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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenazines
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Accession:CHEBI:39201 term browser browse the term
Definition:Any organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives.


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5-methylphenazinium methyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase increases activity ISO Methylphenazonium Methosulfate results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylphenazonium Methosulfate results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 5:165,966,128...165,982,327 JBrowse link
clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430, PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression EXP Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Zfp423 zinc finger protein 423 increases expression EXP Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr19:20,147,201...20,405,999
Ensembl chr19:20,147,037...20,406,003
JBrowse link
phenazine-1-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator affects binding ISO 1-phenazinecarboxylic acid analog binds to BCL2 protein CTD PMID:25765238 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO Pyocyanine results in increased expression of AHR mRNA CTD PMID:31078726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf6 activating transcription factor 6 increases activity EXP Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity EXP Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Il10 interleukin 10 increases expression ISO Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 decreases expression ISO Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il6 interleukin 6 increases expression ISO Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256, PMID:24316274 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256, PMID:24316274 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256, PMID:27613716 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      atom 19768
        nonmetal atom 19642
          nitrogen atom 18532
            nitrogen molecular entity 18532
              organonitrogen compound 18301
                organonitrogen heterocyclic compound 17450
                  phenazines 33
                    (10aS)-10,10a-dihydrophenazine-1-carboxylic acid 0
                    (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylic acid 0
                    (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                    (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid 0
                    (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                    (2R,3R,4R,5S)-6-\{[(3E)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                    (3Z)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-ol 0
                    (4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenyl)oxidanesulfonic acid 0
                    (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                    1,8-dimethoxyphenazine 0
                    1-hydroxyphenazine 0
                    2-(pentaprenyloxy)dihydrophenazine 0
                    3,7-diamino-5-phenylphenazin-5-ium + 0
                    4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenol 0
                    4-bromo-N-(2-phenazinyl)benzamide 0
                    4-chloro-N-(2-methoxy-1-phenazinyl)benzamide 0
                    5,10-dihydro-9-dimethylallylphenazine-1-carboxylic acid 0
                    5,10-dihydrophenazine 0
                    5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                    5,10-dihydrophenazine-1-carboxylic acid 0
                    5-methylphenazinium methyl sulfate 2
                    6-Acetophenazine-1-carboxylic acid 0
                    Esmeraldic acid 0
                    Esmeraldin B 0
                    Izumiphenazine A, (rel)- 0
                    Izumiphenazine B 0
                    Izumiphenazine C 0
                    Janus Green B cation + 0
                    N-(2-methylphenyl)-1-phenazinecarboxamide 0
                    Pelagiomicin A 0
                    Saphenamycin 0
                    Saphenic acid 0
                    Saphenic acid methyl ester 0
                    benthophoenin 0
                    clofazimine 10
                    dihydromethanophenazine 0
                    mauveine A + 0
                    mauveine B + 0
                    mauveine B2 + 0
                    mauveine C + 0
                    methanophenazine 0
                    neutral red base 0
                    phenazine + 0
                    phenazine-1,6-dicarboxylic acid 0
                    phenazine-1-carboxamide 0
                    phenazine-1-carboxylic acid 1
                    pyocyanine 21
                    pyocyanine(1+) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  organic heteropolycyclic compound 17812
                                    organic heterotricyclic compound 14569
                                      phenazines 33
                                        (10aS)-10,10a-dihydrophenazine-1-carboxylic acid 0
                                        (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylic acid 0
                                        (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                                        (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid 0
                                        (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                                        (2R,3R,4R,5S)-6-\{[(3E)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                                        (3Z)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-ol 0
                                        (4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenyl)oxidanesulfonic acid 0
                                        (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                                        1,8-dimethoxyphenazine 0
                                        1-hydroxyphenazine 0
                                        2-(pentaprenyloxy)dihydrophenazine 0
                                        3,7-diamino-5-phenylphenazin-5-ium + 0
                                        4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenol 0
                                        4-bromo-N-(2-phenazinyl)benzamide 0
                                        4-chloro-N-(2-methoxy-1-phenazinyl)benzamide 0
                                        5,10-dihydro-9-dimethylallylphenazine-1-carboxylic acid 0
                                        5,10-dihydrophenazine 0
                                        5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                                        5,10-dihydrophenazine-1-carboxylic acid 0
                                        5-methylphenazinium methyl sulfate 2
                                        6-Acetophenazine-1-carboxylic acid 0
                                        Esmeraldic acid 0
                                        Esmeraldin B 0
                                        Izumiphenazine A, (rel)- 0
                                        Izumiphenazine B 0
                                        Izumiphenazine C 0
                                        Janus Green B cation + 0
                                        N-(2-methylphenyl)-1-phenazinecarboxamide 0
                                        Pelagiomicin A 0
                                        Saphenamycin 0
                                        Saphenic acid 0
                                        Saphenic acid methyl ester 0
                                        benthophoenin 0
                                        clofazimine 10
                                        dihydromethanophenazine 0
                                        mauveine A + 0
                                        mauveine B + 0
                                        mauveine B2 + 0
                                        mauveine C + 0
                                        methanophenazine 0
                                        neutral red base 0
                                        phenazine + 0
                                        phenazine-1,6-dicarboxylic acid 0
                                        phenazine-1-carboxamide 0
                                        phenazine-1-carboxylic acid 1
                                        pyocyanine 21
                                        pyocyanine(1+) 0
paths to the root

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