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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:39211 term browser browse the term
Definition:A two-component mixture comprising spinosyn A and spinosyn D in a ratio of approximately 5:1. Obtained from the fermentation of the naturally occurring soil dwelling bacterium Saccharopolyspora spinosa, it is used for the topical treatment of head lice.
Synonyms:related_synonym: Natroba;   Tracer;   Tracer Naturalyte
 xref: CAS:168316-95-8;   KEGG:D09384
 xref_mesh: MESH:C415329
 xref: PMID:20607816;   PMID:21681919;   PMID:21701441;   PMID:21770013;   PMID:21895692;   PMID:21980712;   PMID:22115944;   PMID:22141112;   PMID:22177544;   PMID:22223469;   PMID:22226761;   PMID:22533085;   PMID:22607066;   PMID:22608138;   PMID:22620695;   PMID:22629193;   PMID:22797324;   PMID:22812139;   PMID:22847768;   PMID:22898623;   PMID:22926932;   PMID:22958307;   PMID:23010868;   PMID:23016960;   PMID:23032800;   Wikipedia:Spinosad

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spinosad term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Ivermectin]
spinosad results in decreased activity of ABCB1 protein
CTD PMID:21321059 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases response to substance ISO CHRNA7 protein mutant form results in decreased susceptibility to spinosad CTD PMID:23016960 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      chemical substance 12983
        mixture 12155
          spinosad 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    p-block element atom 19706
                      carbon group element atom 19628
                        carbon atom 19618
                          organic molecular entity 19618
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18668
                                    carbonyl compound 18668
                                      carboxylic ester 15893
                                        lactone 11248
                                          macrocyclic lactone 5534
                                            macrolide 5482
                                              macrolide antibiotic 396
                                                macrolide pesticide 17
                                                  macrolide insecticide 17
                                                    spinosyn insecticide 2
                                                      spinosyn A 2
                                                        spinosad 2
paths to the root