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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etofenprox
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Accession:CHEBI:39348 term browser browse the term
Definition:An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.
Synonyms:exact_synonym: 1-{[2-(4-ethoxyphenyl)-2-methylpropoxy]methyl}-3-phenoxybenzene
 related_synonym: Ethofenprox;   Ethophenprox;   Formula=C25H28O3;   InChI=1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3;   InChIKey=YREQHYQNNWYQCJ-UHFFFAOYSA-N;   SMILES=CCOc1ccc(cc1)C(C)(C)COCc1cccc(Oc2ccccc2)c1
 xref: Beilstein:7047812;   CAS:80844-07-1;   KEGG:C18410;   KEGG:D09202
 xref_mesh: MESH:C076840
 xref: PMID:10635564;   PMID:11272920;   PMID:11857772;   PMID:9648233;   PPDB:283;   Patent:FR2481695;   Patent:US4397864;   Reaxys:7047812;   Wikipedia:Etofenprox

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etofenprox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA CTD PMID:22467020 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP ethofenprox results in increased activity of CYP1A1 protein CTD PMID:20009351 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:22467020 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP ethofenprox results in decreased activity of ESR1 protein CTD PMID:20410157 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:22467020 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:22467020 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethofenprox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 EXP
ISO		 [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein
ethofenprox results in increased activity of NR1I3 protein		 CTD PMID:22467020 PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA CTD PMID:22467020 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA CTD PMID:22467020 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        aetiopathogenetic role 18974
          allergen 16943
            4-tert-butylphenol 26
              2-(4-ethoxyphenyl)-2-methylpropan-1-ol 11
                etofenprox 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              organic hydroxy compound 18674
                                alcohol 15019
                                  primary alcohol 13921
                                    propan-1-ols 115
                                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol 11
                                        etofenprox 11
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