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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzopyrrole
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Accession:CHEBI:39205 term browser browse the term
Synonyms:related_synonym: dibenzopyrroles


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6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects expression ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCB1 mRNA; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCB1 protein CTD PMID:29545174 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects expression
decreases expression
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCC3 mRNA
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of ABCC3 protein
CTD PMID:29545174 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA] CTD PMID:21212096 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein] CTD PMID:31981641 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of AKT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD inhibits the reaction [Oleic Acid results in decreased phosphorylation of AKT1 protein]]
CTD PMID:25536389 PMID:26450947 PMID:31433112 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases acetylation ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of ARNTL protein CTD PMID:31768571 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA] CTD PMID:29653943 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]] CTD PMID:31433112 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin affects the localization of BAX protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein]
CTD PMID:21593185 PMID:25665036 PMID:26450947 PMID:29653943 PMID:31433112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]] CTD PMID:21593185 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of BCL2 protein]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]
CTD PMID:29653943 PMID:31433112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]] CTD PMID:21593185 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Brd2 bromodomain containing 2 multiple interactions ISO BRD2 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]] CTD PMID:26212199 NCBI chr20:3,910,555...3,921,074
Ensembl chr20:3,910,555...3,917,426
Ensembl chr20:3,910,555...3,917,426
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO BRD4 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]] CTD PMID:26212199 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP1 protein CTD PMID:20370652 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP3 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP3 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]
CTD PMID:20370652 PMID:21593185 PMID:24726431 PMID:25665036 PMID:26450947 PMID:31433112 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP7 protein] CTD PMID:24726431 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [GHRL protein modified form results in increased expression of CAT mRNA] CTD PMID:24486147 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein] CTD PMID:29653943 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]] CTD PMID:31472180 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression
EXP DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CEBPB mRNA] CTD PMID:29653943 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of CLDN1 protein]
CTD PMID:31472180 PMID:31981641 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Col10a1 collagen type X alpha 1 chain multiple interactions
decreases expression
EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein]; Resveratrol inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of COL10A1 protein] CTD PMID:29653943 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Crp C-reactive protein multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Ethanol results in increased expression of CRP protein] CTD PMID:27989594 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of CYP26A1 mRNA] CTD PMID:29990529 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in decreased expression of DDIT3 protein]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CEBPB mRNA]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of PCNA protein]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of RUNX2 mRNA]; DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]
CTD PMID:29653943 PMID:31433112 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
increases acetylation
EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of EIF2AK3 protein
CTD PMID:29653943 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
EXP 4-phenylbutyric acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2S1 protein] CTD PMID:29653943 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:25665036 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]] CTD PMID:25440059 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA CTD PMID:22146233 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of FN1 protein] CTD PMID:31981641 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of and results in increased acetylation of FOXO1 protein
CTD PMID:25665036 PMID:29545174 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased localization of FOXO3 protein CTD PMID:20370652 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gck glucokinase multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA]] CTD PMID:21163946 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [GHRL protein modified form results in increased expression of CAT mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [GHRL protein modified form results in increased expression of SOD2 mRNA] CTD PMID:24486147 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased phosphorylation of GSK3B protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD inhibits the reaction [Oleic Acid results in decreased phosphorylation of GSK3B protein]] CTD PMID:25536389 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein]] CTD PMID:21593185 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] CTD PMID:21212096 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]] CTD PMID:31433112 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:24145604 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in decreased secretion of IL10 protein] CTD PMID:31981641 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP1 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased secretion of IL1B protein]
CTD PMID:20426787 PMID:31981641 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased secretion of IL6 protein] CTD PMID:31981641 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Oleic Acid results in decreased phosphorylation of INSR protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD inhibits the reaction [Oleic Acid results in decreased phosphorylation of INSR protein]] CTD PMID:25536389 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol promotes the reaction [JUN protein binds to REST promoter]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of JUN mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of JUN protein modified form] CTD PMID:26307266 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mafa MAF bZIP transcription factor A multiple interactions EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of MAFA mRNA CTD PMID:22968147 NCBI chr 7:116,779,368...116,781,815
Ensembl chr 7:116,780,681...116,781,766
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[TNF protein co-treated with resveratrol] results in increased expression of MAP1LC3B protein alternative form] CTD PMID:24145604 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]] CTD PMID:31332904 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein]] CTD PMID:31332904 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir34a microRNA 34a decreases expression ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of MIR34A mRNA CTD PMID:24726431 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP1 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of MMP1 mRNA
CTD PMID:20426787 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
EXP Resveratrol inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of MMP13 protein] CTD PMID:29653943 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 protein CTD PMID:20426787 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] CTD PMID:24145604 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased activity of NAMPT protein] CTD PMID:24603648 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nkx6-1 NK6 homeobox 1 multiple interactions EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of NKX6-1 mRNA CTD PMID:22968147 NCBI chr14:9,555,264...9,562,197
Ensembl chr14:9,555,264...9,562,189
JBrowse link
G Nos3 nitric oxide synthase 3 decreases phosphorylation
multiple interactions
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased phosphorylation of NOS3 protein
[salvianolic acid co-treated with Glucose] inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased phosphorylation of NOS3 protein]; Glucose inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased phosphorylation of NOS3 protein]
CTD PMID:30431688 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Ocln occludin multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]] CTD PMID:31472180 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein] CTD PMID:24726431 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of PCNA protein
DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of PCNA protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of PCNA protein]
CTD PMID:29653943 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased phosphorylation of PDGFRB protein] CTD PMID:31981641 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of PDK4 protein]] CTD PMID:26450947 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of PDPK1 protein]] CTD PMID:26450947 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]] CTD PMID:21163946 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:24145604 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rest RE1-silencing transcription factor multiple interactions
increases expression
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol promotes the reaction [JUN protein binds to REST promoter]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased expression of REST mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased expression of REST protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of REST mRNA; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of REST protein
CTD PMID:26307266 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Triiodothyronine results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:30209975 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression
multiple interactions
EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of RUNX2 mRNA
DDIT3 protein affects the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of RUNX2 mRNA]
CTD PMID:29653943 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased acetylation of SDHA protein] CTD PMID:24178296 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Glucose co-treated with Resveratrol] results in increased expression of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [NAD promotes the reaction [Oleic Acid results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased activity of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of SIRT1 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased expression of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [Resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [Resveratrol results in increased expression of GCK mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [Resveratrol results in increased expression of PDX1 mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [Resveratrol results in increased expression of SLC2A2 mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [Resveratrol results in increased expression of TFAM mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Ethanol results in decreased expression of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP1 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 protein; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 protein; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of SIRT1 mRNA; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of SIRT1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Dietary Fats results in decreased expression of SIRT1 protein]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of MAFA mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of NKX6-1 mRNA; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of CCND1 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of PCNA protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of ATF4 mRNA]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of BAX protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 mRNA]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of DDIT3 protein]; SIRT1 protein inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased phosphorylation of EIF2AK3 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Taurine results in increased expression of SIRT1 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Taurine results in increased expression of SIRT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased localization of and results in decreased activity of SIRT1 protein; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Resveratrol; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP1 protein; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP3 protein; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased localization of FOXO3 protein; [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Glucose
CTD PMID:20370652 PMID:20426787 PMID:21163946 PMID:21212096 PMID:22146233 PMID:22968147 PMID:23124026 PMID:23358928 PMID:24064760 PMID:24603648 PMID:24726431 PMID:24998427 PMID:25536389 PMID:25665036 PMID:25849131 PMID:25943029 PMID:26450947 PMID:26518726 PMID:27989594 PMID:29545174 PMID:29653943 PMID:29990529 PMID:31981641 PMID:32017914 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt2 sirtuin 2 decreases activity
decreases expression
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT2 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of SIRT2 protein
CTD PMID:24998427 PMID:26518726 PMID:29545174 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Sirt3 sirtuin 3 decreases activity
multiple interactions
ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT3 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]
CTD PMID:26518726 PMID:31981641 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Sirt4 sirtuin 4 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in decreased expression of SIRT4 protein] CTD PMID:31981641 NCBI chr12:46,862,358...46,876,593
Ensembl chr12:46,868,416...46,876,592
JBrowse link
G Sirt6 sirtuin 6 decreases activity ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT6 protein CTD PMID:26518726 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of SLC2A2 mRNA]] CTD PMID:21163946 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [GHRL protein modified form results in increased expression of SOD2 mRNA]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin results in increased expression of and results in increased activity of SOD2 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SOD2]
CTD PMID:23124026 PMID:24211423 PMID:24486147 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases degradation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased degradation of SQSTM1 protein]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased degradation of SQSTM1 protein
CTD PMID:25943029 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of STAT3 protein modified form]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of STAT3 protein]
CTD PMID:24064760 PMID:31981641 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbx6 T-box transcription factor 6 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in decreased expression of TBX6 mRNA] CTD PMID:29990529 NCBI chr 1:198,214,797...198,218,706
Ensembl chr 1:198,214,797...198,218,706
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]] CTD PMID:21163946 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of and results in increased secretion of TGFB1 protein] CTD PMID:31981641 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]] CTD PMID:31472180 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]] CTD PMID:24145604 PMID:31472180 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases acetylation
multiple interactions
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TRP53 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Antimycin A results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]
Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein]
CTD PMID:21593185 PMID:24040102 PMID:24726431 PMID:25665036 PMID:29545174 PMID:32017914 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRIM63 protein]] CTD PMID:25665036 PMID:26450947 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of USP7 protein]] CTD PMID:25665036 NCBI chr10:6,930,462...7,019,910
Ensembl chr10:6,975,244...7,018,930
JBrowse link
G Vim vimentin multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in increased expression of VIM protein] CTD PMID:31981641 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in decreased expression of WNT3A mRNA] CTD PMID:29990529 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
7H-Dibenzo[c,g]carbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP
ISO
7H-dibenzo(c,g)carbazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNA
7H-dibenzo(c,g)carbazole promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Benzo(a)pyrene promotes the reaction [7H-dibenzo(c,g)carbazole results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the metabolism of and results in increased activity of 7H-dibenzo(c,g)carbazole; CYP1A1 protein results in decreased susceptibility to [Benzo(a)pyrene co-treated with 7H-dibenzo(c,g)carbazole]
CTD PMID:15534862 PMID:23639521 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of and results in increased activity of 7H-dibenzo(c,g)carbazole CTD PMID:15534862 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
9H-carbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO
carbazole binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
carazolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO carazolol promotes the reaction [[Particulate Matter co-treated with n-hexane] results in increased expression of IL1A mRNA] CTD PMID:30503853 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO carazolol results in decreased expression of IL1B mRNA CTD PMID:30503853 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA] CTD PMID:30503853 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA] CTD PMID:30503853 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
carbazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP
ISO
carbazole binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
carbazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Carbazoles analog binds to and affects the activity of CNR1 protein; Carbazoles analog binds to and results in increased activity of CNR1 protein CTD PMID:29963207 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor affects response to substance ISO ERCC6 protein affects the susceptibility to Carbazoles CTD PMID:22280988 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to Carbazoles CTD PMID:22280988 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
decreases activity
ISO
EXP
ABCB1 protein results in increased transport of carvedilol
[Cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol
[carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]] which results in decreased susceptibility to Doxorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]] which results in decreased susceptibility to Paclitaxel; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [carvedilol results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of carvedilol]
CTD PMID:10571255 PMID:11895100 PMID:12708479 PMID:16671962 PMID:17609666 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]
carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA]
CTD PMID:15071347 PMID:18992766 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
carvedilol results in decreased expression of ACTA2 protein
CTD PMID:20403466 PMID:22413959 PMID:30254303 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actn4 actinin alpha 4 decreases expression EXP carvedilol results in decreased expression of ACTN4 protein CTD PMID:20403466 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO carvedilol results in decreased expression of ADIPOQ protein CTD PMID:19367012 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
decreases expression
ISO
EXP
Carvedilol binds to and results in decreased activity of ADRA1A protein; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
carvedilol results in decreased expression of ADRA1A mRNA
CTD PMID:15306222 PMID:20668454 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1B protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1D protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding
increases expression
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to Carvedilol; [Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP; ADRB1 protein polymorphism affects the reaction [[Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]; ADRB1 protein polymorphism affects the susceptibility to [Carvedilol co-treated with Angiotensin Receptor Antagonists]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol binds to and results in decreased activity of ADRB1 protein; Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; CGP 20712A inhibits the reaction [[Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Carvedilol results in increased activity of ADRB1 protein]; Guanine Nucleotides affects the reaction [Carvedilol binds to ADRB1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
carvedilol binds to ADRB1 protein
carvedilol results in increased expression of ADRB1 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; carvedilol results in increased phosphorylation of ADRB1 protein
carvedilol results in increased activity of ADRB1 protein
ADRB1 gene polymorphism affects the susceptibility to carvedilol; ADRB1 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154 PMID:2462161 PMID:7908256 PMID:10372227 PMID:12535855 PMID:12761341 PMID:14502278 PMID:14730417 PMID:15060759 PMID:15306222 PMID:16475467 PMID:17200720 PMID:18075464 PMID:18787115 PMID:20643254 PMID:20668454 PMID:21216836 PMID:21395649 PMID:21516734 PMID:21599570 PMID:22192668 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases phosphorylation
affects binding
increases expression
increases uptake
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to carvedilol; [carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein; [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein; carvedilol binds to and results in decreased activity of ADRB2 protein; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Guanine Nucleotides affects the reaction [carvedilol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]
carvedilol results in increased expression of ADRB2 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
carvedilol results in increased uptake of ADRB2 protein
ADRB2 gene SNP affects the susceptibility to carvedilol; ADRB2 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154 PMID:2462161 PMID:10372227 PMID:10455254 PMID:12198331 PMID:12535855 PMID:12835612 PMID:14730417 PMID:15306222 PMID:16225854 PMID:17925438 PMID:19034036 PMID:19175363 PMID:19422106 PMID:20352314 PMID:20668454 PMID:21216836 PMID:21395649 PMID:21599570 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
decreases expression
affects response to substance
ISO
EXP
carvedilol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
carvedilol results in decreased expression of ADRB3 mRNA
ADRB3 affects the susceptibility to carvedilol
CTD PMID:11159692 PMID:14730417 PMID:17440824 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
decreases expression
EXP
ISO
[Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]
carvedilol results in decreased susceptibility to AGT protein modified form
carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
carvedilol results in decreased expression of AGT protein
CTD PMID:12004934 PMID:12538430 PMID:15741261 PMID:16794485 PMID:16940222 PMID:19183357 PMID:21047287 PMID:21166975 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP
ISO
carvedilol results in increased phosphorylation of AKT1 protein CTD PMID:27288437 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO carvedilol results in decreased expression of APP protein modified form CTD PMID:20579773 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]
CTD PMID:18787115 PMID:24334028 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions
affects localization
ISO
EXP
ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]
ARRB2 promotes the reaction [carvedilol results in increased uptake of Calcium]
carvedilol affects the localization of ARRB2 protein
CTD PMID:17925438 PMID:18787115 PMID:21078978 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
EXP carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]
carvedilol results in increased expression of ATP2A2 mRNA
CTD PMID:15670758 PMID:16026515 PMID:16162791 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of AVP protein
carvedilol inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium]
CTD PMID:12523682 PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of BAK1 mRNA CTD PMID:29122578 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of BAX protein]
carvedilol inhibits the reaction [Cisplatin results in increased expression of BAX protein]
carvedilol results in increased expression of BAX protein
carvedilol results in decreased expression of BAX
CTD PMID:12973927 PMID:15380674 PMID:20079142 PMID:24012798 PMID:25245570 PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
affects expression
EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; carvedilol inhibits the reaction [Potassium Dichromate results in decreased expression of BCL2 protein]
carvedilol results in increased expression of BCL2 mRNA
carvedilol affects the expression of BCL2 protein
CTD PMID:15380674 PMID:16780994 PMID:16909474 PMID:22000973 PMID:25245570 PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP carvedilol results in increased expression of BCL2L1 protein CTD PMID:20079142 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 increases expression EXP carvedilol results in increased expression of BECN1 protein CTD PMID:20079142 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcb calcitonin-related polypeptide, beta multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,271,116...184,276,480
Ensembl chr 1:184,271,590...184,276,475
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Carvedilol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP3 protein]
carvedilol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]
carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
CTD PMID:10728402 PMID:15380674 PMID:21044617 PMID:24012798 PMID:25245570 PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP Carvedilol inhibits the reaction [Arginine results in decreased activity of CAT protein]; Carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]
carvedilol results in increased activity of CAT protein
CTD PMID:12010767 PMID:16909474 PMID:25245570 PMID:32569593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDH1 protein] CTD PMID:30254303 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cfl1 cofilin 1 decreases expression EXP carvedilol results in decreased expression of CFL1 protein CTD PMID:20403466 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
carvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
Carvedilol results in decreased expression of COL1A1 mRNA; Carvedilol results in decreased expression of COL1A1 protein
CTD PMID:10722803 PMID:11181017 PMID:11682445 PMID:19575289 PMID:21216836 PMID:22413959, PMID:11682445 RGD:30296650 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
carvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of COL3A1 protein
CTD PMID:10722803 PMID:11181017 PMID:11682445, PMID:11682445 RGD:30296650 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of CRP protein
Carvedilol inhibits the reaction [Arginine results in increased expression of CRP protein]
CTD PMID:15047035 PMID:32569593 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein] CTD PMID:12722941 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP carvedilol results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects glucuronidation
affects metabolic processing
affects response to substance
ISO CYP2D6 gene polymorphism affects the glucuronidation of carvedilol
CYP2D6 gene polymorphism affects the metabolism of carvedilol; CYP2D6 protein polymorphism affects the metabolism of carvedilol
CYP2D6 gene polymorphism affects the susceptibility to carvedilol
CTD PMID:15001973 PMID:16595916 PMID:16849011 PMID:17329852 PMID:20643254 PMID:20686235 PMID:21599570 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Carvedilol CTD PMID:29415952 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO carvedilol results in decreased expression of DDIT4 mRNA CTD PMID:27288437 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein] CTD PMID:24334028 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Edn1 endothelin 1 decreases secretion
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased secretion of EDN1 protein
carvedilol results in decreased expression of EDN1 mRNA
carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]
carvedilol results in decreased expression of EDN1 mRNA; carvedilol results in decreased expression of EDN1 protein
carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]
CTD PMID:9500873 PMID:11078433 PMID:14711191 PMID:16428915 PMID:18971572 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:22413959 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of FN1 mRNA]; carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein]
carvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of FN1 protein
CTD PMID:11181017 PMID:11682445 PMID:12140129, PMID:11682445 RGD:30296650 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP carvedilol results in decreased expression of GAP43 mRNA; carvedilol results in decreased expression of GAP43 protein CTD PMID:20359859 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gata4 GATA binding protein 4 decreases phosphorylation EXP carvedilol results in decreased phosphorylation of GATA4 protein CTD PMID:21472269 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
decreases phosphorylation
increases phosphorylation
decreases degradation
ISO
EXP
carvedilol results in increased expression of GJA1 mRNA; carvedilol results in increased expression of GJA1 protein
carvedilol affects the localization of GJA1 protein
carvedilol results in decreased phosphorylation of GJA1 protein
carvedilol results in increased phosphorylation of GJA1 protein
carvedilol results in decreased degradation of GJA1 protein
CTD PMID:16448880 PMID:16563290 PMID:17445419 PMID:18971572 PMID:19478468 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP carvedilol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Gnas GNAS complex locus multiple interactions
increases expression
ISO
EXP
[carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein
carvedilol results in increased expression of GNAS mRNA
CTD PMID:10455254 PMID:20668454 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpnmb glycoprotein nmb decreases expression EXP carvedilol results in decreased expression of GPNMB protein CTD PMID:20403466 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30254303 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
decreases expression
increases expression
ISO [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein
carvedilol results in decreased expression of GRK2 protein
carvedilol results in increased expression of GRK2 protein
carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:9788834 PMID:10455254 PMID:12198331 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]
CTD PMID:24334028 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 multiple interactions ISO GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR214 mRNA]
GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
CTD PMID:24334028 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO carvedilol results in increased expression of HMOX1 mRNA CTD PMID:11688356 PMID:12227681 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein] CTD PMID:24334028 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hpca hippocalcin affects localization EXP carvedilol affects the localization of HPCA protein CTD PMID:21078978 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP carvedilol results in increased expression of HSPH1 protein CTD PMID:20403466 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions ISO carvedilol inhibits the reaction [Hemagglutinins results in increased expression of IFNG protein] CTD PMID:15229385 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein]
carvedilol results in increased expression of IL10 mRNA; carvedilol results in increased expression of IL10 protein
CTD PMID:12722941 PMID:16310260 PMID:18971572 PMID:20017808 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of IL1B mRNA
carvedilol results in decreased expression of IL1B mRNA; carvedilol results in decreased expression of IL1B protein
Carvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]
carvedilol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:10722803 PMID:14684360 PMID:15921778 PMID:16310260 PMID:20017808 PMID:32569593 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression EXP carvedilol results in increased expression of IL1RN protein CTD PMID:20017808 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP carvedilol results in decreased expression of IL6 mRNA; carvedilol results in decreased expression of IL6 protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
CTD PMID:10722803 PMID:11406463 PMID:16310260 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 decreases expression ISO carvedilol results in decreased expression of INS protein alternative form CTD PMID:16598518 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jph2 junctophilin 2 increases expression ISO carvedilol results in increased expression of JPH2 protein CTD PMID:22375019 NCBI chr 3:159,709,998...159,776,536
Ensembl chr 3:159,712,325...159,775,643
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP carvedilol binds to and results in decreased activity of KCNA5 protein CTD PMID:22146582 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
affects activity
ISO carvedilol results in decreased activity of KCNH2 protein
carvedilol affects the activity of KCNH2 protein
CTD PMID:11164846 PMID:16314852 PMID:22020101 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases activity ISO carvedilol results in decreased activity of KCNJ11 protein CTD PMID:16325804 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO carvedilol binds to and results in decreased activity of KCNJ4 protein; Phosphatidylinositol Phosphates inhibits the reaction [carvedilol binds to and results in decreased activity of KCNJ4 protein] CTD PMID:21663737 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 decreases activity ISO carvedilol results in decreased activity of KCNK3 protein CTD PMID:21410455 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132
JBrowse link
G Klf13 Kruppel-like factor 13 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of KLF13 mRNA CTD PMID:29122578 NCBI chr 1:124,772,596...124,803,363
Ensembl chr 1:124,772,596...124,803,363
JBrowse link
G Lox lysyl oxidase decreases expression EXP carvedilol results in decreased expression of LOX mRNA CTD PMID:21216836 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK1 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
CTD PMID:11054474 PMID:15306222 PMID:16213474 PMID:17925438 PMID:18787115 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK14 protein] CTD PMID:16213474 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK3 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
carvedilol results in increased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
CTD PMID:11054474 PMID:15306222 PMID:16213474 PMID:17925438 PMID:18787115 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression EXP carvedilol results in decreased expression of MFGE8 protein CTD PMID:20403466 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894
JBrowse link
G Mir125a microRNA 125a multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]
carvedilol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions
increases expression
ISO ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]
[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir125b2 microRNA 125b-2 increases expression ISO Carvedilol results in increased expression of MIR125B2 mRNA CTD PMID:29122578 NCBI chr11:16,097,346...16,097,433 JBrowse link
G Mir150 microRNA 150 multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]
CTD PMID:24334028 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
JBrowse link
G Mir200a microRNA 200a multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of MIR200A mRNA] CTD PMID:30254303 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
carvedilol results in decreased activity of MMP2 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]
carvedilol results in decreased expression of MMP2
CTD PMID:16213474 PMID:16310260 PMID:17964422 PMID:20452391 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases expression ISO carvedilol results in decreased expression of MMP8 mRNA CTD PMID:15921778 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects activity
decreases expression
decreases activity
multiple interactions
ISO
EXP
carvedilol affects the activity of MMP9 protein
carvedilol results in decreased expression of MMP9 mRNA
carvedilol results in decreased activity of MMP9 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
CTD PMID:16213474 PMID:16310260 PMID:16574429 PMID:17964422 PMID:18971572 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]
Carvedilol inhibits the reaction [Arginine results in increased expression of MPO protein]
carvedilol inhibits the reaction [Calcimycin results in increased secretion of MPO protein]; carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MPO protein]
CTD PMID:16601795 PMID:17159805 PMID:18987595 PMID:32569593 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msn moesin decreases expression EXP carvedilol results in decreased expression of MSN protein CTD PMID:20403466 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mstn myostatin decreases expression EXP carvedilol results in decreased expression of MSTN mRNA; carvedilol results in decreased expression of MSTN protein CTD PMID:16968467 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
affects expression
EXP carvedilol results in decreased expression of MYC protein
carvedilol affects the expression of MYC protein
CTD PMID:21472269 PMID:22000973 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl12a myosin light chain 12A decreases expression EXP carvedilol results in decreased expression of MYL12A protein CTD PMID:20403466 NCBI chr 9:119,325,282...119,333,012
Ensembl chr 9:119,325,283...119,332,967
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases phosphorylation EXP carvedilol results in increased phosphorylation of NFATC4 protein CTD PMID:21472269 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; carvedilol promotes the reaction [wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of NOS2 protein]
CTD PMID:17159805 PMID:19439816 PMID:25245570 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
increases phosphorylation
decreases expression
EXP carvedilol results in increased expression of NOS3 mRNA; carvedilol results in increased expression of NOS3 protein
carvedilol results in increased phosphorylation of NOS3 protein
carvedilol results in decreased expression of NOS3 mRNA
CTD PMID:16741616 PMID:17559835 PMID:18971572 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression EXP Carvedilol results in increased expression of NPHS1 CTD PMID:20452391 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A decreases expression
increases expression
decreases degradation
multiple interactions
ISO
EXP
carvedilol results in decreased expression of NPPA protein
carvedilol results in increased expression of NPPA mRNA; carvedilol results in increased expression of NPPA protein
carvedilol results in decreased expression of NPPA mRNA
carvedilol results in decreased degradation of NPPA protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP]
CTD PMID:1378157 PMID:9421401 PMID:10722803 PMID:11206715 PMID:21216836 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
increases expression
ISO
EXP
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
carvedilol inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]
carvedilol results in decreased expression of NPPB protein
carvedilol results in decreased expression of NPPB mRNA; carvedilol results in decreased expression of NPPB protein
carvedilol results in increased expression of NPPB mRNA
CTD PMID:11206715 PMID:19367012 PMID:19650993 PMID:19692266 PMID:20413026 PMID:21055277 PMID:21378469 PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP carvedilol results in decreased expression of NPR3 mRNA CTD PMID:9421401 PMID:11206715 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein] CTD PMID:16055083 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO carvedilol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein] CTD PMID:11904532 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgd phosphogluconate dehydrogenase multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein] CTD PMID:1378361 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:22413959 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP carvedilol results in increased expression of PPARGC1A mRNA CTD PMID:18971572 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP carvedilol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP carvedilol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon increases activity EXP carvedilol results in increased activity of PRKCE protein CTD PMID:16782078 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of PTAFR mRNA] CTD PMID:32569593 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP carvedilol results in decreased expression of PTGS1 mRNA CTD PMID:16741616 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein] CTD PMID:16940222 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of REG3B mRNA] CTD PMID:32569593 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of RELA protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Potassium Dichromate affects the localization of RELA protein] CTD PMID:25245570 PMID:26036690 PMID:30254303 PMID:32569593 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases expression ISO carvedilol results in decreased expression of REN protein CTD PMID:2454358 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ryr2 ryanodine receptor 2 affects activity
increases expression
multiple interactions
increases activity
ISO
EXP
carvedilol affects the activity of RYR2 protein; carvedilol analog affects the activity of RYR2 protein
carvedilol results in increased expression of RYR2 protein
[Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA
carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]
carvedilol results in increased expression of RYR2 mRNA
carvedilol results in increased activity of RYR2 protein
carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]; carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 PMID:19620082 PMID:21743453 PMID:21924056 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression EXP carvedilol results in decreased expression of S100A10 protein CTD PMID:20403466 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a11 S100 calcium binding protein A11 decreases expression EXP carvedilol results in decreased expression of S100A11 protein CTD PMID:20403466 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP carvedilol results in decreased expression of S100A6 protein CTD PMID:20403466 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein] CTD PMID:10722803 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO carvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380 PMID:21697722 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] CTD PMID:30254303 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression EXP
ISO
carvedilol results in increased expression of SOX2 mRNA CTD PMID:27288437 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:22413959 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of STAT1 protein] CTD PMID:32569593 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Terf2 telomeric repeat binding factor 2 affects expression EXP carvedilol affects the expression of TERF2 protein CTD PMID:22000973 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of TGFB1 mRNA
carvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of TGFB1 mRNA; carvedilol results in decreased expression of TGFB1 protein
Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Sodium, Dietary results in increased expression of TGFB1 mRNA]
CTD PMID:11682445 PMID:11688356 PMID:12227681 PMID:15921778 PMID:16310260 PMID:19692266 PMID:22413959 PMID:30254303, PMID:11682445 RGD:30296650 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein]
carvedilol results in decreased expression of TH mRNA; carvedilol results in decreased expression of TH protein
CTD PMID:20359859 PMID:22413959 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 protein]
carvedilol results in decreased expression of TIMP1 mRNA
CTD PMID:21216836 PMID:22413959 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol results in decreased expression of TNF mRNA; carvedilol results in decreased expression of TNF protein
Carvedilol inhibits the reaction [Arginine results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TNF protein]
CTD PMID:15229385 PMID:16310260 PMID:17964422 PMID:20017808 PMID:22413959 PMID:25245570 PMID:26036690 PMID:32569593 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
EXP carvedilol affects the expression of TP53 protein
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TP53 protein]
CTD PMID:22000973 PMID:25245570 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP carvedilol results in increased expression of TXN1 protein CTD PMID:20403466 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects metabolic processing
affects glucuronidation
ISO UGT1A1 protein results in increased glucuronidation of carvedilol
UGT1A1 gene polymorphism affects the metabolism of carvedilol
UGT1A1 gene polymorphism affects the glucuronidation of carvedilol
CTD PMID:14744946 PMID:16849011 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects glucuronidation
affects metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the metabolism of carvedilol
CTD PMID:14744946 PMID:16849011 PMID:17329852 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vim vimentin multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of VIM protein]; Carvedilol inhibits the reaction [Streptozocin results in increased expression of VIM protein] CTD PMID:12140129 PMID:30254303 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
Olivacine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [olivacine analog co-treated with Tetrachlorodibenzodioxin] results in increased activity of AHR protein
olivacine analog results in increased activity of AHR protein
CTD PMID:14709624 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects metabolic processing ISO CYP1A1 protein affects the metabolism of olivacine analog CTD PMID:14709624 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
ISO olivacine analog results in increased expression of and results in increased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of olivacine analog
CTD PMID:14709624 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing ISO FMO3 protein affects the metabolism of olivacine analog CTD PMID:14709624 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
Ondansetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein] CTD PMID:31332906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Ondansetron CTD PMID:15286053 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
affects metabolic processing
ISO CYP2D6 protein results in increased metabolism of Ondansetron
CYP2D6 protein affects the metabolism of Ondansetron
CTD PMID:12464242 PMID:15286053 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Ondansetron CTD PMID:15286053 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Ondansetron inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein] CTD PMID:16794574 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Ondansetron inhibits the reaction [Cocaine results in decreased phosphorylation of GRIN2B protein]; Ondansetron inhibits the reaction [Cocaine results in increased expression of GRIN2B protein] CTD PMID:16794574 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Ondansetron promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] CTD PMID:24001450 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects binding
ISO
EXP
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]; Ondansetron binds to and results in decreased activity of HTR3A protein
Ondansetron binds to HTR3A protein
CTD PMID:11919526 PMID:12130853 PMID:17201744 PMID:21486038 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G L1cam L1 cell adhesion molecule multiple interactions EXP Ondansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein] CTD PMID:16900104 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Ondansetron promotes the reaction [Cisplatin results in increased expression of LCN2 mRNA] CTD PMID:24001450 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]
Ondansetron inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]
CTD PMID:21599003 PMID:24001450 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases response to substance
multiple interactions
ISO SLC47A1 gene mutant form results in decreased susceptibility to Ondansetron
Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]
Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]
CTD PMID:21599003 PMID:24001450 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin] CTD PMID:21599003 PMID:24001450 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                organonitrogen heterocyclic compound 17526
                  dibenzopyrrole 227
                    carbazoles + 227
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      dibenzopyrrole 227
                                        carbazoles + 227
paths to the root