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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-(4-chlorophenyl)-3-methylbutyric acid
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Accession:CHEBI:39345 term browser browse the term
Definition:A monocarboxylic acid consisting of isovaleric acid having a 4-chlorophenyl group at the 2-position.
Synonyms:exact_synonym: 2-(4-chlorophenyl)-3-methylbutanoic acid
 related_synonym: Formula=C11H13ClO2;   InChI=1S/C11H13ClO2/c1-7(2)10(11(13)14)8-3-5-9(12)6-4-8/h3-7,10H,1-2H3,(H,13,14);   InChIKey=VTJMSIIXXKNIDJ-UHFFFAOYSA-N;   SMILES=CC(C)C(C(O)=O)c1ccc(Cl)cc1
 xref: CAS:2012-74-0


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fenvalerate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
fenvalerate results in decreased activity of ABCB1 protein
CTD PMID:21783720 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme affects methylation ISO fenvalerate affects the methylation of ACE gene CTD PMID:23548413 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
decreases activity
affects activity
EXP [cypermethrin co-treated with fenvalerate] results in decreased activity of ACHE protein
fenvalerate results in increased activity of ACHE protein
fenvalerate results in decreased activity of ACHE protein
fenvalerate affects the activity of ACHE protein
CTD PMID:8385837, PMID:10355540, PMID:15186033 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity EXP fenvalerate metabolite results in increased activity of ACOX1 protein CTD PMID:10630566 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of AKT1 protein
fenvalerate results in increased phosphorylation of AKT1 protein
CTD PMID:28949029 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases activity
ISO
EXP
fenvalerate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]; fenvalerate inhibits the reaction [Progesterone results in increased activity of ALPL protein]
fenvalerate results in increased activity of ALPL protein
CTD PMID:15696646, PMID:16326432, PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
decreases activity
ISO [Dihydrotestosterone co-treated with fenvalerate] results in decreased expression of AR mRNA; Dihydrotestosterone inhibits the reaction [fenvalerate results in increased activity of AR protein]; fenvalerate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]
fenvalerate results in increased expression of AR protein
fenvalerate results in decreased activity of AR protein
CTD PMID:15064155, PMID:16125883, PMID:16857237, PMID:20410157, PMID:21232584 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of BCL2 protein CTD PMID:28949029 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of BCL2L1 protein CTD PMID:28949029 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP fenvalerate results in increased expression of BDNF mRNA CTD PMID:16166269 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in decreased expression of BID protein CTD PMID:28949029 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Brca1 BRCA1, DNA repair associated affects binding ISO fenvalerate binds to BRCA1 protein CTD PMID:32278787 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G C3 complement C3 affects expression
multiple interactions
ISO fenvalerate affects the expression of C3 protein
fenvalerate affects the expression of and results in increased activity of C3 protein
CTD PMID:21557984 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Calm1 calmodulin 1 increases expression ISO fenvalerate results in increased expression of CALM1 mRNA; fenvalerate results in increased expression of CALM1 protein CTD PMID:22437841 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; [U 0126 co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]] CTD PMID:28949029 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
EXP [cypermethrin co-treated with fenvalerate] results in increased activity of CAT protein
fenvalerate results in increased activity of CAT protein
fenvalerate metabolite results in decreased activity of CAT protein; fenvalerate results in decreased activity of CAT protein
CTD PMID:10355540, PMID:15892188 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO fenvalerate results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd36 CD36 molecule decreases expression ISO fenvalerate results in decreased expression of CD36 mRNA CTD PMID:28369636 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
affects binding
multiple interactions
ISO fenvalerate results in increased expression of CDK2 mRNA
fenvalerate binds to CDK2 protein
CDKN1B protein inhibits the reaction [fenvalerate results in increased expression of CDK2 mRNA]
CTD PMID:22850687, PMID:32278787 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
decreases response to substance
decreases expression
ISO CDKN1B protein inhibits the reaction [fenvalerate results in increased expression of CDK2 mRNA]
CDKN1B protein results in decreased susceptibility to fenvalerate
fenvalerate results in decreased expression of CDKN1B mRNA; fenvalerate results in decreased expression of CDKN1B protein
CTD PMID:22850687 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ces1d carboxylesterase 1D increases metabolic processing ISO CES1 protein results in increased metabolism of fenvalerate CTD PMID:19249324 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cnst consortin, connexin sorting protein increases expression ISO fenvalerate results in increased expression of CNST mRNA CTD PMID:23397585 NCBI chr13:97,838,325...97,915,131
Ensembl chr13:97,838,361...97,913,082
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO fenvalerate results in increased expression of COL1A1 mRNA CTD PMID:20230880 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression
increases expression
ISO
EXP
fenvalerate results in decreased activity of CYP11A1 protein
fenvalerate results in decreased expression of CYP11A1 mRNA; fenvalerate results in decreased expression of CYP11A1 protein
fenvalerate results in increased expression of CYP11A1 mRNA
CTD PMID:15907653, PMID:16001830, PMID:18053657, PMID:19683566, PMID:19892000, PMID:20063364 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO fenvalerate results in decreased expression of CYP17A1 mRNA; fenvalerate results in decreased expression of CYP17A1 protein CTD PMID:20063364, PMID:20138952 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity ISO fenvalerate results in increased activity of CYP1A2 protein CTD PMID:22310298 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP fenvalerate results in increased expression of CYP2B1 mRNA CTD PMID:11377398 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
decreases activity
multiple interactions
increases expression
ISO fenvalerate results in increased activity of CYP2B6 protein
fenvalerate results in decreased activity of CYP2B6 protein
fenvalerate inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
fenvalerate results in increased expression of CYP2B6 mRNA; fenvalerate results in increased expression of CYP2B6 protein
CTD PMID:15548381, PMID:22310298, PMID:22634058 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO fenvalerate results in increased expression of CYP2C19 mRNA CTD PMID:22310298 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO fenvalerate results in increased expression of CYP2C8 mRNA CTD PMID:22310298 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO fenvalerate results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO fenvalerate inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
fenvalerate results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP Dexamethasone promotes the reaction [fenvalerate results in increased expression of CYP3A23-3A1 mRNA]; fenvalerate promotes the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:20599767 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity
increases expression
EXP fenvalerate metabolite results in increased activity of CYP4A22 protein
fenvalerate metabolite results in increased expression of CYP4A22 protein
CTD PMID:10630566 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP fenvalerate metabolite results in increased activity of EPHX1 protein CTD PMID:10630566 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 increases activity EXP fenvalerate metabolite results in increased activity of EPHX2 protein CTD PMID:10630566 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
affects binding
multiple interactions
ISO
EXP
fenvalerate results in increased activity of ESR1 protein
fenvalerate results in increased expression of ESR1 mRNA
fenvalerate binds to ESR1 protein
fenvalerate binds to and results in increased activity of ESR1 protein
CTD PMID:12396874, PMID:15064155, PMID:16626760, PMID:20410157, PMID:24388911 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO fenvalerate binds to and results in increased activity of ESR2 protein CTD PMID:16626760 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Foxo3 forkhead box O3 affects methylation ISO fenvalerate affects the methylation of FOXO3 gene CTD PMID:23548413 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP fenvalerate results in decreased activity of G6PDX protein CTD PMID:12507254 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 affects expression EXP fenvalerate affects the expression of GGT1 CTD PMID:12479040 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP fenvalerate results in increased activity of GOT1 protein CTD PMID:15186033 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP fenvalerate results in increased activity of GPT protein CTD PMID:15186033 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP fenvalerate results in decreased expression of GRIA2 protein CTD PMID:26961610 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP fenvalerate metabolite results in decreased activity of GSR protein; fenvalerate results in decreased activity of GSR protein CTD PMID:15892188 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO fenvalerate results in decreased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G Gusb glucuronidase, beta increases activity ISO fenvalerate results in increased activity of GUSB protein CTD PMID:7175102 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hap1 huntingtin-associated protein 1 affects methylation ISO fenvalerate affects the methylation of HAP1 gene CTD PMID:23548413 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
affects expression
EXP
ISO
fenvalerate results in decreased expression of HSD17B1 mRNA
fenvalerate affects the expression of HSD17B1 protein
CTD PMID:16001830, PMID:21232584 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO fenvalerate results in increased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
decreases secretion
ISO fenvalerate results in decreased expression of IGF1 mRNA
fenvalerate results in decreased secretion of IGF1 protein
CTD PMID:22210404 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression ISO fenvalerate results in decreased expression of IGF2 mRNA CTD PMID:28369636 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Itgb5 integrin subunit beta 5 decreases expression ISO fenvalerate results in decreased expression of ITGB5 mRNA CTD PMID:23397585 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression ISO fenvalerate results in increased expression of ITPR1 mRNA CTD PMID:19428952 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 increases expression ISO fenvalerate results in increased expression of ITPR3 mRNA CTD PMID:19428952 NCBI chr20:5,645,894...5,711,702
Ensembl chr20:5,646,097...5,711,702
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity ISO fenvalerate results in increased activity of KYAT1 protein CTD PMID:7175102 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Kynu kynureninase decreases activity ISO fenvalerate results in decreased activity of KYNU protein CTD PMID:7175102 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Maoa monoamine oxidase A decreases activity EXP fenvalerate results in decreased activity of MAOA protein CTD PMID:8385837 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO fenvalerate results in decreased phosphorylation of MAPK1 protein
[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of MAPK1 protein
fenvalerate results in increased phosphorylation of MAPK1 protein
CTD PMID:22210404, PMID:28949029 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO fenvalerate results in decreased phosphorylation of MAPK3 protein
fenvalerate results in increased phosphorylation of MAPK3 protein
[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased phosphorylation of MAPK3 protein
CTD PMID:22210404, PMID:28949029 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein] CTD PMID:28949029 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of MCL1 protein CTD PMID:28949029 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO fenvalerate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
EXP
ISO
fenvalerate results in increased activity of NR1I2 protein
fenvalerate results in increased activity of NR1I2 protein; fenvalerate results in increased activity of NR1I2 protein polymorphism
fenvalerate binds to and results in increased activity of NR1I2 protein
CTD PMID:15548381, PMID:16054614, PMID:19249324, PMID:21115097, PMID:22206814, PMID:26921727 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO fenvalerate results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects methylation
multiple interactions
ISO fenvalerate affects the methylation of NR3C2 gene
fenvalerate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
CTD PMID:23548413, PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor multiple interactions ISO fenvalerate inhibits the reaction [Progesterone results in increased expression of PGR protein] CTD PMID:16326432 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein] CTD PMID:28949029 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold affects methylation ISO fenvalerate affects the methylation of PML gene CTD PMID:23548413 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ptgfrn prostaglandin F2 receptor inhibitor affects methylation ISO fenvalerate affects the methylation of PTGFRN gene CTD PMID:23548413 NCBI chr 2:203,423,143...203,494,391
Ensembl chr 2:203,423,143...203,494,391
JBrowse link
G Rxra retinoid X receptor alpha increases activity ISO fenvalerate results in increased activity of RXRA protein CTD PMID:20143881 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO fenvalerate binds to RXRG protein CTD PMID:32278787 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Ryr1 ryanodine receptor 1 decreases expression ISO fenvalerate results in decreased expression of RYR1 mRNA CTD PMID:19428952 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions EXP fenvalerate affects the reaction [SCN10A protein results in increased transport of Sodium] CTD PMID:16051293 NCBI chr 8:128,298,593...128,416,896
Ensembl chr 8:128,298,594...128,416,650
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 multiple interactions EXP fenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions EXP fenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions EXP fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 multiple interactions EXP fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium] CTD PMID:18538810 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO fenvalerate binds to SHBG protein CTD PMID:32278787 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Slc38a1 solute carrier family 38, member 1 decreases expression ISO fenvalerate results in decreased expression of SLC38A1 mRNA CTD PMID:28369636 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression ISO fenvalerate results in decreased expression of SLC38A2 mRNA CTD PMID:28369636 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases activity
decreases activity
EXP [cypermethrin co-treated with fenvalerate] results in increased activity of SOD1 protein
fenvalerate results in increased activity of SOD1 protein
fenvalerate metabolite results in decreased activity of SOD1 protein; fenvalerate results in decreased activity of SOD1 protein
CTD PMID:10355540, PMID:15892188 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
increases expression
ISO
EXP
fenvalerate results in decreased expression of STAR mRNA; fenvalerate results in decreased expression of STAR protein
fenvalerate results in increased expression of STAR mRNA; fenvalerate results in increased expression of STAR protein
CTD PMID:15907653, PMID:18053657, PMID:19892000 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO fenvalerate results in increased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO fenvalerate results in increased expression of TFF1 mRNA CTD PMID:10064545, PMID:12396874 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO
EXP
fenvalerate results in decreased expression of THRA mRNA
fenvalerate results in decreased expression of THRA protein
CTD PMID:28369636, PMID:32693020 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression
decreases localization
ISO
EXP
fenvalerate results in decreased expression of THRB mRNA
fenvalerate results in decreased expression of THRB protein
fenvalerate results in decreased localization of THRB protein
CTD PMID:28369636, PMID:32693020 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO fenvalerate results in decreased expression of VEGFA mRNA CTD PMID:28369636 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wnt10b Wnt family member 10B increases expression ISO fenvalerate results in increased expression of WNT10B mRNA CTD PMID:12437293 NCBI chr 7:140,448,284...140,466,159
Ensembl chr 7:140,448,465...140,454,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with fenvalerate] results in increased expression of XIAP protein CTD PMID:28949029 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              plant metabolite 17359
                isovaleric acid 100
                  2-(4-chlorophenyl)-3-methylbutyric acid 90
                    fenvalerate + 90
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            short-chain fatty acid 15498
                                              fatty acid 4:0 7010
                                                butyric acid 5292
                                                  methylbutyric acid 979
                                                    isovaleric acid 100
                                                      2-(4-chlorophenyl)-3-methylbutyric acid 90
                                                        fenvalerate + 90
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.