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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiamethoxam
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Accession:CHEBI:39185 term browser browse the term
Definition:An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Synonyms:exact_synonym: 3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
 related_synonym: 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine;   Formula=C8H10ClN5O3S;   InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3;   InChIKey=NWWZPOKUUAIXIW-UHFFFAOYSA-N;   SMILES=CN1COCN(Cc2cnc(Cl)s2)C1=N[N+]([O-])=O;   TMX
 xref: Beilstein:8555232;   CAS:153719-23-4;   KEGG:C18513
 xref_mesh: MESH:C416660
 xref: PMID:11695183;   PMID:12075996;   PMID:15716476;   PMID:15716477;   PMID:16652252;   PMID:19459179;   PMID:19481804;   PMID:21681919;   PMID:21713483;   PMID:21870159;   PMID:22065124;   PMID:22404231;   PMID:22461498;   PMID:22489844;   PMID:24700817;   PMID:25132224;   PMID:25348589;   PMID:25528611;   PMID:25529677;   PMID:25626153;   PMID:25655818;   PMID:25710849;   PMID:25825679;   PMID:25884469;   PPDB:631;   Pesticides:thiamethoxam;   Reaxys:8555232;   Wikipedia:Thiamethoxam

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thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465 		JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity		 ISO thiamethoxam results in increased expression of CYP19A1 mRNA
thiamethoxam results in increased activity of CYP19A1 protein		 CTD PMID:26464060 PMID:28750898 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Thiamethoxam binds to ESR1 protein CTD PMID:31550567 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity		 ISO [thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde CTD PMID:29197058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions		 EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]		 CTD PMID:30520268 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990 		JBrowse link
(E)-thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465 		JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity		 ISO Thiamethoxam results in increased expression of CYP19A1 mRNA
Thiamethoxam results in increased activity of CYP19A1 protein		 CTD PMID:26464060 PMID:28750898 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Thiamethoxam binds to ESR1 protein CTD PMID:31550567 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP Thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions		 ISO Thiamethoxam metabolite results in decreased activity of NOS2 protein
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde		 CTD PMID:29197058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions		 EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]		 CTD PMID:30520268 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        xenobiotic 18393
          thiamethoxam 15
            (E)-thiamethoxam 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  heteroarene 16512
                                    monocyclic heteroarene 13362
                                      azole 12537
                                        thiazoles 1253
                                          1,3-thiazoles 645
                                            2-chlorothiazole 370
                                              thiamethoxam 15
                                                (E)-thiamethoxam 15
paths to the root