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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenazines
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Accession:CHEBI:39201 term browser browse the term
Definition:Any organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives.


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5-methylphenazinium methyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase increases activity ISO Methylphenazonium Methosulfate results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylphenazonium Methosulfate results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 5:159,582,746...159,598,945 JBrowse link
clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression EXP Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Zfp423 zinc finger protein 423 increases expression EXP Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr19:19,111,538...19,407,371
Ensembl chr19:19,110,238...19,407,373
JBrowse link
phenazine-1-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator affects binding ISO 1-phenazinecarboxylic acid analog binds to BCL2 protein CTD PMID:25765238 NCBI chr13:22,689,783...22,853,920 JBrowse link
pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression
multiple interactions
ISO Pyocyanine results in increased expression of AHR mRNA
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter]
CTD PMID:28476168 PMID:31078726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf6 activating transcription factor 6 increases activity EXP Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity EXP Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Il10 interleukin 10 increases expression ISO Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases expression ISO Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il6 interleukin 6 increases expression ISO Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] CTD PMID:28476168 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18761
            nitrogen molecular entity 18761
              organonitrogen compound 18533
                organonitrogen heterocyclic compound 17639
                  phenazines 34
                    (10aS)-10,10a-dihydrophenazine-1-carboxylic acid 0
                    (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylic acid 0
                    (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                    (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid 0
                    (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                    (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate 0
                    (2R,3R,4R,5S)-6-\{[(3E)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                    (3Z)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-ol 0
                    (4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenyl)oxidanesulfonic acid 0
                    (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                    1,8-dimethoxyphenazine 0
                    1-hydroxyphenazine 0
                    2-(pentaprenyloxy)dihydrophenazine 0
                    3,7-diamino-5-phenylphenazin-5-ium + 0
                    4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenol 0
                    4-bromo-N-(2-phenazinyl)benzamide 0
                    4-chloro-N-(2-methoxy-1-phenazinyl)benzamide 0
                    5,10-dihydro-9-dimethylallylphenazine-1-carboxylic acid 0
                    5,10-dihydrophenazine 0
                    5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                    5,10-dihydrophenazine-1-carboxylic acid 0
                    5-methylphenazinium methyl sulfate 2
                    6-Acetophenazine-1-carboxylic acid 0
                    D-alanylgriseoluteic acid zwitterion 0
                    Esmeraldic acid 0
                    Esmeraldin B 0
                    Izumiphenazine A, (rel)- 0
                    Izumiphenazine B 0
                    Izumiphenazine C 0
                    Janus Green B cation + 0
                    N-(2-methylphenyl)-1-phenazinecarboxamide 0
                    Pelagiomicin A 0
                    Saphenamycin 0
                    Saphenic acid 0
                    Saphenic acid methyl ester 0
                    benthophoenin 0
                    clofazimine 10
                    dihydromethanophenazine 0
                    mauveine A + 0
                    mauveine B + 0
                    mauveine B2 + 0
                    mauveine C + 0
                    methanophenazine 0
                    neutral red base 0
                    phenazine + 0
                    phenazine-1,6-dicarboxylic acid 0
                    phenazine-1-carboxamide 0
                    phenazine-1-carboxylic acid 1
                    phenazine-2-carboxylic acid 0
                    pyocyanine 22
                    pyocyanine(1+) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotricyclic compound 14650
                                      phenazines 34
                                        (10aS)-10,10a-dihydrophenazine-1-carboxylic acid 0
                                        (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylic acid 0
                                        (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylic acid 0
                                        (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylic acid 0
                                        (1R,5aS,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylic acid 0
                                        (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate 0
                                        (2R,3R,4R,5S)-6-\{[(3E)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-yl]oxy\}-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                                        (3Z)-5-(4-chlorophenyl)-2-[(4-chlorophenyl)amino]-3-(isopropylimino)phenazin-1-ol 0
                                        (4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenyl)oxidanesulfonic acid 0
                                        (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylic acid 0
                                        1,8-dimethoxyphenazine 0
                                        1-hydroxyphenazine 0
                                        2-(pentaprenyloxy)dihydrophenazine 0
                                        3,7-diamino-5-phenylphenazin-5-ium + 0
                                        4-\{[(3Z)-5-(4-chlorophenyl)-3-(isopropylimino)phenazin-2-yl]amino\}phenol 0
                                        4-bromo-N-(2-phenazinyl)benzamide 0
                                        4-chloro-N-(2-methoxy-1-phenazinyl)benzamide 0
                                        5,10-dihydro-9-dimethylallylphenazine-1-carboxylic acid 0
                                        5,10-dihydrophenazine 0
                                        5,10-dihydrophenazine-1,6-dicarboxylic acid 0
                                        5,10-dihydrophenazine-1-carboxylic acid 0
                                        5-methylphenazinium methyl sulfate 2
                                        6-Acetophenazine-1-carboxylic acid 0
                                        D-alanylgriseoluteic acid zwitterion 0
                                        Esmeraldic acid 0
                                        Esmeraldin B 0
                                        Izumiphenazine A, (rel)- 0
                                        Izumiphenazine B 0
                                        Izumiphenazine C 0
                                        Janus Green B cation + 0
                                        N-(2-methylphenyl)-1-phenazinecarboxamide 0
                                        Pelagiomicin A 0
                                        Saphenamycin 0
                                        Saphenic acid 0
                                        Saphenic acid methyl ester 0
                                        benthophoenin 0
                                        clofazimine 10
                                        dihydromethanophenazine 0
                                        mauveine A + 0
                                        mauveine B + 0
                                        mauveine B2 + 0
                                        mauveine C + 0
                                        methanophenazine 0
                                        neutral red base 0
                                        phenazine + 0
                                        phenazine-1,6-dicarboxylic acid 0
                                        phenazine-1-carboxamide 0
                                        phenazine-1-carboxylic acid 1
                                        phenazine-2-carboxylic acid 0
                                        pyocyanine 22
                                        pyocyanine(1+) 0
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