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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cryptolepine
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Accession:CHEBI:3930 term browser browse the term
Definition:An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.
Synonyms:related_synonym: 5-METHYL-5H-INDOLO[3,2-B]QUINOLINE;   CCRIS 9019;   Formula=C16H12N2;   InChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3;   InChIKey=KURWKDDWCJELSV-UHFFFAOYSA-N;   SMILES=Cn1c2c(cc3ccccc13)nc1ccccc21
 alt_id: CHEBI:42177
 xref: CAS:480-26-2;   KEGG:C09142;   KNApSAcK:C00001710
 xref_mesh: MESH:C024015
 xref: PDBeChem:DR1;   PMID:20623717;   PMID:21369934;   PMID:21946165;   PMID:22091398;   PMID:22221099;   PMID:22436019;   PMID:22477022;   PMID:22926067;   PMID:23092722;   PMID:23507189;   PMID:23737832;   PMID:24391229;   Reaxys:15814;   Wikipedia:Cryptolepine


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cryptolepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cryptolepine results in increased expression of BAX mRNA; cryptolepine results in increased expression of BAX protein CTD PMID:16120219 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO cryptolepine results in decreased expression of BIRC3 mRNA CTD PMID:16120219 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO cryptolepine results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO cryptolepine results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cryptolepine results in decreased expression of CCNA2 mRNA; cryptolepine results in decreased expression of CCNA2 protein CTD PMID:16120219 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO cryptolepine results in decreased expression of CCNB1 mRNA; cryptolepine results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO cryptolepine results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO cryptolepine results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdc34 cell division cycle 34, ubiquitin conjugating enzyme decreases expression ISO cryptolepine results in decreased expression of CDC34 mRNA CTD PMID:16120219 NCBI chr 7:10,668,209...10,674,206
Ensembl chr 7:10,017,588...10,023,186 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO cryptolepine results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr11:95,689,702...95,714,980
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO cryptolepine results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cryptolepine results in increased expression of CDKN1A mRNA; cryptolepine results in increased expression of CDKN1A protein CTD PMID:16120219 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO cryptolepine results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr15:22,502,299...22,513,725
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Cenpf centromere protein F decreases expression ISO cryptolepine results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr13:103,715,344...103,760,931
Ensembl chr13:101,184,127...101,229,669 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO cryptolepine results in increased expression of GDF15 mRNA CTD PMID:16120219 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO cryptolepine results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO cryptolepine results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO cryptolepine results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr12:22,155,921...22,163,320
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO cryptolepine results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 3:140,539,590...140,569,891
Ensembl chr 3:120,086,763...120,117,008 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO cryptolepine results in increased expression of MDM2 mRNA; cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO cryptolepine results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 3:189,263,569...189,327,844
Ensembl chr 3:168,886,089...168,950,341 		JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO cryptolepine results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr13:105,936,809...105,950,054
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases activity		 ISO cryptolepine results in increased expression of TP53 protein
cryptolepine results in increased activity of TP53 protein		 CTD PMID:16120219 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttk Ttk protein kinase decreases expression ISO cryptolepine results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        anti-inflammatory agent 16678
          cryptolepine 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  organic heteropolycyclic compound 18302
                                    organic heterotetracyclic compound 9232
                                      cryptolepine 24
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