Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetramethrin
go back to main search page
Accession:CHEBI:39397 term browser browse the term
Definition:A phthalimide insecticide that has formula C19H25NO4.
Synonyms:exact_synonym: (1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
 related_synonym: Formula=C19H25NO4;   InChI=1S/C19H25NO4/c1-11(2)9-14-15(19(14,3)4)18(23)24-10-20-16(21)12-7-5-6-8-13(12)17(20)22/h9,14-15H,5-8,10H2,1-4H3;   InChIKey=CXBMCYHAMVGWJQ-UHFFFAOYSA-N;   Neo-pynamin;   Neopinamin;   Phthalthrin;   SMILES=CC(C)=CC1C(C(=O)OCN2C(=O)C3=C(CCCC3)C2=O)C1(C)C
 xref: Beilstein:1547171;   CAS:7696-12-0;   Drug_Central:4730;   KEGG:C18373;   KEGG:D07368
 xref_mesh: MESH:C009424
 xref: PPDB:628



show annotations for term's descendants           Sort by:
 
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
ISO tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008 PMID:16621434 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Brca1 BRCA1, DNA repair associated affects binding ISO tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases metabolic processing
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of tetramethrin CTD PMID:19249324 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Folh1 folate hydrolase 1 decreases expression ISO tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G S100g S100 calcium binding protein G decreases expression
multiple interactions
EXP tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      application 19760
        pesticide 17328
          insecticide 15576
            phthalimide insecticide 15
              tetramethrin 15
                (1R)-tetramethrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      dicarboxylic acids and O-substituted derivatives 10401
                                        dicarboxylic acid 10395
                                          C4-dicarboxylic acid 941
                                            butenedioic acid 604
                                              maleic acid 576
                                                maleimides 155
                                                  tetramethrin 15
                                                    (1R)-tetramethrin 0
paths to the root