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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:emamectin B1b
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Accession:CHEBI:39232 term browser browse the term
Definition:An emamectin that has formula C48H73NO13.
Synonyms:exact_synonym: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-6'-(propan-2-yl)-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside
 related_synonym: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside;   Formula=C48H73NO13;   InChI=1S/C48H73NO13/c1-25(2)42-28(5)17-18-47(62-42)23-34-20-33(61-47)16-15-27(4)43(26(3)13-12-14-32-24-55-45-41(50)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-11)44(31(8)57-39)60-38-21-36(53-10)40(49-9)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,16,20-24H2,1-11H3/b13-12+,27-15+,32-14+/t26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,47+,48+/m0/s1;   InChIKey=DXIOOXFZLKCVHK-UTAOKEBVSA-N;   SMILES=[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](NC)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(O2)O[C@]([H])(C(C)C)[C@@H](C)C=C1)[C@]34O

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emamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity
multiple interactions		 ISO
EXP		 emamectin results in decreased activity of ABCB1 protein
emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCB1A protein
emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]		 CTD PMID:25865432 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
decreases activity		 ISO
EXP		 emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCC1 protein		 CTD PMID:25865432 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; emamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585 		JBrowse link
emamectin benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity		 EXP Plant Oils inhibits the reaction [emamectin benzoate results in decreased activity of CAT protein] CTD PMID:29268245 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of CYP2E1 mRNA] CTD PMID:29268245 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases activity ISO emamectin benzoate results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 4:107,291,465...107,307,168
Ensembl chr 4:107,291,465...107,307,169 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions
increases expression		 EXP Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of MGST1 mRNA] CTD PMID:29268245 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755 		JBrowse link
G Nts neurotensin affects activity ISO emamectin benzoate affects the activity of NTS protein CTD PMID:23611293 NCBI chr10:102,481,756...102,490,418
Ensembl chr10:102,481,756...102,490,486 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21549
    role 21527
      biological role 21525
        biochemical role 20689
          metabolite 20639
            prokaryotic metabolite 18931
              bacterial metabolite 18931
                emamectins 9
                  emamectin B1b 9
                    emamectin + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 21549
    subatomic particle 21534
      composite particle 21534
        hadron 21534
          baryon 21534
            nucleon 21534
              atomic nucleus 21534
                atom 21534
                  main group element atom 21437
                    p-block element atom 21437
                      carbon group element atom 21227
                        carbon atom 21124
                          organic molecular entity 21124
                            organic group 19557
                              organic divalent group 19547
                                organodiyl group 19547
                                  carbonyl group 19528
                                    carbonyl compound 19528
                                      carboxylic ester 14692
                                        lactone 6048
                                          macrocyclic lactone 1755
                                            macrolide 1622
                                              emamectins 9
                                                emamectin B1b 9
                                                  emamectin + 9
paths to the root