CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: thiamethoxam
Accession: CHEBI:39185
browse the term
Definition: An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Synonyms: exact_synonym: 3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
related_synonym: 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine; Formula=C8H10ClN5O3S; InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3; InChIKey=NWWZPOKUUAIXIW-UHFFFAOYSA-N; SMILES=CN1COCN(Cc2cnc(Cl)s2)C1=N[N+]([O-])=O; TMX
xref: Beilstein:8555232; CAS:153719-23-4; KEGG:C18513
xref_mesh: MESH:C416660
xref: PMID:11695183; PMID:12075996; PMID:15716476; PMID:15716477; PMID:16652252; PMID:19459179; PMID:19481804; PMID:21681919; PMID:21713483; PMID:21870159; PMID:22065124; PMID:22404231; PMID:22461498; PMID:22489844; PMID:24700817; PMID:25132224; PMID:25348589; PMID:25528611; PMID:25529677; PMID:25626153; PMID:25655818; PMID:25710849; PMID:25825679; PMID:25884469; PPDB:631; Pesticides:thiamethoxam; Reaxys:8555232; Wikipedia:Thiamethoxam
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions increases activity
EXP
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein] Thiamethoxam results in increased activity of ALPL protein
CTD
PMID:30621503
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Anxa10
annexin A10
increases expression
ISO
Thiamethoxam results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
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Ar
androgen receptor
affects binding
ISO
Thiamethoxam binds to AR protein
CTD
PMID:31550567
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg1
arginase 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Atf3
activating transcription factor 3
increases expression
ISO
Thiamethoxam results in increased expression of ATF3 mRNA
CTD
PMID:33533595
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Thiamethoxam results in increased expression of BAX protein
CTD
PMID:33533595
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Thiamethoxam results in decreased expression of BCL2 protein
CTD
PMID:33533595
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl6
BCL6, transcription repressor
decreases expression
ISO
Thiamethoxam results in decreased expression of BCL6 mRNA
CTD
PMID:33533595
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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Btg1
BTG anti-proliferation factor 1
increases expression
ISO
Thiamethoxam results in increased expression of BTG1 mRNA
CTD
PMID:33533595
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Casp3
caspase 3
increases cleavage
ISO
Thiamethoxam results in increased cleavage of CASP3 protein
CTD
PMID:33533595
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
increases expression decreases expression multiple interactions decreases activity
ISO EXP
Thiamethoxam results in increased expression of CAT mRNA Thiamethoxam results in decreased expression of CAT mRNA [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]
CTD
PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Thiamethoxam results in increased expression of CCL2 mRNA
CTD
PMID:33533595
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
EXP
thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]
CTD
PMID:16981889
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Cxcl6
C-X-C motif chemokine ligand 6
increases expression
ISO
Thiamethoxam results in increased expression of CXCL5 mRNA
CTD
PMID:33533595
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions decreases expression
EXP
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]
CTD
PMID:34181816
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of CYP17A1 mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD
PMID:34181816
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression multiple interactions increases activity
ISO EXP
thiamethoxam results in increased expression of CYP19A1 mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA] thiamethoxam results in increased activity of CYP19A1 protein
CTD
PMID:26464060 PMID:28750898 PMID:34181816
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam
CTD
PMID:16153789
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein
CTD
PMID:33533595
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Esr1
estrogen receptor 1
affects binding decreases expression
ISO
Thiamethoxam binds to ESR1 protein Thiamethoxam results in decreased expression of ESR1 protein
CTD
PMID:31550567 PMID:33533595
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Foxo3
forkhead box O3
increases expression
ISO
Thiamethoxam results in increased expression of FOXO3 mRNA
CTD
PMID:33533595
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Fshr
follicle stimulating hormone receptor
decreases expression
ISO
Thiamethoxam results in decreased expression of FSHR protein
CTD
PMID:33533595
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
Thiamethoxam results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gadd45b
growth arrest and DNA-damage-inducible, beta
decreases expression
ISO
Thiamethoxam results in decreased expression of GADD45B mRNA
CTD
PMID:33533595
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Got1
glutamic-oxaloacetic transaminase 1
increases activity multiple interactions
EXP
Thiamethoxam results in increased activity of GOT1 protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]
CTD
PMID:30621503
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
decreases activity
EXP
thiamethoxam results in decreased activity of GPT protein
CTD
PMID:29197058
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
increases expression decreases expression decreases activity multiple interactions
ISO EXP
Thiamethoxam results in increased expression of GPX1 mRNA Thiamethoxam results in decreased expression of GPX1 mRNA Thiamethoxam results in decreased activity of GPX1 protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]
CTD
PMID:30621503 PMID:33533595 PMID:36958429
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of HSD3B1 mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]
CTD
PMID:34181816
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein
CTD
PMID:33533595
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Il1b
interleukin 1 beta
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein] Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein
CTD
PMID:36958429
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]
CTD
PMID:36958429
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ITPR1 mRNA
CTD
PMID:33533595
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Thiamethoxam results in decreased expression of JUNB mRNA
CTD
PMID:33533595
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Ldha
lactate dehydrogenase A
multiple interactions increases activity
EXP
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein] Thiamethoxam results in increased activity of LDHA protein
CTD
PMID:30621503
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
decreases expression increases expression multiple interactions
ISO EXP
Thiamethoxam results in decreased expression of LHCGR protein Thiamethoxam results in increased expression of LHCGR mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD
PMID:33533595 PMID:34181816
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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Lst1
leukocyte specific transcript 1
increases expression
ISO
Thiamethoxam results in increased expression of LST1 mRNA
CTD
PMID:33533595
NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
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Mc4r
melanocortin 4 receptor
decreases expression
ISO
Thiamethoxam results in decreased expression of MC4R mRNA
CTD
PMID:33533595
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mmp7
matrix metallopeptidase 7
increases expression
ISO
Thiamethoxam results in increased expression of MMP7 mRNA
CTD
PMID:33533595
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Nos2
nitric oxide synthase 2
multiple interactions increases expression decreases activity
ISO EXP
[thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde Thiamethoxam results in increased expression of NOS2 mRNA Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
CTD
PMID:29197058 PMID:36958429
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Plcg2
phospholipase C, gamma 2
decreases expression
ISO
Thiamethoxam results in decreased expression of PLCG2 mRNA
CTD
PMID:33533595
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Prnp
prion protein
increases expression
ISO
Thiamethoxam results in increased expression of PRNP mRNA
CTD
PMID:33533595
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Thiamethoxam results in decreased expression of PTGS2 mRNA
CTD
PMID:33533595
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pthlh
parathyroid hormone-like hormone
decreases expression
ISO
Thiamethoxam results in decreased expression of PTHLH mRNA
CTD
PMID:33533595
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Ptx3
pentraxin 3
increases expression
ISO
Thiamethoxam results in increased expression of PTX3 mRNA
CTD
PMID:33533595
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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Scarb1
scavenger receptor class B, member 1
multiple interactions decreases expression
EXP
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]
CTD
PMID:34181816
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Sesn2
sestrin 2
increases expression
ISO
Thiamethoxam results in increased expression of SESN2 mRNA
CTD
PMID:33533595
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Slc22a2
solute carrier family 22 member 2
decreases activity
ISO
Thiamethoxam results in decreased activity of SLC22A2 protein
CTD
PMID:31364238
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Thiamethoxam results in increased expression of SLC7A11 mRNA
CTD
PMID:33533595
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Sod1
superoxide dismutase 1
decreases activity decreases expression multiple interactions
EXP
Thiamethoxam results in decreased activity of SOD1 protein Thiamethoxam results in decreased expression of SOD1 mRNA [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]
CTD
PMID:30621503 PMID:36958429
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Star
steroidogenic acute regulatory protein
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of STAR mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD
PMID:34181816
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stc2
stanniocalcin 2
increases expression
ISO
Thiamethoxam results in increased expression of STC2 mRNA
CTD
PMID:33533595
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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Thbs4
thrombospondin 4
decreases expression
ISO
Thiamethoxam results in decreased expression of THBS4 mRNA
CTD
PMID:33533595
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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Thra
thyroid hormone receptor alpha
affects binding
ISO
Thiamethoxam binds to THRA protein
CTD
PMID:31550567
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein] Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein
CTD
PMID:36958429
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnnt2
troponin T2, cardiac type
increases secretion multiple interactions
EXP
Thiamethoxam results in increased secretion of TNNT2 protein fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD
PMID:30520268
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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Alpl
alkaline phosphatase, biomineralization associated
increases activity multiple interactions
EXP
Thiamethoxam results in increased activity of ALPL protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]
CTD
PMID:30621503
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
G
Anxa10
annexin A10
increases expression
ISO
Thiamethoxam results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
G
Ar
androgen receptor
affects binding
ISO
Thiamethoxam binds to AR protein
CTD
PMID:31550567
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Arg1
arginase 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
G
Atf3
activating transcription factor 3
increases expression
ISO
Thiamethoxam results in increased expression of ATF3 mRNA
CTD
PMID:33533595
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Thiamethoxam results in increased expression of BAX protein
CTD
PMID:33533595
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Thiamethoxam results in decreased expression of BCL2 protein
CTD
PMID:33533595
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl6
BCL6, transcription repressor
decreases expression
ISO
Thiamethoxam results in decreased expression of BCL6 mRNA
CTD
PMID:33533595
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
G
Btg1
BTG anti-proliferation factor 1
increases expression
ISO
Thiamethoxam results in increased expression of BTG1 mRNA
CTD
PMID:33533595
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
G
Casp3
caspase 3
increases cleavage
ISO
Thiamethoxam results in increased cleavage of CASP3 protein
CTD
PMID:33533595
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
increases expression multiple interactions decreases activity decreases expression
ISO EXP
Thiamethoxam results in increased expression of CAT mRNA [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]
CTD
PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Thiamethoxam results in increased expression of CCL2 mRNA
CTD
PMID:33533595
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
EXP
Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]
CTD
PMID:16981889
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
G
Cxcl6
C-X-C motif chemokine ligand 6
increases expression
ISO
Thiamethoxam results in increased expression of CXCL5 mRNA
CTD
PMID:33533595
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of CYP11A1 mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]
CTD
PMID:34181816
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of CYP17A1 mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD
PMID:34181816
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression increases activity multiple interactions
ISO EXP
Thiamethoxam results in increased expression of CYP19A1 mRNA Thiamethoxam results in increased activity of CYP19A1 protein Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
CTD
PMID:26464060 PMID:28750898 PMID:34181816
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam
CTD
PMID:16153789
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Thiamethoxam results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein
CTD
PMID:33533595
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Esr1
estrogen receptor 1
affects binding decreases expression
ISO
Thiamethoxam binds to ESR1 protein Thiamethoxam results in decreased expression of ESR1 protein
CTD
PMID:31550567 PMID:33533595
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Foxo3
forkhead box O3
increases expression
ISO
Thiamethoxam results in increased expression of FOXO3 mRNA
CTD
PMID:33533595
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Fshr
follicle stimulating hormone receptor
decreases expression
ISO
Thiamethoxam results in decreased expression of FSHR protein
CTD
PMID:33533595
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
Thiamethoxam results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Gadd45b
growth arrest and DNA-damage-inducible, beta
decreases expression
ISO
Thiamethoxam results in decreased expression of GADD45B mRNA
CTD
PMID:33533595
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Got1
glutamic-oxaloacetic transaminase 1
increases activity multiple interactions
EXP
Thiamethoxam results in increased activity of GOT1 protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]
CTD
PMID:30621503
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
decreases activity
EXP
Thiamethoxam results in decreased activity of GPT protein
CTD
PMID:29197058
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
increases expression multiple interactions decreases activity decreases expression
ISO EXP
Thiamethoxam results in increased expression of GPX1 mRNA [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]
CTD
PMID:30621503 PMID:33533595 PMID:36958429
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
multiple interactions decreases expression
EXP
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]
CTD
PMID:34181816
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein
CTD
PMID:33533595
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Il1b
interleukin 1 beta
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein] Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein
CTD
PMID:36958429
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA]
CTD
PMID:36958429
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
decreases expression
ISO
Thiamethoxam results in decreased expression of ITPR1 mRNA
CTD
PMID:33533595
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Thiamethoxam results in decreased expression of JUNB mRNA
CTD
PMID:33533595
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Ldha
lactate dehydrogenase A
increases activity multiple interactions
EXP
Thiamethoxam results in increased activity of LDHA protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]
CTD
PMID:30621503
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
decreases expression increases expression multiple interactions
ISO EXP
Thiamethoxam results in decreased expression of LHCGR protein Thiamethoxam results in increased expression of LHCGR mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD
PMID:33533595 PMID:34181816
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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Lst1
leukocyte specific transcript 1
increases expression
ISO
Thiamethoxam results in increased expression of LST1 mRNA
CTD
PMID:33533595
NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
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Mc4r
melanocortin 4 receptor
decreases expression
ISO
Thiamethoxam results in decreased expression of MC4R mRNA
CTD
PMID:33533595
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mmp7
matrix metallopeptidase 7
increases expression
ISO
Thiamethoxam results in increased expression of MMP7 mRNA
CTD
PMID:33533595
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Nos2
nitric oxide synthase 2
decreases activity multiple interactions increases expression
ISO EXP
Thiamethoxam metabolite results in decreased activity of NOS2 protein [Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde Thiamethoxam results in increased expression of NOS2 mRNA Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
CTD
PMID:29197058 PMID:36958429
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Plcg2
phospholipase C, gamma 2
decreases expression
ISO
Thiamethoxam results in decreased expression of PLCG2 mRNA
CTD
PMID:33533595
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Prnp
prion protein
increases expression
ISO
Thiamethoxam results in increased expression of PRNP mRNA
CTD
PMID:33533595
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Thiamethoxam results in decreased expression of PTGS2 mRNA
CTD
PMID:33533595
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pthlh
parathyroid hormone-like hormone
decreases expression
ISO
Thiamethoxam results in decreased expression of PTHLH mRNA
CTD
PMID:33533595
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Ptx3
pentraxin 3
increases expression
ISO
Thiamethoxam results in increased expression of PTX3 mRNA
CTD
PMID:33533595
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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Scarb1
scavenger receptor class B, member 1
multiple interactions decreases expression
EXP
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA]
CTD
PMID:34181816
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Sesn2
sestrin 2
increases expression
ISO
Thiamethoxam results in increased expression of SESN2 mRNA
CTD
PMID:33533595
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Slc22a2
solute carrier family 22 member 2
decreases activity
ISO
Thiamethoxam results in decreased activity of SLC22A2 protein
CTD
PMID:31364238
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Thiamethoxam results in increased expression of SLC7A11 mRNA
CTD
PMID:33533595
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Sod1
superoxide dismutase 1
decreases activity multiple interactions decreases expression
EXP
Thiamethoxam results in decreased activity of SOD1 protein [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]
CTD
PMID:30621503 PMID:36958429
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Star
steroidogenic acute regulatory protein
decreases expression multiple interactions
EXP
Thiamethoxam results in decreased expression of STAR mRNA Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD
PMID:34181816
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stc2
stanniocalcin 2
increases expression
ISO
Thiamethoxam results in increased expression of STC2 mRNA
CTD
PMID:33533595
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
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Thbs4
thrombospondin 4
decreases expression
ISO
Thiamethoxam results in decreased expression of THBS4 mRNA
CTD
PMID:33533595
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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Thra
thyroid hormone receptor alpha
affects binding
ISO
Thiamethoxam binds to THRA protein
CTD
PMID:31550567
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein] Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein
CTD
PMID:36958429
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnnt2
troponin T2, cardiac type
increases secretion multiple interactions
EXP
Thiamethoxam results in increased secretion of TNNT2 protein fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD
PMID:30520268
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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