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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorobutyric acid
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Accession:CHEBI:39426 term browser browse the term
Definition:A monocarboxylic acid that is perfluorinated butyric acid.
Synonyms:exact_synonym: heptafluorobutanoic acid
 related_synonym: Formula=C4HF7O2;   Heptafluoro-1-butanoic acid;   Heptafluorobutyric acid;   InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13);   InChIKey=YPJUNDFVDDCYIH-UHFFFAOYSA-N;   Perfluorobutanoic acid;   Perfluoropropanecarboxylic acid;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)F
 xref: Beilstein:1426882;   CAS:375-22-4
 xref_mesh: MESH:C033094
 xref: PMID:24114467;   PMID:24756992;   Reaxys:1426882;   Wikipedia:Heptafluorobutyric_acid



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perfluorobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO perfluorobutyric acid results in decreased expression of A2M mRNA CTD PMID:36251517 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO perfluorobutyric acid results in increased expression of ABCA1 mRNA CTD PMID:35337807 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO perfluorobutyric acid results in increased expression of ABCB4 mRNA CTD PMID:34474067 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO perfluorobutyric acid results in increased expression of ABCC2 mRNA CTD PMID:34474067 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO perfluorobutyric acid results in increased expression of ABCC3 mRNA CTD PMID:34474067 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP
ISO
perfluorobutyric acid analog results in increased expression of ACACA mRNA
perfluorobutyric acid results in increased expression of ACACA mRNA
CTD PMID:21878386 PMID:36251517 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP perfluorobutyric acid results in increased expression of ACOT1 mRNA CTD PMID:19407336 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP
ISO
perfluorobutyric acid analog results in increased expression of ACOX1 mRNA; perfluorobutyric acid results in increased expression of ACOX1 mRNA CTD PMID:19359353 PMID:19407336 PMID:21878386 PMID:34474067 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Actb actin, beta decreases expression ISO perfluorobutyric acid results in decreased expression of ACTB mRNA CTD PMID:23567314 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Alb albumin affects binding EXP
ISO
perfluorobutyric acid binds to ALB protein CTD PMID:38518100 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression ISO perfluorobutyric acid results in increased expression of ALDOA mRNA CTD PMID:34474067 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO perfluorobutyric acid results in decreased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO perfluorobutyric acid results in increased expression of APEX1 mRNA CTD PMID:34474067 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP perfluorobutyric acid analog results in decreased expression of APOA1 mRNA CTD PMID:21878386 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP perfluorobutyric acid affects the expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apob apolipoprotein B decreases expression ISO perfluorobutyric acid results in decreased expression of APOB mRNA CTD PMID:36251517 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Ar androgen receptor multiple interactions ISO perfluorobutyric acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:29601859 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO perfluorobutyric acid results in increased expression of ATF4 mRNA CTD PMID:36251517 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO perfluorobutyric acid results in increased expression of ATF6 mRNA CTD PMID:36251517 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg3 autophagy related 3 increases expression ISO perfluorobutyric acid results in increased expression of ATG3 mRNA CTD PMID:37806615 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO perfluorobutyric acid results in increased expression of BTG2 mRNA CTD PMID:34474067 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Ccng1 cyclin G1 increases expression ISO perfluorobutyric acid results in increased expression of CCNG1 mRNA CTD PMID:34474067 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd36 CD36 molecule increases expression ISO perfluorobutyric acid results in increased expression of CD36 mRNA CTD PMID:34474067 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO perfluorobutyric acid results in increased expression of CDKN1A mRNA CTD PMID:36251517 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chst9 carbohydrate sulfotransferase 9 decreases expression ISO perfluorobutyric acid results in decreased expression of CHST9 mRNA CTD PMID:36251517 NCBI chr18:6,576,391...6,851,078
Ensembl chr18:6,577,348...6,850,868
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain decreases expression ISO perfluorobutyric acid results in decreased expression of COL17A1 mRNA CTD PMID:36251517 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632
JBrowse link
G Col4a1 collagen type IV alpha 1 chain increases expression ISO perfluorobutyric acid results in increased expression of COL4A1 mRNA CTD PMID:34474067 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO perfluorobutyric acid results in decreased expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorobutyric acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO perfluorobutyric acid results in decreased expression of CXCL1 mRNA CTD PMID:36251517 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO perfluorobutyric acid results in decreased expression of CXCL1 mRNA CTD PMID:36251517 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP
ISO
perfluorobutyric acid analog results in decreased expression of CYP1A1 mRNA
perfluorobutyric acid results in decreased expression of CYP1A1 mRNA
CTD PMID:21878386 PMID:23567314 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP2B2 mRNA CTD PMID:21878386 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP3A23-3A1 mRNA CTD PMID:21878386 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP4A1 mRNA; perfluorobutyric acid results in increased expression of CYP4A1 mRNA CTD PMID:19407336 PMID:21878386 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP7A1 mRNA CTD PMID:21878386 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression EXP perfluorobutyric acid analog results in decreased expression of DIO1 mRNA CTD PMID:21878386 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Egr3 early growth response 3 multiple interactions ISO perfluorobutyric acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA] CTD PMID:33111528 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions
ISO
EXP
perfluorobutyric acid results in increased expression of EHHADH mRNA
perfluorobutyric acid affects the reaction [perfluorooctanoic acid results in increased expression of EHHADH mRNA]
CTD PMID:23567314 PMID:34474067 PMID:34695511 PMID:35337807 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in increased expression of EIF4EBP1 protein CTD PMID:37806615 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO perfluorobutyric acid results in increased expression of ERN1 mRNA CTD PMID:36251517 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO perfluorobutyric acid binds to [ESR1 protein binds to Estradiol] CTD PMID:33111528 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 increases expression ISO perfluorobutyric acid results in increased expression of EXTL1 mRNA CTD PMID:36251517 NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
affects expression
ISO perfluorobutyric acid results in increased expression of FABP1 mRNA
perfluorobutyric acid affects the expression of FABP1 mRNA
CTD PMID:23567314 PMID:34474067 PMID:36251517 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO perfluorobutyric acid results in increased expression of FABP5 mRNA CTD PMID:34474067 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
affects expression
EXP
ISO
perfluorobutyric acid analog results in increased expression of FASN mRNA
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of FASN protein
perfluorobutyric acid affects the expression of FASN mRNA
perfluorobutyric acid results in increased expression of FASN mRNA
CTD PMID:21878386 PMID:34474067 PMID:35337807 PMID:36251517 PMID:37806615 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression EXP perfluorobutyric acid results in decreased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fgf23 fibroblast growth factor 23 increases expression ISO perfluorobutyric acid results in increased expression of FGF23 mRNA CTD PMID:36251517 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO perfluorobutyric acid results in increased expression of GADD45A mRNA CTD PMID:34474067 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 increases expression ISO perfluorobutyric acid results in increased expression of GAL3ST1 mRNA CTD PMID:36251517 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO perfluorobutyric acid results in increased expression of GCLC mRNA CTD PMID:34474067 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression ISO perfluorobutyric acid results in increased expression of GPAM mRNA CTD PMID:35337807 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO perfluorobutyric acid results in increased expression of GSR mRNA CTD PMID:34474067 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP perfluorobutyric acid results in decreased expression of HADHA mRNA CTD PMID:22071372 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP perfluorobutyric acid results in decreased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hbq1b hemoglobin subunit theta 1B increases expression ISO perfluorobutyric acid results in increased expression of HBQ1 mRNA CTD PMID:36251517 NCBI chr10:15,334,293...15,336,061
Ensembl chr10:15,320,762...15,321,397
Ensembl chr10:15,320,762...15,321,397
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP perfluorobutyric acid results in decreased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO perfluorobutyric acid results in increased expression of HMGCS1 mRNA CTD PMID:35337807 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hpn hepsin increases expression ISO perfluorobutyric acid results in increased expression of HPN mRNA CTD PMID:34474067 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO perfluorobutyric acid results in increased expression of HSPA5 mRNA CTD PMID:36251517 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO perfluorobutyric acid results in decreased expression of IL1B mRNA CTD PMID:36251517 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO perfluorobutyric acid results in increased expression of IL24 mRNA CTD PMID:36251517 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 increases expression ISO perfluorobutyric acid results in increased expression of IL6 mRNA CTD PMID:36251517 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ipo4 importin 4 increases expression ISO perfluorobutyric acid results in increased expression of IPO4 mRNA CTD PMID:34474067 NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285
JBrowse link
G Krt18 keratin 18 increases expression ISO perfluorobutyric acid results in increased expression of KRT18 mRNA CTD PMID:34474067 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt7 keratin 7 increases expression ISO perfluorobutyric acid results in increased expression of KRT7 mRNA CTD PMID:36251517 NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Krt8 keratin 8 increases expression ISO perfluorobutyric acid results in increased expression of KRT8 mRNA CTD PMID:34474067 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lpl lipoprotein lipase increases expression ISO perfluorobutyric acid results in increased expression of LPL mRNA CTD PMID:34474067 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lss lanosterol synthase increases expression ISO perfluorobutyric acid results in increased expression of LSS mRNA CTD PMID:34474067 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mal mal, T-cell differentiation protein increases expression EXP perfluorobutyric acid analog results in increased expression of MAL mRNA CTD PMID:21878386 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in increased expression of MAP1LC3B protein CTD PMID:37806615 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO perfluorobutyric acid results in increased expression of MTTP mRNA CTD PMID:35337807 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myl10 myosin light chain 10 decreases expression ISO perfluorobutyric acid results in decreased expression of MYL10 mRNA CTD PMID:36251517 NCBI chr12:19,969,174...19,982,627
Ensembl chr12:19,970,055...19,978,614
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO perfluorobutyric acid results in decreased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO perfluorobutyric acid results in increased expression of NQO1 mRNA CTD PMID:34474067 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
ISO perfluorobutyric acid results in increased activity of NR1I2 protein
perfluorobutyric acid results in increased expression of NR1I2 mRNA
CTD PMID:28115241 PMID:35337807 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO perfluorobutyric acid results in increased expression of NR1I3 mRNA CTD PMID:35337807 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO perfluorobutyric acid results in decreased expression of NUPR1 mRNA CTD PMID:36251517 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G Osmr oncostatin M receptor increases expression ISO perfluorobutyric acid results in increased expression of OSMR mRNA CTD PMID:34474067 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorobutyric acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP perfluorobutyric acid analog results in increased expression of PCNA mRNA CTD PMID:21878386 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorobutyric acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO perfluorobutyric acid results in increased expression of PIK3C3 mRNA CTD PMID:37806615 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorobutyric acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Pltp phospholipid transfer protein increases expression ISO perfluorobutyric acid results in increased expression of PLTP mRNA CTD PMID:34474067 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP perfluorobutyric acid analog results in increased expression of POR mRNA CTD PMID:21878386 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
increases expression
decreases expression
affects response to substance
ISO perfluorobutyric acid results in increased activity of PPARA protein
perfluorobutyric acid results in increased expression of PPARA protein
perfluorobutyric acid results in decreased expression of PPARA mRNA
PPARA protein affects the susceptibility to perfluorobutyric acid
CTD PMID:19359353 PMID:23391484 PMID:28857218 PMID:34474067 PMID:37806615 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
increases expression
ISO perfluorobutyric acid results in increased activity of PPARG protein
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of PPARG protein
perfluorobutyric acid results in increased expression of PPARG mRNA
CTD PMID:24998974 PMID:37806615 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorobutyric acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO perfluorobutyric acid results in increased expression of HLA-DRB1 mRNA CTD PMID:36251517 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G S100a7a S100 calcium binding protein A7A increases expression ISO perfluorobutyric acid results in increased expression of S100A7A mRNA CTD PMID:34474067 NCBI chr 2:176,151,405...176,155,846
Ensembl chr 2:176,151,288...176,156,441
JBrowse link
G Scd stearoyl-CoA desaturase increases expression
multiple interactions
affects expression
ISO perfluorobutyric acid results in increased expression of SCD1 mRNA
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of SCD protein
perfluorobutyric acid affects the expression of SCD1 mRNA
perfluorobutyric acid results in increased expression of SCD mRNA; perfluorobutyric acid results in increased expression of SCD protein
CTD PMID:23567314 PMID:34474067 PMID:35337807 PMID:36251517 PMID:37806615 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G Sdc2 syndecan 2 decreases expression ISO perfluorobutyric acid results in decreased expression of SDC2 mRNA CTD PMID:36251517 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO perfluorobutyric acid results in increased expression of SERPINB2 mRNA CTD PMID:36251517 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO perfluorobutyric acid results in increased expression of SERPINE1 mRNA CTD PMID:34474067 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO perfluorobutyric acid results in increased expression of SOD1 mRNA CTD PMID:35337807 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression ISO perfluorobutyric acid affects the expression of SPP1 mRNA CTD PMID:36251517 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO perfluorobutyric acid results in increased expression of SREBF1 mRNA; perfluorobutyric acid results in increased expression of SREBF1 protein
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of SREBF1 protein
CTD PMID:35337807 PMID:36251517 PMID:37806615 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Susd2 sushi domain containing 2 decreases expression ISO perfluorobutyric acid results in decreased expression of SUSD2 mRNA CTD PMID:36251517 NCBI chr20:13,017,516...13,024,820
Ensembl chr20:13,017,477...13,024,903
JBrowse link
G Tf transferrin decreases expression ISO perfluorobutyric acid results in decreased expression of TF mRNA CTD PMID:36251517 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO perfluorobutyric acid inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA] CTD PMID:33111528 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thrsp thyroid hormone responsive increases expression EXP perfluorobutyric acid analog results in increased expression of THRSP mRNA CTD PMID:21878386 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO perfluorobutyric acid results in increased expression of TIMP2 mRNA CTD PMID:36251517 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO perfluorobutyric acid results in decreased expression of TIMP3 mRNA CTD PMID:36251517 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tmem52b transmembrane protein 52B decreases expression ISO perfluorobutyric acid results in decreased expression of TMEM52B mRNA CTD PMID:36251517 NCBI chr 4:162,954,025...162,959,220
Ensembl chr 4:162,954,025...162,959,220
JBrowse link
G Tnf tumor necrosis factor increases expression ISO perfluorobutyric acid results in increased expression of TNF mRNA CTD PMID:36251517 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression ISO perfluorobutyric acid results in increased expression of TSLP mRNA CTD PMID:34474067 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO perfluorobutyric acid results in decreased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP perfluorobutyric acid analog results in increased expression of UGT1A1 mRNA CTD PMID:21878386 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Zbtb7c zinc finger and BTB domain containing 7C decreases expression ISO perfluorobutyric acid results in decreased expression of ZBTB7C mRNA CTD PMID:36251517 NCBI chr18:69,441,616...69,765,744
Ensembl chr18:69,441,616...69,765,297
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    role 19885
      biological role 19883
        xenobiotic 18760
          perfluorobutyric acid 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19542
                              organochalcogen compound 19302
                                organooxygen compound 19218
                                  carbon oxoacid 18664
                                    carboxylic acid 18661
                                      monocarboxylic acid 18025
                                        fatty acid 16833
                                          short-chain fatty acid 15938
                                            fatty acid 4:0 8225
                                              butyric acid 6736
                                                perfluorobutyric acid 111
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