Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetramethrin
go back to main search page
Accession:CHEBI:39397 term browser browse the term
Definition:A phthalimide insecticide that has formula C19H25NO4.
Synonyms:exact_synonym: (1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
 related_synonym: Formula=C19H25NO4;   InChI=1S/C19H25NO4/c1-11(2)9-14-15(19(14,3)4)18(23)24-10-20-16(21)12-7-5-6-8-13(12)17(20)22/h9,14-15H,5-8,10H2,1-4H3;   InChIKey=CXBMCYHAMVGWJQ-UHFFFAOYSA-N;   Neo-pynamin;   Neopinamin;   Phthalthrin;   SMILES=CC(C)=CC1C(C(=O)OCN2C(=O)C3=C(CCCC3)C2=O)C1(C)C
 xref: Beilstein:1547171;   CAS:7696-12-0;   Drug_Central:4730;   KEGG:C18373;   KEGG:D07368
 xref_mesh: MESH:C009424
 xref: PPDB:628


show annotations for term's descendants           Sort by:
 
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions
decreases expression		 EXP tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA		 CTD PMID:12711008 PMID:16621434 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G BRCA1 BRCA1 DNA repair associated affects binding EXP tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G CES2 carboxylesterase 2 multiple interactions
increases metabolic processing		 EXP CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin		 CTD PMID:19249324 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing EXP CYP3A4 protein results in increased metabolism of tetramethrin CTD PMID:19249324 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression ISO tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 increases expression ISO tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FOLH1 folate hydrolase 1 decreases expression EXP tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr11:49,145,092...49,208,602
Ensembl chr11:49,145,092...49,208,638 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF2 insulin like growth factor 2 multiple interactions ISO tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KLK3 kallikrein related peptidase 3 increases expression EXP tetramethrin results in increased expression of KLK3 mRNA CTD PMID:12711008 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764 		JBrowse link
G NKX3-1 NK3 homeobox 1 decreases expression EXP tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity		 EXP
ISO		 CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions EXP [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G S100G S100 calcium binding protein G decreases expression
multiple interactions		 ISO tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]		 CTD PMID:16326440 NCBI chr  X:16,650,158...16,654,670
Ensembl chr  X:16,650,158...16,654,670 		JBrowse link
G SHBG sex hormone binding globulin affects binding EXP tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP tetramethrin results in increased expression of TMPRSS2 mRNA CTD PMID:12711008 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25538
    role 25475
      application 24658
        pesticide 19793
          insecticide 17713
            phthalimide insecticide 17
              tetramethrin 17
                (1R)-tetramethrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 25538
    subatomic particle 25509
      composite particle 25509
        hadron 25509
          baryon 25509
            nucleon 25509
              atomic nucleus 25509
                atom 25509
                  main group element atom 25358
                    p-block element atom 25358
                      carbon group element atom 24926
                        carbon atom 24902
                          organic molecular entity 24902
                            organic group 22995
                              organic divalent group 22973
                                organodiyl group 22973
                                  carbonyl group 22967
                                    carbonyl compound 22967
                                      dicarboxylic acids and O-substituted derivatives 10784
                                        dicarboxylic acid 10778
                                          C4-dicarboxylic acid 948
                                            butenedioic acid 608
                                              maleic acid 580
                                                maleimides 158
                                                  tetramethrin 17
                                                    (1R)-tetramethrin 0
paths to the root