CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cucurbitacin B
Accession: CHEBI:3941
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Definition: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Synonyms: exact_synonym: (2S,4R,23E)-2,16beta,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
related_synonym: 1,2-dihydro-alpha-elaterin; 2beta,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 25-acetate; 2beta,16alpha,20,25-tetrahydroxy-9-methyl-3,11,22-trioxo-19-nor-9beta,10alpha-lanosta-5,23-dien-25-yl acetate; Formula=C32H46O8; InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1; InChIKey=IXQKXEUSCPEQRD-DKRGWESNSA-N; SMILES=[H][C@@]12C[C@H](O)C(=O)C(C)(C)C1=CC[C@@]1([H])[C@]3(C)C[C@@H](O)[C@]([H])([C@@](C)(O)C(=O)\\C=C\\C(C)(C)OC(C)=O)[C@@]3(C)CC(=O)[C@@]21C
xref: CAS:6199-67-3; KEGG:C08794; KNApSAcK:C00003683; LIPID_MAPS_instance:LMST01010104
xref_mesh: MESH:C041246
xref: PMID:18309509; PMID:18442812; PMID:18561312; PMID:19700240; PMID:20153103; PMID:20483353; PMID:21344491; PMID:4384331; PMID:5640163; Reaxys:2068869
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]
CTD
PMID:29250925
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression
ISO
cucurbitacin B results in decreased expression of ADIPOQ mRNA
CTD
PMID:24316209
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAX mRNA]
CTD
PMID:29250925
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 mRNA]
CTD
PMID:29250925
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cat
catalase
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD
PMID:29250925
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Gefitinib results in increased expression of CCL2 mRNA]
CTD
PMID:33248157
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnd1
cyclin D1
decreases expression
ISO
cucurbitacin B results in decreased expression of CCND1
CTD
PMID:24316209
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd36
CD36 molecule
decreases expression
ISO
cucurbitacin B results in decreased expression of CD36 mRNA
CTD
PMID:24316209
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cebpa
CCAAT/enhancer binding protein alpha
decreases expression multiple interactions
ISO
cucurbitacin B results in decreased expression of CEBPA mRNA STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]
CTD
PMID:24316209
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cebpd
CCAAT/enhancer binding protein delta
decreases expression
ISO
cucurbitacin B results in decreased expression of CEBPD
CTD
PMID:24316209
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD
PMID:29250925
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Fabp4
fatty acid binding protein 4
decreases expression
ISO
cucurbitacin B results in decreased expression of FABP4 mRNA
CTD
PMID:24316209
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Il1b
interleukin 1 beta
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
CTD
PMID:29250925
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Klf5
KLF transcription factor 5
increases expression
ISO
cucurbitacin B results in increased expression of KLF5
CTD
PMID:24316209
NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA]
CTD
PMID:29250925
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions decreases expression
ISO
STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA]
CTD
PMID:24316209
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Stat3
signal transducer and activator of transcription 3
multiple interactions affects response to substance
ISO
[WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin B; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]; cucurbitacin B results in decreased phosphorylation of and results in decreased activity of STAT3 protein; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA] STAT3 protein affects the susceptibility to cucurbitacin B
CTD
PMID:24316209 PMID:29250925
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
CTD
PMID:29250925
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions
ISO
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:29250925
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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