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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2,4-triazines
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Accession:CHEBI:39410 term browser browse the term
Definition:Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.
Synonyms:xref: PMID:20194696


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azaribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Umps uridine monophosphate synthetase increases activity ISO azaribine results in increased activity of UMPS protein CTD PMID:1036874 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
ceftriaxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP Ceftriaxone results in decreased expression of ACE2 mRNA CTD PMID:29745864 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Actb actin, beta increases expression EXP Ceftriaxone results in increased expression of ACTB mRNA CTD PMID:29745864 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Bace1 beta-secretase 1 decreases expression EXP Ceftriaxone results in decreased expression of BACE1 mRNA CTD PMID:29745864 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO
EXP
Ceftriaxone results in decreased expression of CAT protein
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD PMID:19442074 PMID:25053526 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Ceftriaxone results in increased expression of ECE1 mRNA CTD PMID:29745864 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Epo erythropoietin increases expression EXP Ceftriaxone results in increased expression of EPO mRNA CTD PMID:29745864 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ide insulin degrading enzyme increases expression EXP Ceftriaxone results in increased expression of IDE mRNA CTD PMID:29745864 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mme membrane metallo-endopeptidase increases expression EXP Ceftriaxone results in increased expression of MME mRNA CTD PMID:29745864 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Ceftriaxone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [JZL195 results in decreased expression of and affects the folding of SLC1A2 protein]; Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
Ceftriaxone results in increased expression of SLC1A2 protein
CTD PMID:19625514 PMID:19717140 PMID:28257918 PMID:29045497 PMID:29432698 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein] CTD PMID:19717140 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
lamotrigine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO lamotrigine results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP lamotrigine results in increased expression of BCL2 mRNA; lamotrigine results in increased expression of BCL2 protein CTD PMID:18719996 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP lamotrigine results in increased expression of BDNF mRNA; lamotrigine results in increased expression of BDNF protein CTD PMID:18719996 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases glutathionylation EXP CYP1A1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases glutathionylation ISO CYP2B6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity
increases glutathionylation
multiple interactions
EXP CYP2C11 protein results in increased activity of lamotrigine
CYP2C11 protein results in increased glutathionylation of lamotrigine
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases glutathionylation EXP CYP2C6V1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases glutathionylation EXP CYP2D2 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases glutathionylation ISO CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases glutathionylation
multiple interactions
ISO CYP2E1 protein results in increased glutathionylation of lamotrigine
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases glutathionylation EXP CYP3A23-3A1 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Drd2 dopamine receptor D2 increases response to substance ISO DRD2 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Hrh1 histamine receptor H 1 increases response to substance ISO HRH1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO lamotrigine results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO lamotrigine results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP lamotrigine results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mc2r melanocortin 2 receptor increases response to substance ISO MC2R protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mir155 microRNA 155 increases expression ISO lamotrigine results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir18a microRNA 18a increases expression ISO lamotrigine results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir21 microRNA 21 increases expression ISO lamotrigine results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP lamotrigine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases response to substance ISO NR3C1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO lamotrigine results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation
ISO [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine
UGT1A4 protein results in increased glucuronidation of lamotrigine
CTD PMID:17151188 PMID:19845433 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
pymetrozine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta affects binding ISO pymetrozine binds to THRB protein CTD PMID:28973306 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    chemical entity 19761
      atom 19759
        nonmetal atom 19641
          nitrogen atom 18572
            nitrogen molecular entity 18572
              organonitrogen compound 18361
                organonitrogen heterocyclic compound 17521
                  triazines 4169
                    1,2,4-triazines 44
                      1,2,4-triazine 0
                      2-[(6-methyl-5-oxo-2H-1,2,4-triazin-3-yl)hydrazinylidene]propanoic acid 0
                      3-(2,5-dimethyl-3-furanyl)-5,6-diphenyl-1,2,4-triazine 0
                      3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine 0
                      5,6-diphenyl-3-pyridin-4-yl-1,2,4-triazine 0
                      5-[2-[(5-methyl-2-furanyl)methylidene]hydrazinyl]-2H-1,2,4-triazin-3-one 0
                      5-phenyl-3-(2-pyridinyl)-1,2,4-triazine 0
                      6-azathymine + 0
                      6-azauracil 0
                      6-methyl-3-sulfanylidene-1,2-dihydro-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one 0
                      6-phenyl-3-(2-pyridinyl)-1,2,4-triazine 0
                      ML228 0
                      N-glycosyl-1,2,4-triazine + 1
                      ceftriaxone 13
                      ferrozine free acid 0
                      lamotrigine 29
                      metamitron + 0
                      metamitron-desamino 0
                      metribuzin 0
                      metribuzin-diketo 0
                      pymetrozine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  heteroarene 16517
                                    azaarene 5378
                                      triazines 4169
                                        1,2,4-triazines 44
                                          1,2,4-triazine 0
                                          2-[(6-methyl-5-oxo-2H-1,2,4-triazin-3-yl)hydrazinylidene]propanoic acid 0
                                          3-(2,5-dimethyl-3-furanyl)-5,6-diphenyl-1,2,4-triazine 0
                                          3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine 0
                                          5,6-diphenyl-3-pyridin-4-yl-1,2,4-triazine 0
                                          5-[2-[(5-methyl-2-furanyl)methylidene]hydrazinyl]-2H-1,2,4-triazin-3-one 0
                                          5-phenyl-3-(2-pyridinyl)-1,2,4-triazine 0
                                          6-azathymine + 0
                                          6-azauracil 0
                                          6-methyl-3-sulfanylidene-1,2-dihydro-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one 0
                                          6-phenyl-3-(2-pyridinyl)-1,2,4-triazine 0
                                          ML228 0
                                          N-glycosyl-1,2,4-triazine + 1
                                          ceftriaxone 13
                                          ferrozine free acid 0
                                          lamotrigine 29
                                          metamitron + 0
                                          metamitron-desamino 0
                                          metribuzin 0
                                          metribuzin-diketo 0
                                          pymetrozine 1
paths to the root