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ONTOLOGY REPORT - ANNOTATIONS


Term:bosutinib
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Accession:CHEBI:39112 term browser browse the term
Definition:An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.
Synonyms:exact_synonym: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
 related_synonym: 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile;   Formula=C26H29Cl2N5O3;   InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31);   InChIKey=UBPYILGKFZZVDX-UHFFFAOYSA-N;   SKI-606;   SMILES=COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
 alt_id: MESH:C471992
 xref: Beilstein:9100307 "Beilstein";   CAS:380843-75-4 "ChemIDplus";   Drug_Central:4359 "DrugCentral";   KEGG:D03252;   LINCS:LSM-1190
 xref_mesh: MESH:C471992
 xref: PDBeChem:DB8;   PMID:18483306 "Europe PMC";   PMID:19039322 "Europe PMC";   PMID:19509264 "Europe PMC";   PMID:21148045 "Europe PMC";   PMID:21544849 "Europe PMC";   PMID:21680801 "Europe PMC";   PMID:21691746 "Europe PMC";   PMID:21700731 "Europe PMC";   PMID:21865346 "Europe PMC";   PMID:22031512 "Europe PMC";   PMID:22036634 "Europe PMC";   PMID:22037769 "Europe PMC";   PMID:22065400 "Europe PMC";   PMID:22179664 "Europe PMC";   PMID:22271876 "Europe PMC";   PMID:22311495 "Europe PMC";   PMID:22371878 "Europe PMC";   PMID:22425385 "Europe PMC";   PMID:22462037 "Europe PMC";   PMID:22471705 "Europe PMC";   PMID:22493660 "Europe PMC";   PMID:22588706 "Europe PMC";   PMID:22830347 "Europe PMC";   PMID:22884766 "Europe PMC";   PMID:22915985 "Europe PMC";   PMID:22937303 "Europe PMC";   PMID:22949154 "Europe PMC";   Reaxys:9100307 "Reaxys";   Wikipedia:Bosutinib


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bosutinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Csk C-terminal Src kinase JBrowse link 8 62,405,714 62,424,707 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6480464
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6480464
G Slc16a2 solute carrier family 16 member 2 JBrowse link X 74,578,600 74,706,068 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Tcf4 transcription factor 4 JBrowse link 18 65,285,320 65,507,983 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    chemical entity 19612
      group 19527
        pseudohalo group 2769
          cyano group 2769
            nitrile 2769
              bosutinib 19
                bosutinib hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    main group molecular entity 19489
                      s-block molecular entity 19262
                        hydrogen molecular entity 19253
                          hydrides 18169
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16891
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        tertiary amino compound 8526
                                          N-alkylpiperazine 2960
                                            N-methylpiperazine 840
                                              bosutinib 19
                                                bosutinib hydrate 0
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