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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(E)-thiamethoxam
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Accession:CHEBI:39186 term browser browse the term
Definition:A thiamethoxam that has formula C8H10ClN5O3S.
Synonyms:exact_synonym: (4E)-3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
 related_synonym: Formula=C8H10ClN5O3S;   InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8+;   InChIKey=NWWZPOKUUAIXIW-DHZHZOJOSA-N;   SMILES=CN1COCN(Cc2cnc(Cl)s2)\\C1=N\\[N+]([O-])=O
 xref: Beilstein:8491021;   CAS:153719-23-4;   KEGG:C18513
 xref_mesh: MESH:C416660


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(E)-thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity
ISO Thiamethoxam results in increased expression of CYP19A1 mRNA
Thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060 PMID:28750898 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Thiamethoxam binds to ESR1 protein CTD PMID:31550567 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP Thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions
ISO Thiamethoxam metabolite results in decreased activity of NOS2 protein
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD PMID:29197058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19877
    role 19827
      biological role 19827
        xenobiotic 18456
          thiamethoxam 15
            (E)-thiamethoxam 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19877
    subatomic particle 19875
      composite particle 19875
        hadron 19875
          baryon 19875
            nucleon 19875
              atomic nucleus 19875
                atom 19875
                  main group element atom 19765
                    p-block element atom 19765
                      carbon group element atom 19670
                        carbon atom 19659
                          organic molecular entity 19659
                            organic molecule 19589
                              organic cyclic compound 19398
                                organic heterocyclic compound 18511
                                  heteroarene 16565
                                    monocyclic heteroarene 13376
                                      azole 12546
                                        thiazoles 1251
                                          1,3-thiazoles 644
                                            2-chlorothiazole 370
                                              thiamethoxam 15
                                                (E)-thiamethoxam 15
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