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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetramethrin
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Accession:CHEBI:39397 term browser browse the term
Definition:A phthalimide insecticide that has formula C19H25NO4.
Synonyms:exact_synonym: (1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
 related_synonym: Formula=C19H25NO4;   InChI=1S/C19H25NO4/c1-11(2)9-14-15(19(14,3)4)18(23)24-10-20-16(21)12-7-5-6-8-13(12)17(20)22/h9,14-15H,5-8,10H2,1-4H3;   InChIKey=CXBMCYHAMVGWJQ-UHFFFAOYSA-N;   Neo-pynamin;   Neopinamin;   Phthalthrin;   SMILES=CC(C)=CC1C(C(=O)OCN2C(=O)C3=C(CCCC3)C2=O)C1(C)C
 xref: Beilstein:1547171;   CAS:7696-12-0;   Drug_Central:4730;   KEGG:C18373;   KEGG:D07368
 xref_mesh: MESH:C009424
 xref: PPDB:628



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tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions
decreases expression
EXP tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008 PMID:16621434 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G BRCA1 BRCA1 DNA repair associated affects binding EXP tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G CES2 carboxylesterase 2 multiple interactions
increases metabolic processing
EXP CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing EXP CYP3A4 protein results in increased metabolism of tetramethrin CTD PMID:19249324 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR1 estrogen receptor 1 decreases expression ISO tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 increases expression ISO tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FOLH1 folate hydrolase 1 decreases expression EXP tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr11:49,145,092...49,208,602
Ensembl chr11:49,145,092...49,208,638
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF2 insulin like growth factor 2 multiple interactions ISO tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KLK3 kallikrein related peptidase 3 increases expression EXP tetramethrin results in increased expression of KLK3 mRNA CTD PMID:12711008 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G NKX3-1 NK3 homeobox 1 decreases expression EXP tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP
ISO
CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions EXP [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G S100G S100 calcium binding protein G decreases expression
multiple interactions
ISO tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:16,650,158...16,654,670
Ensembl chr  X:16,650,158...16,654,670
JBrowse link
G SHBG sex hormone binding globulin affects binding EXP tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP tetramethrin results in increased expression of TMPRSS2 mRNA CTD PMID:12711008 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25538
    role 25475
      application 24658
        pesticide 19793
          insecticide 17713
            phthalimide insecticide 17
              tetramethrin 17
                (1R)-tetramethrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 25538
    subatomic particle 25509
      composite particle 25509
        hadron 25509
          baryon 25509
            nucleon 25509
              atomic nucleus 25509
                atom 25509
                  main group element atom 25358
                    p-block element atom 25358
                      carbon group element atom 24926
                        carbon atom 24902
                          organic molecular entity 24902
                            organic group 22995
                              organic divalent group 22973
                                organodiyl group 22973
                                  carbonyl group 22967
                                    carbonyl compound 22967
                                      dicarboxylic acids and O-substituted derivatives 10784
                                        dicarboxylic acid 10778
                                          C4-dicarboxylic acid 948
                                            butenedioic acid 608
                                              maleic acid 580
                                                maleimides 158
                                                  tetramethrin 17
                                                    (1R)-tetramethrin 0
paths to the root