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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
ISO |
Methylphenazonium Methosulfate results in increased activity of G6PD protein |
CTD |
PMID:1901343 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Pgd |
phosphogluconate dehydrogenase |
increases activity |
ISO |
Methylphenazonium Methosulfate results in increased activity of PGD protein |
CTD |
PMID:1901343 |
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NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
Clofazimine results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 PMID:23956101 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases expression |
EXP |
Clofazimine results in increased expression of ACACA mRNA |
CTD |
PMID:31393584 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression |
EXP |
Clofazimine results in increased expression of CEBPA protein |
CTD |
PMID:31393584 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
decreases expression |
EXP |
Clofazimine results in decreased expression of DGAT1 mRNA |
CTD |
PMID:31393584 |
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NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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G |
Fas |
Fas cell surface death receptor |
increases expression |
EXP |
Clofazimine results in increased expression of FAS mRNA |
CTD |
PMID:31393584 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Clofazimine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
EXP |
Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein |
CTD |
PMID:31393584 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
EXP |
Clofazimine results in increased expression of SREBF1 mRNA |
CTD |
PMID:31393584 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Zfp423 |
zinc finger protein 423 |
increases expression |
EXP |
Clofazimine results in increased expression of ZFP423 mRNA |
CTD |
PMID:31393584 |
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NCBI chr19:19,111,213...19,407,373
Ensembl chr19:19,110,238...19,407,373
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G |
Bcl2 |
BCL2, apoptosis regulator |
affects binding |
ISO |
1-phenazinecarboxylic acid analog binds to BCL2 protein |
CTD |
PMID:25765238 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of AHR mRNA Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 PMID:31078726 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24015256 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atf6 |
activating transcription factor 6 |
increases activity |
EXP |
Pyocyanine results in increased activity of ATF6 protein |
CTD |
PMID:27613716 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein |
CTD |
PMID:31078726 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ctnnb1 |
catenin beta 1 |
increases expression |
ISO |
Pyocyanine results in increased expression of CTNNB1 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Pyocyanine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of EGFR protein |
CTD |
PMID:24015256 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of FABP4 mRNA |
CTD |
PMID:31078726 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of GCLC mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] |
CTD |
PMID:24015256 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
EXP |
Pyocyanine results in increased activity of HSF1 protein |
CTD |
PMID:27613716 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Il10 |
interleukin 10 |
increases expression |
ISO |
Pyocyanine results in increased expression of IL10 protein |
CTD |
PMID:31078726 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of IL13 protein |
CTD |
PMID:31078726 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
Pyocyanine results in increased expression of IL6 protein |
CTD |
PMID:31078726 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K1 protein |
CTD |
PMID:24015256 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K2 protein |
CTD |
PMID:24015256 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Pyocyanine results in increased phosphorylation of MAPK3 protein Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity |
ISO EXP |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein] Pyocyanine results in increased activity of NFE2L2 protein |
CTD |
PMID:24015256 PMID:27613716 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of NQO1 mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA] |
CTD |
PMID:24015256 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
Pyocyanine results in decreased expression of PPARG mRNA |
CTD |
PMID:31078726 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 |
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NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
Pyocyanine results in increased expression of TNF mRNA |
CTD |
PMID:31078726 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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