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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dibenzopyran
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Accession:CHEBI:39203 term browser browse the term
Definition:Any organic heteropolycyclic compound based on a skeleton consisting of a pyran ring fused with two benzene rings.
Synonyms:related_synonym: dibenzopyrans


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2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions EXP Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 increases export
multiple interactions		 EXP ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]		 CTD PMID:16156793 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939 		JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases export
increases transport		 ISO
EXP		 ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]		 CTD PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 More... NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions
increases transport		 ISO
EXP		 [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]		 CTD PMID:24907646 PMID:31348918 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions
increases transport		 EXP Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] CTD PMID:31348918 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939 		JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A8 solute carrier family 22 member 8 multiple interactions
increases transport		 EXP quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions EXP ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 increases export EXP ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects export
multiple interactions		 EXP ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]		 CTD PMID:11477083 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G SLC22A11 solute carrier family 22 member 11 multiple interactions
increases uptake
increases import		 EXP glutaric acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; p-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]; Sulpiride inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein] CTD PMID:20639259 PMID:28597291 NCBI chr11:64,555,941...64,572,875
Ensembl chr11:64,555,690...64,572,875 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions
increases import		 EXP 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein] CTD PMID:28629854 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 increases import
multiple interactions		 EXP SLC22A8 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]		 CTD PMID:28629854 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization EXP mangostin affects the localization of AIFM1 protein CTD PMID:24480042 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP mangostin results in decreased phosphorylation of AKT1 protein CTD PMID:23954321 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP mangostin results in increased expression of BAX protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP mangostin results in decreased expression of BCL2 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP mangostin results in decreased expression of BID protein CTD PMID:24480042 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:26357513 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity		 EXP ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein] CTD PMID:24480042 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 increases activity EXP mangostin results in increased activity of CASP8 protein CTD PMID:24480042 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity EXP mangostin results in increased activity of CASP9 protein CTD PMID:23954321 PMID:24480042 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP mangostin results in increased expression of CYCS protein CTD PMID:24480042 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
affects response to substance		 EXP ESR1 protein affects the reaction [mangostin results in increased activity of CASP7 protein]
mangostin results in decreased expression of ESR1 protein
ESR1 protein affects the susceptibility to mangostin		 CTD PMID:24480042 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K2 protein CTD PMID:28722351 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAP2K4 protein CTD PMID:28722351 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP mangostin results in decreased expression of and results in decreased phosphorylation of MAPK1 protein
mangostin analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP mangostin results in decreased expression of and results in decreased phosphorylation of MAPK3 protein
mangostin analog results in increased phosphorylation of MAPK3 protein		 CTD PMID:23954321 PMID:28722351 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAPK8 protein CTD PMID:28722351 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP mangostin analog results in increased phosphorylation of MAPK9 protein CTD PMID:28722351 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]
mangostin analog results in decreased expression of MMP2 mRNA; mangostin analog results in decreased expression of MMP2 protein		 CTD PMID:28722351 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]
mangostin analog results in decreased expression of MMP9 mRNA; mangostin analog results in decreased expression of MMP9 protein		 CTD PMID:28722351 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP mangostin results in increased cleavage of PARP1 protein CTD PMID:23954321 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein] CTD PMID:18424012 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TFF1 trefoil factor 1 decreases expression EXP mangostin results in decreased expression of TFF1 protein CTD PMID:24480042 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO mangostin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:18424012 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP mangostin results in increased expression of TP53 protein
mangostin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 mRNA]		 CTD PMID:24480042 PMID:26357513 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases secretion
increases export		 EXP
ISO		 [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]		 CTD PMID:10571255 PMID:12235267 PMID:16442095 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects export
increases export
increases import
affects transport
multiple interactions		 EXP
ISO		 ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]		 CTD PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18955043 More... NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects export
increases abundance
multiple interactions
affects transport		 EXP ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon		 CTD PMID:15670588 PMID:15848949 PMID:22027652 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects transport EXP ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522 		JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases export
increases activity
affects export
increases secretion
increases transport		 EXP
ISO		 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
calcein AM results in increased activity of ABCB1 protein mutant form		 CTD PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 More... NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 affects export
multiple interactions		 ISO ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]		 CTD PMID:10617675 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 increases transport
multiple interactions		 EXP ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]		 CTD PMID:19239227 PMID:19647055 PMID:27376922 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases transport
increases export		 EXP
ISO		 ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]		 CTD PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions
increases transport		 EXP ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]		 CTD PMID:15210835 PMID:15979871 PMID:19647055 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions EXP Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 multiple interactions EXP Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
Cannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity EXP Cannabinol results in decreased activity of ABCC1 protein CTD PMID:18619955 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G CNR1 cannabinoid receptor 1 affects binding ISO Cannabinol binds to CNR1 protein CTD PMID:19679411 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 increases metabolic processing
multiple interactions		 EXP CYP2J2 protein results in increased metabolism of Cannabinol
Cannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]		 CTD PMID:29689453 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of FOS protein CTD PMID:10670588 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G IFNG interferon gamma multiple interactions ISO Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:11520904 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL2 interleukin 2 multiple interactions ISO Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]; Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]; Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]; KN 93 inhibits the reaction [Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]] CTD PMID:8662742 PMID:10670588 PMID:11809870 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of JUN protein CTD PMID:10670588 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G PRL prolactin multiple interactions EXP Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein] CTD PMID:31154070 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO Cannabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:19910459 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 multiple interactions
increases activity		 EXP [Cannabinol results in increased activity of TRPA1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584 		JBrowse link
G TRPV2 transient receptor potential cation channel subfamily V member 2 multiple interactions ISO Cannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr17:16,415,571...16,437,003
Ensembl chr17:16,415,571...16,437,003 		JBrowse link
cudratricusxanthone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNB1 interferon beta 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 protein] CTD PMID:31350693 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein] CTD PMID:31350693 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the phosphorylation of and affects the expression of and affects the localization of JUN protein] CTD PMID:31350693 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:31350693 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:31350693 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31350693 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,478...38,143,022 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein] CTD PMID:31350693 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:31350693 NCBI chr11:65,653,601...65,662,916
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TICAM1 protein] CTD PMID:31350693 NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31350693 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO cudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31350693 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Fluo-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export ISO ABCC1 protein affects the export of Fluo-3 CTD PMID:15948026 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
increases secretion		 ISO Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] CTD PMID:9794919 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
fluorescein (lactone form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP [CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP [CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Sulfaphenazole inhibits the reaction [[CYP2C9 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Fluorescein results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases uptake
multiple interactions		 EXP SLCO1B3 protein results in increased uptake of Fluorescein
bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]		 CTD PMID:27989701 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
G SLCO3A1 solute carrier organic anion transporter family member 3A1 increases uptake
multiple interactions		 EXP SLCO3A1 protein results in increased uptake of Fluorescein
Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]		 CTD PMID:28887287 NCBI chr15:91,853,708...92,172,435
Ensembl chr15:91,853,708...92,172,435 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Fluorescein CTD PMID:7835232 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 affects binding EXP Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:75,051,048...75,156,283
Ensembl chr  X:75,051,048...75,156,732 		JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G ANXA4 annexin A4 affects binding EXP Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112 		JBrowse link
G ARHGAP6 Rho GTPase activating protein 6 affects binding EXP Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:11,137,544...11,665,920
Ensembl chr  X:11,117,651...11,665,920 		JBrowse link
G AZI2 5-azacytidine induced 2 affects binding EXP Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 3:28,321,047...28,348,824
Ensembl chr 3:28,315,003...28,349,050 		JBrowse link
G CAPZB capping actin protein of muscle Z-line subunit beta affects binding EXP Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 1:19,338,775...19,485,539
Ensembl chr 1:19,338,775...19,485,539 		JBrowse link
G CCNI2 cyclin I family member 2 affects binding EXP Fluorescein-5-isothiocyanate binds to CCNI2 protein CTD PMID:27129696 NCBI chr 5:132,747,426...132,756,065
Ensembl chr 5:132,747,426...132,754,403 		JBrowse link
G CD109 CD109 molecule affects binding EXP Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 6:73,679,192...73,828,313
Ensembl chr 6:73,695,785...73,828,316 		JBrowse link
G CD180 CD180 molecule affects binding EXP Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr 5:67,179,613...67,196,799
Ensembl chr 5:67,179,613...67,196,799 		JBrowse link
G CD86 CD86 molecule increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CD93 CD93 molecule affects binding EXP Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr20:23,079,360...23,086,324
Ensembl chr20:23,079,360...23,086,324 		JBrowse link
G CDC20 cell division cycle 20 affects binding EXP Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203 		JBrowse link
G COPA COPI coat complex subunit alpha affects binding EXP Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr 1:160,288,594...160,343,250
Ensembl chr 1:160,288,594...160,343,566 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G DCAF4 DDB1 and CUL4 associated factor 4 affects binding EXP Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr14:72,926,464...72,962,098
Ensembl chr14:72,926,377...72,959,703 		JBrowse link
G DOT1L DOT1 like histone lysine methyltransferase affects binding EXP Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr19:2,163,933...2,232,578
Ensembl chr19:2,163,933...2,232,578 		JBrowse link
G ELAC1 elaC ribonuclease Z 1 affects binding EXP Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:50,968,040...50,988,121
Ensembl chr18:50,967,991...50,988,121 		JBrowse link
G ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding EXP Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,730,943...79,742,219 		JBrowse link
G FLRT3 fibronectin leucine rich transmembrane protein 3 affects binding EXP Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr20:14,322,985...14,337,612
Ensembl chr20:14,322,985...14,337,614 		JBrowse link
G FN1 fibronectin 1 affects binding EXP Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein		 CTD PMID:27871981 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 affects binding EXP Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 affects binding EXP Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675 		JBrowse link
G IFNG interferon gamma multiple interactions ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta affects binding EXP Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKZF4 IKAROS family zinc finger 4 affects binding EXP Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr12:56,007,504...56,038,435
Ensembl chr12:56,007,659...56,038,435 		JBrowse link
G IL17RE interleukin 17 receptor E affects binding EXP Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 3:9,902,093...9,916,402
Ensembl chr 3:9,902,612...9,916,402 		JBrowse link
G IL31RA interleukin 31 receptor A affects binding EXP Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr 5:55,839,789...55,922,850
Ensembl chr 5:55,851,357...55,922,854 		JBrowse link
G IL4 interleukin 4 increases expression
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased expression of IL4 protein
[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]		 CTD PMID:27871981 PMID:29198882 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G LYPD3 LY6/PLAUR domain containing 3 affects binding EXP Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr19:43,460,787...43,465,608
Ensembl chr19:43,460,787...43,465,608 		JBrowse link
G MAFF MAF bZIP transcription factor F increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 affects binding EXP Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 2:173,075,517...173,268,015
Ensembl chr 2:173,075,435...173,268,015 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:27129696 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein		 CTD PMID:27129696 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]		 CTD PMID:27129696 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein		 CTD PMID:27129696 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MT2A metallothionein 2A increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MYBPC1 myosin binding protein C1 affects binding EXP Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr12:101,594,971...101,695,841
Ensembl chr12:101,568,353...101,686,028 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP
ISO		 Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]		 CTD PMID:20491607 PMID:27871981 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP15 poly(ADP-ribose) polymerase family member 15 affects binding EXP Fluorescein-5-isothiocyanate binds to PARP15 protein CTD PMID:27129696 NCBI chr 3:122,577,650...122,639,047
Ensembl chr 3:122,577,628...122,639,047 		JBrowse link
G PLCE1 phospholipase C epsilon 1 affects binding EXP Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr10:93,993,931...94,332,823
Ensembl chr10:93,993,931...94,332,823 		JBrowse link
G POSTN periostin affects binding EXP Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844 		JBrowse link
G PPRC1 PPARG related coactivator 1 affects binding EXP Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr10:102,119,889...102,150,333
Ensembl chr10:102,132,994...102,150,333 		JBrowse link
G PRKCB protein kinase C beta increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611 		JBrowse link
G PSD4 pleckstrin and Sec7 domain containing 4 affects binding EXP Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 2:113,173,971...113,209,391
Ensembl chr 2:113,157,325...113,209,396 		JBrowse link
G PSMD14 proteasome 26S subunit, non-ATPase 14 affects binding EXP Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 2:161,308,425...161,411,717
Ensembl chr 2:161,308,425...161,411,717 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr11:65,653,601...65,662,916
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 affects binding EXP Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,687 		JBrowse link
G SKOR1 SKI family transcriptional corepressor 1 affects binding EXP Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr15:67,825,509...67,834,582
Ensembl chr15:67,819,704...67,834,582 		JBrowse link
G SLC38A10 solute carrier family 38 member 10 affects binding EXP Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr17:81,244,811...81,295,307
Ensembl chr17:81,244,811...81,295,547 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]		 CTD PMID:27871981 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,540 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]		 CTD PMID:27871981 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 increases phosphorylation
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]		 CTD PMID:27871981 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 affects binding EXP Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584 		JBrowse link
G TSLP thymic stromal lymphopoietin increases expression
multiple interactions		 ISO Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]		 CTD PMID:27871981 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026 		JBrowse link
G TXN thioredoxin increases expression EXP Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G USP3 ubiquitin specific peptidase 3 affects binding EXP Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr15:63,504,593...63,594,633
Ensembl chr15:63,504,511...63,594,640 		JBrowse link
G ZNF256 zinc finger protein 256 affects binding EXP Fluorescein-5-isothiocyanate binds to ZNF256 protein CTD PMID:27129696 NCBI chr19:57,940,833...57,947,706
Ensembl chr19:57,940,833...57,947,706 		JBrowse link
G ZNF836 zinc finger protein 836 affects binding EXP Fluorescein-5-isothiocyanate binds to ZNF836 protein CTD PMID:27129696 NCBI chr19:52,154,107...52,171,621
Ensembl chr19:52,153,864...52,171,643 		JBrowse link
gallein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
gamma-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO
EXP		 gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
[gamma-mangostin co-treated with MK 2206] results in decreased expression of ACTA2 protein; diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]		 CTD PMID:30502394 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP gamma-mangostin results in decreased phosphorylation of AKT1 protein
[gamma-mangostin co-treated with MK 2206] results in decreased phosphorylation of AKT1 protein		 CTD PMID:30502394 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30502394 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HDAC1 histone deacetylase 1 increases expression EXP gamma-mangostin results in increased expression of HDAC1 protein CTD PMID:30502394 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G HMGB1 high mobility group box 1 decreases secretion
multiple interactions		 EXP
ISO		 gamma-mangostin results in decreased secretion of HMGB1 protein
gamma-mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]
diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]; gamma-mangostin affects the localization of and results in decreased acetylation of HMGB1 protein; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]		 CTD PMID:30502394 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression		 EXP
ISO		 SIRT3 protein affects the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein affects the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]
gamma-mangostin results in increased expression of SIRT3 protein
[gamma-mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion of SIRT3 protein		 CTD PMID:30502394 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
mangiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression		 EXP Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein]
mangiferin results in increased expression of ABCB1 mRNA; mangiferin results in increased expression of ABCB1 protein		 CTD PMID:20513373 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases expression EXP mangiferin results in decreased expression of ABL1 mRNA CTD PMID:15498116 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,016...130,887,675 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 ISO dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of ACACA protein] CTD PMID:22292039 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity
multiple interactions		 ISO mangiferin results in decreased activity of ACHE protein
mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]		 CTD PMID:19182383 PMID:22426032 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:20683903 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G ADRB3 adrenoceptor beta 3 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein CTD PMID:32417366 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599 		JBrowse link
G AGER advanced glycosylation end-product specific receptor decreases expression ISO mangiferin results in decreased expression of AGER mRNA; mangiferin results in decreased expression of AGER protein CTD PMID:24036348 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AGT angiotensinogen multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] CTD PMID:17645561 PMID:19706694 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:17645561 PMID:19706694 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] CTD PMID:19201465 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of AKT1 protein]
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]		 CTD PMID:19201465 PMID:22465218 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALB albumin affects binding EXP mangiferin binds to ALB protein CTD PMID:19157745 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions ISO mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] CTD PMID:23451106 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433 		JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:20683903 NCBI chr 8:86,098,910...86,154,225
Ensembl chr 8:85,987,323...86,154,225 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]		 CTD PMID:19201465 PMID:23451106 PMID:24095822 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of BCL2 protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]		 CTD PMID:21420233 PMID:22118634 PMID:23451106 PMID:24095822 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP mangiferin results in decreased expression of BCL2L1 protein CTD PMID:21547680 PMID:26996543 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP mangiferin results in decreased expression of BIRC5 protein CTD PMID:26996543 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G C3 complement C3 decreases expression ISO mangiferin results in decreased expression of C3 mRNA CTD PMID:15135318 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CALCR calcitonin receptor multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:20683903 NCBI chr 7:93,424,486...93,574,724
Ensembl chr 7:93,424,486...93,574,730 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]
mangiferin results in increased activity of CASP3 protein
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP3 protein]		 CTD PMID:21547680 PMID:22118634 PMID:22310181 PMID:23451106 PMID:26996543 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP8 caspase 8 increases expression EXP mangiferin results in increased expression of CASP8 protein CTD PMID:32420661 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions ISO mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP9 protein]		 CTD PMID:22118634 PMID:23451106 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
increases activity		 ISO
EXP		 mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CAT mRNA]; mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
mangiferin results in increased activity of CAT protein		 CTD PMID:15161907 PMID:16076520 PMID:16584858 PMID:16697266 PMID:17433543 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression ISO mangiferin results in decreased expression of CCL2 mRNA CTD PMID:15135318 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein] CTD PMID:15135318 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCNB1 cyclin B1 increases expression EXP mangiferin results in increased expression of CCNB1 mRNA CTD PMID:20518311 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CD36 CD36 molecule multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [mangiferin results in increased expression of CD36 protein] CTD PMID:22292039 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CDH1 cadherin 1 increases expression
affects expression
multiple interactions		 EXP mangiferin results in increased expression of CDH1 protein
mangiferin affects the expression of CDH1 protein
lipopolysaccharide, Escherichia coli O111 B4 affects the reaction [mangiferin affects the expression of CDH1 protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression EXP mangiferin results in increased expression of CDK1 mRNA CTD PMID:20518311 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of CHUK protein]		 CTD PMID:21420233 PMID:22310181 PMID:23451106 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CIDEA cell death inducing DFFA like effector a multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CIDEA mRNA CTD PMID:32417366 NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA] CTD PMID:19706694 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA] CTD PMID:19706694 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression
multiple interactions		 ISO mangiferin results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of CPT1A protein]		 CTD PMID:22292039 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]
mangiferin results in decreased expression of CSF2 mRNA		 CTD PMID:15135318 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CSF3 colony stimulating factor 3 multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]
mangiferin results in decreased expression of CSF3 mRNA		 CTD PMID:15135318 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813 		JBrowse link
G CTNNB1 catenin beta 1 decreases response to substance EXP CTNNB1 protein results in decreased susceptibility to mangiferin CTD PMID:23707762 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CTNND1 catenin delta 1 multiple interactions EXP mangiferin inhibits the reaction [Paraquat results in decreased expression of and affects the localization of CTNND1 protein]; mangiferin inhibits the reaction [Paraquat results in decreased expression of CTNND1 mRNA alternative form] CTD PMID:24912632 NCBI chr11:57,761,802...57,819,540
Ensembl chr11:57,753,243...57,819,546 		JBrowse link
G CTSD cathepsin D multiple interactions ISO mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573 		JBrowse link
G CTSK cathepsin K multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:20683903 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
affects expression		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
mangiferin affects the expression of CXCL15 protein		 CTD PMID:21420233 PMID:21837981 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 multiple interactions EXP mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CXCR4 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] CTD PMID:21420233 PMID:32420661 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP mangiferin results in increased expression of CYP1A1 mRNA CTD PMID:22815239 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases expression		 ISO
EXP		 mangiferin results in decreased activity of CYP1A2 protein
mangiferin results in increased expression of CYP1A2 mRNA		 CTD PMID:18053976 PMID:22815239 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 decreases activity EXP mangiferin results in decreased activity of CYP2A6 protein CTD PMID:22815239 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity ISO mangiferin results in decreased activity of CYP2C6V1 protein CTD PMID:18053976 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP mangiferin results in decreased activity of CYP2C9 protein CTD PMID:22815239 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity EXP mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO mangiferin results in decreased activity of CYP2E1 protein CTD PMID:18053976 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP mangiferin results in decreased activity of CYP3A4 protein CTD PMID:22815239 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:20683903 NCBI chr 8:104,339,796...104,356,689
Ensembl chr 8:104,339,087...104,356,689 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 decreases expression
affects expression
multiple interactions		 ISO mangiferin results in decreased expression of DGAT2 protein
mangiferin affects the expression of DGAT2 mRNA; mangiferin affects the expression of DGAT2 protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of DGAT2 protein]		 CTD PMID:22292039 PMID:25123789 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535 		JBrowse link
G DNM1L dynamin 1 like multiple interactions EXP mangiferin inhibits the reaction [Methylmercury Compounds results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:28071871 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
G F10 coagulation factor X decreases activity EXP mangiferin analog results in decreased activity of F10 protein CTD PMID:21732671 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP mangiferin results in increased expression of FAS protein CTD PMID:17634039 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FBP1 fructose-bisphosphatase 1 decreases expression ISO mangiferin results in decreased expression of FBP1 mRNA CTD PMID:19028559 NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249 		JBrowse link
G FN1 fibronectin 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G GCG glucagon multiple interactions ISO [mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form CTD PMID:22948814 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404 		JBrowse link
G GLO1 glyoxalase I increases expression
multiple interactions		 ISO mangiferin results in increased expression of GLO1 mRNA
mangiferin results in increased expression of and results in increased activity of GLO1 protein		 CTD PMID:24036348 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO mangiferin inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO
EXP		 mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Methylmercury Compounds results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]		 CTD PMID:16697266 PMID:18816296 PMID:23451106 PMID:28071871 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GUSB glucuronidase beta multiple interactions ISO mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein] CTD PMID:19172585 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in decreased expression of HMOX1 protein] CTD PMID:22310181 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
mangiferin results in decreased expression of ICAM1 mRNA		 CTD PMID:15135318 PMID:15161907 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G ICAM2 intercellular adhesion molecule 2 decreases expression ISO mangiferin results in decreased expression of ICAM2 mRNA CTD PMID:15135318 NCBI chr17:64,002,595...64,020,633
Ensembl chr17:64,002,594...64,020,634 		JBrowse link
G ICAM5 intercellular adhesion molecule 5 decreases expression ISO mangiferin results in decreased expression of ICAM5 mRNA CTD PMID:15135318 NCBI chr19:10,289,952...10,296,778
Ensembl chr19:10,289,952...10,296,778 		JBrowse link
G IFNA1 interferon alpha 1 increases expression ISO mangiferin results in increased expression of IFNA1 mRNA CTD PMID:15135318 NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316 		JBrowse link
G IFNB1 interferon beta 1 increases expression ISO mangiferin results in increased expression of IFNB1 mRNA CTD PMID:15135318 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma multiple interactions ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of IFNG mRNA]		 CTD PMID:12694877 PMID:15135318 PMID:15177302 PMID:15177305 PMID:15222974 More... NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein]		 CTD PMID:21420233 PMID:22310181 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in decreased expression of IL10 mRNA] CTD PMID:22310181 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A decreases expression ISO mangiferin results in decreased expression of IL12A mRNA CTD PMID:15135318 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] CTD PMID:22310181 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL18 interleukin 18 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1A interleukin 1 alpha decreases expression ISO mangiferin results in decreased expression of IL1A mRNA CTD PMID:15135318 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in increased expression of IL1B mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:15381052 PMID:22310181 PMID:27125760 PMID:27474068 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2RB interleukin 2 receptor subunit beta decreases expression ISO mangiferin results in decreased expression of IL2RB mRNA CTD PMID:15135318 NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,125,843...37,175,054 		JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 mangiferin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL6 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein]
mangiferin results in decreased expression of IL6 mRNA		 CTD PMID:15135318 PMID:21420233 PMID:22310181 PMID:23087136 PMID:27474068 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF1 interferon regulatory factor 1 decreases expression ISO mangiferin results in decreased expression of IRF1 mRNA CTD PMID:15135318 NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719 		JBrowse link
G LPL lipoprotein lipase multiple interactions
increases activity
increases expression		 EXP MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA] CTD PMID:15975614 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 decreases phosphorylation EXP mangiferin results in decreased phosphorylation of MAP3K14 protein CTD PMID:26996543 NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
decreases activity
affects binding
multiple interactions		 ISO
EXP		 mangiferin results in increased phosphorylation of MAPK1 protein
mangiferin metabolite results in decreased activity of MAPK1 protein
mangiferin metabolite binds to MAPK1 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases activity
increases phosphorylation		 ISO
EXP		 mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
mangiferin metabolite results in decreased activity of MAPK3 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
mangiferin results in increased phosphorylation of MAPK3 protein		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases expression ISO mangiferin results in decreased expression of MAPK8 mRNA CTD PMID:15135318 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 decreases expression ISO mangiferin results in decreased expression of MAPK9 mRNA CTD PMID:15135318 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MAX MYC associated factor X decreases expression ISO mangiferin results in decreased expression of MAX mRNA CTD PMID:15135318 NCBI chr14:65,006,101...65,102,695
Ensembl chr14:65,006,174...65,102,695 		JBrowse link
G MMP7 matrix metallopeptidase 7 decreases expression EXP mangiferin results in decreased expression of MMP7 protein CTD PMID:23707762 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions
decreases activity		 EXP
ISO		 mangiferin results in decreased expression of MMP9 mRNA; mangiferin results in decreased expression of MMP9 protein
mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
mangiferin results in decreased expression of and results in decreased secretion of MMP9 protein
mangiferin results in decreased activity of MMP9 protein		 CTD PMID:22465218 PMID:23707762 PMID:27125760 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO mangiferin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:27125760 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO mangiferin affects the reaction [Galactosamine affects the localization of NFE2L2 protein]; mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFE2L2 protein] CTD PMID:22310181 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,227,595...177,392,697 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:15161907 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
increases expression		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]
mangiferin results in increased expression of NFKBIA protein
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]		 CTD PMID:15161907 PMID:20683903 PMID:22310181 PMID:23451106 PMID:27474068 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749 		JBrowse link
G NFKBIB NFKB inhibitor beta decreases expression
multiple interactions		 ISO
EXP		 mangiferin results in decreased expression of NFKBIB mRNA
mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]		 CTD PMID:15135318 PMID:21420233 NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893 		JBrowse link
G NFKBIE NFKB inhibitor epsilon decreases expression ISO mangiferin results in decreased expression of NFKBIE mRNA CTD PMID:15135318 NCBI chr 6:44,258,166...44,265,551
Ensembl chr 6:44,258,166...44,265,788 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 decreases expression ISO mangiferin results in decreased expression of NFKBIL1 mRNA CTD PMID:15135318 NCBI chr 6:31,546,851...31,558,829
Ensembl chr 6:31,546,870...31,558,829 		JBrowse link
G NGF nerve growth factor increases secretion EXP mangiferin results in increased secretion of NGF protein CTD PMID:20303935 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of NLRP3 protein] CTD PMID:32420661 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNFB protein] results in increased expression of NOS2 mRNA]		 CTD PMID:12694877 PMID:15381052 PMID:22118634 PMID:22310181 PMID:27474068 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO mangiferin inhibits the reaction [Galactosamine results in decreased expression of NQO1 protein] CTD PMID:22310181 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PER1 period circadian regulator 1 multiple interactions
affects expression		 EXP mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of PER1 protein]
mangiferin affects the expression of PER1 protein		 CTD PMID:32420661 NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,472...8,156,506 		JBrowse link
G PLA2G2A phospholipase A2 group IIA decreases activity EXP mangiferin results in decreased activity of PLA2G2A protein CTD PMID:15177302 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416 		JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
increases activity		 EXP
ISO		 MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARA mRNA		 CTD PMID:15975614 PMID:32417366 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein		 CTD PMID:29223569 PMID:32417366 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A protein CTD PMID:32417366 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRDM16 PR/SET domain 16 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 protein CTD PMID:32417366 NCBI chr 1:3,069,203...3,438,621
Ensembl chr 1:3,069,168...3,438,621 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein CTD PMID:22292039 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects expression		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
mangiferin affects the expression of PTGS2 mRNA		 CTD PMID:15161907 PMID:15381052 PMID:18621015 PMID:19026997 PMID:21420233 More... NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO mangiferin results in decreased expression of RAF1 mRNA CTD PMID:15135318 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
decreases expression
decreases localization		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the localization of RELA protein
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [Galactosamine results in increased expression of RELA protein]
mangiferin results in decreased expression of RELA mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]
mangiferin results in decreased localization of RELA protein		 CTD PMID:15135318 PMID:15161907 PMID:19182383 PMID:19201465 PMID:20683903 More... NCBI chr11:65,653,601...65,662,916
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit decreases expression ISO mangiferin results in decreased expression of RELB mRNA CTD PMID:15135318 NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,449...45,038,198 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 decreases expression ISO mangiferin results in decreased expression of RIPK1 mRNA CTD PMID:15135318 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
G SAA1 serum amyloid A1 decreases expression ISO mangiferin results in decreased expression of SAA1 mRNA CTD PMID:15135318 NCBI chr11:18,266,264...18,269,967
Ensembl chr11:18,266,260...18,269,977 		JBrowse link
G SELE selectin E decreases expression ISO mangiferin results in decreased expression of SELE mRNA CTD PMID:15135318 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SELPLG selectin P ligand decreases expression ISO mangiferin results in decreased expression of SELPLG mRNA CTD PMID:15135318 NCBI chr12:108,621,895...108,633,894
Ensembl chr12:108,621,895...108,633,894 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA] CTD PMID:19706694 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 increases expression ISO mangiferin results in increased expression of SLC22A1 mRNA CTD PMID:21348301 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A12 solute carrier family 22 member 12 decreases expression ISO mangiferin results in decreased expression of SLC22A12 mRNA; mangiferin results in decreased expression of SLC22A12 protein CTD PMID:21348301 NCBI chr11:64,591,220...64,602,344
Ensembl chr11:64,590,641...64,602,353 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 increases expression ISO mangiferin results in increased expression of SLC22A2 mRNA CTD PMID:21348301 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A4 solute carrier family 22 member 4 increases expression ISO mangiferin results in increased expression of SLC22A4 mRNA CTD PMID:21348301 NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 increases expression ISO mangiferin results in increased expression of SLC22A5 mRNA CTD PMID:21348301 NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; mangiferin affects the localization of and results in increased activity of SLC2A4 protein; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Glucose]
mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
mangiferin results in increased expression of SLC2A4 mRNA		 CTD PMID:19477051 PMID:29223569 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression EXP mangiferin results in decreased expression of SNAI1 protein CTD PMID:23707762 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 decreases expression EXP mangiferin results in decreased expression of SNAI2 protein CTD PMID:23707762 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA] CTD PMID:17433543 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases activity EXP mangiferin results in decreased activity of SRD5A2 protein CTD PMID:20823678 NCBI chr 2:31,522,480...31,663,009
Ensembl chr 2:31,522,480...31,580,938 		JBrowse link
G SRF serum response factor decreases expression ISO mangiferin results in decreased expression of SRF mRNA CTD PMID:15135318 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 decreases expression ISO mangiferin results in decreased expression of TAB1 mRNA CTD PMID:15135318 NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060 		JBrowse link
G TBK1 TANK binding kinase 1 decreases expression ISO mangiferin results in decreased expression of TBK1 mRNA CTD PMID:15135318 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TERT telomerase reverse transcriptase decreases activity EXP mangiferin results in decreased activity of TERT protein CTD PMID:17634039 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; mangiferin inhibits the reaction [Streptozocin results in increased secretion of TGFB1 protein]		 CTD PMID:12694877 PMID:19706694 PMID:19960420 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TLR6 toll like receptor 6 decreases expression ISO mangiferin results in decreased expression of TLR6 mRNA CTD PMID:15135318 NCBI chr 4:38,822,897...38,868,390
Ensembl chr 4:38,822,897...38,856,817 		JBrowse link
G TLR7 toll like receptor 7 decreases expression ISO mangiferin results in decreased expression of TLR7 mRNA CTD PMID:15135318 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361 		JBrowse link
G TLR8 toll like receptor 8 decreases expression ISO mangiferin results in decreased expression of TLR8 mRNA CTD PMID:15135318 NCBI chr  X:12,906,620...12,923,169
Ensembl chr  X:12,906,620...12,923,169 		JBrowse link
G TLR9 toll like receptor 9 decreases expression ISO mangiferin results in decreased expression of TLR9 mRNA CTD PMID:15135318 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
affects expression
increases secretion		 EXP
ISO		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein]; mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
mangiferin results in decreased expression of TNF mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the expression of TNF protein
mangiferin results in increased secretion of TNF protein		 CTD PMID:12694877 PMID:15135318 PMID:15161907 PMID:15177305 PMID:15222974 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a decreases expression ISO mangiferin results in decreased expression of TNFRSF11A mRNA CTD PMID:15135318 NCBI chr18:62,325,310...62,391,288
Ensembl chr18:62,325,287...62,391,288 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:20683903 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO mangiferin inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:10657591 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TRADD TNFRSF1A associated via death domain decreases expression ISO mangiferin results in decreased expression of TRADD mRNA CTD PMID:15135318 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G TRAF6 TNF receptor associated factor 6 decreases expression ISO mangiferin results in decreased expression of TRAF6 mRNA CTD PMID:15135318 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G UCP1 uncoupling protein 1 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP1 protein CTD PMID:32417366 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression
decreases activity		 EXP mangiferin results in increased expression of UGT1A1 mRNA
mangiferin results in decreased activity of UGT1A1 protein		 CTD PMID:22815239 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases expression EXP mangiferin results in increased expression of UGT1A9 mRNA CTD PMID:22815239 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 decreases activity EXP mangiferin results in decreased activity of UGT2B7 protein CTD PMID:22815239 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G UMOD uromodulin affects expression ISO mangiferin affects the expression of UMOD protein CTD PMID:21348301 NCBI chr16:20,333,051...20,356,301
Ensembl chr16:20,333,051...20,356,301 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 decreases expression ISO mangiferin results in decreased expression of VCAM1 mRNA CTD PMID:15135318 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:21420233 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIM vimentin decreases expression
multiple interactions		 EXP mangiferin results in decreased expression of VIM protein
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of VIM protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions
decreases expression		 EXP mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]
mangiferin results in decreased expression of XIAP protein		 CTD PMID:21420233 PMID:21547680 PMID:26996543 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976 		JBrowse link
norathyriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP norathyriol results in increased expression of ABCB1 protein CTD PMID:20513373 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects binding
decreases activity		 EXP
ISO		 norathyriol binds to MAPK1 protein
norathyriol results in decreased activity of MAPK1 protein		 CTD PMID:22084399 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases activity ISO norathyriol results in decreased activity of MAPK3 protein CTD PMID:22084399 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] CTD PMID:18393431 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions EXP norathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein] CTD PMID:18393431 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] CTD PMID:18393431 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSLP thymic stromal lymphopoietin multiple interactions ISO Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026 		JBrowse link
Propantheline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Propantheline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
psorospermin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP psorospermin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:7083125 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
rhodamine 123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases uptake
increases export		 EXP
ISO		 3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5-hydroxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; daidzein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Quercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; tangeretin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]
[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123]		 CTD PMID:25058526 PMID:27816545 PMID:30391378 PMID:31756430 PMID:33321149 More... NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases export
multiple interactions		 EXP ABCG2 protein results in increased export of Rhodamine 123
abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123]		 CTD PMID:27816545 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
rhodamine 6G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity EXP rhodamine 6G results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
rose bengal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP Rose Bengal results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases activity ISO Rose Bengal results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Rose Bengal results in decreased activity of CYP3A4 protein CTD PMID:20041016 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G IYD iodotyrosine deiodinase decreases activity EXP Rose Bengal results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 6:150,369,012...150,405,969
Ensembl chr 6:150,368,892...150,405,969 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KLKB1 kallikrein B1 multiple interactions
decreases response to substance		 ISO 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] CTD PMID:25339356 NCBI chr 4:186,210,853...186,258,471
Ensembl chr 4:186,208,979...186,258,471 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases activity EXP Rose Bengal results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
vadimezan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export
affects transport		 EXP ABCC1 protein affects the export of vadimezan metabolite
ABCC1 protein affects the transport of vadimezan analog		 CTD PMID:15282097 PMID:15784341 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
affects export		 EXP ABCC2 protein affects the transport of vadimezan analog
ABCC2 protein affects the export of vadimezan metabolite		 CTD PMID:15282097 PMID:15784341 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases oxidation		 EXP Acridines analog inhibits the reaction [CYP1A2 protein results in increased oxidation of vadimezan] CTD PMID:16120190 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G IL1A interleukin 1 alpha increases expression ISO vadimezan results in increased expression of IL1A protein CTD PMID:16944150 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL6 interleukin 6 increases expression ISO vadimezan results in increased expression of IL6 protein CTD PMID:16944150 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 ISO TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
vadimezan results in increased expression of TNF protein		 CTD PMID:15060740 PMID:16944150 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression ISO vadimezan results in increased expression of VEGFA protein CTD PMID:16944150 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
xanthenes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity
multiple interactions
increases export
increases transport		 EXP
ISO		 Xanthenes results in decreased activity of ABCB1 protein
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; Rafoxanide results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; triclabendazole results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; triclabendazole sulfoxide results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]; valspodar results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes
ABCB1 protein results in increased export of Xanthenes
ABCB1 protein results in increased transport of Xanthenes
[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of Xanthenes; Calcium deficiency inhibits the reaction [ABCB1 protein results in increased export of Xanthenes]		 CTD PMID:18686201 PMID:20041016 PMID:20513441 PMID:21436125 PMID:25862123 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO
EXP		 Xanthenes binds to and results in increased activity of AHR protein CTD PMID:21431309 PMID:28186253 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP Xanthenes results in decreased activity of CYP3A4 protein CTD PMID:18686201 PMID:20041016 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 decreases activity EXP Xanthenes results in decreased activity of UGT1A6 protein CTD PMID:18686201 PMID:20041016 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
xanthone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 multiple interactions ISO xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G LEP leptin multiple interactions ISO xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
xanthones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of FOS protein] CTD PMID:21232528 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein] CTD PMID:21232528 NCBI chr  X:154,010,507...154,019,902
Ensembl chr  X:154,010,506...154,019,902 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of JUN protein] CTD PMID:21232528 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:21232528 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:21232528 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Xanthones inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21232528 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25349
    chemical entity 25323
      atom 25315
        nonmetal atom 24865
          oxygen atom 24100
            oxygen molecular entity 24100
              organooxygen compound 23439
                oxacycle 19691
                  dibenzopyran 250
                    1-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-1H-pyrrole-2,5-dione 0
                    Cannabinol 11
                    JWH-133 0
                    xanthenes + 244
Path 2
Term Annotations click to browse term
  CHEBI ontology 25349
    subatomic particle 25315
      composite particle 25315
        hadron 25315
          baryon 25315
            nucleon 25315
              atomic nucleus 25315
                atom 25315
                  main group element atom 25208
                    main group molecular entity 25208
                      p-block molecular entity 25202
                        carbon group molecular entity 24797
                          organic molecular entity 24772
                            organic molecule 24621
                              organic cyclic compound 23929
                                organic heterocyclic compound 21950
                                  organic heteropolycyclic compound 21144
                                    dibenzopyran 250
                                      1-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-1H-pyrrole-2,5-dione 0
                                      Cannabinol 11
                                      JWH-133 0
                                      xanthenes + 244
paths to the root