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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spinosyn
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Accession:CHEBI:39207 term browser browse the term
Definition:A family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa.



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spinosad term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
ISO spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of Ivermectin]
spinosad results in decreased activity of ABCB1 protein
CTD PMID:21321059 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases response to substance ISO CHRNA7 protein mutant form results in decreased susceptibility to spinosad CTD PMID:23016960 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            prokaryotic metabolite 18629
              bacterial metabolite 18654
                spinosyn 2
                  spinosyn A + 2
                  spinosyn B 0
                  spinosyn D + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic ester 15960
                                        lactone 11302
                                          macrocyclic lactone 5604
                                            macrolide 5556
                                              spinosyn 2
                                                spinosyn A + 2
                                                spinosyn B 0
                                                spinosyn D + 2
paths to the root