNA

NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229

G

solute carrier family 25 member 36

increases expression

Itraconazole results in increased expression of SLC25A36 mRNA

NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703

G

smoothened, frizzled class receptor

decreases expression

Itraconazole results in decreased expression of SMO mRNA

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

signal transducer and activator of transcription 1

multiple interactions

Itraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

syntaxin 8

increases expression

Itraconazole results in increased expression of STX8 mRNA

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

synaptonemal complex protein 3

increases expression

Itraconazole results in increased expression of SYCP3 mRNA

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

TBC1 domain family member 9

increases expression

Itraconazole results in increased expression of TBC1D9 mRNA

NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129

G

transmembrane protein 138

decreases expression

Itraconazole results in decreased expression of TMEM138 mRNA

NCBI chr 1:207,219,113...207,226,159

G

thymosin beta 4, X-linked

decreases expression

Itraconazole results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

tumor necrosis factor

multiple interactions

Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thymic stromal lymphopoietin

multiple interactions

4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

tetraspanin 8

decreases expression

Itraconazole results in decreased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

zinc finger protein 451

increases expression

Itraconazole results in increased expression of ZFP451 mRNA

NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652

ketoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

Ketoconazole results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

aminoadipate aminotransferase

affects expression

Ketoconazole affects the expression of AADAT mRNA

NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332

G

angio-associated, migratory cell protein

increases expression

Ketoconazole results in increased expression of AAMP mRNA

NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547

G

apoptosis antagonizing transcription factor

decreases expression

Ketoconazole results in decreased expression of AATF mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

4-aminobutyrate aminotransferase

increases expression

Ketoconazole results in increased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]
Ketoconazole results in decreased expression of ABCA1 mRNA

PMID:14690017 PMID:37077353

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 3

decreases expression

Ketoconazole results in decreased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases transport
decreases expression
multiple interactions
affects expression
decreases activity

ABCB1 protein results in increased transport of Ketoconazole
Ketoconazole results in decreased expression of ABCB1A mRNA
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]
Ketoconazole affects the expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole results in decreased activity of ABCB1 protein
[Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA]

PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCB4 protein
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA

PMID:28437613 PMID:30985903

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCC2 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]

PMID:19070657 PMID:19766108

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily D member 2

increases expression

Ketoconazole results in increased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily G member 2

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA]
Ketoconazole results in increased expression of ABCG2 mRNA

PMID:32185415 PMID:37077353

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABRA C-terminal like

decreases expression

Ketoconazole results in decreased expression of ABRACL mRNA

NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207

G

acetyl-CoA acyltransferase 1A

increases expression

Ketoconazole results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA acyltransferase 2

increases expression

Ketoconazole results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acyl-CoA dehydrogenase, long chain

increases expression

Ketoconazole results in increased expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

increases expression

Ketoconazole results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

increases expression

Ketoconazole results in increased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

angiotensin converting enzyme 2

increases expression

Ketoconazole results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 8

increases expression

Ketoconazole results in increased expression of ACOT8 mRNA

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

G

acyl-CoA synthetase long-chain family member 4

decreases expression

Ketoconazole results in decreased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

increases expression

Ketoconazole results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

Ketoconazole results in decreased expression of ACSM1 mRNA

NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495

G

ADAM metallopeptidase domain 9

affects expression

Ketoconazole affects the expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenylate cyclase 6

decreases expression

Ketoconazole results in decreased expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Ketoconazole results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

acireductone dioxygenase 1

decreases expression

Ketoconazole results in decreased expression of ADI1 mRNA

NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842

G

adiponectin, C1Q and collagen domain containing

increases expression

Ketoconazole results in increased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

increases expression

Ketoconazole results in increased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adenosine A1 receptor

increases expression

Ketoconazole results in increased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adrenoceptor beta 2

increases expression

Ketoconazole results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AE binding protein 2

decreases expression

Ketoconazole results in decreased expression of AEBP2 mRNA

NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100

G

alkylglycerone phosphate synthase

increases expression

Ketoconazole results in increased expression of AGPS mRNA

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

agouti related neuropeptide

decreases expression

Ketoconazole results in decreased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

angiotensinogen

increases expression

Ketoconazole results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions
increases expression
increases activity

AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]
Ketoconazole results in increased expression of AHR mRNA
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein

PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA
Ketoconazole results in increased expression of AHRR mRNA

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

alpha-2-HS-glycoprotein

increases expression

Ketoconazole results in increased expression of AHSG mRNA

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

A-kinase anchoring protein 12

decreases expression

Ketoconazole results in decreased expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldo-keto reductase family 1, member B7

increases expression

Ketoconazole results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldo-keto reductase family 1, member C15

increases expression

Ketoconazole results in increased expression of AKR1C15 mRNA

NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061

G

5'-aminolevulinate synthase 1

increases expression

Ketoconazole results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

affects expression

Ketoconazole affects the expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Ketoconazole affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

Ketoconazole results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

alkB homolog 7

decreases expression

Ketoconazole results in decreased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]
Ketoconazole results in increased expression of ALPL protein

PMID:21542014 PMID:31099283

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

amidohydrolase domain containing 1

decreases expression

Ketoconazole results in decreased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

anti-Mullerian hormone

increases expression

Ketoconazole results in increased expression of AMH protein

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

angiogenin

increases expression

Ketoconazole results in increased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

annexin A1

decreases expression

Ketoconazole results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

aldehyde oxidase 1

decreases expression

Ketoconazole results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Ketoconazole results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 3 subunit mu 1

decreases expression

Ketoconazole results in decreased expression of AP3M1 mRNA

NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844

G

apoptotic peptidase activating factor 1

decreases expression

Ketoconazole results in decreased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apolipoprotein A1

increases expression

Ketoconazole results in increased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A4

affects expression

Ketoconazole affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

increases expression

Ketoconazole results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

androgen receptor

multiple interactions
decreases expression
increases activity
decreases activity

[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Ketoconazole results in decreased expression of AR protein
Ketoconazole results in increased activity of AR protein
Ketoconazole results in decreased activity of AR protein

PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

increases expression

Ketoconazole results in increased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ankyrin repeat and SOCS box-containing 17

increases expression

Ketoconazole results in increased expression of ASB17 mRNA

NCBI chr 2:242,775,887...242,786,950
Ensembl chr 2:242,775,994...242,786,903

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Ketoconazole results in increased expression of ASNS mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

Ketoconazole results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 2

increases expression

Ketoconazole results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 1

multiple interactions

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

ATP synthase membrane subunit c locus 2

increases expression

Ketoconazole results in increased expression of ATP5MC2 mRNA

NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733

G

ATP synthase peripheral stalk subunit OSCP

increases expression

Ketoconazole results in increased expression of ATP5PO mRNA

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit D

increases expression

Ketoconazole results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

arginine vasopressin

increases expression

Ketoconazole results in increased expression of AVP mRNA

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

beta-secretase 1

decreases expression

Ketoconazole results in decreased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

increases expression

Ketoconazole results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA]

PMID:21542014 PMID:31629065

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA]

PMID:21542014 PMID:31629065

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

increases expression

Ketoconazole results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

beclin 1

increases expression

Ketoconazole results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

betaine-homocysteine S-methyltransferase

affects expression

Ketoconazole affects the expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

BicC family RNA binding protein 1

decreases expression

Ketoconazole results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

BH3 interacting domain death agonist

increases expression

Ketoconazole results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

increases expression

Ketoconazole results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 5

increases expression

Ketoconazole results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 2

multiple interactions

Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

decreases expression

Ketoconazole results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

increases expression

Ketoconazole results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

basonuclin zinc finger protein 1

decreases expression

Ketoconazole results in decreased expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

BCL2 interacting protein 1

increases expression

Ketoconazole results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 2

increases expression

Ketoconazole results in increased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BCL2 interacting protein 3

increases expression

Ketoconazole results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

decreases expression

Ketoconazole results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

similar to human chromosome 5 open reading frame 15

increases expression

Ketoconazole results in increased expression of C5ORF15 mRNA

NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1 mRNA

NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831

G

C1GALT1-specific chaperone 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C3

increases expression

Ketoconazole results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 1 open reading frame 174

increases expression

Ketoconazole results in increased expression of C1ORF174 mRNA

NCBI chr 5:164,515,578...164,520,022
Ensembl chr 5:164,515,559...164,520,021

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

Ketoconazole results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel subunit alpha1 I

decreases expression

Ketoconazole results in decreased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

increases expression

Ketoconazole results in increased expression of CACNA2D3 mRNA

NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

increases expression

Ketoconazole results in increased expression of CACNA2D4 mRNA

NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Ketoconazole results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit gamma 3

increases expression

Ketoconazole results in increased expression of CACNG3 mRNA

NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024

G

calcium voltage-gated channel auxiliary subunit gamma 4

decreases expression

Ketoconazole results in decreased expression of CACNG4 mRNA

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

calbindin 1

decreases expression

Ketoconazole results in decreased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calbindin 2

decreases expression

Ketoconazole results in decreased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

cyclase associated actin cytoskeleton regulatory protein 1

increases expression

Ketoconazole results in increased expression of CAP1 mRNA

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

carbonic anhydrase 2

increases expression

Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

capping protein regulator and myosin 1 linker 1

decreases expression

Ketoconazole results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

caspase 12

increases expression

Ketoconazole results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
multiple interactions

Ketoconazole results in increased activity of CASP3 protein
Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]

PMID:17936189 PMID:19631732

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

decreases expression
increases expression

Ketoconazole results in decreased expression of CASP6 mRNA
Ketoconazole results in increased expression of CASP6 mRNA

PMID:25787151 PMID:25808816

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

Ketoconazole results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8 associated protein 2

affects expression

Ketoconazole affects the expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

caspase 9

increases expression

Ketoconazole results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

Ketoconazole results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Ketoconazole results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

chromobox 7

increases expression

Ketoconazole results in increased expression of CBX7 mRNA

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

coiled-coil domain containing 8

increases expression

Ketoconazole results in increased expression of CCDC8 mRNA

NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090

G

cholecystokinin

increases expression

Ketoconazole results in increased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
Ketoconazole results in increased expression of CCL2 mRNA

PMID:16784723 PMID:37077353

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 27

multiple interactions

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 5

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole results in increased expression of CCL5 mRNA

PMID:16784723 PMID:23688403 PMID:37077353

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression
affects expression

Ketoconazole results in increased expression of CCN1 mRNA
Ketoconazole affects the expression of CCN1 mRNA

PMID:36621641 PMID:36653537

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin G1

increases expression

Ketoconazole results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd200 molecule

increases expression

Ketoconazole results in increased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

Cd247 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263

G

CD274 molecule

decreases expression

Ketoconazole results in decreased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd28 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD3 delta subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

CD3 epsilon subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

CD3 gamma subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

Cd47 molecule

increases expression

Ketoconazole results in increased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CDC42 effector protein 2

decreases expression

Ketoconazole results in decreased expression of CDC42EP2 mRNA

NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897

G

CDC42 effector protein 3

increases expression

Ketoconazole results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

cyclin dependent kinase 2

decreases expression

Ketoconazole results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

decreases expression

Ketoconazole results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression

Ketoconazole results in increased expression of CDKN1A mRNA

PMID:16483768 PMID:25808816 PMID:37077353

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Ketoconazole results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2C

affects expression

Ketoconazole affects the expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CCAAT/enhancer binding protein alpha

increases expression

Ketoconazole results in increased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein U

decreases expression

Ketoconazole results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 15

increases expression

Ketoconazole results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

centrosomal protein 19

increases expression

Ketoconazole results in increased expression of CEP19 mRNA

NCBI chr11:68,677,869...68,687,117
Ensembl chr11:68,677,871...68,687,022

G

carboxylesterase 2H

affects expression

Ketoconazole affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor B

increases expression

Ketoconazole results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

glycoprotein hormones, alpha polypeptide

decreases expression

Ketoconazole results in decreased expression of CGA mRNA

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

chromatin accessibility complex subunit 1

increases expression

Ketoconazole results in increased expression of CHRAC1 mRNA

NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136

G

CBY1 interacting BAR domain containing 1

decreases expression

Ketoconazole results in decreased expression of CIBAR1 mRNA

NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489

G

cell death-inducing DFFA-like effector a

increases expression

Ketoconazole results in increased expression of CIDEA mRNA

PMID:36653537 PMID:37077353

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytoskeleton associated protein 2-like

decreases expression

Ketoconazole results in decreased expression of CKAP2L mRNA

NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366

G

cardiotrophin-like cytokine factor 1

increases expression

Ketoconazole results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

C-type lectin domain family 4, member E

increases expression

Ketoconazole results in increased expression of CLEC4E mRNA

NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767

G

calmin

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA]

NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272

G

CLN5, intracellular trafficking protein

affects expression

Ketoconazole affects the expression of CLN5 mRNA

NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438

G

clusterin

affects expression
decreases expression

Ketoconazole affects the expression of CLU mRNA
Ketoconazole results in decreased expression of CLU mRNA

PMID:17558187 PMID:18289764

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

CKLF-like MARVEL transmembrane domain containing 6

affects expression

Ketoconazole affects the expression of CMTM6 mRNA

NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033

G

CKLF-like MARVEL transmembrane domain containing 7

increases expression

Ketoconazole results in increased expression of CMTM7 mRNA

NCBI chr 8:114,448,037...114,474,958
Ensembl chr 8:114,448,042...114,474,621

G

cannabinoid receptor 2

decreases expression

Ketoconazole results in decreased expression of CNR2 mRNA

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

collagen type I alpha 1 chain

decreases expression

Ketoconazole results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

COMM domain containing 2

decreases expression

Ketoconazole results in decreased expression of COMMD2 mRNA

NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888

G

COP1, E3 ubiquitin ligase

decreases expression

Ketoconazole results in decreased expression of COP1 mRNA

NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890

G

COPI coat complex subunit zeta 1

decreases expression

Ketoconazole results in decreased expression of COPZ1 mRNA

NCBI chr 7:134,409,523...134,435,661
Ensembl chr 7:134,409,799...134,435,662

G

cytochrome c oxidase assembly factor COX18

affects expression

Ketoconazole affects the expression of COX18 mRNA

NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480

G

carboxypeptidase N subunit 2

decreases expression

Ketoconazole results in decreased expression of CPN2 mRNA

NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472

G

calcineurin-like phosphoesterase domain containing 1

affects expression

Ketoconazole affects the expression of CPPED1 mRNA

NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054

G

carnitine palmitoyltransferase 1B

decreases expression

Ketoconazole results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 2

increases expression

Ketoconazole results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

complement C3d receptor 2

increases expression

Ketoconazole results in increased expression of CR2 mRNA

NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235

G

cAMP responsive element binding protein 1

multiple interactions
decreases expression

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]
Ketoconazole results in decreased expression of CREB1 mRNA
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]

PMID:12164941 PMID:17680988 PMID:37077353

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element modulator

affects expression
decreases expression

Ketoconazole affects the expression of CREM mRNA
Ketoconazole results in decreased expression of CREM mRNA

PMID:18355885 PMID:36653537

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone receptor 2

decreases expression

Ketoconazole results in decreased expression of CRHR2 mRNA

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

cardiolipin synthase 1

increases expression

Ketoconazole results in increased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

G

crystallin, mu

decreases expression

Ketoconazole results in decreased expression of CRYM mRNA

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

catenin beta 1

decreases expression

Ketoconazole results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin L

decreases expression

Ketoconazole results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cathepsin S

affects expression

Ketoconazole affects the expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X-C motif chemokine ligand 10

multiple interactions

Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 14

increases expression

Ketoconazole results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

cytochrome b-245 alpha chain

increases expression

Ketoconazole results in increased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

decreases expression
increases expression

Ketoconazole results in decreased expression of CYCS mRNA
Ketoconazole results in increased expression of CYCS mRNA

PMID:25787151 PMID:37077353

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome c, testis

increases expression

Ketoconazole results in increased expression of CYCT mRNA

NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

Ketoconazole results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions
decreases activity

Ketoconazole binds to and results in decreased activity of CYP11B1 protein
Ketoconazole results in decreased activity of CYP11B1 protein

PMID:15743198 PMID:31982514

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

decreases activity
multiple interactions
increases expression

Ketoconazole results in decreased activity of CYP11B2 protein
Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]
Ketoconazole results in increased expression of CYP11B2 mRNA

PMID:15743198 PMID:16935330 PMID:31982514

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity
decreases expression
multiple interactions

Ketoconazole results in decreased activity of CYP17A1 protein
Ketoconazole results in decreased expression of CYP17A1 mRNA
Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]

PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 More...

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions
decreases activity

Ketoconazole results in increased activity of CYP19A1 protein
Ketoconazole results in decreased expression of CYP19A1 mRNA
[Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione
Ketoconazole results in decreased activity of CYP19A1 protein

PMID:20087668 PMID:27159630 PMID:31330226 PMID:36374910 PMID:36653537

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions
decreases activity

Ketoconazole results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA
Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein
Ketoconazole results in decreased activity of CYP1A1 protein
[Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]
Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein
Ketoconazole results in decreased activity of CYP1A2 protein
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]

PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP1B1 protein

PMID:14709627 PMID:18420780

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions
decreases activity

[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
Ketoconazole results in decreased activity of CYP24A1 protein

PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 26, subfamily a, polypeptide 1

decreases response to substance
increases expression
decreases activity
multiple interactions

Ketoconazole results in decreased susceptibility to CYP26A1 protein
Ketoconazole results in increased expression of CYP26A1 mRNA
Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]

PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 More...

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]
Ketoconazole results in decreased activity of CYP26B1

PMID:14532297 PMID:21906690

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 26, subfamily C, polypeptide 1

multiple interactions

Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin]

NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP27B1 protein

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression
decreases activity
increases expression

Ketoconazole affects the expression of CYP2A1 mRNA
Ketoconazole results in decreased activity of CYP2A1 protein
Ketoconazole results in increased expression of CYP2A1 protein

PMID:7986207 PMID:15879494 PMID:18355885

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

Ketoconazole results in decreased activity of CYP2A4 protein

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 15

affects expression

Ketoconazole affects the expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity
increases expression
multiple interactions

Ketoconazole results in decreased activity of CYP2B6 protein
Ketoconazole results in decreased activity of CYP2B10 protein
Ketoconazole results in increased expression of CYP2B10 mRNA
Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]

PMID:14709627 PMID:16608920 PMID:17438109 PMID:17966066 PMID:18420780

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C11 protein

PMID:15879494 PMID:19858067

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C29 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Ketoconazole results in decreased activity of CYP2C19 protein
Ketoconazole results in decreased activity of CYP2C6 protein

PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:18420780 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity
multiple interactions

Ketoconazole results in decreased activity of CYP2C8 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

PMID:14709627 PMID:15601807 PMID:24120545

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression
decreases activity

Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]
Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein
Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein
Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]

PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

Ketoconazole results in decreased activity of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression
increases response to substance
decreases activity
increases expression
increases metabolic processing

Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Ketoconazole results in decreased expression of CYP3A4 mRNA; Ketoconazole results in decreased expression of CYP3A4 protein
CYP3A4 protein results in increased susceptibility to Ketoconazole
Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein
Ketoconazole results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased metabolism of Ketoconazole
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein

PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
decreases activity
affects expression

[Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA]
Ketoconazole results in decreased activity of CYP3A23-3A1 protein
Ketoconazole affects the expression of CYP3A23-3A1 mRNA

PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 More...

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
affects response to substance
decreases activity

CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole
Ketoconazole results in decreased activity of CYP3A5 protein

PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 More...

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

Ketoconazole results in increased expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP4F12 protein

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily f, polypeptide 4

affects expression

Ketoconazole affects the expression of CYP4F2 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 51

decreases activity
increases expression
decreases response to substance
multiple interactions
increases activity

Ketoconazole results in decreased activity of CYP51A1 protein
Ketoconazole results in increased expression of CYP51 mRNA
CYP51A1 gene results in decreased susceptibility to Ketoconazole
[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein

PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 More...

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
increases expression

[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA
Ketoconazole results in increased expression of CYP7A1 mRNA

PMID:30985903 PMID:31099283

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DDB1 and CUL4 associated factor 8

affects expression

Ketoconazole affects the expression of DCAF8 mRNA

NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726

G

dephospho-CoA kinase domain containing

increases expression

Ketoconazole results in increased expression of DCAKD mRNA

NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054

G

damage-specific DNA binding protein 1

increases expression

Ketoconazole results in increased expression of DDB1 mRNA

NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676

G

DNA-damage inducible transcript 3

increases expression
affects expression
multiple interactions

Ketoconazole results in increased expression of DDIT3 mRNA
Ketoconazole affects the expression of DDIT3 mRNA
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]

PMID:16330322 PMID:31099283 PMID:36621641

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

decreases expression
increases expression

Ketoconazole results in decreased expression of DEPP1 mRNA
Ketoconazole results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

desumoylating isopeptidase 2

decreases expression

Ketoconazole results in decreased expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

diacylglycerol kinase, alpha

decreases expression

Ketoconazole results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

7-dehydrocholesterol reductase

increases expression

Ketoconazole results in increased expression of DHCR7 mRNA

PMID:28263823 PMID:36621641 PMID:36653537

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 3

increases expression

Ketoconazole results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DExH-box helicase 9

increases expression

Ketoconazole results in increased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

dihydrolipoamide S-acetyltransferase

decreases expression

Ketoconazole results in decreased expression of DLAT mRNA

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

DLC1 Rho GTPase activating protein

decreases expression

Ketoconazole results in decreased expression of DLC1 mRNA

NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439

G

delta like non-canonical Notch ligand 1

decreases expression

Ketoconazole results in decreased expression of DLK1 mRNA

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

DNA meiotic recombinase 1

increases expression

Ketoconazole results in increased expression of DMC1 mRNA

NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952

G

Dmx-like 1

decreases expression

Ketoconazole results in decreased expression of DMXL1 mRNA

NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456

G

deoxyribonuclease 1-like 1

decreases expression

Ketoconazole results in decreased expression of DNASE1L1 mRNA

NCBI chr X:152,056,942...152,065,518
Ensembl chr X:152,056,942...152,065,518

G

DNA methyltransferase 3 alpha

increases expression
decreases expression

Ketoconazole results in increased expression of DNMT3A mRNA
Ketoconazole results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

decreases expression

Ketoconazole results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dedicator of cyto-kinesis 1

decreases expression

Ketoconazole results in decreased expression of DOCK1 mRNA

NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768

G

dedicator of cytokinesis 6

increases expression

Ketoconazole results in increased expression of DOCK6 mRNA

NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552

G

docking protein 7

decreases expression

Ketoconazole results in decreased expression of DOK7 mRNA

NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386

G

deleted in primary ciliary dyskinesia

increases expression

Ketoconazole results in increased expression of DPCD mRNA

NCBI chr 1:244,408,766...244,426,891
Ensembl chr 1:244,408,785...244,426,888

G

dopamine receptor D4

decreases expression
multiple interactions

Ketoconazole results in decreased expression of DRD4 mRNA
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA]

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

drosha ribonuclease III

decreases expression

Ketoconazole results in decreased expression of DROSHA mRNA

NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688

G

dual specificity phosphatase 1

increases expression

Ketoconazole results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

endothelin receptor type B

increases expression

Ketoconazole results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor

increases uptake
multiple interactions

Ketoconazole results in increased uptake of EGF protein
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]
Ketoconazole results in decreased expression of EGFR mRNA

PMID:23125191 PMID:37077353

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

increases expression

Ketoconazole results in increased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

egl-9 family hypoxia-inducible factor 3

increases expression

Ketoconazole results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 1A domain containing

increases expression

Ketoconazole results in increased expression of EIF1AD mRNA

NCBI chr 1:202,674,362...202,679,662
Ensembl chr 1:202,674,185...202,679,658

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 3 subunit E

decreases expression

Ketoconazole results in decreased expression of EIF3E mRNA

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

eukaryotic translation initiation factor 3, subunit M

increases expression

Ketoconazole results in increased expression of EIF3M mRNA

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 4B

affects expression

Ketoconazole affects the expression of EIF4B mRNA

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

Ketoconazole results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

elaC ribonuclease Z 1

increases expression

Ketoconazole results in increased expression of ELAC1 mRNA

NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936

G

ELOVL fatty acid elongase 5

decreases expression

Ketoconazole results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ELOVL fatty acid elongase 6

decreases expression

Ketoconazole results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

Ketoconazole results in decreased expression of ENPP3 mRNA

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

endothelial PAS domain protein 1

increases expression

Ketoconazole results in increased expression of EPAS1 mRNA

PMID:36621641 PMID:37077353

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythrocyte membrane protein band 4.1-like 3

decreases expression

Ketoconazole results in decreased expression of EPB41L3 mRNA

NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607

G

epoxide hydrolase 1

affects expression
increases expression

Ketoconazole affects the expression of EPHX1 mRNA
Ketoconazole results in increased expression of EPHX1 mRNA

PMID:18355885 PMID:37077353

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erythropoietin

multiple interactions

Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

epididymal peptidase inhibitor

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA]

NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310

G

Era-like 12S mitochondrial rRNA chaperone 1

decreases expression

Ketoconazole results in decreased expression of ERAL1 mRNA

NCBI chr10:62,961,725...62,968,747
Ensembl chr10:62,961,730...62,968,994

G

ELKS/RAB6-interacting/CAST family member 1

decreases expression

Ketoconazole results in decreased expression of ERC1 mRNA

NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639

G

epiregulin

increases expression

Ketoconazole results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum oxidoreductase 1 alpha

decreases expression

Ketoconazole results in decreased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

endoplasmic reticulum protein 29

affects expression

Ketoconazole affects the expression of ERP29 mRNA

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Ketoconazole results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen receptor 1

decreases expression

Ketoconazole results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen related receptor, alpha

increases expression

Ketoconazole results in increased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ETS proto-oncogene 1, transcription factor

decreases expression

Ketoconazole results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

exocyst complex component 6B

increases expression

Ketoconazole results in increased expression of EXOC6B mRNA

NCBI chr 4:117,094,741...117,550,221
Ensembl chr 4:117,094,741...117,550,180

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

increases expression

Ketoconazole results in increased expression of EZH1 mRNA

NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

Ketoconazole results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor III, tissue factor

increases expression

Ketoconazole results in increased expression of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 1

increases expression

Ketoconazole results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557 PMID:17567588 PMID:36653537

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 3

increases expression

Ketoconazole results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

increases expression

Ketoconazole results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

increases expression

Ketoconazole results in increased expression of FABP5 mRNA

PMID:31099283 PMID:37077353

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

Fas associated factor 1

increases expression

Ketoconazole results in increased expression of FAF1 mRNA

NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977

G

FAM20C, golgi associated secretory pathway kinase

increases expression

Ketoconazole results in increased expression of FAM20C mRNA

NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543

G

Fas cell surface death receptor

increases expression
multiple interactions

Ketoconazole results in increased expression of FAS mRNA
Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]

PMID:15703382 PMID:25808816

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box and leucine-rich repeat protein 14

decreases expression

Ketoconazole results in decreased expression of FBXL14 mRNA

NCBI chr 4:152,662,542...152,666,360
Ensembl chr 4:152,662,542...152,666,360

G

F-box and leucine-rich repeat protein 15

decreases expression

Ketoconazole results in decreased expression of FBXL15 mRNA

NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007

G

F-box protein 21

increases expression

Ketoconazole results in increased expression of FBXO21 mRNA

NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133

G

F-box and WD repeat domain containing 2

increases expression

Ketoconazole results in increased expression of FBXW2 mRNA

NCBI chr 3:18,088,859...18,114,387
Ensembl chr 3:18,088,865...18,114,381

G

farnesyl diphosphate farnesyl transferase 1

increases expression

Ketoconazole results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

increases expression

Ketoconazole results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin 1

decreases expression

Ketoconazole results in decreased expression of FDX1 mRNA

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

Fez family zinc finger 1

decreases expression

Ketoconazole results in decreased expression of FEZF1 mRNA

NCBI chr 4:51,762,751...51,766,078
Ensembl chr 4:51,762,751...51,766,078

G

fibroblast growth factor binding protein 3

increases expression

Ketoconazole results in increased expression of FGFBP3 mRNA

NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547

G

flavin adenine dinucleotide synthetase 1

decreases expression

Ketoconazole results in decreased expression of FLAD1 mRNA

NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977

G

fibronectin 1

decreases expression

Ketoconazole results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 4

increases expression

Ketoconazole results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

FOS like 1, AP-1 transcription factor subunit

decreases expression
increases expression

Ketoconazole results in decreased expression of FOSL1 mRNA
Ketoconazole results in increased expression of FOSL1 mRNA

PMID:25787151 PMID:31099283

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box A2

increases expression

Ketoconazole results in increased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box L2

increases expression

Ketoconazole results in increased expression of FOXL2 mRNA

NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427

G

forkhead box P2

increases expression

Ketoconazole results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

fascin actin-bundling protein 1

decreases expression

Ketoconazole results in decreased expression of FSCN1 mRNA

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

follicle stimulating hormone subunit beta

multiple interactions

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

FYVE and coiled-coil domain autophagy adaptor 1

increases expression
decreases expression

Ketoconazole results in increased expression of FYCO1 mRNA
Ketoconazole results in decreased expression of FYCO1 mRNA

PMID:36621641 PMID:36653537

NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021

G

G0/G1switch 2

decreases expression

Ketoconazole results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

affects expression

Ketoconazole affects the expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases expression

Ketoconazole results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

increases expression

Ketoconazole results in increased expression of GABARAPL2 mRNA

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
Ensembl chr 8:39,910,534...39,924,628

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

Ketoconazole results in increased expression of GABBR1 mRNA

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type B receptor subunit 2

increases expression

Ketoconazole results in increased expression of GABBR2 mRNA

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Ketoconazole results in increased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha 5

decreases expression

Ketoconazole results in decreased expression of GABRA5 mRNA

NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917

G

gamma-aminobutyric acid type A receptor subunit delta

increases expression

Ketoconazole results in increased expression of GABRD mRNA

NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit epsilon

decreases expression

Ketoconazole results in decreased expression of GABRE mRNA

NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693

G

gamma-aminobutyric acid type A receptor subunit theta

decreases expression

Ketoconazole results in decreased expression of GABRQ mRNA

NCBI chr X:150,696,161...150,712,948
Ensembl chr X:150,696,427...150,709,919

G

glutamate decarboxylase 1

decreases expression

Ketoconazole results in decreased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Ketoconazole results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Ketoconazole results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 3

increases expression

Ketoconazole results in increased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucokinase

decreases expression

Ketoconazole results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glucokinase regulator

affects expression

Ketoconazole affects the expression of GCKR mRNA

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

GDP dissociation inhibitor 2

increases expression

Ketoconazole results in increased expression of GDI2 mRNA

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Ketoconazole results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

GDP-L-fucose synthase

increases expression

Ketoconazole results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

G

growth hormone receptor

decreases expression

Ketoconazole results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

gap junction protein, beta 1

decreases expression

Ketoconazole results in decreased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases expression

Ketoconazole results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glutaminase 2

affects expression

Ketoconazole affects the expression of GLS2 mRNA

NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426

G

G protein subunit alpha i1

increases expression

Ketoconazole results in increased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit gamma 11

decreases expression

Ketoconazole results in decreased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

G protein nucleolar 3

decreases expression

Ketoconazole results in decreased expression of GNL3 mRNA

NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392

G

gonadotropin releasing hormone 1

affects secretion

Ketoconazole affects the secretion of GNRH1 protein

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

golgin A3

decreases expression

Ketoconazole results in decreased expression of GOLGA3 mRNA

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509

G

golgi membrane protein 1

decreases expression

Ketoconazole results in decreased expression of GOLM1 mRNA

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

golgi phosphoprotein 3-like

decreases expression

Ketoconazole results in decreased expression of GOLPH3L mRNA

NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083

G

glutamic-oxaloacetic transaminase 1

increases expression

Ketoconazole results in increased expression of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic-oxaloacetic transaminase 2

affects expression

Ketoconazole affects the expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

Ketoconazole results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

G patch domain containing 2

increases expression

Ketoconazole results in increased expression of GPATCH2 mRNA

NCBI chr13:98,784,993...98,925,696
Ensembl chr13:98,784,969...98,925,661

G

glycerol-3-phosphate dehydrogenase 1

multiple interactions
increases expression
decreases expression

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA]
Ketoconazole results in increased expression of GPD1 mRNA

PMID:19587329 PMID:37077353

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

G protein-coupled receptor 12

increases expression

Ketoconazole results in increased expression of GPR12 mRNA

NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973

G

G protein-coupled receptor 17

decreases expression
increases expression

Ketoconazole results in decreased expression of GPR17 mRNA
Ketoconazole results in increased expression of GPR17 mRNA

NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966

G

G protein-coupled receptor 37

increases expression

Ketoconazole results in increased expression of GPR37 mRNA

NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001

G

G protein-coupled receptor 6

decreases expression

Ketoconazole results in decreased expression of GPR6 mRNA

NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Ketoconazole results in increased expression of GPT protein
Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein]

PMID:31099283 PMID:31168027 PMID:32162908 PMID:34627953

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 4

increases expression

Ketoconazole results in increased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

growth factor receptor bound protein 14

affects expression

Ketoconazole affects the expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

growth regulating estrogen receptor binding 1

increases expression

Ketoconazole results in increased expression of GREB1 mRNA

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

Grid2 interacting protein

increases expression

Ketoconazole results in increased expression of GRID2IP mRNA

NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676

G

glutamate ionotropic receptor kainate type subunit 2

decreases expression

Ketoconazole results in decreased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

Ketoconazole results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

glutamate metabotropic receptor 3

increases expression

Ketoconazole results in increased expression of GRM3 mRNA

NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804

G

glutamate metabotropic receptor 4

affects expression

Ketoconazole affects the expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

glutathione-disulfide reductase

increases expression
multiple interactions

Ketoconazole results in increased expression of GSR mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA]
Ketoconazole results in decreased expression of GSTA1 mRNA

PMID:16608920 PMID:31168027 PMID:32185415

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

decreases expression

Ketoconazole results in decreased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

increases expression

Ketoconazole results in increased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

affects expression

Ketoconazole affects the expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions

Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

GTP binding protein 8

decreases expression

Ketoconazole results in decreased expression of GTPBP8 mRNA

NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635

G

GDNF-inducible zinc finger protein 1

increases expression

Ketoconazole results in increased expression of GZF1 mRNA

NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

decreases expression
increases expression

Ketoconazole results in decreased expression of H6PD mRNA
Ketoconazole results in increased expression of H6PD mRNA

PMID:36621641 PMID:37077353

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression
decreases expression

Ketoconazole results in increased expression of HADHA mRNA
Ketoconazole results in decreased expression of HADHA mRNA

PMID:36621641 PMID:37077353

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Ketoconazole results in increased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidine ammonia lyase

affects expression

Ketoconazole affects the expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hepcidin antimicrobial peptide

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole results in decreased expression of HAMP protein

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hyaluronan synthase 2

increases expression

Ketoconazole results in increased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

hepatitis A virus cellular receptor 1

decreases expression

Ketoconazole results in decreased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hemoglobin subunit beta

decreases expression

Ketoconazole results in decreased expression of HBB mRNA; Ketoconazole results in decreased expression of HBB-B1 mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heme binding protein 1

increases expression

Ketoconazole results in increased expression of HEBP1 mRNA

NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854

G

hes family bHLH transcription factor 6

decreases expression

Ketoconazole results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

3-hydroxyisobutyrate dehydrogenase

increases expression

Ketoconazole results in increased expression of HIBADH mRNA

NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617

G

hypoxia inducible factor 1 subunit alpha inhibitor

increases expression

Ketoconazole results in increased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

histone cluster 1 H4 family member B

decreases expression

Ketoconazole results in decreased expression of HIST1H4B mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

HIVEP zinc finger 1

increases expression

Ketoconazole results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

high mobility group AT-hook 2

increases expression

Ketoconazole results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 2

affects expression

Ketoconazole affects the expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity
decreases expression
increases expression
decreases activity
multiple interactions

Ketoconazole results in increased activity of HMGCR protein
Ketoconazole results in decreased expression of HMGCR mRNA
Ketoconazole results in increased expression of HMGCR mRNA
Ketoconazole results in decreased activity of HMGCR protein
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA

PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 PMID:37077353

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Ketoconazole results in increased expression of HMGCS1 mRNA

PMID:28263823 PMID:31099283

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Ketoconazole results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

affects expression
increases expression
multiple interactions

Ketoconazole affects the expression of HMOX1 mRNA
Ketoconazole results in increased expression of HMOX1 mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]

PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 PMID:37077353

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HORMA domain containing 1

increases expression

Ketoconazole results in increased expression of HORMAD1 mRNA

NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383

G

homeo box A4

decreases expression

Ketoconazole results in decreased expression of HOXA4 mRNA

NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685

G

hepsin

increases expression

Ketoconazole results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

HRas proto-oncogene, GTPase

decreases expression

Ketoconazole results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Ketoconazole results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid (17-beta) dehydrogenase 2

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA]

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions
increases expression

Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Ketoconazole results in increased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid (17-beta) dehydrogenase 7

increases expression

Ketoconazole results in increased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

Ketoconazole results in decreased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

multiple interactions
decreases expression

[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA
Ketoconazole results in decreased expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family D (Hsp60) member 1

decreases expression

Ketoconazole results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

hyaluronidase 2

increases expression

Ketoconazole results in increased expression of HYAL2 mRNA

NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850

G

hyccin PI4KA lipid kinase complex subunit 1

decreases expression

Ketoconazole results in decreased expression of HYCC1 mRNA

NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113

G

integrin-binding sialoprotein

multiple interactions

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA]

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

inhibitor of DNA binding 4

increases expression

Ketoconazole results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isopentenyl-diphosphate delta isomerase 1

increases expression
multiple interactions

Ketoconazole results in increased expression of IDI1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]

PMID:16330322 PMID:28263823

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon induced with helicase C domain 1

increases expression

Ketoconazole results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

insulin-like growth factor binding protein 1

increases expression

Ketoconazole results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 5

increases expression

Ketoconazole results in increased expression of IGFBP5 mRNA

PMID:36653537 PMID:37077353

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

insulin-like growth factor binding protein 6

increases expression

Ketoconazole results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

insulin-like growth factor binding protein 7

increases expression

Ketoconazole results in increased expression of IGFBP7 mRNA

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

immunoglobulin heavy constant epsilon

multiple interactions

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]

G

immunoglobulin kappa constant

decreases expression

Ketoconazole results in decreased expression of IGKC mRNA

G

immunoglobulin superfamily, member 10

decreases expression

Ketoconazole results in decreased expression of IGSF10 mRNA

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

Indian hedgehog signaling molecule

increases expression

Ketoconazole results in increased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 1 alpha

increases expression

Ketoconazole results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
Ketoconazole results in increased expression of IL1B mRNA

PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA]

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 24

increases expression

Ketoconazole results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 33

affects expression
increases expression

Ketoconazole affects the expression of IL33 mRNA
Ketoconazole results in increased expression of IL33 mRNA

PMID:18355885 PMID:37077353

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]

PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]

PMID:17966066 PMID:31168027

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitor of growth family, member 1

decreases expression

Ketoconazole results in decreased expression of ING1 mRNA

NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264

G

inhibitor of growth family, member 2

decreases expression

Ketoconazole results in decreased expression of ING2 mRNA

NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482

G

inhibin subunit beta E

increases expression

Ketoconazole results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

INTS3 and NABP interacting protein

increases expression

Ketoconazole results in increased expression of INIP mRNA

NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628

G

insulin induced gene 1

increases expression

Ketoconazole results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin-like 3

decreases expression

Ketoconazole results in decreased expression of INSL3 mRNA

NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560

G

insulin receptor

decreases expression

Ketoconazole results in decreased expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

importin 5

decreases expression

Ketoconazole results in decreased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

importin 7

increases expression

Ketoconazole results in increased expression of IPO7 mRNA

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938

G

insulin receptor substrate 1

decreases expression

Ketoconazole results in decreased expression of IRS1 mRNA

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

Ketoconazole results in increased expression of ITPR1 mRNA

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

isovaleryl-CoA dehydrogenase

increases expression

Ketoconazole results in increased expression of IVD mRNA

NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575

G

potassium channel modulatory factor 1

increases expression

Ketoconazole results in increased expression of KCMF1 mRNA

NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234

G

potassium voltage-gated channel subfamily A member 5

decreases activity

Ketoconazole results in decreased activity of KCNA5 protein

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

G

potassium voltage-gated channel subfamily E regulatory subunit 2

increases expression

Ketoconazole results in increased expression of KCNE2 mRNA

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

G

potassium voltage-gated channel subfamily H member 1

decreases expression

Ketoconazole results in decreased expression of KCNH1 mRNA

NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740

G

potassium voltage-gated channel subfamily H member 2

affects activity
decreases response to substance
multiple interactions
decreases activity
affects localization

Ketoconazole affects the activity of KCNH2 protein mutant form
KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole
[Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]
Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein
Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form

PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 More...

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

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potassium channel tetramerization domain containing 12

decreases expression

Ketoconazole results in decreased expression of KCTD12 mRNA

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

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potassium channel tetramerisation domain containing 12b

decreases expression

Ketoconazole results in decreased expression of KCTD12B mRNA

NCBI chr X:17,643,707...17,654,820
Ensembl chr X:17,643,615...17,654,820

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lysine demethylase 2B

affects expression

Ketoconazole affects the expression of KDM2B mRNA

NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355

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lysine demethylase 3A

increases expression

Ketoconazole results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

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Kelch-like ECH-associated protein 1

increases expression

Ketoconazole results in increased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

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KLF transcription factor 11

decreases expression

Ketoconazole results in decreased expression of KLF11 mRNA

NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550

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kallikrein 1

increases expression

Ketoconazole results in increased expression of KLK1 mRNA

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

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kallikrein 1-related peptidase C10

multiple interactions

[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

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kallikrein related-peptidase 6

multiple interactions
increases expression

Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]
Ketoconazole results in increased expression of KLK6 mRNA

PMID:26485663 PMID:37077353

NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121

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karyopherin subunit alpha 3

increases expression

Ketoconazole results in increased expression of KPNA3 mRNA

NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419

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laminin subunit beta 3

increases expression

Ketoconazole results in increased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

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lysosomal protein transmembrane 4 alpha

increases expression

Ketoconazole results in increased expression of LAPTM4A mRNA

NCBI chr 6:31,719,287...31,737,023
Ensembl chr 6:31,718,976...31,737,020

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lipocalin 2

decreases expression

Ketoconazole results in decreased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

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luteinizing hormone subunit beta

multiple interactions

Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

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luteinizing hormone/choriogonadotropin receptor

decreases expression

Ketoconazole results in decreased expression of LHCGR mRNA

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

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phospholysine phosphohistidine inorganic pyrophosphate phosphatase

increases expression

Ketoconazole results in increased expression of LHPP mRNA

NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578

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LIM homeobox 1

increases expression

Ketoconazole results in increased expression of LHX1 mRNA

NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617

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lamin B1

decreases expression

Ketoconazole results in decreased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

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lunapark, ER junction formation factor

increases expression

Ketoconazole results in increased expression of LNPK mRNA

NCBI chr 3:59,418,872...59,487,029
Ensembl chr 3:59,424,286...59,486,518

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lysyl oxidase

affects expression

Ketoconazole affects the expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

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leucine rich repeat containing 17

decreases expression

Ketoconazole results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

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leucine rich repeat containing 28

decreases expression

Ketoconazole results in decreased expression of LRRC28 mRNA

NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784

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leucine rich repeat containing 41

decreases expression

Ketoconazole results in decreased expression of LRRC41 mRNA

NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449

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leucine rich repeat containing 75A

increases expression

Ketoconazole results in increased expression of LRRC75A mRNA

NCBI chr10:47,298,222...47,343,301
Ensembl chr10:47,297,288...47,343,664

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LRR binding FLII interacting protein 2

decreases expression

Ketoconazole results in decreased expression of LRRFIP2 mRNA

NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255

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LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Ketoconazole results in increased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

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lanosterol synthase

increases expression

Ketoconazole results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

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mannose-6-phosphate receptor, cation dependent

decreases expression

Ketoconazole results in decreased expression of M6PR mRNA

NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216

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macroH2A.1 histone

affects expression

Ketoconazole affects the expression of MACROH2A1 mRNA

NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072

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mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

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mitochondrial assembly of ribosomal large subunit 1

increases expression

Ketoconazole results in increased expression of MALSU1 mRNA

NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905

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mannosidase beta

affects expression

Ketoconazole affects the expression of MANBA mRNA

NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983

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mitogen-activated protein kinase kinase kinase kinase 5

decreases expression

Ketoconazole results in decreased expression of MAP4K5 mRNA

NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799

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mitogen activated protein kinase 14

decreases expression

Ketoconazole results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

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mitogen-activated protein kinase 8

increases phosphorylation
increases expression

Ketoconazole results in increased phosphorylation of MAPK8 protein
Ketoconazole results in increased expression of MAPK8 mRNA

PMID:19631732 PMID:25787151

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

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muscleblind-like splicing regulator 1

decreases expression

Ketoconazole results in decreased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

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melanocortin 3 receptor

decreases expression

Ketoconazole results in decreased expression of MC3R mRNA

NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444

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MCL1 apoptosis regulator, BCL2 family member

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

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minichromosome maintenance complex component 7

increases expression

Ketoconazole results in increased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

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malate dehydrogenase 1

increases expression

Ketoconazole results in increased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

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malic enzyme 1

increases expression

Ketoconazole results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

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MET proto-oncogene, receptor tyrosine kinase

increases expression

Ketoconazole results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

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mitofusin 1

increases expression

Ketoconazole results in increased expression of MFN1 mRNA

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

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monoglyceride lipase

increases expression

Ketoconazole results in increased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

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matrix Gla protein

affects expression

Ketoconazole affects the expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

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microsomal glutathione S-transferase 1

increases expression

Ketoconazole results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

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microsomal glutathione S-transferase 2

increases expression

Ketoconazole results in increased expression of MGST2 mRNA

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

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MHC class I polypeptide-related sequence B

increases expression

Ketoconazole results in increased expression of MICB mRNA

NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827

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mitochondrial calcium uptake 1

increases expression

Ketoconazole results in increased expression of MICU1 mRNA

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

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MHC I like leukocyte 1

increases expression

Ketoconazole results in increased expression of MICA mRNA

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

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marker of proliferation Ki-67

increases expression

Ketoconazole results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

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makorin, ring finger protein, 3

decreases expression

Ketoconazole results in decreased expression of MKRN3 mRNA

NCBI chr 1:115,926,774...115,929,288
Ensembl chr 1:115,926,776...115,929,283

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MAX dimerization protein MLX

affects expression

Ketoconazole affects the expression of MLX mRNA

NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350

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malonyl-CoA decarboxylase

increases expression

Ketoconazole results in increased expression of MLYCD mRNA

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

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metabolism of cobalamin associated B

increases expression

Ketoconazole results in increased expression of MMAB mRNA

NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490

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matrix metallopeptidase 14

decreases expression

Ketoconazole results in decreased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

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myelin protein zero-like 1

decreases expression

Ketoconazole results in decreased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

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melanocortin 2 receptor accessory protein 2

increases expression

Ketoconazole results in increased expression of MRAP2 mRNA

NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886

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muscle RAS oncogene homolog

increases expression

Ketoconazole results in increased expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

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mitochondrial ribosomal protein L11

decreases expression

Ketoconazole results in decreased expression of MRPL11 mRNA

NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756

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mitochondrial ribosomal protein L18

increases expression

Ketoconazole results in increased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

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mitochondrial ribosomal protein L32

increases expression

Ketoconazole results in increased expression of MRPL32 mRNA

NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010

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mitochondrial ribosomal protein S18B

affects expression

Ketoconazole affects the expression of MRPS18B mRNA

NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260

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mitochondrial ribosomal protein S30

decreases expression

Ketoconazole results in decreased expression of MRPS30 mRNA

NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105

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mitochondrial ribosomal protein S31

increases expression

Ketoconazole results in increased expression of MRPS31 mRNA

NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654

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MRT4 homolog, ribosome maturation factor

increases expression

Ketoconazole results in increased expression of MRTO4 mRNA

NCBI chr 5:151,601,780...151,608,533
Ensembl chr 5:151,601,780...151,608,287

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methylsterol monooxygenase 1

affects expression
increases expression
multiple interactions

Ketoconazole affects the expression of MSMO1 mRNA
Ketoconazole results in increased expression of MSMO1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]

PMID:16330322 PMID:18355885

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

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moesin

increases expression

Ketoconazole results in increased expression of MSN mRNA

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

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metallothionein 1

increases expression

Ketoconazole results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

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mitochondrial carrier 2

increases expression

Ketoconazole results in increased expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

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methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

decreases expression

Ketoconazole results in decreased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

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myotubularin related protein 2

decreases expression

Ketoconazole results in decreased expression of MTMR2 mRNA

NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172

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mevalonate diphosphate decarboxylase

increases expression

Ketoconazole results in increased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

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MYD88, innate immune signal transduction adaptor

increases expression

Ketoconazole results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

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myosin heavy chain 14

increases expression

Ketoconazole results in increased expression of MYH14 mRNA

NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836

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myosin heavy chain 7

decreases expression

Ketoconazole results in decreased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

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myelin transcription factor 1

increases expression

Ketoconazole results in increased expression of MYT1 mRNA

NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341

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nuclear autoantigenic sperm protein

increases expression

Ketoconazole results in increased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

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NCBP2 antisense 2 (head to head)

increases expression

Ketoconazole results in increased expression of NCBP2AS2 mRNA

NCBI chr11:68,829,950...68,830,715
Ensembl chr11:68,829,983...68,830,708

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neutrophil cytosolic factor 1

decreases expression
increases expression

Ketoconazole results in decreased expression of NCF1 mRNA
Ketoconazole results in increased expression of NCF1 mRNA

PMID:25787151 PMID:37077353

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

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nuclear receptor coactivator 1

multiple interactions

Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]

PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 More...

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

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nuclear receptor co-repressor 2

multiple interactions

Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]

PMID:12072427 PMID:29356861

NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319

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natural killer cell cytotoxicity receptor 3 ligand 1

increases expression

Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein

NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466

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N-myc downstream regulated 1

increases expression

Ketoconazole results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

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NADH:ubiquinone oxidoreductase subunit A5

increases expression

Ketoconazole results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

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nei-like DNA glycosylase 2

increases expression

Ketoconazole results in increased expression of NEIL2 mRNA

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863

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neuroepithelial cell transforming 1

increases expression

Ketoconazole results in increased expression of NET1 mRNA

NCBI chr17:66,341,251...66,370,445
Ensembl chr17:66,340,728...66,370,441

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neuropilin and tolloid like 1

decreases expression

Ketoconazole results in decreased expression of NETO1 mRNA

NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030

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NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein
Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein

PMID:21753779 PMID:31168027 PMID:37077353

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

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NFKB inhibitor alpha

multiple interactions

Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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nerve growth factor receptor

increases expression

Ketoconazole results in increased expression of NGFR mRNA

NCBI