CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: bioresmethrin
Accession: CHEBI:39280
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Definition: A resmethrin that has formula C22H26O3.
Synonyms: exact_synonym: (5-benzylfuran-3-yl)methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
related_synonym: (+)-trans-Resmethrin; 1R-trans-Resemethrin; 5-Benzyl-3-furylmethyl (+)-trans-chrysanthemate; 5-Benzyl-3-furylmethyl (1R)-trans-chrysanthemate; Biobenzyfuroline; Formula=C22H26O3; InChI=1S/C22H26O3/c1-15(2)10-19-20(22(19,3)4)21(23)25-14-17-12-18(24-13-17)11-16-8-6-5-7-9-16/h5-10,12-13,19-20H,11,14H2,1-4H3/t19-,20+/m1/s1; InChIKey=VEMKTZHHVJILDY-UXHICEINSA-N; SMILES=CC(C)=C[C@@H]1[C@@H](C(=O)OCc2coc(Cc3ccccc3)c2)C1(C)C
xref: CAS:28434-01-7; KEGG:C16810
xref_mesh: MESH:C002842
xref: PPDB:81
G
Ces1d
carboxylesterase 1D
multiple interactions increases hydrolysis increases metabolic processing
ISO EXP
27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin] CES1 protein results in increased hydrolysis of bioresmethrin
CTD
PMID:16387282 PMID:19249324 PMID:19761868
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
bioresmethrin results in increased expression of CYP3A4 mRNA
CTD
PMID:19249324
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO EXP
bioresmethrin results in increased activity of NR1I2 protein bioresmethrin binds to and results in increased activity of NR1I2 protein
CTD
PMID:19249324 PMID:31538121
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
EXP
bioresmethrin binds to and results in decreased activity of NR1I3 protein
CTD
PMID:31538121
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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