CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: thiamethoxam
Accession: CHEBI:39185
browse the term
Definition: An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Synonyms: exact_synonym: 3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
related_synonym: 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine; Formula=C8H10ClN5O3S; InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3; InChIKey=NWWZPOKUUAIXIW-UHFFFAOYSA-N; SMILES=CN1COCN(Cc2cnc(Cl)s2)C1=N[N+]([O-])=O; TMX
xref: Beilstein:8555232; CAS:153719-23-4; KEGG:C18513
xref_mesh: MESH:C416660
xref: PMID:11695183; PMID:12075996; PMID:15716476; PMID:15716477; PMID:16652252; PMID:19459179; PMID:19481804; PMID:21681919; PMID:21713483; PMID:21870159; PMID:22065124; PMID:22404231; PMID:22461498; PMID:22489844; PMID:24700817; PMID:25132224; PMID:25348589; PMID:25528611; PMID:25529677; PMID:25626153; PMID:25655818; PMID:25710849; PMID:25825679; PMID:25884469; PPDB:631; Pesticides:thiamethoxam; Reaxys:8555232; Wikipedia:Thiamethoxam
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Anxa10
annexin A10
increases expression
ISO
Thiamethoxam results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
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Ar
androgen receptor
affects binding
ISO
Thiamethoxam binds to AR protein
CTD
PMID:31550567
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Arg1
arginase 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
EXP
thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]
CTD
PMID:16981889
NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression increases activity
ISO
thiamethoxam results in increased expression of CYP19A1 mRNA thiamethoxam results in increased activity of CYP19A1 protein
CTD
PMID:26464060 PMID:28750898
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
multiple interactions
ISO
[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam
CTD
PMID:16153789
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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Esr1
estrogen receptor 1
affects binding
ISO
Thiamethoxam binds to ESR1 protein
CTD
PMID:31550567
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
Thiamethoxam results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
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Gpt
glutamic--pyruvic transaminase
decreases activity
EXP
thiamethoxam results in decreased activity of GPT protein
CTD
PMID:29197058
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Nos2
nitric oxide synthase 2
multiple interactions decreases activity
ISO
[thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD
PMID:29197058
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Slc22a2
solute carrier family 22 member 2
decreases activity
ISO
Thiamethoxam results in decreased activity of SLC22A2 protein
CTD
PMID:31364238
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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Thra
thyroid hormone receptor alpha
affects binding
ISO
Thiamethoxam binds to THRA protein
CTD
PMID:31550567
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
G
Tnnt2
troponin T2, cardiac type
increases secretion multiple interactions
EXP
Thiamethoxam results in increased secretion of TNNT2 protein fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD
PMID:30520268
NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
G
Anxa10
annexin A10
increases expression
ISO
Thiamethoxam results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
G
Ar
androgen receptor
affects binding
ISO
Thiamethoxam binds to AR protein
CTD
PMID:31550567
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Arg1
arginase 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
EXP
Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]
CTD
PMID:16981889
NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression increases activity
ISO
Thiamethoxam results in increased expression of CYP19A1 mRNA Thiamethoxam results in increased activity of CYP19A1 protein
CTD
PMID:26464060 PMID:28750898
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
G
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
multiple interactions
ISO
[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam
CTD
PMID:16153789
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
G
Esr1
estrogen receptor 1
affects binding
ISO
Thiamethoxam binds to ESR1 protein
CTD
PMID:31550567
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
Thiamethoxam results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
G
Gpt
glutamic--pyruvic transaminase
decreases activity
EXP
Thiamethoxam results in decreased activity of GPT protein
CTD
PMID:29197058
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Nos2
nitric oxide synthase 2
decreases activity multiple interactions
ISO
Thiamethoxam metabolite results in decreased activity of NOS2 protein [Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD
PMID:29197058
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Slc22a2
solute carrier family 22 member 2
decreases activity
ISO
Thiamethoxam results in decreased activity of SLC22A2 protein
CTD
PMID:31364238
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
G
Thra
thyroid hormone receptor alpha
affects binding
ISO
Thiamethoxam binds to THRA protein
CTD
PMID:31550567
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
G
Tnnt2
troponin T2, cardiac type
increases secretion multiple interactions
EXP
Thiamethoxam results in increased secretion of TNNT2 protein fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD
PMID:30520268
NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
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