CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perfluorobutyric acid
Accession: CHEBI:39426
browse the term
Definition: A monocarboxylic acid that is perfluorinated butyric acid.
Synonyms: exact_synonym: heptafluorobutanoic acid
related_synonym: Formula=C4HF7O2; Heptafluoro-1-butanoic acid; Heptafluorobutyric acid; InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13); InChIKey=YPJUNDFVDDCYIH-UHFFFAOYSA-N; Perfluorobutanoic acid; Perfluoropropanecarboxylic acid; SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)F
xref: Beilstein:1426882; CAS:375-22-4
xref_mesh: MESH:C033094
xref: PMID:24114467; PMID:24756992; Reaxys:1426882; Wikipedia:Heptafluorobutyric_acid
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A2m
alpha-2-macroglobulin
decreases expression
ISO
perfluorobutyric acid results in decreased expression of A2M mRNA
CTD
PMID:36251517
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
perfluorobutyric acid results in increased expression of ABCA1 mRNA
CTD
PMID:35337807
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb4
ATP binding cassette subfamily B member 4
increases expression
ISO
perfluorobutyric acid results in increased expression of ABCB4 mRNA
CTD
PMID:34474067
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
perfluorobutyric acid results in increased expression of ABCC2 mRNA
CTD
PMID:34474067
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
ISO
perfluorobutyric acid results in increased expression of ABCC3 mRNA
CTD
PMID:34474067
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Acaca
acetyl-CoA carboxylase alpha
increases expression
EXP ISO
perfluorobutyric acid analog results in increased expression of ACACA mRNA perfluorobutyric acid results in increased expression of ACACA mRNA
CTD
PMID:21878386 PMID:36251517
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acot1
acyl-CoA thioesterase 1
increases expression
EXP
perfluorobutyric acid results in increased expression of ACOT1 mRNA
CTD
PMID:19407336
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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Acox1
acyl-CoA oxidase 1
increases expression
EXP ISO
perfluorobutyric acid analog results in increased expression of ACOX1 mRNA; perfluorobutyric acid results in increased expression of ACOX1 mRNA
CTD
PMID:19359353 PMID:19407336 PMID:21878386 PMID:34474067
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Actb
actin, beta
decreases expression
ISO
perfluorobutyric acid results in decreased expression of ACTB mRNA
CTD
PMID:23567314
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Alb
albumin
affects binding
EXP ISO
perfluorobutyric acid binds to ALB protein
CTD
PMID:38518100
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldoc
aldolase, fructose-bisphosphate C
increases expression
ISO
perfluorobutyric acid results in increased expression of ALDOA mRNA
CTD
PMID:34474067
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Angptl4
angiopoietin-like 4
decreases expression
ISO
perfluorobutyric acid results in decreased expression of ANGPTL4 mRNA
CTD
PMID:23567314
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
ISO
perfluorobutyric acid results in increased expression of APEX1 mRNA
CTD
PMID:34474067
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apoa1
apolipoprotein A1
decreases expression
EXP
perfluorobutyric acid analog results in decreased expression of APOA1 mRNA
CTD
PMID:21878386
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa4
apolipoprotein A4
affects expression
EXP
perfluorobutyric acid affects the expression of APOA4 mRNA
CTD
PMID:22071372
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apob
apolipoprotein B
decreases expression
ISO
perfluorobutyric acid results in decreased expression of APOB mRNA
CTD
PMID:36251517
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Ar
androgen receptor
multiple interactions
ISO
perfluorobutyric acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:29601859
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atf4
activating transcription factor 4
increases expression
ISO
perfluorobutyric acid results in increased expression of ATF4 mRNA
CTD
PMID:36251517
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atf6
activating transcription factor 6
increases expression
ISO
perfluorobutyric acid results in increased expression of ATF6 mRNA
CTD
PMID:36251517
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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Atg3
autophagy related 3
increases expression
ISO
perfluorobutyric acid results in increased expression of ATG3 mRNA
CTD
PMID:37806615
NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
perfluorobutyric acid results in increased expression of BTG2 mRNA
CTD
PMID:34474067
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Ccng1
cyclin G1
increases expression
ISO
perfluorobutyric acid results in increased expression of CCNG1 mRNA
CTD
PMID:34474067
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cd36
CD36 molecule
increases expression
ISO
perfluorobutyric acid results in increased expression of CD36 mRNA
CTD
PMID:34474067
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
perfluorobutyric acid results in increased expression of CDKN1A mRNA
CTD
PMID:36251517
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chst9
carbohydrate sulfotransferase 9
decreases expression
ISO
perfluorobutyric acid results in decreased expression of CHST9 mRNA
CTD
PMID:36251517
NCBI chr18:6,576,391...6,851,078
Ensembl chr18:6,577,348...6,850,868
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Col17a1
collagen type XVII alpha 1 chain
decreases expression
ISO
perfluorobutyric acid results in decreased expression of COL17A1 mRNA
CTD
PMID:36251517
NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632
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Col4a1
collagen type IV alpha 1 chain
increases expression
ISO
perfluorobutyric acid results in increased expression of COL4A1 mRNA
CTD
PMID:34474067
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
ISO
perfluorobutyric acid results in decreased expression of CPT1A mRNA
CTD
PMID:23567314
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cpt1b
carnitine palmitoyltransferase 1B
increases expression
ISO
perfluorobutyric acid results in increased expression of CPT1B mRNA
CTD
PMID:23567314
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
ISO
perfluorobutyric acid results in decreased expression of CXCL1 mRNA
CTD
PMID:36251517
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
perfluorobutyric acid results in decreased expression of CXCL1 mRNA
CTD
PMID:36251517
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
EXP ISO
perfluorobutyric acid analog results in decreased expression of CYP1A1 mRNA perfluorobutyric acid results in decreased expression of CYP1A1 mRNA
CTD
PMID:21878386 PMID:23567314
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
perfluorobutyric acid analog results in increased expression of CYP2B2 mRNA
CTD
PMID:21878386
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
perfluorobutyric acid analog results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:21878386
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression
EXP
perfluorobutyric acid analog results in increased expression of CYP4A1 mRNA; perfluorobutyric acid results in increased expression of CYP4A1 mRNA
CTD
PMID:19407336 PMID:21878386
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
EXP
perfluorobutyric acid analog results in increased expression of CYP7A1 mRNA
CTD
PMID:21878386
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dio1
iodothyronine deiodinase 1
decreases expression
EXP
perfluorobutyric acid analog results in decreased expression of DIO1 mRNA
CTD
PMID:21878386
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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Egr3
early growth response 3
multiple interactions
ISO
perfluorobutyric acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]
CTD
PMID:33111528
NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
increases expression multiple interactions
ISO EXP
perfluorobutyric acid results in increased expression of EHHADH mRNA perfluorobutyric acid affects the reaction [perfluorooctanoic acid results in increased expression of EHHADH mRNA]
CTD
PMID:23567314 PMID:34474067 PMID:34695511 PMID:35337807
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in increased expression of EIF4EBP1 protein
CTD
PMID:37806615
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
perfluorobutyric acid results in increased expression of ERN1 mRNA
CTD
PMID:36251517
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Esr1
estrogen receptor 1
affects binding
ISO
perfluorobutyric acid binds to [ESR1 protein binds to Estradiol]
CTD
PMID:33111528
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Extl1
exostosin-like glycosyltransferase 1
increases expression
ISO
perfluorobutyric acid results in increased expression of EXTL1 mRNA
CTD
PMID:36251517
NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
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Fabp1
fatty acid binding protein 1
increases expression affects expression
ISO
perfluorobutyric acid results in increased expression of FABP1 mRNA perfluorobutyric acid affects the expression of FABP1 mRNA
CTD
PMID:23567314 PMID:34474067 PMID:36251517
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fabp5
fatty acid binding protein 5
increases expression
ISO
perfluorobutyric acid results in increased expression of FABP5 mRNA
CTD
PMID:34474067
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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Fasn
fatty acid synthase
increases expression multiple interactions affects expression
EXP ISO
perfluorobutyric acid analog results in increased expression of FASN mRNA [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of FASN protein perfluorobutyric acid affects the expression of FASN mRNA perfluorobutyric acid results in increased expression of FASN mRNA
CTD
PMID:21878386 PMID:34474067 PMID:35337807 PMID:36251517 PMID:37806615
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
EXP
perfluorobutyric acid results in decreased expression of FDFT1 mRNA
CTD
PMID:22071372
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Fgf23
fibroblast growth factor 23
increases expression
ISO
perfluorobutyric acid results in increased expression of FGF23 mRNA
CTD
PMID:36251517
NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
perfluorobutyric acid results in increased expression of GADD45A mRNA
CTD
PMID:34474067
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gal3st1
galactose-3-O-sulfotransferase 1
increases expression
ISO
perfluorobutyric acid results in increased expression of GAL3ST1 mRNA
CTD
PMID:36251517
NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
perfluorobutyric acid results in increased expression of GCLC mRNA
CTD
PMID:34474067
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
ISO
perfluorobutyric acid results in increased expression of GPAM mRNA
CTD
PMID:35337807
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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Gsr
glutathione-disulfide reductase
increases expression
ISO
perfluorobutyric acid results in increased expression of GSR mRNA
CTD
PMID:34474067
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
decreases expression
EXP
perfluorobutyric acid results in decreased expression of HADHA mRNA
CTD
PMID:22071372
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
decreases expression
EXP
perfluorobutyric acid results in decreased expression of HADHB mRNA
CTD
PMID:22071372
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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Hbq1b
hemoglobin subunit theta 1B
increases expression
ISO
perfluorobutyric acid results in increased expression of HBQ1 mRNA
CTD
PMID:36251517
NCBI chr10:15,334,293...15,336,061
Ensembl chr10:15,320,762...15,321,397 Ensembl chr10:15,320,762...15,321,397
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Hhex
hematopoietically expressed homeobox
decreases expression
EXP
perfluorobutyric acid results in decreased expression of HHEX mRNA
CTD
PMID:22071372
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
perfluorobutyric acid results in increased expression of HMGCS1 mRNA
CTD
PMID:35337807
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hpn
hepsin
increases expression
ISO
perfluorobutyric acid results in increased expression of HPN mRNA
CTD
PMID:34474067
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
perfluorobutyric acid results in increased expression of HSPA5 mRNA
CTD
PMID:36251517
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Il1b
interleukin 1 beta
decreases expression
ISO
perfluorobutyric acid results in decreased expression of IL1B mRNA
CTD
PMID:36251517
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il24
interleukin 24
increases expression
ISO
perfluorobutyric acid results in increased expression of IL24 mRNA
CTD
PMID:36251517
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Il6
interleukin 6
increases expression
ISO
perfluorobutyric acid results in increased expression of IL6 mRNA
CTD
PMID:36251517
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ipo4
importin 4
increases expression
ISO
perfluorobutyric acid results in increased expression of IPO4 mRNA
CTD
PMID:34474067
NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285
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Krt18
keratin 18
increases expression
ISO
perfluorobutyric acid results in increased expression of KRT18 mRNA
CTD
PMID:34474067
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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Krt7
keratin 7
increases expression
ISO
perfluorobutyric acid results in increased expression of KRT7 mRNA
CTD
PMID:36251517
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Krt8
keratin 8
increases expression
ISO
perfluorobutyric acid results in increased expression of KRT8 mRNA
CTD
PMID:34474067
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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Lpl
lipoprotein lipase
increases expression
ISO
perfluorobutyric acid results in increased expression of LPL mRNA
CTD
PMID:34474067
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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Lss
lanosterol synthase
increases expression
ISO
perfluorobutyric acid results in increased expression of LSS mRNA
CTD
PMID:34474067
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Mal
mal, T-cell differentiation protein
increases expression
EXP
perfluorobutyric acid analog results in increased expression of MAL mRNA
CTD
PMID:21878386
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
[perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in increased expression of MAP1LC3B protein
CTD
PMID:37806615
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mttp
microsomal triglyceride transfer protein
increases expression
ISO
perfluorobutyric acid results in increased expression of MTTP mRNA
CTD
PMID:35337807
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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Myl10
myosin light chain 10
decreases expression
ISO
perfluorobutyric acid results in decreased expression of MYL10 mRNA
CTD
PMID:36251517
NCBI chr12:19,969,174...19,982,627
Ensembl chr12:19,970,055...19,978,614
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Nos2
nitric oxide synthase 2
decreases expression
ISO
perfluorobutyric acid results in decreased expression of NOS2 mRNA
CTD
PMID:23567314
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
perfluorobutyric acid results in increased expression of NQO1 mRNA
CTD
PMID:34474067
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity increases expression
ISO
perfluorobutyric acid results in increased activity of NR1I2 protein perfluorobutyric acid results in increased expression of NR1I2 mRNA
CTD
PMID:28115241 PMID:35337807
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
ISO
perfluorobutyric acid results in increased expression of NR1I3 mRNA
CTD
PMID:35337807
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nupr1
nuclear protein 1, transcriptional regulator
decreases expression
ISO
perfluorobutyric acid results in decreased expression of NUPR1 mRNA
CTD
PMID:36251517
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Osmr
oncostatin M receptor
increases expression
ISO
perfluorobutyric acid results in increased expression of OSMR mRNA
CTD
PMID:34474067
NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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Pax8
paired box 8
increases expression
EXP
perfluorobutyric acid results in increased expression of PAX8 mRNA
CTD
PMID:22071372
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
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Pcna
proliferating cell nuclear antigen
increases expression
EXP
perfluorobutyric acid analog results in increased expression of PCNA mRNA
CTD
PMID:21878386
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
perfluorobutyric acid results in increased expression of PDK4 mRNA
CTD
PMID:23567314
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
increases expression
ISO
perfluorobutyric acid results in increased expression of PIK3C3 mRNA
CTD
PMID:37806615
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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Plin2
perilipin 2
increases expression
ISO
perfluorobutyric acid results in increased expression of PLIN2 mRNA
CTD
PMID:23567314
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Pltp
phospholipid transfer protein
increases expression
ISO
perfluorobutyric acid results in increased expression of PLTP mRNA
CTD
PMID:34474067
NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
perfluorobutyric acid analog results in increased expression of POR mRNA
CTD
PMID:21878386
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppara
peroxisome proliferator activated receptor alpha
increases activity increases expression decreases expression affects response to substance
ISO
perfluorobutyric acid results in increased activity of PPARA protein perfluorobutyric acid results in increased expression of PPARA protein perfluorobutyric acid results in decreased expression of PPARA mRNA PPARA protein affects the susceptibility to perfluorobutyric acid
CTD
PMID:19359353 PMID:23391484 PMID:28857218 PMID:34474067 PMID:37806615
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
increases activity multiple interactions increases expression
ISO
perfluorobutyric acid results in increased activity of PPARG protein [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of PPARG protein perfluorobutyric acid results in increased expression of PPARG mRNA
CTD
PMID:24998974 PMID:37806615
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
multiple interactions
ISO
perfluorobutyric acid binds to and results in decreased activity of PTPN11 protein
CTD
PMID:27572461
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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RT1-Db1
RT1 class II, locus Db1
increases expression
ISO
perfluorobutyric acid results in increased expression of HLA-DRB1 mRNA
CTD
PMID:36251517
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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S100a7a
S100 calcium binding protein A7A
increases expression
ISO
perfluorobutyric acid results in increased expression of S100A7A mRNA
CTD
PMID:34474067
NCBI chr 2:176,151,405...176,155,846
Ensembl chr 2:176,151,288...176,156,441
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Scd
stearoyl-CoA desaturase
increases expression multiple interactions affects expression
ISO
perfluorobutyric acid results in increased expression of SCD1 mRNA [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of SCD protein perfluorobutyric acid affects the expression of SCD1 mRNA perfluorobutyric acid results in increased expression of SCD mRNA; perfluorobutyric acid results in increased expression of SCD protein
CTD
PMID:23567314 PMID:34474067 PMID:35337807 PMID:36251517 PMID:37806615
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sdc2
syndecan 2
decreases expression
ISO
perfluorobutyric acid results in decreased expression of SDC2 mRNA
CTD
PMID:36251517
NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
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Serpinb2
serpin family B member 2
increases expression
ISO
perfluorobutyric acid results in increased expression of SERPINB2 mRNA
CTD
PMID:36251517
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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Serpine1
serpin family E member 1
increases expression
ISO
perfluorobutyric acid results in increased expression of SERPINE1 mRNA
CTD
PMID:34474067
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sod1
superoxide dismutase 1
increases expression
ISO
perfluorobutyric acid results in increased expression of SOD1 mRNA
CTD
PMID:35337807
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Spp1
secreted phosphoprotein 1
affects expression
ISO
perfluorobutyric acid affects the expression of SPP1 mRNA
CTD
PMID:36251517
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression multiple interactions
ISO
perfluorobutyric acid results in increased expression of SREBF1 mRNA; perfluorobutyric acid results in increased expression of SREBF1 protein [perfluorooctanoic acid co-treated with perfluorobutyric acid co-treated with perfluorotetradecanoic acid] results in decreased expression of SREBF1 protein
CTD
PMID:35337807 PMID:36251517 PMID:37806615
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Susd2
sushi domain containing 2
decreases expression
ISO
perfluorobutyric acid results in decreased expression of SUSD2 mRNA
CTD
PMID:36251517
NCBI chr20:13,017,516...13,024,820
Ensembl chr20:13,017,477...13,024,903
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Tf
transferrin
decreases expression
ISO
perfluorobutyric acid results in decreased expression of TF mRNA
CTD
PMID:36251517
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tff1
trefoil factor 1
multiple interactions
ISO
perfluorobutyric acid inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]
CTD
PMID:33111528
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Thrsp
thyroid hormone responsive
increases expression
EXP
perfluorobutyric acid analog results in increased expression of THRSP mRNA
CTD
PMID:21878386
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
perfluorobutyric acid results in increased expression of TIMP2 mRNA
CTD
PMID:36251517
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Timp3
TIMP metallopeptidase inhibitor 3
decreases expression
ISO
perfluorobutyric acid results in decreased expression of TIMP3 mRNA
CTD
PMID:36251517
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tmem52b
transmembrane protein 52B
decreases expression
ISO
perfluorobutyric acid results in decreased expression of TMEM52B mRNA
CTD
PMID:36251517
NCBI chr 4:162,954,025...162,959,220
Ensembl chr 4:162,954,025...162,959,220
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Tnf
tumor necrosis factor
increases expression
ISO
perfluorobutyric acid results in increased expression of TNF mRNA
CTD
PMID:36251517
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tslp
thymic stromal lymphopoietin
increases expression
ISO
perfluorobutyric acid results in increased expression of TSLP mRNA
CTD
PMID:34474067
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Ttr
transthyretin
multiple interactions
ISO
perfluorobutyric acid affects the reaction [Thyroxine binds to TTR protein]
CTD
PMID:27528273
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Txnip
thioredoxin interacting protein
decreases expression
ISO
perfluorobutyric acid results in decreased expression of TXNIP mRNA
CTD
PMID:23567314
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
perfluorobutyric acid analog results in increased expression of UGT1A1 mRNA
CTD
PMID:21878386
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Zbtb7c
zinc finger and BTB domain containing 7C
decreases expression
ISO
perfluorobutyric acid results in decreased expression of ZBTB7C mRNA
CTD
PMID:36251517
NCBI chr18:69,441,616...69,765,744
Ensembl chr18:69,441,616...69,765,297
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