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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiamethoxam
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Accession:CHEBI:39185 term browser browse the term
Definition:An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Synonyms:exact_synonym: 3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
 related_synonym: 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine;   Formula=C8H10ClN5O3S;   InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3;   InChIKey=NWWZPOKUUAIXIW-UHFFFAOYSA-N;   SMILES=CN1COCN(Cc2cnc(Cl)s2)C1=N[N+]([O-])=O;   TMX
 xref: Beilstein:8555232;   CAS:153719-23-4;   KEGG:C18513
 xref_mesh: MESH:C416660
 xref: PMID:11695183;   PMID:12075996;   PMID:15716476;   PMID:15716477;   PMID:16652252;   PMID:19459179;   PMID:19481804;   PMID:21681919;   PMID:21713483;   PMID:21870159;   PMID:22065124;   PMID:22404231;   PMID:22461498;   PMID:22489844;   PMID:24700817;   PMID:25132224;   PMID:25348589;   PMID:25528611;   PMID:25529677;   PMID:25626153;   PMID:25655818;   PMID:25710849;   PMID:25825679;   PMID:25884469;   PPDB:631;   Pesticides:thiamethoxam;   Reaxys:8555232;   Wikipedia:Thiamethoxam



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thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiamethoxam results in increased expression of ATF3 mRNA CTD PMID:33533595 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thiamethoxam results in increased expression of BAX protein CTD PMID:33533595 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thiamethoxam results in decreased expression of BCL2 protein CTD PMID:33533595 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Thiamethoxam results in decreased expression of BCL6 mRNA CTD PMID:33533595 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Thiamethoxam results in increased expression of BTG1 mRNA CTD PMID:33533595 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Thiamethoxam results in increased cleavage of CASP3 protein CTD PMID:33533595 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity
ISO
EXP
Thiamethoxam results in increased expression of CAT mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]
CTD PMID:33533595 PMID:34181816 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Thiamethoxam results in increased expression of CCL2 mRNA CTD PMID:33533595 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Thiamethoxam results in increased expression of CXCL5 mRNA CTD PMID:33533595 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA] CTD PMID:34181816 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD PMID:34181816 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO
EXP
thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060 PMID:28750898 PMID:34181816 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein CTD PMID:33533595 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Esr1 estrogen receptor 1 affects binding
decreases expression
ISO Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein
CTD PMID:31550567 PMID:33533595 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO Thiamethoxam results in decreased expression of FSHR protein CTD PMID:33533595 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Thiamethoxam results in decreased expression of GADD45B mRNA CTD PMID:33533595 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Thiamethoxam results in increased expression of GPX1 mRNA CTD PMID:33533595 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of HSD3B1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]
CTD PMID:34181816 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein CTD PMID:33533595 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Thiamethoxam results in decreased expression of ITPR1 mRNA CTD PMID:33533595 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Thiamethoxam results in decreased expression of JUNB mRNA CTD PMID:33533595 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
increases expression
multiple interactions
ISO
EXP
Thiamethoxam results in decreased expression of LHCGR protein
Thiamethoxam results in increased expression of LHCGR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD PMID:33533595 PMID:34181816 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO Thiamethoxam results in increased expression of LST1 mRNA CTD PMID:33533595 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression ISO Thiamethoxam results in decreased expression of MC4R mRNA CTD PMID:33533595 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Thiamethoxam results in increased expression of MMP7 mRNA CTD PMID:33533595 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
ISO [thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde CTD PMID:29197058 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Plcg2 phospholipase C, gamma 2 decreases expression ISO Thiamethoxam results in decreased expression of PLCG2 mRNA CTD PMID:33533595 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Prnp prion protein increases expression ISO Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Thiamethoxam results in decreased expression of PTGS2 mRNA CTD PMID:33533595 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Thiamethoxam results in decreased expression of PTHLH mRNA CTD PMID:33533595 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Thiamethoxam results in increased expression of PTX3 mRNA CTD PMID:33533595 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA] CTD PMID:34181816 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Thiamethoxam results in increased expression of SESN2 mRNA CTD PMID:33533595 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Thiamethoxam results in increased expression of SLC7A11 mRNA CTD PMID:33533595 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD PMID:34181816 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Thiamethoxam results in increased expression of STC2 mRNA CTD PMID:33533595 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Thbs4 thrombospondin 4 decreases expression ISO Thiamethoxam results in decreased expression of THBS4 mRNA CTD PMID:33533595 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
(E)-thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiamethoxam results in increased expression of ATF3 mRNA CTD PMID:33533595 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thiamethoxam results in increased expression of BAX protein CTD PMID:33533595 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thiamethoxam results in decreased expression of BCL2 protein CTD PMID:33533595 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Thiamethoxam results in decreased expression of BCL6 mRNA CTD PMID:33533595 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Thiamethoxam results in increased expression of BTG1 mRNA CTD PMID:33533595 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Thiamethoxam results in increased cleavage of CASP3 protein CTD PMID:33533595 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression
decreases activity
multiple interactions
ISO
EXP
Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased activity of CAT protein
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]
CTD PMID:33533595 PMID:34181816 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Thiamethoxam results in increased expression of CCL2 mRNA CTD PMID:33533595 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Thiamethoxam results in increased expression of CXCL5 mRNA CTD PMID:33533595 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP11A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]
CTD PMID:34181816 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD PMID:34181816 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO
EXP
Thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
Thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060 PMID:28750898 PMID:34181816 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein CTD PMID:33533595 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Esr1 estrogen receptor 1 affects binding
decreases expression
ISO Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein
CTD PMID:31550567 PMID:33533595 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO Thiamethoxam results in decreased expression of FSHR protein CTD PMID:33533595 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Thiamethoxam results in decreased expression of GADD45B mRNA CTD PMID:33533595 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP Thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Thiamethoxam results in increased expression of GPX1 mRNA CTD PMID:33533595 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA] CTD PMID:34181816 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein CTD PMID:33533595 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Thiamethoxam results in decreased expression of ITPR1 mRNA CTD PMID:33533595 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Thiamethoxam results in decreased expression of JUNB mRNA CTD PMID:33533595 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
multiple interactions
increases expression
ISO
EXP
Thiamethoxam results in decreased expression of LHCGR protein
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD PMID:33533595 PMID:34181816 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO Thiamethoxam results in increased expression of LST1 mRNA CTD PMID:33533595 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression ISO Thiamethoxam results in decreased expression of MC4R mRNA CTD PMID:33533595 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Thiamethoxam results in increased expression of MMP7 mRNA CTD PMID:33533595 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions
ISO Thiamethoxam metabolite results in decreased activity of NOS2 protein
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD PMID:29197058 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Plcg2 phospholipase C, gamma 2 decreases expression ISO Thiamethoxam results in decreased expression of PLCG2 mRNA CTD PMID:33533595 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Prnp prion protein increases expression ISO Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Thiamethoxam results in decreased expression of PTGS2 mRNA CTD PMID:33533595 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Thiamethoxam results in decreased expression of PTHLH mRNA CTD PMID:33533595 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Thiamethoxam results in increased expression of PTX3 mRNA CTD PMID:33533595 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA] CTD PMID:34181816 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Thiamethoxam results in increased expression of SESN2 mRNA CTD PMID:33533595 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Thiamethoxam results in increased expression of SLC7A11 mRNA CTD PMID:33533595 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD PMID:34181816 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Thiamethoxam results in increased expression of STC2 mRNA CTD PMID:33533595 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Thbs4 thrombospondin 4 decreases expression ISO Thiamethoxam results in decreased expression of THBS4 mRNA CTD PMID:33533595 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        xenobiotic 18434
          thiamethoxam 50
            (E)-thiamethoxam 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  heteroarene 16539
                                    monocyclic heteroarene 13505
                                      azole 12710
                                        thiazoles 1723
                                          1,3-thiazoles 1165
                                            2-chlorothiazole 415
                                              thiamethoxam 50
                                                (E)-thiamethoxam 50
paths to the root