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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etofenprox
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Accession:CHEBI:39348 term browser browse the term
Definition:An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.
Synonyms:exact_synonym: 1-{[2-(4-ethoxyphenyl)-2-methylpropoxy]methyl}-3-phenoxybenzene
 related_synonym: Ethofenprox;   Ethophenprox;   Formula=C25H28O3;   InChI=1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3;   InChIKey=YREQHYQNNWYQCJ-UHFFFAOYSA-N;   SMILES=CCOc1ccc(cc1)C(C)(C)COCc1cccc(Oc2ccccc2)c1
 xref: Beilstein:7047812;   CAS:80844-07-1;   KEGG:C18410;   KEGG:D09202
 xref_mesh: MESH:C076840
 xref: PMID:10635564;   PMID:11272920;   PMID:11857772;   PMID:9648233;   PPDB:283;   Patent:FR2481695;   Patent:US4397864;   Reaxys:7047812;   Wikipedia:Etofenprox


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etofenprox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA CTD PMID:22467020 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP ethofenprox results in increased activity of CYP1A1 protein CTD PMID:20009351 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:22467020 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP ethofenprox results in decreased activity of ESR1 protein CTD PMID:20410157 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:22467020 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:22467020 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethofenprox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 EXP
ISO		 [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein
ethofenprox results in increased activity of NR1I3 protein		 CTD PMID:22467020 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA CTD PMID:22467020 NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA CTD PMID:22467020 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        aetiopathogenetic role 19288
          allergen 17522
            4-tert-butylphenol 27
              2-(4-ethoxyphenyl)-2-methylpropan-1-ol 11
                etofenprox 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      chalcogen 19713
                        oxygen atom 19681
                          oxygen molecular entity 19681
                            hydroxides 19434
                              organic hydroxy compound 18990
                                alcohol 15199
                                  primary alcohol 14095
                                    propan-1-ols 118
                                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol 11
                                        etofenprox 11
paths to the root