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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cryptolepine
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Accession:CHEBI:3930 term browser browse the term
Definition:An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.
Synonyms:related_synonym: 5-METHYL-5H-INDOLO[3,2-B]QUINOLINE;   CCRIS 9019;   Formula=C16H12N2;   InChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3;   InChIKey=KURWKDDWCJELSV-UHFFFAOYSA-N;   SMILES=Cn1c2c(cc3ccccc13)nc1ccccc21
 alt_id: CHEBI:42177
 xref: CAS:480-26-2;   KEGG:C09142;   KNApSAcK:C00001710
 xref_mesh: MESH:C024015
 xref: PDBeChem:DR1;   PMID:20623717;   PMID:21369934;   PMID:21946165;   PMID:22091398;   PMID:22221099;   PMID:22436019;   PMID:22477022;   PMID:22926067;   PMID:23092722;   PMID:23507189;   PMID:23737832;   PMID:24391229;   Reaxys:15814;   Wikipedia:Cryptolepine


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cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 3:125,470,499...125,500,795
Ensembl chr 3:125,470,551...125,500,795
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Tp53 tumor protein p53 increases expression
increases activity
ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein
CTD PMID:16120219 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          cryptolepine 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotetracyclic compound 4332
                                      cryptolepine 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.