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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzoisoquinoline
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Accession:CHEBI:39200 term browser browse the term
Synonyms:related_synonym: benzoisoquinolines


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4-amino-1,8-naphthalimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase multiple interactions
affects response to substance
increases phosphorylation
ISO ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to 4-amino-1,8-naphthalimide
CTD PMID:16556909 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin affects the localization of BAX protein] CTD PMID:15456408 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein] CTD PMID:25972196 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 4-amino-1,8-naphthalimide promotes the reaction [arsenic trioxide results in increased expression of CASP3 protein]; 4-amino-1,8-naphthalimide promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]
4-amino-1,8-naphthalimide results in increased activity of CASP3 protein
CTD PMID:15456408, PMID:18695944, PMID:25499136 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 mRNA]; 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in decreased expression of CCNB1 protein] CTD PMID:25499136 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO 4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein
PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]
CTD PMID:16556909 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide results in increased expression of NOS2 protein] CTD PMID:25972196 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
decreases activity
ISO 4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein]
4-amino-1,8-naphthalimide results in decreased expression of PARP1 protein
ATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]
CTD PMID:15456408, PMID:16556909, PMID:25499136 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit affects response to substance
multiple interactions
ISO PRKDC protein affects the susceptibility to 4-amino-1,8-naphthalimide
PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]
CTD PMID:16556909 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-amino-1,8-naphthalimide inhibits the reaction [arsenic trioxide affects the localization of RELA protein] CTD PMID:25972196 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 affects response to substance ISO XRCC5 protein affects the susceptibility to 4-amino-1,8-naphthalimide CTD PMID:16556909 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
lucifer yellow dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
increases uptake
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] CTD PMID:31348918, PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          nitrogen atom 18542
            nitrogen molecular entity 18542
              organonitrogen compound 18312
                organonitrogen heterocyclic compound 17461
                  benzoisoquinoline 12
                    4-amino-1,8-naphthalimide + 12
                    Chrome fast yellow 8GL (acid form) 0
                    GRI977143 0
                    benzo[de]isoquinoline + 0
                    lissamine flavine FF free acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      benzoisoquinoline 12
                                        4-amino-1,8-naphthalimide + 12
                                        Chrome fast yellow 8GL (acid form) 0
                                        GRI977143 0
                                        benzo[de]isoquinoline + 0
                                        lissamine flavine FF free acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.