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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dibenzopyran
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Accession:CHEBI:39203 term browser browse the term
Definition:Any organic heteropolycyclic compound based on a skeleton consisting of a pyran ring fused with two benzene rings.
Synonyms:related_synonym: dibenzopyrans


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2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc5 ATP-binding cassette, sub-family C member 5 increases export
multiple interactions		 ISO ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]		 CTD PMID:16156793 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144 		JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 affects transport
multiple interactions
increases export
increases transport		 ISO ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]		 CTD PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 More... NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions
increases transport		 ISO [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]		 CTD PMID:24907646 PMID:31348918 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc5 ATP-binding cassette, sub-family C member 5 multiple interactions
increases uptake
increases transport		 ISO Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC5 protein results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein		 CTD PMID:31348918 PMID:35066093 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144 		JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions
increases transport		 ISO quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 increases export ISO ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects export
multiple interactions		 ISO ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]		 CTD PMID:11477083 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 increases import
increases uptake
multiple interactions		 ISO SLC22A6 protein results in increased import of 6-carboxyfluorescein
SLC22A6 protein results in increased uptake of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Unithiol analog inhibits the reaction [SLC22A6 protein results in increased uptake of 6-carboxyfluorescein]		 CTD PMID:20237588 PMID:28629854 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases import
increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased import of 6-carboxyfluorescein
SLC22A8 protein results in increased uptake of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Unithiol analog inhibits the reaction [SLC22A8 protein results in increased uptake of 6-carboxyfluorescein]		 CTD PMID:20237588 PMID:28629854 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
decreases expression		 ISO
EXP		 [mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [mangostin results in decreased expression of ACTA2 protein]; mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]
mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:30502394 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO mangostin affects the localization of AIFM1 protein CTD PMID:24480042 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions		 ISO mangostin results in decreased phosphorylation of AKT1 protein
[mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein		 CTD PMID:23954321 PMID:30502394 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO mangostin results in increased expression of BAX protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO mangostin results in decreased expression of BCL2 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO mangostin results in decreased expression of BID protein CTD PMID:24480042 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:26357513 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein] CTD PMID:24480042 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 increases activity ISO mangostin results in increased activity of CASP8 protein CTD PMID:24480042 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity ISO mangostin results in increased activity of CASP9 protein CTD PMID:23954321 PMID:24480042 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mangostin results in increased expression of CYCS protein CTD PMID:24480042 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression
affects response to substance		 ISO ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein]
mangostin results in decreased expression of ESR1 protein
ESR1 protein affects the susceptibility to mangostin		 CTD PMID:24480042 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases secretion		 ISO
EXP		 diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein]; mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]
mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]		 CTD PMID:30502394 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
mangostin analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO mangostin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
mangostin analog results in increased phosphorylation of MAPK3 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK8 protein CTD PMID:28722351 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO mangostin analog results in increased phosphorylation of MAPK9 protein CTD PMID:28722351 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]
mangostin analog results in decreased expression of MMP2 mRNA; mangostin analog results in decreased expression of MMP2 protein		 CTD PMID:28722351 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]
mangostin analog results in decreased expression of MMP9 mRNA; mangostin analog results in decreased expression of MMP9 protein		 CTD PMID:28722351 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] CTD PMID:18424012 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression		 ISO
EXP		 SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [mangostin results in decreased secretion of HMGB1 protein]
[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein
mangostin results in increased expression of SIRT3 protein		 CTD PMID:30502394 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO mangostin results in decreased expression of TFF1 protein CTD PMID:24480042 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:18424012 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO mangostin results in increased expression of TP53 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
bellidifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 a disintegrin and metallopeptidase domain 17 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of ADAM17 mRNA] CTD PMID:37528096 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of AKT1 mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:36518482 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions EXP bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 protein] CTD PMID:37528096 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein] CTD PMID:37127800 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 increases expression ISO bellidifolin results in increased expression of CASP3 protein CTD PMID:33299414 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases expression ISO bellidifolin results in increased expression of CASP8 protein CTD PMID:33299414 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO bellidifolin results in decreased expression of CEBPB mRNA CTD PMID:33299414 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Gck glucokinase decreases activity EXP bellidifolin results in decreased activity of GCK protein CTD PMID:19962285 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO bellidifolin results in increased expression of GCLC mRNA; bellidifolin results in increased expression of GCLC protein CTD PMID:30800665 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form]; bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSDMD protein] CTD PMID:37127800 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B protein] CTD PMID:36518482 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO bellidifolin results in increased expression of HMOX1 mRNA; bellidifolin results in increased expression of HMOX1 protein CTD PMID:30800665 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL18 protein] CTD PMID:37127800 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL1B protein] CTD PMID:37127800 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Insr insulin receptor increases expression EXP bellidifolin results in increased expression of INSR CTD PMID:19962285 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Irs1 insulin receptor substrate 1 increases expression EXP bellidifolin results in increased expression of IRS1 CTD PMID:19962285 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein] CTD PMID:37528096 NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein] CTD PMID:37127800 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 protein] CTD PMID:37528096 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nppa natriuretic peptide type A multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] CTD PMID:37528096 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:37528096 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein] CTD PMID:33995055 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases expression ISO bellidifolin results in decreased expression of PARP1 protein CTD PMID:33299414 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) decreases expression ISO bellidifolin results in decreased expression of PTGER2 mRNA CTD PMID:33299414 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) decreases expression ISO bellidifolin results in decreased expression of PTGER4 mRNA CTD PMID:33299414 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO bellidifolin results in decreased expression of PTGS2 protein CTD PMID:33299414 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PYCARD protein] CTD PMID:37127800 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein] CTD PMID:33995055 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:33995055 PMID:35586685 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein] CTD PMID:33995055 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of SOX9 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]		 CTD PMID:35586685 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO bellidifolin results in decreased expression of and results in decreased phosphorylation of STAT3 protein
bellidifolin results in decreased expression of STAT3 mRNA		 CTD PMID:33299414 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:33995055 PMID:35586685 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein] CTD PMID:33995055 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein] CTD PMID:33995055 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA] CTD PMID:37528096 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases secretion
increases export		 ISO
EXP		 [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]		 CTD PMID:10571255 PMID:12235267 PMID:16442095 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects export
increases export
increases import
affects transport
multiple interactions		 ISO
EXP		 ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
[Glycyrrhetinic Acid affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [Indomethacin affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [matairesinol affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [verlukast affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]		 CTD PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18204840 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects export
increases abundance
multiple interactions
affects transport		 ISO ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon		 CTD PMID:15670588 PMID:15848949 PMID:22027652 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 affects transport ISO ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726 		JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 affects export
multiple interactions		 EXP ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]		 CTD PMID:10617675 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases transport
increases export
multiple interactions
increases activity
affects export
increases secretion		 ISO ABCB1 protein results in increased transport of calcein AM
ABCB1 protein results in increased export of calcein AM
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
calcein AM results in increased activity of ABCB1 protein mutant form		 CTD PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 increases transport
multiple interactions		 ISO ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]		 CTD PMID:19239227 PMID:19647055 PMID:27376922 PMID:34896433 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects transport
multiple interactions
increases transport
increases export		 ISO ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]		 CTD PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 affects transport
multiple interactions
increases transport		 ISO ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]		 CTD PMID:15210835 PMID:15979871 PMID:19647055 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions ISO Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions ISO Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
Cannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity ISO Cannabinol results in decreased activity of ABCC1 protein CTD PMID:18619955 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects binding ISO Cannabinol binds to CNR1 protein CTD PMID:19679411 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 multiple interactions
increases metabolic processing		 ISO Cannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]
CYP2J2 protein results in increased metabolism of Cannabinol		 CTD PMID:29689453 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of FOS protein CTD PMID:10670588 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:11520904 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]; Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]; Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]; KN 93 inhibits the reaction [Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]] CTD PMID:8662742 PMID:10670588 PMID:11809870 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of JUN protein CTD PMID:10670588 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Prl prolactin multiple interactions ISO Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein] CTD PMID:31154070 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Cannabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:19910459 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity		 ISO [Cannabinol results in increased activity of TRPA1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions ISO Cannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr11:62,465,312...62,491,131
Ensembl chr11:62,465,312...62,491,341 		JBrowse link
cudratricusxanthone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein] CTD PMID:31350693 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein] CTD PMID:31350693 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the phosphorylation of and affects the expression of and affects the localization of JUN protein] CTD PMID:31350693 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:31350693 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:31350693 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31350693 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein] CTD PMID:31350693 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:31350693 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TICAM1 protein] CTD PMID:31350693 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31350693 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31350693 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
euxanthone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:34655103 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:34655103 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:34655103 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein] CTD PMID:34655103 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:34655103 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO euxanthone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:34655103 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
Fluo-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 affects export EXP ABCC1 protein affects the export of Fluo-3 CTD PMID:15948026 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
increases secretion		 ISO Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] CTD PMID:9794919 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
fluorescein (lactone form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO [CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Sulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Fluorescein results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
increases uptake		 ISO bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein] CTD PMID:27989701 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 increases uptake
multiple interactions		 ISO SLCO3A1 protein results in increased uptake of Fluorescein
Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]		 CTD PMID:28887287 NCBI chr 7:73,925,166...74,204,528
Ensembl chr 7:73,925,167...74,204,528 		JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP-binding cassette, sub-family B member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:103,324,171...103,457,452
Ensembl chr  X:103,324,263...103,457,462 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566 		JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:167,578,091...168,087,436
Ensembl chr  X:167,578,095...168,087,431 		JBrowse link
G Azi2 5-azacytidine induced gene 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 9:117,869,510...117,898,866
Ensembl chr 9:117,869,567...117,898,862 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 4:138,920,210...139,019,131
Ensembl chr 4:138,920,210...139,019,129 		JBrowse link
G Cd109 CD109 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 9:78,522,828...78,623,542
Ensembl chr 9:78,522,828...78,623,535 		JBrowse link
G Cd180 CD180 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr13:102,830,055...102,843,139
Ensembl chr13:102,830,066...102,876,137 		JBrowse link
G Cd86 CD86 antigen increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cd93 CD93 antigen affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 2:148,278,571...148,285,455
Ensembl chr 2:148,278,560...148,285,483 		JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549 		JBrowse link
G Copa coatomer protein complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr 1:171,909,885...171,949,899
Ensembl chr 1:171,910,096...171,949,897 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr12:83,567,145...83,588,768
Ensembl chr12:83,567,240...83,588,694 		JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr10:80,590,935...80,631,295
Ensembl chr10:80,591,040...80,631,295 		JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:73,868,109...73,887,589
Ensembl chr18:73,868,109...73,887,550 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr11:118,879,007...118,884,047
Ensembl chr11:118,879,014...118,884,047 		JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 2:140,500,118...140,513,396
Ensembl chr 2:140,492,834...140,513,389 		JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein		 CTD PMID:27871981 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa5 heat shock protein 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa9 heat shock protein 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 PMID:36870414 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr10:128,466,708...128,505,668
Ensembl chr10:128,466,712...128,505,227 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein CTD PMID:36870414 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 6:113,435,659...113,447,719
Ensembl chr 6:113,435,445...113,447,719 		JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr13:112,649,439...112,717,266
Ensembl chr13:112,656,432...112,730,894 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression		 EXP [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:29198882 PMID:36870414 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 7:24,335,995...24,340,543
Ensembl chr 7:24,335,975...24,340,543 		JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 2:72,115,970...72,272,954
Ensembl chr 2:72,115,981...72,272,954 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:27129696 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein		 CTD PMID:27129696 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]		 CTD PMID:27129696 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]		 CTD PMID:27129696 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mt2 metallothionein 2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mybpc1 myosin binding protein C, slow-type affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr10:88,354,141...88,441,051
Ensembl chr10:88,354,141...88,441,014 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions		 ISO
EXP		 Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]		 CTD PMID:20491607 PMID:27871981 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474 		JBrowse link
G Postn periostin, osteoblast specific factor affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458 		JBrowse link
G Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr19:46,044,955...46,061,348
Ensembl chr19:46,033,325...46,061,354 		JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 2:24,257,571...24,299,882
Ensembl chr 2:24,257,592...24,304,966 		JBrowse link
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 2:61,542,038...61,630,720
Ensembl chr 2:61,542,038...61,630,720 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 9:63,045,446...63,056,243
Ensembl chr 9:63,045,452...63,056,243 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 multiple interactions
increases uptake		 ISO Taurocholic Acid promotes the reaction [SLC10A1 protein results in increased uptake of Fluorescein-5-isothiocyanate] CTD PMID:32209977 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr11:119,994,777...120,042,177
Ensembl chr11:119,994,786...120,042,172 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]		 CTD PMID:27871981 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases phosphorylation
multiple interactions		 EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]		 CTD PMID:27871981 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
increases phosphorylation		 EXP diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions		 EXP Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]		 CTD PMID:27871981 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 9:66,421,573...66,501,996
Ensembl chr 9:66,421,919...66,500,424 		JBrowse link
gallein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of AKT1 protein] CTD PMID:35901927 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]] CTD PMID:35901927 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2 protein] CTD PMID:35901927 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2L1 protein] CTD PMID:35901927 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Cat catalase multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of CAT protein] CTD PMID:35901927 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of GPX1 protein] CTD PMID:35901927 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of MAPK1 protein] CTD PMID:35901927 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of MAPK3 protein] CTD PMID:35901927 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
JBIR-99 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO JBIR-99 results in increased expression of BAX protein CTD PMID:31433962 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO JBIR-99 results in decreased expression of BCL2 protein CTD PMID:31433962 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression ISO JBIR-99 results in increased expression of CASP3 protein CTD PMID:31433962 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO JBIR-99 results in increased expression of CYCS protein CTD PMID:31433962 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases expression ISO JBIR-99 results in increased expression of IKBKB protein CTD PMID:31433962 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 decreases expression ISO JBIR-99 results in decreased expression of PARP1 protein CTD PMID:31433962 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases expression ISO JBIR-99 results in increased expression of RELA protein CTD PMID:31433962 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
mangiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases expression		 ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein]
mangiferin results in increased expression of ABCB1 mRNA; mangiferin results in increased expression of ABCB1 protein		 CTD PMID:20513373 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase decreases expression ISO mangiferin results in decreased expression of ABL1 mRNA CTD PMID:15498116 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
increases phosphorylation		 ISO dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of ACACA protein] CTD PMID:22292039 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP mangiferin results in decreased activity of ACHE protein
mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]		 CTD PMID:19182383 PMID:22426032 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:20683903 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions EXP [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein CTD PMID:32417366 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression ISO mangiferin results in decreased expression of AGER mRNA; mangiferin results in decreased expression of AGER protein CTD PMID:24036348 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] CTD PMID:17645561 PMID:19706694 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:17645561 PMID:19706694 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] CTD PMID:19201465 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of AKT1 protein]
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]		 CTD PMID:19201465 PMID:22465218 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO mangiferin binds to ALB protein CTD PMID:19157745 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions EXP mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] CTD PMID:23451106 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:20683903 NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP		 mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]		 CTD PMID:19201465 PMID:23451106 PMID:24095822 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of BCL2 protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]		 CTD PMID:21420233 PMID:22118634 PMID:23451106 PMID:24095822 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO mangiferin results in decreased expression of BCL2L1 protein CTD PMID:21547680 PMID:26996543 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO mangiferin results in decreased expression of BIRC5 protein CTD PMID:26996543 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G C3 complement component 3 decreases expression EXP mangiferin results in decreased expression of C3 mRNA CTD PMID:15135318 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Calcr calcitonin receptor multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:20683903 NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]
mangiferin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]
mangiferin results in increased activity of CASP3 protein
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP3 protein]		 CTD PMID:21547680 PMID:22118634 PMID:22310181 PMID:23451106 PMID:26996543 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases expression
multiple interactions		 ISO mangiferin results in increased expression of CASP8 protein
mangiferin inhibits the reaction [aluminum maltolate results in increased activity of CASP8 protein]		 CTD PMID:32420661 PMID:37455591 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO		 mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
mangiferin inhibits the reaction [aluminum maltolate results in increased activity of CASP9 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP9 protein]		 CTD PMID:22118634 PMID:23451106 PMID:37455591 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP
ISO		 mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CAT mRNA]; mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
mangiferin results in increased activity of CAT protein		 CTD PMID:15161907 PMID:16076520 PMID:16584858 PMID:16697266 PMID:17433543 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP mangiferin results in decreased expression of CCL2 mRNA CTD PMID:15135318 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein] CTD PMID:15135318 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO mangiferin results in increased expression of CCNB1 mRNA CTD PMID:20518311 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [mangiferin results in increased expression of CD36 protein] CTD PMID:22292039 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
multiple interactions		 ISO mangiferin results in increased expression of CDH1 protein
mangiferin affects the expression of CDH1 protein
lipopolysaccharide, Escherichia coli O111 B4 affects the reaction [mangiferin affects the expression of CDH1 protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression ISO mangiferin results in increased expression of CDK1 mRNA CTD PMID:20518311 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of CHUK protein]		 CTD PMID:21420233 PMID:22310181 PMID:23451106 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions EXP [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CIDEA mRNA CTD PMID:32417366 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA] CTD PMID:19706694 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col4a1 collagen, type IV, alpha 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA] CTD PMID:19706694 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions		 ISO mangiferin results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of CPT1A protein]		 CTD PMID:22292039 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions
decreases expression		 EXP mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]
mangiferin results in decreased expression of CSF2 mRNA		 CTD PMID:15135318 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) multiple interactions
decreases expression		 EXP mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]
mangiferin results in decreased expression of CSF3 mRNA		 CTD PMID:15135318 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Ctnnb1 catenin beta 1 decreases response to substance ISO CTNNB1 protein results in decreased susceptibility to mangiferin CTD PMID:23707762 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions ISO mangiferin inhibits the reaction [Paraquat results in decreased expression of and affects the localization of CTNND1 protein]; mangiferin inhibits the reaction [Paraquat results in decreased expression of CTNND1 mRNA alternative form] CTD PMID:24912632 NCBI chr 2:84,417,440...84,489,321
Ensembl chr 2:84,430,415...84,481,109
Ensembl chr 2:84,430,415...84,481,109 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsk cathepsin K multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:20683903 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
affects expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
mangiferin affects the expression of CXCL15 protein		 CTD PMID:21420233 PMID:21837981 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CXCR4 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] CTD PMID:21420233 PMID:32420661 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO mangiferin results in increased expression of CYP1A1 mRNA CTD PMID:22815239 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO mangiferin results in decreased activity of CYP1A2 protein
mangiferin results in increased expression of CYP1A2 mRNA		 CTD PMID:18053976 PMID:22815239 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 decreases activity ISO mangiferin results in decreased activity of CYP2A6 protein CTD PMID:22815239 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO mangiferin results in decreased activity of CYP2C6V1 protein CTD PMID:18053976 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO mangiferin results in decreased activity of CYP2C9 protein CTD PMID:22815239 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO mangiferin results in decreased activity of CYP2E1 protein CTD PMID:18053976 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:20683903 NCBI chr15:39,609,326...39,624,334
Ensembl chr15:39,609,326...39,624,334 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression
affects expression
multiple interactions		 ISO mangiferin results in decreased expression of DGAT2 protein
mangiferin affects the expression of DGAT2 mRNA; mangiferin affects the expression of DGAT2 protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of DGAT2 protein]		 CTD PMID:22292039 PMID:25123789 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO mangiferin inhibits the reaction [Methylmercury Compounds results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:28071871 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G F10 coagulation factor X decreases activity ISO mangiferin analog results in decreased activity of F10 protein CTD PMID:21732671 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO mangiferin results in increased expression of FAS protein CTD PMID:17634039 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression EXP mangiferin results in decreased expression of FBP1 mRNA CTD PMID:19028559 NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Gcg glucagon multiple interactions ISO [mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form CTD PMID:22948814 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Glo1 glyoxalase 1 increases expression
multiple interactions		 ISO mangiferin results in increased expression of GLO1 mRNA
mangiferin results in increased expression of and results in increased activity of GLO1 protein		 CTD PMID:24036348 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO mangiferin inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP
ISO		 mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Methylmercury Compounds results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]		 CTD PMID:16697266 PMID:18816296 PMID:23451106 PMID:28071871 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein] CTD PMID:19172585 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA]]; mangiferin inhibits the reaction [Galactosamine results in decreased expression of HMOX1 protein]; mangiferin inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA] CTD PMID:22310181 PMID:36249937 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
mangiferin results in decreased expression of ICAM1 mRNA		 CTD PMID:15135318 PMID:15161907 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Icam2 intercellular adhesion molecule 2 decreases expression EXP mangiferin results in decreased expression of ICAM2 mRNA CTD PMID:15135318 NCBI chr11:106,268,482...106,278,948
Ensembl chr11:106,268,482...106,278,901 		JBrowse link
G Icam5 intercellular adhesion molecule 5, telencephalin decreases expression EXP mangiferin results in decreased expression of ICAM5 mRNA CTD PMID:15135318 NCBI chr 9:20,943,372...20,950,331
Ensembl chr 9:20,943,369...20,950,332 		JBrowse link
G Ifna1 interferon alpha 1 increases expression EXP mangiferin results in increased expression of IFNA1 mRNA CTD PMID:15135318 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast increases expression EXP mangiferin results in increased expression of IFNB1 mRNA CTD PMID:15135318 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO		 mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of IFNG mRNA]		 CTD PMID:12694877 PMID:15135318 PMID:15177302 PMID:15177305 PMID:15222974 More... NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein]		 CTD PMID:21420233 PMID:22310181 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in decreased expression of IL10 mRNA] CTD PMID:22310181 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12a interleukin 12a decreases expression EXP mangiferin results in decreased expression of IL12A mRNA CTD PMID:15135318 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880 		JBrowse link
G Il12b interleukin 12b multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] CTD PMID:22310181 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha decreases expression EXP mangiferin results in decreased expression of IL1A mRNA CTD PMID:15135318 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL1B mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:15381052 PMID:22310181 PMID:27125760 PMID:27474068 PMID:36249937 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2rb interleukin 2 receptor, beta chain decreases expression EXP mangiferin results in decreased expression of IL2RB mRNA CTD PMID:15135318 NCBI chr15:78,363,456...78,396,569
Ensembl chr15:78,363,456...78,379,471 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 mangiferin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein]
mangiferin results in decreased expression of IL6 mRNA		 CTD PMID:15135318 PMID:21420233 PMID:22310181 PMID:23087136 PMID:27474068 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions
affects expression		 EXP
ISO		 [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CIDEA mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARA mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A protein; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 protein; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP1 protein
[mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of INS1 protein; mangiferin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]
mangiferin affects the expression of INS1 protein		 CTD PMID:22948814 PMID:24167738 PMID:32417366 PMID:37044004 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression EXP mangiferin results in decreased expression of IRF1 mRNA CTD PMID:15135318 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity
increases expression		 ISO MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA] CTD PMID:15975614 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases phosphorylation ISO mangiferin results in decreased phosphorylation of MAP3K14 protein CTD PMID:26996543 NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
decreases activity
affects binding
multiple interactions		 EXP
ISO		 mangiferin results in increased phosphorylation of MAPK1 protein
mangiferin metabolite results in decreased activity of MAPK1 protein
mangiferin metabolite binds to MAPK1 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 multiple interactions ISO mangiferin inhibits the reaction [aluminum maltolate results in increased expression of and results in increased activity of MAPK10 protein] CTD PMID:37455591 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases activity
increases phosphorylation		 EXP
ISO		 mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
mangiferin metabolite results in decreased activity of MAPK3 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
mangiferin results in increased phosphorylation of MAPK3 protein		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP mangiferin results in decreased expression of MAPK8 mRNA CTD PMID:15135318 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP mangiferin results in decreased expression of MAPK9 mRNA CTD PMID:15135318 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Max Max protein decreases expression EXP mangiferin results in decreased expression of MAX mRNA CTD PMID:15135318 NCBI chr12:76,984,045...77,009,123
Ensembl chr12:76,984,043...77,008,975 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO mangiferin results in decreased expression of MMP7 protein CTD PMID:23707762 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
decreases activity		 ISO
EXP		 mangiferin results in decreased expression of MMP9 mRNA; mangiferin results in decreased expression of MMP9 protein
mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
mangiferin results in decreased expression of and results in decreased secretion of MMP9 protein
mangiferin results in decreased activity of MMP9 protein		 CTD PMID:22465218 PMID:23707762 PMID:27125760 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP mangiferin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:27125760 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA]]; mangiferin affects the reaction [Galactosamine affects the localization of NFE2L2 protein]; mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFE2L2 protein]; mangiferin inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA] CTD PMID:22310181 PMID:36249937 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of NFKB1 mRNA]]; mangiferin inhibits the reaction [Methotrexate results in increased expression of NFKB1 mRNA]		 CTD PMID:15161907 PMID:36249937 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]
mangiferin results in increased expression of NFKBIA protein
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]		 CTD PMID:15161907 PMID:20683903 PMID:22310181 PMID:23451106 PMID:27474068 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta decreases expression
multiple interactions		 EXP
ISO		 mangiferin results in decreased expression of NFKBIB mRNA
mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]		 CTD PMID:15135318 PMID:21420233 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon decreases expression EXP mangiferin results in decreased expression of NFKBIE mRNA CTD PMID:15135318 NCBI chr17:45,866,626...45,874,095
Ensembl chr17:45,866,629...45,874,095 		JBrowse link
G Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 decreases expression EXP mangiferin results in decreased expression of NFKBIL1 mRNA CTD PMID:15135318 NCBI chr17:35,439,151...35,455,457
Ensembl chr17:35,439,151...35,454,768 		JBrowse link
G Ngf nerve growth factor increases secretion ISO mangiferin results in increased secretion of NGF protein CTD PMID:20303935 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of NLRP3 protein] CTD PMID:32420661 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of NOS2 mRNA]]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [Methotrexate results in increased expression of NOS2 mRNA]; mangiferin promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNFB protein] results in increased expression of NOS2 mRNA]		 CTD PMID:12694877 PMID:15381052 PMID:22118634 PMID:22310181 PMID:27474068 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in decreased expression of NQO1 protein] CTD PMID:22310181 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Oga O-GlcNAcase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of OGA protein]]; mangiferin inhibits the reaction [Methotrexate results in increased expression of OGA protein] CTD PMID:36249937 NCBI chr19:45,738,698...45,772,274
Ensembl chr19:45,738,698...45,772,276 		JBrowse link
G Per1 period circadian clock 1 multiple interactions
affects expression		 ISO mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of PER1 protein]
mangiferin affects the expression of PER1 protein		 CTD PMID:32420661 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) decreases activity ISO mangiferin results in decreased activity of PLA2G2A protein CTD PMID:15177302 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity		 ISO
EXP		 MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARA mRNA		 CTD PMID:15975614 PMID:32417366 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]]; mangiferin inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein		 CTD PMID:29223569 PMID:32417366 PMID:36249937 PMID:37044004 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A protein CTD PMID:32417366 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prdm16 PR domain containing 16 multiple interactions EXP [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 protein CTD PMID:32417366 NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions ISO dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein CTD PMID:22292039 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
mangiferin affects the expression of PTGS2 mRNA		 CTD PMID:15161907 PMID:15381052 PMID:18621015 PMID:19026997 PMID:21420233 More... NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 decreases expression EXP mangiferin results in decreased expression of RAF1 mRNA CTD PMID:15135318 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
affects localization
decreases expression
decreases localization		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the localization of RELA protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [Galactosamine results in increased expression of RELA protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]; mangiferin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
mangiferin results in decreased expression of RELA mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]
mangiferin results in decreased localization of RELA protein		 CTD PMID:15135318 PMID:15161907 PMID:19182383 PMID:19201465 PMID:20683903 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B decreases expression EXP mangiferin results in decreased expression of RELB mRNA CTD PMID:15135318 NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 decreases expression EXP mangiferin results in decreased expression of RIPK1 mRNA CTD PMID:15135318 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Saa1 serum amyloid A 1 decreases expression EXP mangiferin results in decreased expression of SAA1 mRNA CTD PMID:15135318 NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404 		JBrowse link
G Sele selectin, endothelial cell decreases expression EXP mangiferin results in decreased expression of SELE mRNA CTD PMID:15135318 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Selplg selectin, platelet (p-selectin) ligand decreases expression EXP mangiferin results in decreased expression of SELPLG mRNA CTD PMID:15135318 NCBI chr 5:113,955,859...113,970,576
Ensembl chr 5:113,956,597...113,970,705 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA] CTD PMID:19706694 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 increases expression EXP mangiferin results in increased expression of SLC22A1 mRNA CTD PMID:21348301 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 decreases expression EXP mangiferin results in decreased expression of SLC22A12 mRNA; mangiferin results in decreased expression of SLC22A12 protein CTD PMID:21348301 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 increases expression EXP mangiferin results in increased expression of SLC22A2 mRNA CTD PMID:21348301 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 increases expression EXP mangiferin results in increased expression of SLC22A4 mRNA CTD PMID:21348301 NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases expression EXP mangiferin results in increased expression of SLC22A5 mRNA CTD PMID:21348301 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases expression		 EXP
ISO		 2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; mangiferin affects the localization of and results in increased activity of SLC2A4 protein; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Glucose]
mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
mangiferin results in increased expression of SLC2A4 mRNA		 CTD PMID:19477051 PMID:29223569 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Snai1 snail family zinc finger 1 decreases expression ISO mangiferin results in decreased expression of SNAI1 protein CTD PMID:23707762 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Snai2 snail family zinc finger 2 decreases expression ISO mangiferin results in decreased expression of SNAI2 protein CTD PMID:23707762 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA] CTD PMID:17433543 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO mangiferin results in decreased activity of SRD5A2 protein CTD PMID:20823678 NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911 		JBrowse link
G Srf serum response factor decreases expression EXP mangiferin results in decreased expression of SRF mRNA CTD PMID:15135318 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases expression EXP mangiferin results in decreased expression of TAB1 mRNA CTD PMID:15135318 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908 		JBrowse link
G Tbk1 TANK-binding kinase 1 decreases expression EXP mangiferin results in decreased expression of TBK1 mRNA CTD PMID:15135318 NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO mangiferin results in decreased activity of TERT protein CTD PMID:17634039 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; mangiferin inhibits the reaction [Streptozocin results in increased secretion of TGFB1 protein]		 CTD PMID:12694877 PMID:19706694 PMID:19960420 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tlr6 toll-like receptor 6 decreases expression EXP mangiferin results in decreased expression of TLR6 mRNA CTD PMID:15135318 NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440 		JBrowse link
G Tlr7 toll-like receptor 7 decreases expression EXP mangiferin results in decreased expression of TLR7 mRNA CTD PMID:15135318 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tlr8 toll-like receptor 8 decreases expression EXP mangiferin results in decreased expression of TLR8 mRNA CTD PMID:15135318 NCBI chr  X:166,024,119...166,047,325
Ensembl chr  X:166,025,692...166,047,325 		JBrowse link
G Tlr9 toll-like receptor 9 decreases expression EXP mangiferin results in decreased expression of TLR9 mRNA CTD PMID:15135318 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
affects expression
increases secretion		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein]; mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of TNF protein]; mangiferin inhibits the reaction [Streptozocin results in increased expression of TNF protein]
mangiferin results in decreased expression of TNF mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the expression of TNF protein
mangiferin results in increased secretion of TNF protein		 CTD PMID:12694877 PMID:15135318 PMID:15161907 PMID:15177305 PMID:15222974 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator decreases expression EXP mangiferin results in decreased expression of TNFRSF11A mRNA CTD PMID:15135318 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:20683903 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases expression EXP mangiferin results in decreased expression of TRADD mRNA CTD PMID:15135318 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241 		JBrowse link
G Traf6 TNF receptor-associated factor 6 decreases expression EXP mangiferin results in decreased expression of TRAF6 mRNA CTD PMID:15135318 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO mangiferin inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:10657591 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions EXP [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP1 protein CTD PMID:32417366 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
decreases activity		 ISO mangiferin results in increased expression of UGT1A1 mRNA
mangiferin results in decreased activity of UGT1A1 protein		 CTD PMID:22815239 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases expression ISO mangiferin results in increased expression of UGT1A9 mRNA CTD PMID:22815239 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 decreases activity ISO mangiferin results in decreased activity of UGT2B7 protein CTD PMID:22815239 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G Umod uromodulin affects expression EXP mangiferin affects the expression of UMOD protein CTD PMID:21348301 NCBI chr 7:119,061,931...119,078,485
Ensembl chr 7:119,061,934...119,078,505 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP mangiferin results in decreased expression of VCAM1 mRNA CTD PMID:15135318 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:21420233 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO mangiferin results in decreased expression of VIM protein
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of VIM protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]
mangiferin results in decreased expression of XIAP protein		 CTD PMID:21420233 PMID:21547680 PMID:26996543 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
norathyriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO norathyriol results in increased expression of ABCB1 protein CTD PMID:20513373 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects binding
decreases activity		 ISO
EXP		 norathyriol binds to MAPK1 protein
norathyriol results in decreased activity of MAPK1 protein		 CTD PMID:22084399 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases activity EXP norathyriol results in decreased activity of MAPK3 protein CTD PMID:22084399 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] CTD PMID:18393431 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions ISO norathyriol inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased activity of PPARD protein] CTD PMID:18393431 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] CTD PMID:18393431 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
norswertianolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO norswertianolin results in increased expression of GCLC mRNA; norswertianolin results in increased expression of GCLC protein CTD PMID:30800665 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO norswertianolin results in increased expression of HMOX1 mRNA; norswertianolin results in increased expression of HMOX1 protein CTD PMID:30800665 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions EXP Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
Propantheline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Propantheline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
psorospermin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO psorospermin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:7083125 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
rhodamine 123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
decreases uptake
increases export		 ISO 3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5-hydroxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of Rhodamine 123; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; daidzein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Quercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; tangeretin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]		 CTD PMID:25058526 PMID:27816545 PMID:30391378 PMID:31756430 PMID:33321149 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases export
multiple interactions		 ISO ABCG2 protein results in increased export of Rhodamine 123
abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123]		 CTD PMID:27816545 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
rhodamine 6G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO rhodamine 6G results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
rose bengal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO Rose Bengal results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Rose Bengal results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Rose Bengal results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Klkb1 kallikrein B, plasma 1 multiple interactions
decreases response to substance		 EXP 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] CTD PMID:25339356 NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases activity ISO Rose Bengal results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
vadimezan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 affects export
affects transport		 ISO ABCC1 protein affects the export of vadimezan metabolite
ABCC1 protein affects the transport of vadimezan analog		 CTD PMID:15282097 PMID:15784341 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects transport
affects export		 ISO ABCC2 protein affects the transport of vadimezan analog
ABCC2 protein affects the export of vadimezan metabolite		 CTD PMID:15282097 PMID:15784341 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]] CTD PMID:37046119 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases oxidation		 ISO Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan] CTD PMID:16120190 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:37046119 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast increases expression EXP vadimezan results in increased expression of IFNB1 mRNA CTD PMID:36958387 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO vadimezan results in increased expression of IL1A protein CTD PMID:16944150 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 vadimezan results in increased expression of IL6 protein
vadimezan results in increased expression of IL6 mRNA
vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 protein]]		 CTD PMID:16944150 PMID:36958387 PMID:37046119 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf3 interferon regulatory factor 3 increases phosphorylation EXP vadimezan results in increased phosphorylation of IRF3 protein CTD PMID:36958387 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 multiple interactions EXP [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of RELA protein; [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of STING1 protein; [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of TBK1 protein; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of CCL2 protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of GPT protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of IL6 protein]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]]; vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen] CTD PMID:37046119 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of RELA protein CTD PMID:37046119 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 multiple interactions EXP [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of STING1 protein CTD PMID:37046119 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607 		JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions EXP [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of TBK1 protein CTD PMID:37046119 NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]]; vadimezan affects the reaction [P2RX1 protein affects the reaction [Acetaminophen results in increased expression of TNF protein]]
vadimezan results in increased expression of TNF mRNA
vadimezan results in increased expression of TNF protein		 CTD PMID:15060740 PMID:16944150 PMID:36958387 PMID:37046119 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO vadimezan results in increased expression of VEGFA protein CTD PMID:16944150 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
xanthenes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity
multiple interactions
increases export
increases transport		 ISO
EXP		 Xanthenes results in decreased activity of ABCB1 protein
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; Rafoxanide results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; triclabendazole results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; triclabendazole sulfoxide results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; valspodar results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes
ABCB1 protein results in increased export of Xanthenes
ABCB1 protein results in increased transport of Xanthenes
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; Calcium deficiency inhibits the reaction [ABCB1 protein results in increased export of Xanthenes]		 CTD PMID:18686201 PMID:20041016 PMID:20513441 PMID:21436125 PMID:25862123 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Xanthenes binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B decreases activity ISO Xanthenes results in decreased activity of UGT1A6 protein CTD PMID:18686201 PMID:20041016 NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725 		JBrowse link
xanthone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO xanthone inhibits the reaction [[Isoproterenol results in decreased activity of ACE2 protein] which results in decreased abundance of angiotensin I (1-7)]; xanthone inhibits the reaction [Isoproterenol results in decreased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 PMID:36414029 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in increased expression of ACTA2 protein] CTD PMID:36414029 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Agt angiotensinogen multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in increased expression of AGT protein] CTD PMID:36414029 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] CTD PMID:36414029 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lep leptin multiple interactions ISO xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mir122 microRNA 122 multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in increased expression of MIR122 mRNA] CTD PMID:36414029 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in decreased expression of PRKAA2 mRNA] CTD PMID:36414029 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Sirt6 sirtuin 6 multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in decreased expression of SIRT6 mRNA] CTD PMID:36414029 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO xanthone inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:36414029 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
xanthones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos FBJ osteosarcoma oncogene multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of FOS protein] CTD PMID:21232528 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein] CTD PMID:21232528 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of JUN protein] CTD PMID:21232528 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21232528 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21232528 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21232528 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      atom 22170
        nonmetal atom 22055
          oxygen atom 21437
            oxygen molecular entity 21409
              organooxygen compound 20806
                oxacycle 18822
                  dibenzopyran 281
                    (+)-trichothecrotocin H 0
                    (+)-trichothecrotocin I 0
                    (+/-)-cochlearol T 0
                    (+/-)-cochlearol U 0
                    (-)-trichothecrotocin H 0
                    (-)-trichothecrotocin I 0
                    1-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-1H-pyrrole-2,5-dione 0
                    4,5-Diaminofluorescein 0
                    Alternethanoxin D 0
                    Cannabinol 11
                    Cochlearol V 0
                    Floricolin H 0
                    JWH-133 0
                    xanthenes + 275
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      p-block molecular entity 22104
                        carbon group molecular entity 21904
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    dibenzopyran 281
                                      (+)-trichothecrotocin H 0
                                      (+)-trichothecrotocin I 0
                                      (+/-)-cochlearol T 0
                                      (+/-)-cochlearol U 0
                                      (-)-trichothecrotocin H 0
                                      (-)-trichothecrotocin I 0
                                      1-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-1H-pyrrole-2,5-dione 0
                                      4,5-Diaminofluorescein 0
                                      Alternethanoxin D 0
                                      Cannabinol 11
                                      Cochlearol V 0
                                      Floricolin H 0
                                      JWH-133 0
                                      xanthenes + 275
paths to the root