Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorobutyric acid
go back to main search page
Accession:CHEBI:39426 term browser browse the term
Definition:A monocarboxylic acid that is perfluorinated butyric acid.
Synonyms:exact_synonym: heptafluorobutanoic acid
 related_synonym: Formula=C4HF7O2;   Heptafluoro-1-butanoic acid;   Heptafluorobutyric acid;   InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13);   InChIKey=YPJUNDFVDDCYIH-UHFFFAOYSA-N;   Perfluorobutanoic acid;   Perfluoropropanecarboxylic acid;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)F
 xref: Beilstein:1426882;   CAS:375-22-4
 xref_mesh: MESH:C033094
 xref: PMID:24114467;   PMID:24756992;   Reaxys:1426882;   Wikipedia:Heptafluorobutyric_acid


show annotations for term's descendants           Sort by:
 
perfluorobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases expression EXP perfluorobutyric acid analog results in increased expression of ACACA mRNA CTD PMID:21878386 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression EXP perfluorobutyric acid results in increased expression of ACOT1 mRNA CTD PMID:19407336 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP
ISO
perfluorobutyric acid analog results in increased expression of ACOX1 mRNA; perfluorobutyric acid results in increased expression of ACOX1 mRNA CTD PMID:19359353 PMID:19407336 PMID:21878386 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Actb actin, beta decreases expression ISO perfluorobutyric acid results in decreased expression of ACTB mRNA CTD PMID:23567314 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression ISO perfluorobutyric acid results in decreased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP perfluorobutyric acid analog results in decreased expression of APOA1 mRNA CTD PMID:21878386 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP perfluorobutyric acid affects the expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ar androgen receptor multiple interactions ISO perfluorobutyric acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:29601859 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO perfluorobutyric acid results in decreased expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorobutyric acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP
ISO
perfluorobutyric acid analog results in decreased expression of CYP1A1 mRNA
perfluorobutyric acid results in decreased expression of CYP1A1 mRNA
CTD PMID:21878386 PMID:23567314 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP2B2 mRNA CTD PMID:21878386 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP3A23-3A1 mRNA CTD PMID:21878386 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP4A1 mRNA; perfluorobutyric acid results in increased expression of CYP4A1 mRNA CTD PMID:19407336 PMID:21878386 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP perfluorobutyric acid analog results in increased expression of CYP7A1 mRNA CTD PMID:21878386 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression EXP perfluorobutyric acid analog results in decreased expression of DIO1 mRNA CTD PMID:21878386 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO perfluorobutyric acid results in increased expression of EHHADH mRNA CTD PMID:23567314 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorobutyric acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fasn fatty acid synthase increases expression EXP perfluorobutyric acid analog results in increased expression of FASN mRNA CTD PMID:21878386 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression EXP perfluorobutyric acid results in decreased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP perfluorobutyric acid results in decreased expression of HADHA mRNA CTD PMID:22071372 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP perfluorobutyric acid results in decreased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP perfluorobutyric acid results in decreased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Mal mal, T-cell differentiation protein increases expression EXP perfluorobutyric acid analog results in increased expression of MAL mRNA CTD PMID:21878386 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO perfluorobutyric acid results in decreased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO perfluorobutyric acid results in increased activity of NR1I2 protein CTD PMID:28115241 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorobutyric acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:1,527,316...1,586,019
Ensembl chr 3:1,527,279...1,584,946
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP perfluorobutyric acid analog results in increased expression of PCNA mRNA CTD PMID:21878386 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorobutyric acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorobutyric acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP perfluorobutyric acid analog results in increased expression of POR mRNA CTD PMID:21878386 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
affects response to substance
ISO perfluorobutyric acid results in increased activity of PPARA protein
PPARA protein affects the susceptibility to perfluorobutyric acid
CTD PMID:19359353 PMID:23391484 PMID:28857218 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorobutyric acid results in increased activity of PPARG protein CTD PMID:24998974 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorobutyric acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorobutyric acid results in increased expression of SCD1 mRNA CTD PMID:23567314 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Thrsp thyroid hormone responsive increases expression EXP perfluorobutyric acid analog results in increased expression of THRSP mRNA CTD PMID:21878386 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO perfluorobutyric acid results in decreased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP perfluorobutyric acid analog results in increased expression of UGT1A1 mRNA CTD PMID:21878386 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        xenobiotic 18425
          perfluorobutyric acid 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        monocarboxylic acid 17609
                                          fatty acid 16010
                                            short-chain fatty acid 15700
                                              fatty acid 4:0 7891
                                                butyric acid 6262
                                                  perfluorobutyric acid 39
paths to the root