CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: etofenprox
Accession: CHEBI:39348
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Definition: An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.
Synonyms: exact_synonym: 1-{[2-(4-ethoxyphenyl)-2-methylpropoxy]methyl}-3-phenoxybenzene
related_synonym: Ethofenprox; Ethophenprox; Formula=C25H28O3; InChI=1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3; InChIKey=YREQHYQNNWYQCJ-UHFFFAOYSA-N; SMILES=CCOc1ccc(cc1)C(C)(C)COCc1cccc(Oc2ccccc2)c1
xref: Beilstein:7047812; CAS:80844-07-1; KEGG:C18410; KEGG:D09202
xref_mesh: MESH:C076840
xref: PMID:10635564; PMID:11272920; PMID:11857772; PMID:9648233; PPDB:283; Patent:FR2481695; Patent:US4397864; Reaxys:7047812; Wikipedia:Etofenprox
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Akr7a3
aldo-keto reductase family 7 member A3
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD
PMID:22467020
NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity
EXP
ethofenprox results in increased activity of CYP1A1 protein
CTD
PMID:20009351
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA
CTD
PMID:22467020
NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
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Esr1
estrogen receptor 1
decreases activity
EXP
ethofenprox results in decreased activity of ESR1 protein
CTD
PMID:20410157
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Gsta5
glutathione S-transferase alpha 5
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
CTD
PMID:22467020
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
CTD
PMID:22467020
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
ethofenprox binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions increases activity
EXP ISO
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein ethofenprox results in increased activity of NR1I3 protein
CTD
PMID:22467020 PMID:28927721
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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Sult2a1
sulfotransferase family 2A member 1
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA
CTD
PMID:22467020
NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
CTD
PMID:22467020
NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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