2-chlorothiazole - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2-chlorothiazole	go back to main search page
Accession:	CHEBI:39187	browse the term
Definition:	A 1,3-thiazole that has formula C3H2ClNS.
Synonyms:	exact_synonym:	2-chloro-1,3-thiazole
	related_synonym:	Formula=C3H2ClNS; InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H; InChIKey=KLEYVGWAORGTIT-UHFFFAOYSA-N; SMILES=Clc1nccs1
	xref:	Beilstein:105723; CAS:3034-52-4

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Rat (453 ) Mouse (458 ) Human (500 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (453)

(E)-thiamethoxam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

EXP

Thiamethoxam results in increased activity of ALPL protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

annexin A10

increases expression

ISO

Thiamethoxam results in increased expression of ANXA10 mRNA

NCBI chr16:32,505,025...32,571,961
Ensembl chr16:32,467,126...32,571,961

G

androgen receptor

affects binding

ISO

Thiamethoxam binds to AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

arginase 1

decreases expression

ISO

Thiamethoxam results in decreased expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

activating transcription factor 3

increases expression

ISO

Thiamethoxam results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Thiamethoxam results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Thiamethoxam results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL6, transcription repressor

decreases expression

ISO

Thiamethoxam results in decreased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BTG anti-proliferation factor 1

increases expression

ISO

Thiamethoxam results in increased expression of BTG1 mRNA

NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406

G

caspase 3

increases cleavage

ISO

Thiamethoxam results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

increases expression
multiple interactions
decreases activity
decreases expression

ISO
EXP

Thiamethoxam results in increased expression of CAT mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]

PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

increases expression

ISO

Thiamethoxam results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

EXP

Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

C-X-C motif chemokine ligand 6

increases expression

ISO

Thiamethoxam results in increased expression of CXCL5 mRNA

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of CYP11A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
increases activity
multiple interactions

ISO
EXP

Thiamethoxam results in increased expression of CYP19A1 mRNA
Thiamethoxam results in increased activity of CYP19A1 protein
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]

PMID:26464060 PMID:28750898 PMID:34181816

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

ISO

Thiamethoxam results in decreased expression of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

ISO

Thiamethoxam results in decreased expression of CYP7A1 protein

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

DNA-damage inducible transcript 3

increases expression

ISO

Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

estrogen receptor 1

affects binding
decreases expression

ISO

Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein

PMID:31550567 PMID:33533595

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

forkhead box O3

increases expression

ISO

Thiamethoxam results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

follicle stimulating hormone receptor

decreases expression

ISO

Thiamethoxam results in decreased expression of FSHR protein

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

ISO

Thiamethoxam results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

growth arrest and DNA-damage-inducible, beta

decreases expression

ISO

Thiamethoxam results in decreased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glutamic-oxaloacetic transaminase 1

increases activity
multiple interactions

EXP

Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

decreases activity

EXP

Thiamethoxam results in decreased activity of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression
multiple interactions
decreases activity
decreases expression

ISO
EXP

Thiamethoxam results in increased expression of GPX1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]

PMID:30621503 PMID:33533595 PMID:36958429

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
decreases expression

EXP

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]

NCBI chr 2:188,858,574...188,864,694

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

interleukin 1 beta

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

ISO

Thiamethoxam results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Thiamethoxam results in decreased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

lactate dehydrogenase A

increases activity
multiple interactions

EXP

Thiamethoxam results in increased activity of LDHA protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

luteinizing hormone/choriogonadotropin receptor

decreases expression
increases expression
multiple interactions

ISO
EXP

Thiamethoxam results in decreased expression of LHCGR protein
Thiamethoxam results in increased expression of LHCGR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]

PMID:33533595 PMID:34181816

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

leukocyte specific transcript 1

increases expression

ISO

Thiamethoxam results in increased expression of LST1 mRNA

NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,639,341...3,642,669

G

melanocortin 4 receptor

decreases expression

ISO

Thiamethoxam results in decreased expression of MC4R mRNA

NCBI chr18:62,689,798...62,691,685

G

matrix metallopeptidase 7

increases expression

ISO

Thiamethoxam results in increased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

nitric oxide synthase 2

decreases activity
multiple interactions
increases expression

ISO
EXP

Thiamethoxam metabolite results in decreased activity of NOS2 protein
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
Thiamethoxam results in increased expression of NOS2 mRNA
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]

PMID:29197058 PMID:36958429

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

phospholipase C, gamma 2

decreases expression

ISO

Thiamethoxam results in decreased expression of PLCG2 mRNA

NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684

G

prion protein

increases expression

ISO

Thiamethoxam results in increased expression of PRNP mRNA

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Thiamethoxam results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone-like hormone

decreases expression

ISO

Thiamethoxam results in decreased expression of PTHLH mRNA

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

pentraxin 3

increases expression

ISO

Thiamethoxam results in increased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

scavenger receptor class B, member 1

multiple interactions
decreases expression

EXP

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sestrin 2

increases expression

ISO

Thiamethoxam results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 22 member 2

decreases activity

ISO

Thiamethoxam results in decreased activity of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 7 member 11

increases expression

ISO

Thiamethoxam results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

superoxide dismutase 1

decreases activity
multiple interactions
decreases expression

EXP

Thiamethoxam results in decreased activity of SOD1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]

PMID:30621503 PMID:36958429

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stanniocalcin 2

increases expression

ISO

Thiamethoxam results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

thrombospondin 4

decreases expression

ISO

Thiamethoxam results in decreased expression of THBS4 mRNA

NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:25,718,219...25,761,369

G

thyroid hormone receptor alpha

affects binding

ISO

Thiamethoxam binds to THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

tumor necrosis factor

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin T2, cardiac type

increases secretion
multiple interactions

EXP

Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

increases expression

ISO

clothianidin results in increased expression of ABCA13 mRNA

NCBI chr14:88,087,146...88,589,868
Ensembl chr14:88,087,801...88,589,392

G

ATP binding cassette subfamily B member 6

decreases expression

ISO

clothianidin results in decreased expression of ABCB6 mRNA

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

ATP binding cassette subfamily C member 1

increases expression

ISO

clothianidin results in increased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

EXP

[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA
clothianidin results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily D member 2

decreases expression

ISO

clothianidin results in decreased expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202

G

ATP binding cassette subfamily D member 3

decreases expression

ISO

clothianidin results in decreased expression of ABCD3 mRNA

NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504

G

ATP binding cassette subfamily G member 1

decreases expression

ISO

clothianidin results in decreased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

abhydrolase domain containing 4, N-acyl phospholipase B

decreases expression

ISO

clothianidin results in decreased expression of ABHD4 mRNA

NCBI chr15:31,674,090...31,686,051
Ensembl chr15:31,674,143...31,687,007

G

ABI family member 3 binding protein

decreases expression

ISO

clothianidin results in decreased expression of ABI3BP mRNA

NCBI chr11:57,381,282...57,597,989
Ensembl chr11:57,381,422...57,598,120

G

acetylcholinesterase

decreases expression

ISO

clothianidin results in decreased expression of ACHE mRNA

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adenylate cyclase 2

increases expression

ISO

clothianidin results in increased expression of ADCY2 mRNA

NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645

G

adenylate cyclase 4

decreases expression

ISO

clothianidin results in decreased expression of ADCY4 mRNA

NCBI chr15:33,236,201...33,252,070
Ensembl chr15:33,236,208...33,252,026

G

adhesion G protein-coupled receptor B2

decreases expression

ISO

clothianidin results in decreased expression of ADGRB2 mRNA

NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:147,611,580...147,646,726

G

adhesion G protein-coupled receptor F5

decreases expression

ISO

clothianidin results in decreased expression of ADGRF5 mRNA

NCBI chr 9:25,014,861...25,128,045
Ensembl chr 9:25,018,277...25,121,237

G

adhesion G protein-coupled receptor G6

decreases expression

ISO

clothianidin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:10,633,004...10,774,685
Ensembl chr 1:10,631,829...10,774,023

G

adrenoceptor beta 2

decreases expression

ISO

clothianidin results in decreased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

AGBL carboxypeptidase 3

increases expression

ISO

clothianidin results in increased expression of AGBL3 mRNA

NCBI chr 4:64,416,139...64,498,987
Ensembl chr 4:64,421,397...64,498,985

G

aldo-keto reductase family 1, member B7

increases expression

ISO

clothianidin results in increased expression of AKR1B7 mRNA

NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909

G

aldehyde dehydrogenase 1 family, member A1

increases expression
multiple interactions

EXP

clothianidin results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

archaelysin family metallopeptidase 1

increases expression

ISO

clothianidin results in increased expression of AMZ1 mRNA

NCBI chr12:19,000,448...19,038,625
Ensembl chr12:19,000,448...19,037,925

G

ankyrin 3

decreases expression

ISO

clothianidin results in decreased expression of ANK3 mRNA

NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879

G

ankyrin repeat domain 37

decreases expression

ISO

clothianidin results in decreased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

aprataxin and PNKP like factor

increases expression

ISO

clothianidin results in increased expression of APLF mRNA

NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:121,627,800...121,679,961

G

Rho GTPase activating protein 17

increases expression

ISO

clothianidin results in increased expression of ARHGAP17 mRNA

NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

ISO

clothianidin results in increased expression of ARHGEF2 mRNA

NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:176,358,904...176,417,646

G

ARF like GTPase 11

increases expression

ISO

clothianidin results in increased expression of ARL11 mRNA

NCBI chr15:39,659,404...39,661,651
Ensembl chr15:39,656,050...39,664,105

G

ARF like GTPase 14

increases expression

ISO

clothianidin results in increased expression of ARL14 mRNA

NCBI chr 2:155,778,826...155,780,065
Ensembl chr 2:155,778,826...155,780,065

G

ARF like GTPase 6

increases expression

ISO

clothianidin results in increased expression of ARL6 mRNA

NCBI chr11:54,180,271...54,207,136
Ensembl chr11:54,181,241...54,210,813

G

ankyrin repeat and SOCS box containing 11

increases expression

ISO

clothianidin results in increased expression of ASB11 mRNA

NCBI chr X:33,646,389...33,669,790
Ensembl chr X:33,624,394...33,669,934

G

aspartate beta-hydroxylase domain containing 1

decreases expression

ISO

clothianidin results in decreased expression of ASPHD1 mRNA

NCBI chr 1:190,983,506...190,987,440
Ensembl chr 1:190,983,506...190,987,440

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

ISO

clothianidin results in decreased expression of ATP1A2 mRNA

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

ATP23 metallopeptidase and ATP synthase assembly factor homolog

increases expression

ISO

clothianidin results in increased expression of XRCC6BP1 mRNA

NCBI chr 7:64,600,100...64,615,240
Ensembl chr 7:64,600,100...64,615,392

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

ISO

clothianidin results in decreased expression of ATP2B3 mRNA

NCBI chr X:156,367,582...156,464,085
Ensembl chr X:156,367,852...156,438,153

G

ATPase H+ transporting V0 subunit D2

increases expression

ISO

clothianidin results in increased expression of ATP6V0D2 mRNA

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

acyl-CoA wax alcohol acyltransferase 1

increases expression

ISO

clothianidin results in increased expression of AWAT1 mRNA

NCBI chr X:69,708,286...69,714,531
Ensembl chr X:69,708,286...69,714,531

G

axin 1

decreases expression

ISO

clothianidin results in decreased expression of AXIN1 mRNA

NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092

G

antizyme inhibitor 2

decreases expression

ISO

clothianidin results in decreased expression of AZIN2 mRNA

NCBI chr 5:146,568,187...146,594,777
Ensembl chr 5:146,565,437...146,594,777

G

BarH-like homeobox 1

increases expression

ISO

clothianidin results in increased expression of BARHL1 mRNA

NCBI chr 3:32,639,283...32,646,605
Ensembl chr 3:32,638,644...32,646,605

G

BCR activator of RhoGEF and GTPase

decreases expression

ISO

clothianidin results in decreased expression of BCR mRNA

NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,468,732...13,596,333

G

BICD cargo adaptor 2

decreases expression

ISO

clothianidin results in decreased expression of BICD2 mRNA

NCBI chr17:15,449,011...15,511,423
Ensembl chr17:15,435,894...15,511,305

G

BRICHOS domain containing 5

decreases expression

ISO

clothianidin results in decreased expression of BRICD5 mRNA

NCBI chr10:14,003,276...14,004,809
Ensembl chr10:14,003,130...14,004,809

G

similar to human chromosome 21 open reading frame 140

increases expression

ISO

clothianidin results in increased expression of C21ORF140 mRNA

NCBI chr11:31,549,689...31,552,257
Ensembl chr11:45,023,033...45,038,353

G

similar to human chromosome 22 open reading frame 31

decreases expression

ISO

clothianidin results in decreased expression of C22ORF31 mRNA

G

similar to human chromosome 4 open reading frame 36

decreases expression

ISO

clothianidin results in decreased expression of C4ORF36 mRNA

NCBI chr14:6,058,581...6,065,848
Ensembl chr14:6,363,215...6,370,478

G

similar to human chromosome 5 open reading frame 46

increases expression

ISO

clothianidin results in increased expression of C5ORF46 mRNA

NCBI chr18:35,948,402...35,969,502
Ensembl chr18:36,199,309...36,220,409

G

similar to human chromosome 16 open reading frame 74

decreases expression

ISO

clothianidin results in decreased expression of C16ORF74 mRNA

NCBI chr19:65,568,997...65,594,994
Ensembl chr19:65,568,997...65,595,460

G

similar to human chromosome 21 open reading frame 58

decreases expression

ISO

clothianidin results in decreased expression of C21ORF58 mRNA

NCBI chr20:12,165,853...12,187,271
Ensembl chr20:12,174,928...12,186,503

G

C2 calcium-dependent domain containing 4B

increases expression

ISO

clothianidin results in increased expression of C2CD4B mRNA

NCBI chr 8:77,254,327...77,277,620
Ensembl chr 8:77,238,551...77,279,879

G

similar to human chromosome 5 open reading frame 34

increases expression

ISO

clothianidin results in increased expression of C5ORF34 mRNA

NCBI chr 2:53,287,353...53,309,804
Ensembl chr 2:53,287,957...53,309,806

G

carbonic anhydrase 3

increases expression

ISO

clothianidin results in increased expression of CA3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calcium voltage-gated channel auxiliary subunit beta 2

decreases expression

ISO

clothianidin results in decreased expression of CACNB2 mRNA

NCBI chr17:82,473,097...82,818,564
Ensembl chr17:82,473,129...82,818,564

G

calcium homeostasis modulator 3

increases expression

ISO

clothianidin results in increased expression of CALHM3 mRNA

NCBI chr 1:255,984,593...255,989,594
Ensembl chr 1:255,983,410...256,007,697

G

calpain 5

increases expression

ISO

clothianidin results in increased expression of CAPN5 mRNA

NCBI chr 1:161,827,474...161,884,142
Ensembl chr 1:161,827,474...161,884,142

G

calcyphosine

decreases expression

ISO

clothianidin results in decreased expression of CAPS mRNA

NCBI chr 9:1,630,871...1,632,758

G

capping protein regulator and myosin 1 linker 1

decreases expression

ISO

clothianidin results in decreased expression of CARMIL1 mRNA

NCBI chr17:41,235,819...41,516,204
Ensembl chr17:41,236,229...41,516,221

G

capping protein regulator and myosin 1 linker 3

increases expression

ISO

clothianidin results in increased expression of CARMIL3 mRNA

NCBI chr15:32,948,228...32,965,829
Ensembl chr15:32,948,856...32,965,811

G

coiled-coil domain containing 17

decreases expression

ISO

clothianidin results in decreased expression of CCDC17 mRNA

NCBI chr 5:135,288,799...135,293,339
Ensembl chr 5:135,289,576...135,293,336

G

coiled-coil domain containing 8

increases expression

ISO

clothianidin results in increased expression of CCDC8 mRNA

NCBI chr 1:86,807,607...86,810,935
Ensembl chr 1:86,806,942...86,814,204

G

coiled-coil serine-rich protein 1

decreases expression

ISO

clothianidin results in decreased expression of CCSER1 mRNA

NCBI chr 4:91,483,896...92,720,439
Ensembl chr 4:91,483,770...92,718,789

G

CD226 molecule

decreases expression

ISO

clothianidin results in decreased expression of CD226 mRNA

NCBI chr18:84,723,330...84,819,836
Ensembl chr18:84,725,242...84,819,835

G

CD34 molecule

increases expression

ISO

clothianidin results in increased expression of CD34 mRNA

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315

G

CD74 molecule

increases expression

ISO

clothianidin results in increased expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

CD8 subunit beta

increases expression

ISO

clothianidin results in increased expression of CD8B mRNA

NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:104,870,893...104,886,868

G

cadherin 8

decreases expression

ISO

clothianidin results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,552...5,901,950
Ensembl chr19:5,500,221...5,902,627

G

CMT1A duplicated region transcript 15 like 2

increases expression

ISO

clothianidin results in increased expression of CDRT15L2 mRNA

NCBI chr16:11,226,012...11,231,967

G

CEA cell adhesion molecule 6

increases expression

ISO

clothianidin results in increased expression of CEACAM6 mRNA

NCBI chr 1:89,544,415...89,562,552
Ensembl chr 1:89,544,400...89,562,552

G

cell migration inducing hyaluronidase 1

increases expression

ISO

clothianidin results in increased expression of CEMIP mRNA

NCBI chr 1:147,316,052...147,471,552
Ensembl chr 1:147,316,052...147,471,768

G

carboxylesterase 2H

multiple interactions

ISO

[clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

cilia and flagella associated protein 107

decreases expression

ISO

clothianidin results in decreased expression of CFAP107 mRNA

NCBI chr 5:161,495,655...161,514,751
Ensembl chr 5:161,495,655...161,514,751

G

choline O-acetyltransferase

decreases expression

ISO

clothianidin results in decreased expression of CHAT mRNA

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

ISO

clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105

G

cholinergic receptor nicotinic alpha 7 subunit

decreases expression
increases activity

ISO

clothianidin results in decreased expression of CHRNA7 mRNA
clothianidin results in increased activity of CHRNA7 protein; clothianidin results in increased activity of CHRNA7 protein mutant form

PMID:35264496 PMID:39393466

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

EXP
ISO

clothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; clothianidin results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]
clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

PMID:16981889 PMID:21538459 PMID:25459289

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

carbohydrate sulfotransferase 3

increases expression

ISO

clothianidin results in increased expression of CHST3 mRNA

NCBI chr20:28,657,308...28,694,976
Ensembl chr20:28,657,308...28,694,526

G

claudin 14

decreases expression

ISO

clothianidin results in decreased expression of CLDN14 mRNA

NCBI chr11:46,701,940...46,799,049
Ensembl chr11:46,701,940...46,799,096

G

C-type lectin domain family 3, member B

increases expression

ISO

clothianidin results in increased expression of CLEC3B mRNA

NCBI chr 8:131,687,575...131,693,292

G

CKLF-like MARVEL transmembrane domain containing 5

increases expression

ISO

clothianidin results in increased expression of CMTM5 mRNA

NCBI chr15:32,382,171...32,385,288
Ensembl chr15:32,382,608...32,385,271

G

contactin associated protein 1

decreases expression

ISO

clothianidin results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,610,140...86,625,896
Ensembl chr10:86,611,890...86,631,730

G

collagen type XII alpha 1 chain

decreases expression

ISO

clothianidin results in decreased expression of COL12A1 mRNA

NCBI chr 8:89,427,834...89,545,886
Ensembl chr 8:89,427,834...89,545,711

G

collagen type I alpha 1 chain

decreases expression

ISO

clothianidin results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type V alpha 2 chain

decreases expression

ISO

clothianidin results in decreased expression of COL5A2 mRNA

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

collagen type VI alpha 2 chain

increases expression

ISO

clothianidin results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,265...12,057,042

G

collagen type VII alpha 1 chain

decreases expression

ISO

clothianidin results in decreased expression of COL7A1 mRNA

NCBI chr 8:118,483,364...118,515,736
Ensembl chr 8:118,483,364...118,517,439

G

coronin 2B

decreases expression

ISO

clothianidin results in decreased expression of CORO2B mRNA

NCBI chr 8:71,802,329...71,912,739
Ensembl chr 8:71,802,329...71,912,739

G

cytoplasmic polyadenylation element binding protein 3

decreases expression

ISO

clothianidin results in decreased expression of CPEB3 mRNA

NCBI chr 1:244,161,690...244,343,765
Ensembl chr 1:244,161,690...244,343,561

G

copine 4

increases expression

ISO

clothianidin results in increased expression of CPNE4 mRNA

NCBI chr 8:114,056,152...114,531,855
Ensembl chr 8:113,993,703...114,531,855

G

CUB and Sushi multiple domains 1

increases expression

ISO

clothianidin results in increased expression of CSMD1 mRNA

NCBI chr16:78,920,549...80,520,710
Ensembl chr16:78,921,002...80,519,944

G

CXADR, Ig-like cell adhesion molecule

increases expression

ISO

clothianidin results in increased expression of CXADR mRNA

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:30,469,526...30,516,988

G

cytochrome b-245 alpha chain

decreases expression

ISO

clothianidin results in decreased expression of CYBA mRNA

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects expression

ISO

clothianidin affects the expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

ISO

[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA
clothianidin results in increased expression of CYP1A2 mRNA

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

ISO

[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

EXP

clothianidin results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

[clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

ISO

clothianidin results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

ISO

clothianidin results in increased expression of CYP3A4 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

EXP

[enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA
clothianidin results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
increases expression

ISO

[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
clothianidin results in increased expression of CYP3A5 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
decreases expression

EXP

[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA
clothianidin results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytohesin 4

increases expression

ISO

clothianidin results in increased expression of CYTH4 mRNA

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:112,032,775...112,057,204

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

ISO

clothianidin results in decreased expression of DACT1 mRNA

NCBI chr 6:95,526,645...95,538,625
Ensembl chr 6:95,526,690...95,551,053

G

defensin alpha 5

decreases expression

ISO

clothianidin results in decreased expression of DEFA5 mRNA

NCBI chr16:77,044,994...77,047,318
Ensembl chr16:77,044,994...77,047,318

G

desmin

increases expression

ISO

clothianidin results in increased expression of DES mRNA

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

diacylglycerol kinase, delta

increases expression

ISO

clothianidin results in increased expression of DGKD mRNA

NCBI chr 9:95,964,507...96,055,160
Ensembl chr 9:95,964,148...96,055,160

G

iodothyronine deiodinase 3

increases expression

ISO

clothianidin results in increased expression of DIO3 mRNA

NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:135,107,074...135,107,985

G

delta like canonical Notch ligand 3

decreases expression

ISO

clothianidin results in decreased expression of DLL3 mRNA

NCBI chr 1:92,689,577...92,698,125
Ensembl chr 1:92,689,577...92,697,406

G

dynein axonemal intermediate chain 7

decreases expression

ISO

clothianidin results in decreased expression of DNAI7 mRNA

NCBI chr 4:179,874,338...179,910,716
Ensembl chr 4:179,873,522...179,910,780

G

DnaJ heat shock protein family (Hsp40) member C21

increases expression

ISO

clothianidin results in increased expression of DNAJC21 mRNA

NCBI chr 2:61,146,669...61,173,908
Ensembl chr 2:61,145,142...61,174,126

G

DnaJ heat shock protein family (Hsp40) member C28

decreases expression

ISO

clothianidin results in decreased expression of DNAJC28 mRNA

NCBI chr11:44,341,528...44,344,348
Ensembl chr11:44,338,646...44,344,482

G

DnaJ heat shock protein family (Hsp40) member C5 gamma

increases expression

ISO

clothianidin results in increased expression of DNAJC5G mRNA

NCBI chr 6:25,260,087...25,264,251
Ensembl chr 6:30,979,869...30,984,115

G

deoxyribonuclease 1 like 2

decreases expression

ISO

clothianidin results in decreased expression of DNASE1L2 mRNA

NCBI chr10:13,976,012...13,978,574
Ensembl chr10:13,976,012...13,978,366

G

dynein heavy chain domain 1

decreases expression

ISO

clothianidin results in decreased expression of DNHD1 mRNA

NCBI chr 1:169,402,615...169,486,684
Ensembl chr 1:169,394,884...169,487,646

G

docking protein 5

decreases expression

ISO

clothianidin results in decreased expression of DOK5 mRNA

NCBI chr 3:179,934,419...180,071,334
Ensembl chr 3:179,934,552...180,071,333

G

dihydrouridine synthase 3-like

increases expression

ISO

clothianidin results in increased expression of DUS3L mRNA

NCBI chr 9:1,593,491...1,598,663
Ensembl chr 9:1,675,819...1,686,367

G

dual specificity phosphatase 15

increases expression

ISO

clothianidin results in increased expression of DUSP15 mRNA

NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:161,868,749...161,879,250

G

dual specificity phosphatase 16

decreases expression

ISO

clothianidin results in decreased expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508

G

ELL associated factor 2

decreases expression

ISO

clothianidin results in decreased expression of EAF2 mRNA

NCBI chr11:77,465,585...77,509,993
Ensembl chr11:77,406,020...77,509,993

G

endothelin-converting enzyme 2

increases expression

ISO

clothianidin results in increased expression of ECE2 mRNA

NCBI chr11:93,767,559...93,782,896
Ensembl chr11:93,767,559...93,793,292

G

EF-hand calcium binding domain 12

decreases expression

ISO

clothianidin results in decreased expression of EFCAB12 mRNA

NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:150,541,982...150,563,286

G

embryonal Fyn-associated substrate

decreases expression

ISO

clothianidin results in decreased expression of EFS mRNA

NCBI chr15:32,362,401...32,374,490
Ensembl chr15:32,361,843...32,371,743

G

eukaryotic translation initiation factor 3, subunit F

decreases expression

ISO

clothianidin results in decreased expression of EIF3F mRNA

NCBI chr 1:172,369,062...172,378,043
Ensembl chr 1:172,369,062...172,378,041

G

E74 like ETS transcription factor 1

increases expression

ISO

clothianidin results in increased expression of ELF1 mRNA

NCBI chr15:61,354,026...61,395,762
Ensembl chr15:61,330,877...61,395,758

G

ELMO domain containing 1

decreases expression

ISO

clothianidin results in decreased expression of ELMOD1 mRNA

NCBI chr 8:63,194,539...63,251,526
Ensembl chr 8:63,137,295...63,251,322

G

elastin

multiple interactions
decreases expression

EXP

[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA
clothianidin results in decreased expression of ELN mRNA

NCBI chr12:27,604,983...27,648,413
Ensembl chr12:27,604,680...27,648,413

G

ecto-NOX disulfide-thiol exchanger 1

increases expression

ISO

clothianidin results in increased expression of ENOX1 mRNA

NCBI chr15:58,924,519...59,488,919
Ensembl chr15:59,215,018...59,488,918

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

increases expression

ISO

clothianidin results in increased expression of ENPP4 mRNA

NCBI chr 9:24,386,351...24,396,248
Ensembl chr 9:24,360,272...24,396,152

G

ependymin related 1

increases expression

ISO

clothianidin results in increased expression of EPDR1 mRNA

NCBI chr17:50,029,591...50,054,254
Ensembl chr17:50,029,256...50,054,250

G

epsin 3

decreases expression

ISO

clothianidin results in decreased expression of EPN3 mRNA

NCBI chr10:79,935,857...79,946,121
Ensembl chr10:79,935,857...79,944,235

G

EGFR pathway substrate 8, signaling adaptor

increases expression

ISO

clothianidin results in increased expression of EPS8 mRNA

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160

G

erb-b2 receptor tyrosine kinase 3

increases expression

ISO

clothianidin results in increased expression of ERBB3 mRNA

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

endoplasmic reticulum-golgi intermediate compartment 1

increases expression

ISO

clothianidin results in increased expression of ERGIC1 mRNA

NCBI chr10:16,531,192...16,626,974
Ensembl chr10:17,035,615...17,131,376

G

exocyst complex component 4

decreases expression

ISO

clothianidin results in decreased expression of EXOC4 mRNA

NCBI chr 4:62,774,896...63,551,541
Ensembl chr 4:62,774,935...63,552,943

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

ISO

clothianidin results in decreased expression of EZH2 mRNA

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

coagulation factor II, thrombin

decreases expression

ISO

clothianidin results in decreased expression of F2 mRNA

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

family with sequence similarity 110, member C

increases expression

ISO

clothianidin results in increased expression of FAM110C mRNA

NCBI chr 6:53,366,013...53,372,270
Ensembl chr 6:53,352,870...53,401,117

G

family with sequence similarity 131, member A

decreases expression

ISO

clothianidin results in decreased expression of FAM131A mRNA

NCBI chr11:80,211,577...80,221,527
Ensembl chr11:93,716,002...93,725,919

G

family with sequence similarity 151, member B

decreases expression

ISO

clothianidin results in decreased expression of FAM151B mRNA

NCBI chr 2:23,674,317...23,710,420
Ensembl chr 2:25,409,383...25,445,466

G

family with sequence similarity 169, member A

increases expression

ISO

clothianidin results in increased expression of FAM169A mRNA

NCBI chr 2:30,115,307...30,175,972
Ensembl chr 2:30,119,381...30,175,962

G

family with sequence similarity 229, member A

decreases expression

ISO

clothianidin results in decreased expression of FAM229A mRNA

NCBI chr 5:141,829,716...141,830,705
Ensembl chr 5:147,113,997...147,114,785

G

Fas ligand

increases expression

ISO

clothianidin results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box protein 33

decreases expression

ISO

clothianidin results in decreased expression of FBXO33 mRNA

NCBI chr 6:82,635,509...82,669,441
Ensembl chr 6:82,635,521...82,667,440

G

fer-1-like family member 4

decreases expression

ISO

clothianidin results in decreased expression of FER1L4 mRNA

NCBI chr 3:164,996,183...165,031,719
Ensembl chr 3:164,996,183...165,031,719

G

Fibroblast growth factor receptor 1

increases expression

ISO

clothianidin results in increased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

fragile histidine triad diadenosine triphosphatase

increases expression

ISO

clothianidin results in increased expression of FHIT mRNA

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621

G

filamin A interacting protein 1

increases expression

ISO

clothianidin results in increased expression of FILIP1 mRNA

NCBI chr 8:89,641,509...89,836,772
Ensembl chr 8:89,644,579...89,802,771

G

fat storage-inducing transmembrane protein 1

increases expression

ISO

clothianidin results in increased expression of FITM1 mRNA

NCBI chr15:33,034,705...33,035,974
Ensembl chr15:33,034,688...33,035,974

G

folate receptor beta

increases expression

ISO

clothianidin results in increased expression of FOLR2 mRNA

NCBI chr 1:165,612,047...165,630,382
Ensembl chr 1:165,612,063...165,617,731

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

clothianidin results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box O1

increases expression

ISO

clothianidin results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O4

decreases expression

ISO

clothianidin results in decreased expression of FOXO4 mRNA

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:70,425,563...70,432,120

G

FYN binding protein 1

decreases expression

ISO

clothianidin results in decreased expression of FYB1 mRNA

NCBI chr 2:57,360,084...57,508,609
Ensembl chr 2:57,360,096...57,508,608

G

gamma-aminobutyric acid type A receptor subunit gamma 1

increases expression

ISO

clothianidin results in increased expression of GABRG1 mRNA

NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,750,292...37,989,945

G

gamma-aminobutyric acid type A receptor subunit pi

decreases expression

ISO

clothianidin results in decreased expression of GABRP mRNA

NCBI chr10:18,647,243...18,673,806
Ensembl chr10:18,647,243...18,673,727

G

golgi associated kinase 1A

increases expression

ISO

clothianidin results in increased expression of FAM198A mRNA

NCBI chr 8:121,610,779...121,643,742
Ensembl chr 8:130,488,354...130,521,242

G

growth differentiation factor 15

increases expression

ISO

clothianidin results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

growth hormone releasing hormone receptor

increases expression

ISO

clothianidin results in increased expression of GHRHR mRNA

NCBI chr 4:85,830,345...85,863,127
Ensembl chr 4:85,830,486...85,863,127

G

GLI family zinc finger 1

decreases expression

ISO

clothianidin results in decreased expression of GLI1 mRNA

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540

G

G protein subunit gamma transducin 1

decreases expression

ISO

clothianidin results in decreased expression of GNGT1 mRNA

NCBI chr 4:32,960,945...32,963,930
Ensembl chr 4:32,960,945...32,963,930

G

glycine N-methyltransferase

decreases expression

ISO

clothianidin results in decreased expression of GNMT mRNA

NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692

G

glypican 6

increases expression

ISO

clothianidin results in increased expression of GPC6 mRNA

NCBI chr15:100,437,415...101,435,038
Ensembl chr15:100,437,943...101,435,027

G

glycerophosphocholine phosphodiesterase 1

increases expression

ISO

clothianidin results in increased expression of GPCPD1 mRNA

NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:140,240,575...140,285,372

G

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

increases expression

ISO

clothianidin results in increased expression of GPIHBP1 mRNA

NCBI chr 7:109,166,334...109,169,448
Ensembl chr 7:109,163,160...109,169,448

G

G protein-coupled receptor 15 ligand

decreases expression

ISO

clothianidin results in decreased expression of GPR15LG mRNA

NCBI chr16:12,888,528...12,896,134
Ensembl chr16:12,888,528...12,896,134

G

glutathione peroxidase 4

decreases expression

ISO

clothianidin results in decreased expression of GPX4 protein

PMID:25960033 PMID:33563863

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

GRAM domain containing 1C

decreases expression

ISO

clothianidin results in decreased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:70,139,184...70,224,478

G

GRAM domain containing 2A

decreases expression

ISO

clothianidin results in decreased expression of GRAMD2A mRNA

NCBI chr 8:68,975,529...69,013,575
Ensembl chr 8:69,003,807...69,013,573

G

GSK3B interacting protein

increases expression

ISO

clothianidin results in increased expression of GSKIP mRNA

NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:130,370,042...130,373,873

G

general transcription factor IIIC subunit 5

increases expression

ISO

clothianidin results in increased expression of GTF3C5 mRNA

NCBI chr 3:32,291,851...32,312,188
Ensembl chr 3:32,291,859...32,312,164

G

gametocyte specific factor 1-like

increases expression

ISO

clothianidin results in increased expression of GTSF1L mRNA

NCBI chr 3:172,155,533...172,158,228
Ensembl chr 3:172,154,100...172,162,042

G

glycophorin C

increases expression

ISO

clothianidin results in increased expression of GYPC mRNA

NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,434,922...24,440,053

G

H1.7 linker histone

increases expression

ISO

clothianidin results in increased expression of H1-7 mRNA

NCBI chr 7:129,408,521...129,409,888
Ensembl chr 7:131,286,654...131,289,110

G

3-hydroxyacyl-CoA dehydratase 2

increases expression

ISO

clothianidin results in increased expression of HACD2 mRNA

NCBI chr11:79,175,470...79,268,975
Ensembl chr11:79,175,482...79,268,126

G

HCK proto-oncogene, Src family tyrosine kinase

increases expression

ISO

clothianidin results in increased expression of HCK mRNA

NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

ISO

clothianidin results in increased expression of HECTD2 mRNA

NCBI chr 1:243,687,248...243,756,069
Ensembl chr 1:243,687,923...243,756,069

G

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

decreases expression

ISO

clothianidin results in decreased expression of HECW2 mRNA

NCBI chr 9:62,853,904...63,247,472
Ensembl chr 9:62,859,645...63,074,758

G

hepatocyte growth factor

decreases expression

ISO

clothianidin results in decreased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

HID1 domain containing

decreases expression

ISO

clothianidin results in decreased expression of HID1 mRNA

NCBI chr10:101,088,526...101,109,011
Ensembl chr10:101,088,526...101,109,011

G

hydroxymethylbilane synthase

increases expression

ISO

clothianidin results in increased expression of HMBS mRNA

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

HNF1 homeobox B

increases expression

ISO

clothianidin results in increased expression of HNF1B mRNA

NCBI chr10:69,233,377...69,287,360
Ensembl chr10:69,233,131...69,287,361

G

hepatocyte nuclear factor 4, alpha

increases expression

ISO

clothianidin results in increased expression of HNF4A mRNA

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

ISO

clothianidin results in decreased expression of HNRNPK mRNA

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

intraflagellar transport 70B

decreases expression

ISO

clothianidin results in decreased expression of IFT70B mRNA

NCBI chr 3:81,263,074...81,265,645

G

interleukin 17 receptor E

decreases expression

ISO

clothianidin results in decreased expression of IL17RE mRNA

NCBI chr 4:148,160,384...148,173,830
Ensembl chr 4:148,159,475...148,173,827

G

interleukin 18 binding protein

decreases expression

ISO

clothianidin results in decreased expression of IL18BP mRNA

NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:165,784,069...165,786,955

G

interleukin 2 receptor subunit gamma

increases expression

ISO

clothianidin results in increased expression of IL2RG mRNA

NCBI chr X:70,435,340...70,439,052
Ensembl chr X:70,435,343...70,439,161

G

inner mitochondrial membrane peptidase subunit 1

increases expression

ISO

clothianidin results in increased expression of IMMP1L mRNA

NCBI chr 3:112,840,015...112,904,297
Ensembl chr 3:112,840,113...112,904,296

G

inhibin subunit beta A

increases expression

ISO

clothianidin results in increased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

inhibitory synaptic factor family member 2B

decreases expression

ISO

clothianidin results in decreased expression of INSYN2B mRNA

NCBI chr10:18,916,721...19,023,859
Ensembl chr10:19,507,084...19,511,298

G

iroquois homeobox 5

decreases expression

ISO

clothianidin results in decreased expression of IRX5 mRNA

NCBI chr19:30,812,033...30,816,885
Ensembl chr19:30,797,202...30,815,029

G

intersectin 1

decreases expression

ISO

clothianidin results in decreased expression of ITSN1 mRNA

NCBI chr11:44,464,515...44,646,598
Ensembl chr11:44,513,186...44,646,598

G

Janus kinase 2

decreases expression

ISO

clothianidin results in decreased expression of JAK2 mRNA

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

lysine acetyltransferase 6B

decreases expression

ISO

clothianidin results in decreased expression of KAT6B mRNA

NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343

G

potassium voltage-gated channel subfamily C member 4

increases expression

ISO

clothianidin results in increased expression of KCNC4 mRNA

NCBI chr 2:197,747,095...197,788,467
Ensembl chr 2:197,759,010...197,788,433

G

potassium voltage-gated channel subfamily D member 3

decreases expression

ISO

clothianidin results in decreased expression of KCND3 mRNA

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium two pore domain channel subfamily K member 1

decreases expression

ISO

clothianidin results in decreased expression of KCNK1 mRNA

NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

ISO

clothianidin results in decreased expression of KCNMA1 mRNA

PMID:31626844 PMID:35690182

NCBI chr15:351,065...1,057,117
Ensembl chr15:351,659...1,057,117

G

kinesin family member 7

increases expression

ISO

clothianidin results in increased expression of KIF7 mRNA

NCBI chr 1:143,041,206...143,067,873
Ensembl chr 1:143,049,036...143,067,890

G

kinesin family member C3

increases expression

ISO

clothianidin results in increased expression of KIFC3 mRNA

NCBI chr19:9,831,159...9,926,405
Ensembl chr19:9,831,159...9,926,405

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

ISO

clothianidin results in increased expression of KIT mRNA

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

kelch domain containing 9

decreases expression

ISO

clothianidin results in decreased expression of KLHDC9 mRNA

NCBI chr13:86,323,004...86,326,237
Ensembl chr13:86,323,004...86,325,653

G

karyopherin subunit alpha 6

increases expression

ISO

clothianidin results in increased expression of KPNA6 mRNA

NCBI chr 5:147,272,466...147,307,523
Ensembl chr 5:147,275,918...147,305,851

G

keratin 28

increases expression

ISO

clothianidin results in increased expression of KRT28 mRNA

NCBI chr10:84,814,516...84,824,857
Ensembl chr10:84,814,516...84,824,857

G

kinase suppressor of ras 1

decreases expression

ISO

clothianidin results in decreased expression of KSR1 mRNA

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082

G

kyphoscoliosis peptidase

multiple interactions
decreases expression

EXP

[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA
clothianidin results in decreased expression of KY mRNA

NCBI chr 8:111,965,862...112,005,206
Ensembl chr 8:111,965,862...112,005,206

G

L3MBTL histone methyl-lysine binding protein 1

decreases expression

ISO

clothianidin results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:172,014,774...172,053,181
Ensembl chr 3:172,021,416...172,053,181

G

galectin 12

increases expression

ISO

clothianidin results in increased expression of LGALS12 mRNA

NCBI chr 1:204,832,065...204,842,759
Ensembl chr 1:214,261,216...214,271,910

G

leucine-rich repeat LGI family, member 4

increases expression

ISO

clothianidin results in increased expression of LGI4 mRNA

NCBI chr 1:95,422,461...95,433,296
Ensembl chr 1:95,414,058...95,433,289

G

LIF, interleukin 6 family cytokine

decreases expression

ISO

clothianidin results in decreased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

lens intrinsic membrane protein 2

increases expression

ISO

clothianidin results in increased expression of LIM2 mRNA

NCBI chr 1:102,974,188...102,980,358
Ensembl chr 1:102,974,188...102,980,358

G

LON peptidase N-terminal domain and ring finger 1

increases expression

ISO

clothianidin results in increased expression of LONRF1 mRNA

NCBI chr16:55,984,572...56,015,156
Ensembl chr16:62,687,746...62,718,520

G

lysyl oxidase

increases expression

ISO

clothianidin results in increased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lysophosphatidic acid receptor 1

decreases expression

ISO

clothianidin results in decreased expression of LPAR1 mRNA

NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:78,024,139...78,142,188

G

leucine-rich repeats and immunoglobulin-like domains 1

increases expression

ISO

clothianidin results in increased expression of LRIG1 mRNA

NCBI chr 4:128,687,723...128,788,219
Ensembl chr 4:128,687,723...128,788,219

G

leucine rich melanocyte differentiation associated

decreases expression

ISO

clothianidin results in decreased expression of LRMDA mRNA

NCBI chr15:1,275,139...2,334,153
Ensembl chr15:1,274,199...2,334,089

G

leucine rich repeat containing 74B

decreases expression

ISO

clothianidin results in decreased expression of LRRC74B mRNA

NCBI chr11:83,450,588...83,468,906
Ensembl chr11:96,954,449...96,974,288

G

leucine zipper protein 2

increases expression

ISO

clothianidin results in increased expression of LUZP2 mRNA

NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:114,733,455...115,119,630

G

LysM domain containing 2

decreases expression

ISO

clothianidin results in decreased expression of LYSMD2 mRNA

NCBI chr 8:85,259,443...85,274,876
Ensembl chr 8:85,259,410...85,275,241

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

clothianidin results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

clothianidin results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

melanin-concentrating hormone receptor 1

increases expression

ISO

clothianidin results in increased expression of MCHR1 mRNA

NCBI chr 7:114,641,721...114,644,913
Ensembl chr 7:114,641,580...114,644,919

G

multiple EGF-like-domains 11

multiple interactions
decreases expression

EXP

[enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA
clothianidin results in decreased expression of MEGF11 mRNA

NCBI chr 8:73,787,568...74,113,228
Ensembl chr 8:73,787,397...74,111,690

G

meiosis specific with coiled-coil domain

increases expression

ISO

clothianidin results in increased expression of MEIOC mRNA

NCBI chr10:87,628,807...87,646,485
Ensembl chr10:88,128,990...88,147,829

G

methyltransferase 16, RNA N6-adenosine

increases expression

ISO

clothianidin results in increased expression of METTL16 mRNA

NCBI chr10:59,640,915...59,697,291
Ensembl chr10:60,139,330...60,187,571

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

ISO

clothianidin results in increased expression of MICAL1 mRNA

NCBI chr20:46,547,983...46,568,487
Ensembl chr20:46,556,536...46,568,487

G

MICAL-like 2

decreases expression

ISO

clothianidin results in decreased expression of MICALL2 mRNA

NCBI chr12:20,013,037...20,041,795
Ensembl chr12:20,012,985...20,041,795

G

melan-A

increases expression

ISO

clothianidin results in increased expression of MLANA mRNA

NCBI chr 1:236,883,075...236,897,693
Ensembl chr 1:236,883,075...236,896,880

G

membrane metallo-endopeptidase

multiple interactions
increases expression

EXP

[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA
clothianidin results in increased expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 10

increases expression

ISO

clothianidin results in increased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

membrane spanning 4-domains A2

decreases expression

ISO

clothianidin results in decreased expression of MS4A2 mRNA

NCBI chr 1:217,864,855...217,873,934
Ensembl chr 1:217,865,159...217,873,108

G

MSS51 mitochondrial translational activator

decreases expression

ISO

clothianidin results in decreased expression of MSS51 mRNA

NCBI chr15:3,855,094...3,868,614
Ensembl chr15:3,855,478...3,868,611

G

mitochondrial ribosome-associated GTPase 1

decreases expression

ISO

clothianidin results in decreased expression of MTG1 mRNA

NCBI chr 1:204,361,176...204,373,917
Ensembl chr 1:204,361,147...204,373,924

G

myosin light chain 11

decreases expression

ISO

clothianidin results in decreased expression of MYL11 mRNA

NCBI chr 1:191,257,432...191,263,046
Ensembl chr 1:191,256,196...191,263,045

G

myosin, light chain 4

decreases expression

ISO

clothianidin results in decreased expression of MYL4 mRNA

NCBI chr10:89,949,733...89,985,308
Ensembl chr10:89,949,404...89,985,308

G

myosin light chain 6

decreases expression

ISO

clothianidin results in decreased expression of MYL6 mRNA

NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:1,495,747...1,498,344

G

myosin IIIB

increases expression

ISO

clothianidin results in increased expression of MYO3B mRNA

NCBI chr 3:75,228,017...75,636,272
Ensembl chr 3:75,228,017...75,636,272

G

myogenesis regulating glycosidase

increases expression

ISO

clothianidin results in increased expression of MYORG mRNA

NCBI chr 5:61,452,956...61,460,500
Ensembl chr 5:61,432,418...61,460,581

G

myelin transcription factor 1-like

increases expression

ISO

clothianidin results in increased expression of MYT1L mRNA

NCBI chr 6:51,892,858...52,291,830
Ensembl chr 6:52,155,754...52,291,828

G

NEDD4 binding protein 2-like 1

increases expression

ISO

clothianidin results in increased expression of N4BP2L1 mRNA

NCBI chr12:4,938,199...4,965,003
Ensembl chr12:4,927,142...4,963,045

G

NAD synthetase 1

decreases expression

ISO

clothianidin results in decreased expression of NADSYN1 mRNA

NCBI chr 1:208,410,914...208,439,242
Ensembl chr 1:208,410,914...208,439,207

G

nuclear autoantigenic sperm protein

decreases expression

ISO

clothianidin results in decreased expression of NASP mRNA

NCBI chr 5:135,294,599...135,319,992
Ensembl chr 5:135,294,032...135,319,591

G

neutrophil cytosolic factor 2

increases expression

ISO

clothianidin results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

NADH:ubiquinone oxidoreductase subunit A10

increases expression

ISO

clothianidin results in increased expression of NDUFA10 mRNA

NCBI chr 9:100,454,498...100,490,023
Ensembl chr 9:100,437,379...100,489,264

G

nectin cell adhesion molecule 4

decreases expression

ISO

clothianidin results in decreased expression of NECTIN4 mRNA

NCBI chr13:86,335,027...86,354,152
Ensembl chr13:86,335,831...86,353,967

G

neuronal differentiation 4

decreases expression

ISO

clothianidin results in decreased expression of NEUROD4 mRNA

NCBI chr 7:7,740,852...7,828,052
Ensembl chr 7:7,740,852...7,752,824

G

neuronal guanine nucleotide exchange factor

increases expression

ISO

clothianidin results in increased expression of NGEF mRNA

NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:95,594,823...95,692,251

G

nerve growth factor receptor

increases expression

ISO

clothianidin results in increased expression of NGFR mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

ninein-like

decreases expression

ISO

clothianidin results in decreased expression of NINL mRNA

NCBI chr 3:139,748,353...139,814,683
Ensembl chr 3:160,196,883...160,275,108

G

nitric oxide synthase 2

increases expression

ISO

clothianidin results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 0, group B, member 2

decreases expression
multiple interactions

ISO

clothianidin results in decreased expression of NR0B2 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

netrin 4

decreases expression

ISO

clothianidin results in decreased expression of NTN4 mRNA

NCBI chr 7:30,073,637...30,187,407
Ensembl chr 7:30,073,333...30,188,309

G

neurotensin

decreases expression

ISO

clothianidin results in decreased expression of NTS mRNA

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nucleoredoxin-like 2

increases expression

ISO

clothianidin results in increased expression of NXNL2 mRNA

NCBI chr17:14,182,849...14,187,595
Ensembl chr17:14,182,849...14,188,208

G

neurexophilin 2

increases expression

ISO

clothianidin results in increased expression of NXPH2 mRNA

NCBI chr 3:26,373,858...26,392,392
Ensembl chr 3:26,153,756...26,391,876

G

OCRL, inositol polyphosphate-5-phosphatase

decreases expression

ISO

clothianidin results in decreased expression of OCRL mRNA

NCBI chr X:131,955,775...132,018,298
Ensembl chr X:131,967,355...132,018,298

G

olfactory receptor 59

increases expression

ISO

clothianidin results in increased expression of OR51E2 mRNA

NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:166,604,141...166,623,265

G

OTU deubiquitinase 6B

increases expression

ISO

clothianidin results in increased expression of OTUD6B mRNA

NCBI chr 5:32,979,190...33,011,781
Ensembl chr 5:32,979,147...33,011,568

G

peptidyl arginine deiminase 4

increases expression

ISO

clothianidin results in increased expression of PADI4 mRNA

NCBI chr 5:158,324,417...158,357,466
Ensembl chr 5:158,324,417...158,360,422

G

p21 (RAC1) activated kinase 5

decreases expression

ISO

clothianidin results in decreased expression of PAK5 mRNA

PMID:31626844 PMID:35690182

NCBI chr 3:143,848,404...144,156,674
Ensembl chr 3:143,849,223...144,156,640

G

progestin and adipoQ receptor family member 8

decreases expression

ISO

clothianidin results in decreased expression of PAQR8 mRNA

NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:30,808,923...30,861,043

G

phenazine biosynthesis-like protein domain containing 1

decreases expression

ISO

clothianidin results in decreased expression of PBLD mRNA

NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,549,974...25,565,226

G

propionyl-CoA carboxylase subunit alpha

decreases expression

ISO

clothianidin results in decreased expression of PCCA mRNA

NCBI chr15:106,034,586...106,374,908
Ensembl chr15:106,034,610...106,374,908

G

proprotein convertase subtilisin/kexin type 1

decreases expression

ISO

clothianidin results in decreased expression of PCSK1 mRNA

NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:6,129,592...6,176,974

G

phosphodiesterase 10A

decreases expression

ISO

clothianidin results in decreased expression of PDE10A mRNA

NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051

G

phosphodiesterase 1C

increases expression

ISO

clothianidin results in increased expression of PDE1C mRNA

NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259

G

phosphodiesterase 4D interacting protein

increases expression

ISO

clothianidin results in increased expression of PDE4DIP mRNA

NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869

G

PDZ domain containing 7

decreases expression

ISO

clothianidin results in decreased expression of PDZD7 mRNA

NCBI chr 1:253,837,454...253,856,919
Ensembl chr 1:253,837,459...253,855,999

G

pellino E3 ubiquitin protein ligase family member 2

decreases expression

ISO

clothianidin results in decreased expression of PELI2 mRNA

NCBI chr15:23,872,984...24,017,448
Ensembl chr15:23,872,984...24,014,817

G

post-GPI attachment to proteins 6

decreases expression

ISO

clothianidin results in decreased expression of PGAP6 mRNA

NCBI chr10:15,643,081...15,652,912
Ensembl chr10:15,643,106...15,652,912

G

progesterone receptor

increases expression

ISO

clothianidin results in increased expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

PH domain containing endocytic trafficking adaptor 2

increases expression

ISO

clothianidin results in increased expression of FAM109B mRNA

NCBI chr 7:115,735,499...115,741,988
Ensembl chr 7:115,734,649...115,742,461

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

decreases expression

ISO

clothianidin results in decreased expression of PIK3C2B mRNA

NCBI chr13:47,046,866...47,107,733
Ensembl chr13:47,047,127...47,107,725

G

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

decreases expression

ISO

clothianidin results in decreased expression of PIP5K1C mRNA

NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:9,048,146...9,076,716

G

phosphatidylinositol-4-phosphate 5-kinase-like 1

decreases expression

ISO

clothianidin results in decreased expression of PIP5KL1 mRNA

NCBI chr 3:36,258,141...36,266,902
Ensembl chr 3:36,258,102...36,266,888

G

phospholipase A2 group IIA

increases expression

ISO

clothianidin results in increased expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

phospholipase B domain containing 1

decreases expression

ISO

clothianidin results in decreased expression of PLBD1 mRNA

NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:171,204,198...171,260,488

G

phospholipase C, delta 1

increases expression

ISO

clothianidin results in increased expression of PLCD1 mRNA

NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939

G

phospholipase C, delta 3

decreases expression

ISO

clothianidin results in decreased expression of PLCD3 mRNA

NCBI chr10:88,526,802...88,548,116
Ensembl chr10:88,526,802...88,548,069

G

phospholipase C-like 1

decreases expression

ISO

clothianidin results in decreased expression of PLCL1 mRNA

NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:64,361,520...64,733,171

G

plasmolipin

increases expression

ISO

clothianidin results in increased expression of PLLP mRNA

NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,321,080...10,342,226

G

patatin-like phospholipase domain containing 1

increases expression

ISO

clothianidin results in increased expression of PNPLA1 mRNA

NCBI chr20:6,919,689...6,953,850
Ensembl chr20:6,919,115...6,955,143

G

RNA polymerase II subunit M

decreases expression

ISO

clothianidin results in decreased expression of POLR2M mRNA

NCBI chr 8:81,012,770...81,020,201
Ensembl chr 8:81,012,771...81,020,302

G

protein phosphatase 1, regulatory subunit 3C

increases expression

ISO

clothianidin results in increased expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835

G

protein phosphatase 3 catalytic subunit gamma

increases expression

ISO

clothianidin results in increased expression of PPP3CC mRNA

NCBI chr15:51,699,586...51,771,763
Ensembl chr15:51,700,255...51,771,538

G

proteoglycan 3, pro eosinophil major basic protein 2

increases expression

ISO

clothianidin results in increased expression of PRG3 mRNA

NCBI chr 3:90,478,627...90,484,760
Ensembl chr 3:90,479,154...90,484,759

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

ISO

clothianidin results in decreased expression of PARK2 mRNA

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

prolactin receptor

decreases expression

ISO

clothianidin results in decreased expression of PRLR mRNA

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

prion like protein doppel

increases expression

ISO

clothianidin results in increased expression of PRND mRNA

NCBI chr 3:139,666,383...139,671,647
Ensembl chr 3:139,666,068...139,671,890

G

proline dehydrogenase 2

increases expression

ISO

clothianidin results in increased expression of PRODH2 mRNA

NCBI chr 1:94,881,000...94,894,609
Ensembl chr 1:94,881,061...94,894,609

G

proline rich 5 like

increases expression

ISO

clothianidin results in increased expression of PRR5L mRNA

NCBI chr 3:108,458,107...108,628,552
Ensembl chr 3:108,458,633...108,537,763

G

peroxiredoxin like 2B

decreases expression

ISO

clothianidin results in decreased expression of PRXL2B mRNA

NCBI chr 5:170,744,953...170,747,556
Ensembl chr 5:170,744,953...170,747,556

G

presenilin 1

decreases expression

ISO

clothianidin results in decreased expression of PSEN1 mRNA

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189

G

proteasome 26S subunit, ATPase 6

decreases expression

ISO

clothianidin results in decreased expression of PSMC6 mRNA

NCBI chr15:21,022,314...21,043,785
Ensembl chr15:21,022,314...21,043,785

G

prostaglandin F receptor

decreases expression

ISO

clothianidin results in decreased expression of PTGFR mRNA

NCBI chr 2:243,390,820...243,426,647
Ensembl chr 2:243,393,350...243,425,623

G

protein tyrosine phosphatase, non-receptor type 3

increases expression

ISO

clothianidin results in increased expression of PTPN3 mRNA

NCBI chr 5:76,703,687...76,822,584
Ensembl chr 5:76,703,687...76,860,470

G

protein tyrosine phosphatase, receptor type, B

decreases expression

ISO

clothianidin results in decreased expression of PTPRB mRNA

NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:53,816,097...53,920,760

G

protein tyrosine phosphatase, receptor type, O

decreases expression

ISO

clothianidin results in decreased expression of PTPRO mRNA

NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:171,895,232...172,105,903

G

glutaminyl-peptide cyclotransferase

increases expression

ISO

clothianidin results in increased expression of QPCT mRNA

NCBI chr 6:21,716,824...21,748,895
Ensembl chr 6:21,716,824...21,748,895

G

recombination activating 1

decreases expression

ISO

clothianidin results in decreased expression of RAG1 mRNA

NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:108,371,978...108,383,261

G

Rap guanine nucleotide exchange factor like 1

decreases expression

ISO

clothianidin results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:84,289,980...84,306,614
Ensembl chr10:84,289,980...84,306,614

G

RNA binding motif protein 26

decreases expression

ISO

clothianidin results in decreased expression of RBM26 mRNA

NCBI chr15:88,299,378...88,379,365
Ensembl chr15:88,301,436...88,378,686

G

RNA binding motif, single stranded interacting protein 1

decreases expression

ISO

clothianidin results in decreased expression of RBMS1 mRNA

NCBI chr 3:65,604,475...65,829,072
Ensembl chr 3:65,606,358...65,829,013

G

regenerating family member 3 gamma

increases expression

ISO

clothianidin results in increased expression of REG3G mRNA

NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:112,482,183...112,484,738

G

Rieske (Fe-S) domain containing

decreases expression

ISO

clothianidin results in decreased expression of RFESD mRNA

NCBI chr 2:5,495,067...5,521,095
Ensembl chr 2:7,237,947...7,247,628

G

regulatory subunit of type II PKA R-subunit domain containing 1

decreases expression

ISO

clothianidin results in decreased expression of RIIAD1 mRNA

NCBI chr 2:182,099,924...182,110,544
Ensembl chr 2:184,790,822...184,799,172

G

Rho family GTPase 1

increases expression

ISO

clothianidin results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

RP1 like 1

increases expression

ISO

clothianidin results in increased expression of RP1L1 mRNA

NCBI chr15:42,435,803...42,447,165
Ensembl chr15:42,435,803...42,447,165

G

ribosomal protein S29

increases expression

ISO

clothianidin results in increased expression of RPS29 mRNA

NCBI chr 6:93,371,293...93,372,731
Ensembl chr13:87,816,954...87,817,267
Ensembl chr 6:87,816,954...87,817,267

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

ISO

clothianidin results in increased expression of RRAD mRNA

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

RT1 class II, locus Bb

increases expression

ISO

clothianidin results in increased expression of HLA-DQB1 mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

S100 calcium binding protein A5

decreases expression

ISO

clothianidin results in decreased expression of S100A5 mRNA

NCBI chr 2:178,392,922...178,397,128
Ensembl chr 2:178,395,121...178,397,128

G

SAM and SH3 domain containing 3

increases expression

ISO

clothianidin results in increased expression of SASH3 mRNA

NCBI chr X:132,204,717...132,219,421
Ensembl chr X:132,204,543...132,219,419

G

sodium voltage-gated channel alpha subunit 7

decreases expression

ISO

clothianidin results in decreased expression of SCN7A mRNA

NCBI chr 3:71,743,873...71,846,454
Ensembl chr 3:71,743,873...71,846,284

G

sodium channel epithelial 1 subunit beta

increases expression

ISO

clothianidin results in increased expression of SCNN1B mRNA

NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:185,854,733...185,916,049

G

semaphorin 3F

decreases expression

ISO

clothianidin results in decreased expression of SEMA3F mRNA

NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:117,236,269...117,265,206

G

stress-associated endoplasmic reticulum protein 1

decreases expression

ISO

clothianidin results in decreased expression of SERP1 mRNA

NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:144,907,205...144,911,187

G

serpin family A member 3N

decreases expression

ISO

clothianidin results in decreased expression of SERPINA3N mRNA

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family C member 1

decreases expression

ISO

clothianidin results in decreased expression of SERPINC1 mRNA

NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643

G

serpin family E member 1

decreases expression

ISO

clothianidin results in decreased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sarcoglycan, delta

increases expression

ISO

clothianidin results in increased expression of SGCD mRNA

NCBI chr10:31,847,713...32,829,554
Ensembl chr10:31,781,748...32,419,064

G

serum/glucocorticoid regulated kinase 2

decreases expression

ISO

clothianidin results in decreased expression of SGK2 mRNA

NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:172,063,776...172,089,011

G

SH3 domain and tetratricopeptide repeats 1

increases expression

ISO

clothianidin results in increased expression of SH3TC1 mRNA

NCBI chr14:75,005,691...75,050,001
Ensembl chr14:79,230,371...79,274,620

G

signal-induced proliferation-associated 1 like 2

increases expression

ISO

clothianidin results in increased expression of SIPA1L2 mRNA

NCBI chr19:53,389,792...53,540,466
Ensembl chr19:70,287,147...70,437,773

G

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

ISO

clothianidin results in decreased expression of SLC14A1 mRNA

NCBI chr18:73,840,568...73,883,925
Ensembl chr18:73,840,569...73,870,489

G

solute carrier family 17 member 7

decreases expression

ISO

clothianidin results in decreased expression of SLC17A7 mRNA

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049

G

solute carrier family 22 member 2

decreases activity

ISO

clothianidin results in decreased activity of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 6

decreases activity

ISO

clothianidin results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

decreases activity

ISO

clothianidin results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 28 member 1

increases expression

ISO

clothianidin results in increased expression of SLC28A1 mRNA

NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:144,490,623...144,531,544

G

solute carrier family 38, member 9

decreases expression

ISO

clothianidin results in decreased expression of SLC38A9 mRNA

NCBI chr 2:46,024,731...46,102,419
Ensembl chr 2:46,024,947...46,105,983

G

solute carrier family 45, member 2

decreases expression

ISO

clothianidin results in decreased expression of SLC45A2 mRNA

NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:61,690,828...61,723,437

G

solute carrier family 47 member 2

decreases activity

ISO

clothianidin results in decreased activity of SLC47A2 protein

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

solute carrier family 48 member 1

increases expression

ISO

clothianidin results in increased expression of SLC48A1 mRNA

NCBI chr 7:130,794,233...130,802,119
Ensembl chr 7:130,794,245...130,803,022

G

solute carrier family 6 member 1

decreases expression
multiple interactions

EXP

clothianidin results in decreased expression of SLC6A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:149,004,635...149,037,839

G

solute carrier organic anion transporter family, member 1c1

increases expression

ISO

clothianidin results in increased expression of SLCO1C1 mRNA

NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395

G

sphingomyelin phosphodiesterase 3

decreases expression

ISO

clothianidin results in decreased expression of SMPD3 mRNA

NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936

G

sorbin and SH3 domain containing 1

increases expression

ISO

clothianidin results in increased expression of SORBS1 mRNA

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:249,057,324...249,279,608

G

spermatogenesis associated 3

increases expression

ISO

clothianidin results in increased expression of SPATA3 mRNA

NCBI chr 9:94,107,832...94,120,280
Ensembl chr 9:94,107,807...94,119,172

G

spire-type actin nucleation factor 2

decreases expression

ISO

clothianidin results in decreased expression of SPIRE2 mRNA

NCBI chr19:68,281,878...68,320,427
Ensembl chr19:68,281,870...68,320,427

G

steroid 5 alpha-reductase 2

increases expression

ISO

clothianidin results in increased expression of SRD5A2 mRNA

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588

G

SCO-spondin

decreases expression

ISO

clothianidin results in decreased expression of SSPOP mRNA

NCBI chr 4:78,725,829...78,781,330
Ensembl chr 4:78,727,275...78,781,315

G

SH3 and cysteine rich domain 2

increases expression

ISO

clothianidin results in increased expression of STAC2 mRNA

NCBI chr10:83,528,741...83,544,583
Ensembl chr10:83,528,741...83,544,583

G

STEAP2 metalloreductase

increases expression

ISO

clothianidin results in increased expression of STEAP2 mRNA

NCBI chr 4:29,302,487...29,323,006
Ensembl chr 4:29,303,381...29,330,620

G

sushi domain containing 4

increases expression

ISO

clothianidin results in increased expression of SUSD4 mRNA

NCBI chr13:96,982,867...97,109,419
Ensembl chr13:96,986,788...97,109,401

G

synaptonemal complex protein 2

decreases expression

ISO

clothianidin results in decreased expression of SYCP2 mRNA

NCBI chr 3:185,814,033...185,876,516
Ensembl chr 3:185,814,035...185,876,492

G

synaptopodin

decreases expression

ISO

clothianidin results in decreased expression of SYNPO mRNA

NCBI chr18:56,326,369...56,347,359
Ensembl chr18:56,319,571...56,353,306

G

tachykinin receptor 1

increases expression

ISO

clothianidin results in increased expression of TACR1 mRNA

NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492

G

TAFA chemokine like family member 2

decreases expression

ISO

clothianidin results in decreased expression of TAFA2 mRNA

NCBI chr 7:60,827,985...61,303,873
Ensembl chr 7:60,891,958...61,303,869

G

TAFA chemokine like family member 5

increases expression

ISO

clothianidin results in increased expression of TAFA5 mRNA

NCBI chr 7:120,493,447...120,714,720
Ensembl chr 7:120,493,060...120,714,718

G

T-box transcription factor 2

increases expression

ISO

clothianidin results in increased expression of TBX2 mRNA

NCBI chr10:71,177,082...71,186,275
Ensembl chr10:71,177,082...71,186,275

G

t-complex protein 10b

increases expression

ISO

clothianidin results in increased expression of TCP10L2 mRNA

NCBI chr 1:52,937,823...52,961,307
Ensembl chr 1:55,485,411...55,508,836

G

tectonin beta-propeller repeat containing 1

decreases expression

ISO

clothianidin results in decreased expression of TECPR1 mRNA

NCBI chr12:15,504,456...15,534,541
Ensembl chr12:15,505,343...15,534,116

G

TEF transcription factor, PAR bZIP family member

increases expression

ISO

clothianidin results in increased expression of TEF mRNA

NCBI chr 7:115,197,180...115,221,930
Ensembl chr 7:115,193,282...115,221,928

G

transforming growth factor, beta induced

increases expression

ISO

clothianidin results in increased expression of TGFBI mRNA

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471

G

transglutaminase 5

decreases expression

ISO

clothianidin results in decreased expression of TGM5 mRNA

NCBI chr 3:128,461,836...128,497,761
Ensembl chr 3:128,461,836...128,497,761

G

thyroid hormone responsive

decreases expression

ISO

clothianidin results in decreased expression of THRSP mRNA

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827

G

TIR domain containing adaptor molecule 1

increases expression

ISO

clothianidin results in increased expression of TICAM1 mRNA

NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892

G

TRAF-interacting protein with forkhead-associated domain

increases expression

ISO

clothianidin results in increased expression of TIFA mRNA

NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:218,909,915...218,956,224

G

TLC domain containing 4

increases expression

ISO

clothianidin results in increased expression of TLCD4 mRNA

NCBI chr 2:211,969,612...212,044,883
Ensembl chr 2:211,974,471...212,026,081

G

toll-like receptor 2

increases expression

ISO

clothianidin results in increased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

T-cell leukemia, homeobox 3

decreases expression

ISO

clothianidin results in decreased expression of TLX3 mRNA

NCBI chr10:18,293,932...18,296,551
Ensembl chr10:18,293,932...18,296,773

G

transmembrane protein 273

increases expression

ISO

clothianidin results in increased expression of TMEM273 mRNA

NCBI chr16:8,055,930...8,088,280
Ensembl chr16:8,055,930...8,088,280

G

transmembrane protein 38a

decreases expression

ISO

clothianidin results in decreased expression of TMEM38A mRNA

NCBI chr16:17,292,215...17,307,704
Ensembl chr16:17,292,215...17,333,132

G

transmembrane protein 71

decreases expression

ISO

clothianidin results in decreased expression of TMEM71 mRNA

NCBI chr 7:100,166,038...100,212,234
Ensembl chr 7:100,166,516...100,204,969

G

thiol methyltransferase 1A

decreases expression

ISO

clothianidin results in decreased expression of TMT1A mRNA

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959

G

tumor necrosis factor

multiple interactions

ISO

clothianidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; clothianidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

decreases expression

ISO

clothianidin results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

tenascin XB

decreases expression

ISO

clothianidin results in decreased expression of TNXB mRNA

Ensembl chr20:4,031,082...4,090,128

G

tropomyosin 1

increases expression

ISO

clothianidin results in increased expression of TPM1 mRNA

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

Tnf receptor associated factor 4

increases expression

ISO

clothianidin results in increased expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

TNF receptor associated factor 6

decreases expression

ISO

clothianidin results in decreased expression of TRAF6 mRNA

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

trafficking protein particle complex subunit 4

increases expression

ISO

clothianidin results in increased expression of TRAPPC4 mRNA

NCBI chr 8:53,626,382...53,630,042
Ensembl chr 8:53,625,474...53,630,241

G

tripartite motif-containing 37

decreases expression

ISO

clothianidin results in decreased expression of TRIM37 mRNA

NCBI chr10:72,440,672...72,572,831
Ensembl chr10:72,440,644...72,572,828

G

tRNA methyltransferase 44

increases expression

ISO

clothianidin results in increased expression of TRMT44 mRNA

NCBI chr14:75,175,331...75,204,291
Ensembl chr14:79,406,647...79,424,761

G

testis-specific serine kinase 6

decreases expression

ISO

clothianidin results in decreased expression of TSSK6 mRNA

NCBI chr16:19,523,626...19,526,074
Ensembl chr16:19,548,473...19,567,061

G

tetratricopeptide repeat domain 28

decreases expression

ISO

clothianidin results in decreased expression of TTC28 mRNA

NCBI chr12:51,002,816...51,443,461
Ensembl chr12:51,005,089...51,443,531

G

tetratricopeptide repeat domain 33

decreases expression

ISO

clothianidin results in decreased expression of TTC33 mRNA

NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:56,007,316...56,054,326

G

tetratricopeptide repeat domain 8

decreases expression

ISO

clothianidin results in decreased expression of TTC8 mRNA

NCBI chr 6:123,927,657...124,025,354
Ensembl chr 6:123,927,907...123,982,117

G

tubulin gamma complex component 3

increases expression

ISO

clothianidin results in increased expression of TUBGCP3 mRNA

NCBI chr16:83,553,950...83,614,626
Ensembl chr16:83,553,959...83,614,623

G

thioredoxin domain containing 2

increases expression

ISO

clothianidin results in increased expression of TXNDC2 mRNA

NCBI chr 9:112,677,459...112,682,027
Ensembl chr 9:112,668,084...112,682,092

G

ubiquitin associated protein 1-like

decreases expression
increases expression

ISO

clothianidin results in decreased expression of UBAP1L mRNA
clothianidin results in increased expression of UBAP1L mRNA

PMID:29044138 PMID:31626844

NCBI chr 8:74,772,794...74,792,753
Ensembl chr 8:74,781,395...74,792,716

G

unc-119 lipid binding chaperone B

increases expression

ISO

clothianidin results in increased expression of UNC119B mRNA

NCBI chr12:47,139,492...47,152,115
Ensembl chr12:47,139,545...47,152,112

G

ubiquitin specific peptidase 43

decreases expression

ISO

clothianidin results in decreased expression of USP43 mRNA

NCBI chr10:53,047,368...53,110,099
Ensembl chr10:53,048,158...53,110,180

G

utrophin

decreases expression

ISO

clothianidin results in decreased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

G

vesicle-associated membrane protein 8

increases expression

ISO

clothianidin results in increased expression of VAMP8 mRNA

NCBI chr 4:106,000,570...106,011,081
Ensembl chr 4:106,000,570...106,011,073

G

vascular endothelial growth factor D

decreases expression

ISO

clothianidin results in decreased expression of VEGFD mRNA

NCBI chr X:33,704,582...33,740,305
Ensembl chr X:33,706,055...33,740,167

G

VPS8 subunit of CORVET complex

decreases expression

ISO

clothianidin results in decreased expression of VPS8 mRNA

NCBI chr11:92,906,702...93,140,844
Ensembl chr11:92,906,700...93,138,570

G

WASH complex subunit 4

increases expression

ISO

clothianidin results in increased expression of WASHC4 mRNA

NCBI chr 7:22,075,546...22,127,847
Ensembl chr 7:22,050,098...22,127,828

G

whirlin

increases expression

ISO

clothianidin results in increased expression of WHRN mRNA

NCBI chr 5:81,843,820...81,933,400
Ensembl chr 5:81,843,820...81,927,381

G

Wnt family member 7B

decreases expression

ISO

clothianidin results in decreased expression of WNT7B mRNA

NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:118,514,684...118,559,316

G

yippee-like 2

increases expression

ISO

clothianidin results in increased expression of YPEL2 mRNA

NCBI chr10:72,243,591...72,301,124
Ensembl chr10:72,243,591...72,301,124

G

yippee-like 3

decreases expression

ISO

clothianidin results in decreased expression of YPEL3 mRNA

NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:190,814,512...190,818,251

G

zinc finger and BTB domain containing 45

decreases expression

ISO

clothianidin results in decreased expression of ZBTB45 mRNA

NCBI chr 1:82,707,633...82,712,926
Ensembl chr 1:82,707,634...82,710,277

G

zinc finger CCHC-type containing 13

decreases expression

ISO

clothianidin results in decreased expression of ZCCHC13 mRNA

NCBI chr X:72,709,319...72,710,422
Ensembl chr X:72,709,152...72,731,030

G

zinc finger protein 18

decreases expression

ISO

clothianidin results in decreased expression of ZNF18 mRNA

NCBI chr10:50,972,531...50,994,796
Ensembl chr10:50,972,572...50,995,329

G

zinc finger protein 219

decreases expression

ISO

clothianidin results in decreased expression of ZNF219 mRNA

NCBI chr15:27,169,335...27,183,555
Ensembl chr15:27,169,339...27,182,926

G

zinc finger protein 467

increases expression

ISO

clothianidin results in increased expression of ZNF467 mRNA

NCBI chr 4:78,716,473...78,725,829
Ensembl chr 4:78,716,666...78,723,135

G

zinc finger protein 470

increases expression

ISO

clothianidin results in increased expression of ZNF470 mRNA

NCBI chr 1:100,200,601...100,248,567

G

zinc finger protein 502

increases expression

ISO

clothianidin results in increased expression of ZNF502 mRNA

NCBI chr 1:30,712,974...30,737,956

G

zinc finger protein 521

decreases expression

ISO

clothianidin results in decreased expression of ZNF521 mRNA

NCBI chr18:5,050,297...5,343,188
Ensembl chr18:5,056,236...5,343,054

G

zinc finger protein 653

decreases expression

ISO

clothianidin results in decreased expression of ZNF653 mRNA

NCBI chr 8:28,862,618...28,881,439
Ensembl chr 8:28,862,618...28,881,070

G

zinc finger protein 865

increases expression

ISO

clothianidin results in increased expression of ZNF784 mRNA

NCBI chr 1:77,834,142...77,838,620
Ensembl chr 1:77,834,107...77,840,131

G

zinc finger with KRAB and SCAN domains 7

increases expression

ISO

clothianidin results in increased expression of ZKSCAN7 mRNA

NCBI chr 8:131,379,514...131,397,065
Ensembl chr 8:131,378,013...131,397,065

G

zinc finger, SWIM-type containing 4

decreases expression

ISO

clothianidin results in decreased expression of ZSWIM4 mRNA

NCBI chr19:23,927,845...23,952,970
Ensembl chr19:40,832,635...40,857,742

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases activity

EXP

[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]
Thiamethoxam results in increased activity of ALPL protein

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

annexin A10

increases expression

ISO

Thiamethoxam results in increased expression of ANXA10 mRNA

NCBI chr16:32,505,025...32,571,961
Ensembl chr16:32,467,126...32,571,961

G

androgen receptor

affects binding

ISO

Thiamethoxam binds to AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

arginase 1

decreases expression

ISO

Thiamethoxam results in decreased expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

activating transcription factor 3

increases expression

ISO

Thiamethoxam results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Thiamethoxam results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Thiamethoxam results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL6, transcription repressor

decreases expression

ISO

Thiamethoxam results in decreased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

BTG anti-proliferation factor 1

increases expression

ISO

Thiamethoxam results in increased expression of BTG1 mRNA

NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406

G

caspase 3

increases cleavage

ISO

Thiamethoxam results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

increases expression
decreases expression
multiple interactions
decreases activity

ISO
EXP

Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased expression of CAT mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]

PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

increases expression

ISO

Thiamethoxam results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

EXP

Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326

G

C-X-C motif chemokine ligand 6

increases expression

ISO

Thiamethoxam results in increased expression of CXCL5 mRNA

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

EXP

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
multiple interactions
increases activity

ISO
EXP

thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
thiamethoxam results in increased activity of CYP19A1 protein

PMID:26464060 PMID:28750898 PMID:34181816

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

ISO

Thiamethoxam results in decreased expression of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

ISO

Thiamethoxam results in decreased expression of CYP7A1 protein

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

DNA-damage inducible transcript 3

increases expression

ISO

Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

estrogen receptor 1

affects binding
decreases expression

ISO

Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein

PMID:31550567 PMID:33533595

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

forkhead box O3

increases expression

ISO

Thiamethoxam results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

follicle stimulating hormone receptor

decreases expression

ISO

Thiamethoxam results in decreased expression of FSHR protein

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

ISO

Thiamethoxam results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

growth arrest and DNA-damage-inducible, beta

decreases expression

ISO

Thiamethoxam results in decreased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glutamic-oxaloacetic transaminase 1

increases activity
multiple interactions

EXP

Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

decreases activity

EXP

thiamethoxam results in decreased activity of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases expression
decreases expression
decreases activity
multiple interactions

ISO
EXP

Thiamethoxam results in increased expression of GPX1 mRNA
Thiamethoxam results in decreased expression of GPX1 mRNA
Thiamethoxam results in decreased activity of GPX1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]

PMID:30621503 PMID:33533595 PMID:36958429

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of HSD3B1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]

NCBI chr 2:188,858,574...188,864,694

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

interleukin 1 beta

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

ISO

Thiamethoxam results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

JunB proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Thiamethoxam results in decreased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

lactate dehydrogenase A

multiple interactions
increases activity

EXP

[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]
Thiamethoxam results in increased activity of LDHA protein

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

luteinizing hormone/choriogonadotropin receptor

decreases expression
increases expression
multiple interactions

ISO
EXP

Thiamethoxam results in decreased expression of LHCGR protein
Thiamethoxam results in increased expression of LHCGR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]

PMID:33533595 PMID:34181816

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

leukocyte specific transcript 1

increases expression

ISO

Thiamethoxam results in increased expression of LST1 mRNA

NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,639,341...3,642,669

G

melanocortin 4 receptor

decreases expression

ISO

Thiamethoxam results in decreased expression of MC4R mRNA

NCBI chr18:62,689,798...62,691,685

G

matrix metallopeptidase 7

increases expression

ISO

Thiamethoxam results in increased expression of MMP7 mRNA

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

nitric oxide synthase 2

multiple interactions
increases expression
decreases activity

ISO
EXP

[thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
Thiamethoxam results in increased expression of NOS2 mRNA
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]

PMID:29197058 PMID:36958429

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

phospholipase C, gamma 2

decreases expression

ISO

Thiamethoxam results in decreased expression of PLCG2 mRNA

NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684

G

prion protein

increases expression

ISO

Thiamethoxam results in increased expression of PRNP mRNA

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Thiamethoxam results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone-like hormone

decreases expression

ISO

Thiamethoxam results in decreased expression of PTHLH mRNA

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

pentraxin 3

increases expression

ISO

Thiamethoxam results in increased expression of PTX3 mRNA

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

scavenger receptor class B, member 1

multiple interactions
decreases expression

EXP

Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sestrin 2

increases expression

ISO

Thiamethoxam results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 22 member 2

decreases activity

ISO

Thiamethoxam results in decreased activity of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 7 member 11

increases expression

ISO

Thiamethoxam results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

superoxide dismutase 1

decreases activity
decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased activity of SOD1 protein
Thiamethoxam results in decreased expression of SOD1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]

PMID:30621503 PMID:36958429

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

steroidogenic acute regulatory protein

decreases expression
multiple interactions

EXP

Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stanniocalcin 2

increases expression

ISO

Thiamethoxam results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

thrombospondin 4

decreases expression

ISO

Thiamethoxam results in decreased expression of THBS4 mRNA

NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:25,718,219...25,761,369

G

thyroid hormone receptor alpha

affects binding

ISO

Thiamethoxam binds to THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

tumor necrosis factor

multiple interactions
increases expression

EXP

Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

troponin T2, cardiac type

increases secretion
multiple interactions

EXP

Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
molecular entity	20859
polyatomic entity	20803
heteroatomic molecular entity	20740
halide	19179
organohalogen compound	18997
organochlorine compound	18749
2-chlorothiazole	453
clothianidin +	403
thiamethoxam +	57
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
organic molecule	20654
organic cyclic compound	20404
organic heterocyclic compound	19388
heteroarene	17448
monocyclic heteroarene	15186
azole	14620
thiazoles	1816
1,3-thiazoles	1249
2-chlorothiazole	453
clothianidin +	403
thiamethoxam +	57

paths to the root