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G |
Scn8a |
sodium voltage-gated channel alpha subunit 8 |
decreases activity |
ISO |
anhydrotetrodotoxin results in decreased activity of SCN8A protein |
CTD |
PMID:17522141 |
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NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA] Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein] |
CTD |
PMID:35946953 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of ARC mRNA] |
CTD |
PMID:25945544 |
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NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO EXP |
Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA] Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]; Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA] 3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide promotes the reaction [Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]]; Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]] |
CTD |
PMID:16166269 PMID:18184782 PMID:26095976 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] |
CTD |
PMID:17973980 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] |
CTD |
PMID:18321476 |
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NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
decreases activity |
ISO |
Tetrodotoxin results in decreased activity of CRH protein |
CTD |
PMID:12906840 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein] |
CTD |
PMID:24070585 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNA |
CTD |
PMID:22341215 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of EGR1 mRNA] |
CTD |
PMID:25945544 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Entpd4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of ENTPD4 mRNA |
CTD |
PMID:22341215 |
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NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706
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G |
Erich5 |
glutamate-rich 5 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of ERICH5 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:65,657,204...65,680,207
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of FOS mRNA; Tetrodotoxin results in decreased expression of FOS protein |
CTD |
PMID:7534335 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
decreases secretion |
ISO |
Tetrodotoxin results in decreased secretion of GNRH1 protein |
CTD |
PMID:28731686 |
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NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
increases localization multiple interactions |
EXP |
Tetrodotoxin results in increased localization of GRIA1 protein [Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein] |
CTD |
PMID:19674091 PMID:29939358 |
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NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
increases localization multiple interactions increases expression |
EXP ISO |
Tetrodotoxin results in increased localization of GRIA2 protein Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIA2 protein] Tetrodotoxin results in increased expression of GRIA2 protein [Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein] |
CTD |
PMID:19674091 PMID:25945544 PMID:29939358 |
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NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein] |
CTD |
PMID:25945544 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein] |
CTD |
PMID:25945544 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] |
CTD |
PMID:16300829 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcnc1 |
potassium voltage-gated channel subfamily C member 1 |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of KCNC1 mRNA |
CTD |
PMID:18775767 |
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NCBI chr 1:96,902,953...96,944,744
Ensembl chr 1:96,902,953...96,944,744
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G |
Kcnc2 |
potassium voltage-gated channel subfamily C member 2 |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of KCNC2 mRNA; Tetrodotoxin results in decreased expression of KCNC2 protein |
CTD |
PMID:18775767 |
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NCBI chr 7:47,700,035...47,883,979
Ensembl chr 7:47,700,288...47,883,968
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G |
Kiss1 |
KiSS-1 metastasis-suppressor |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] |
CTD |
PMID:18948403 |
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NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612
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G |
Kiss1r |
KISS1 receptor |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] |
CTD |
PMID:18948403 |
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NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO EXP |
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein] Tetrodotoxin results in decreased phosphorylation of MAPK1 protein Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15086530 PMID:30205134 PMID:30940546 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO EXP |
Tetrodotoxin results in decreased phosphorylation of MAPK3 protein Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein] Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15086530 PMID:30205134 PMID:30940546 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Masp2 |
MBL associated serine protease 2 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of MASP2 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
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G |
Npy |
neuropeptide Y |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA] |
CTD |
PMID:2233698 |
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NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Prkcb |
protein kinase C, beta |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA |
CTD |
PMID:22341215 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Pvalb |
parvalbumin |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of PVALB mRNA |
CTD |
PMID:18775767 |
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NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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G |
Rhbdl2 |
rhomboid like 2 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of RHBDL2 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 5:136,037,560...136,081,970
Ensembl chr 5:136,037,305...136,081,969
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G |
Scn1b |
sodium voltage-gated channel beta subunit 1 |
multiple interactions |
EXP |
Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]; Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] |
CTD |
PMID:9236205 PMID:21983428 |
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NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
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G |
Scn2a |
sodium voltage-gated channel alpha subunit 2 |
multiple interactions decreases activity |
EXP ISO |
Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein] Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA] Tetrodotoxin results in decreased activity of SCN2A protein |
CTD |
PMID:9236205 PMID:22972919 PMID:25358543 |
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NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
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G |
Scn2b |
sodium voltage-gated channel beta subunit 2 |
multiple interactions |
EXP |
Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] |
CTD |
PMID:21983428 |
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NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
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G |
Scn3a |
sodium voltage-gated channel alpha subunit 3 |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN3A mRNA] |
CTD |
PMID:25358543 |
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NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
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G |
Scn5a |
sodium voltage-gated channel alpha subunit 5 |
decreases activity |
EXP |
Tetrodotoxin results in decreased activity of SCN5A protein |
CTD |
PMID:17978865 |
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NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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G |
Scn8a |
sodium voltage-gated channel alpha subunit 8 |
multiple interactions decreases activity |
ISO EXP |
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCN8A protein]; Tetrodotoxin inhibits the reaction [SCN8A protein results in increased transport of Sodium] Tetrodotoxin results in decreased activity of SCN8A protein Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] |
CTD |
PMID:16020462 PMID:17522141 PMID:21983428 PMID:23382806 PMID:24070585 |
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NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
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G |
Scn9a |
sodium voltage-gated channel alpha subunit 9 |
decreases activity multiple interactions |
ISO |
Tetrodotoxin results in decreased activity of SCN9A protein [Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin inhibits the reaction [SCN9A protein results in increased transport of Sodium] |
CTD |
PMID:16020462 PMID:17522141 PMID:23382806 |
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NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
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G |
Sct |
secretin |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] |
CTD |
PMID:15963647 PMID:16888165 |
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NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
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G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions |
ISO |
[cariporide co-treated with Tetrodotoxin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein] |
CTD |
PMID:24070585 |
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NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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G |
Tcf25 |
transcription factor 25 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of TCF25 mRNA |
CTD |
PMID:26436198 |
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NCBI chr19:51,415,341...51,449,725
Ensembl chr19:51,415,543...51,449,723
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
cariporide promotes the reaction [Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Tetrodotoxin inhibits the reaction [decamethrin results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [Permethrin results in increased secretion of TNF protein]; Tetrodotoxin promotes the reaction [cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] |
CTD |
PMID:24070585 PMID:27655349 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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