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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-hexachlorocyclohexane
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Accession:CHEBI:39096 term browser browse the term
Definition:A hexachlorocyclohexane that has formula C6H6Cl6.
Synonyms:exact_synonym: (1R,2R,3R,4R,5S,6S)-1,2,3,4,5,6-hexachlorocyclohexane
 related_synonym: (1alpha,2alpha,3beta,4beta,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane;   (1r,2c,3t,4t,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane;   1alpha,2alpha,3beta,4alpha,5beta,6beta-Hexachlorocyclohexane;   Formula=C6H6Cl6;   InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m1/s1;   InChIKey=JLYXXMFPNIAWKQ-SHFUYGGZSA-N;   SMILES=Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@H]1Cl;   alpha-BHC;   alpha-HCH;   alpha-Lindane;   alpha-benzene hexachloride;   alpha-hexachlorane
 xref: Beilstein:1907336;   CAS:319-84-6;   Gmelin:794031;   KEGG:C15214
 xref_mesh: MESH:C040534



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alpha-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCB4 mRNA CTD PMID:16940010 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:17785943 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA CTD PMID:16940010 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA CTD PMID:17785943 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ADAP2 mRNA CTD PMID:16940010 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604
JBrowse link
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ADH1 mRNA CTD PMID:16940010 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA CTD PMID:17785943 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Apoc1 apolipoprotein C1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA CTD PMID:16940010 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G App amyloid beta precursor protein increases expression EXP alpha-hexachlorocyclohexane results in increased expression of APP mRNA CTD PMID:17785943 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:10696776 PMID:15084347 PMID:21962538 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA CTD PMID:17785943 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Casp3 caspase 3 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of CASP3 protein CTD PMID:19818741 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
alpha-hexachlorocyclohexane results in increased activity of CAT protein
CTD PMID:1708174 PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbx1 chromobox 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA CTD PMID:16940010 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
JBrowse link
G Cd36 CD36 molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CD36 mRNA CTD PMID:17785943 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdc123 cell division cycle 123 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CDC123 mRNA CTD PMID:16940010 NCBI chr17:72,459,296...72,502,948
Ensembl chr17:72,459,282...72,503,316
JBrowse link
G Cdk17 cyclin-dependent kinase 17 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CDK17 mRNA CTD PMID:16940010 NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CES2 mRNA CTD PMID:17785943 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chchd2l3 coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3 affects expression
decreases expression
increases expression
EXP alpha-hexachlorocyclohexane affects the expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in increased expression of CHCHD2 mRNA
CTD PMID:16940010 NCBI chr 9:94,500,439...94,501,110
NCBI chr 9:94,500,629...94,501,122
Ensembl chr 9:94,500,432...94,501,128
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in increased expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CPN1 mRNA
CTD PMID:16940010 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
JBrowse link
G Ctsc cathepsin C decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of CTSC mRNA
alpha-hexachlorocyclohexane results in increased expression of CTSC mRNA
alpha-hexachlorocyclohexane affects the expression of CTSC mRNA
CTD PMID:16940010 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cyb5a cytochrome b5 type A affects expression EXP alpha-hexachlorocyclohexane affects the expression of CYB5A mRNA CTD PMID:17785943 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA CTD PMID:17785943 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein CTD PMID:11165752 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein CTD PMID:16246485 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases activity
EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2B1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 protein
alpha-hexachlorocyclohexane results in increased activity of CYP2B1 protein
CTD PMID:1372805 PMID:11165752 PMID:16246485 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B15 mRNA CTD PMID:17785943 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein CTD PMID:16246485 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA CTD PMID:17785943 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of CYP2C6V1 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6V1 protein
CTD PMID:16246485 PMID:16940010 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein CTD PMID:16246485 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein
CTD PMID:11165752 PMID:16246485 PMID:16940010 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16940010 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNA CTD PMID:17785943 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP51 mRNA CTD PMID:17785943 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNA
alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNA
alpha-hexachlorocyclohexane affects the expression of ECI1 mRNA
CTD PMID:16940010 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA CTD PMID:17785943 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
increases activity
EXP alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA
alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein
CTD PMID:1372805 PMID:16940010 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
EXP
ISO
alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
alpha-hexachlorocyclohexane results in increased activity of ESR1 protein
CTD PMID:10580743 PMID:26022396 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fev FEV transcription factor, ETS family member decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of FEV mRNA CTD PMID:17785943 NCBI chr 9:76,439,164...76,443,603
Ensembl chr 9:76,439,172...76,443,065
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases response to substance EXP alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein CTD PMID:1715812 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FKBP3 mRNA CTD PMID:17785943 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011
JBrowse link
G Fn1 fibronectin 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA CTD PMID:17785943 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] CTD PMID:1380685 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FTL1 mRNA CTD PMID:16940010 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
multiple interactions
EXP
ISO
alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:9316872 PMID:17785943 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression
decreases expression
increases expression
EXP alpha-hexachlorocyclohexane affects the expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in decreased expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in increased expression of GAPDH mRNA
CTD PMID:16940010 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA CTD PMID:17785943 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of GSR mRNA
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein
CTD PMID:16046044 PMID:17785943 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA5 mRNA CTD PMID:17785943 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTK1 mRNA CTD PMID:16940010 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane results in increased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane affects the expression of GSTM4 mRNA
CTD PMID:16940010 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of GSTP1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of GSTP1 protein
alpha-hexachlorocyclohexane results in increased expression of GSTP1 mRNA
CTD PMID:16246485 PMID:16940010 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP alpha-hexachlorocyclohexane results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA CTD PMID:17785943 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 affects expression EXP alpha-hexachlorocyclohexane affects the expression of KCNJ5 mRNA CTD PMID:17785943 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of KIT mRNA CTD PMID:16940010 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lpl lipoprotein lipase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of LPL mRNA CTD PMID:17785943 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp2 LDL receptor related protein 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of LRP2 mRNA CTD PMID:16940010 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
JBrowse link
G Luc7l2 LUC7-like 2 pre-mRNA splicing factor affects expression EXP alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNA CTD PMID:17785943 NCBI chr 4:67,287,593...67,347,986
Ensembl chr 4:67,287,640...67,347,964
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
affects expression
decreases expression
EXP alpha-hexachlorocyclohexane results in increased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane affects the expression of MAPK1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of MAPK1 mRNA
CTD PMID:16940010 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MAPK6 mRNA CTD PMID:16940010 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Me1 malic enzyme 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ME1 mRNA CTD PMID:17785943 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Meox2 mesenchyme homeobox 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA CTD PMID:17785943 NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression EXP alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA CTD PMID:16940010 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Muc13 mucin 13, cell surface associated decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of MUC13 mRNA CTD PMID:17785943 NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA] CTD PMID:28273962 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncl nucleolin increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NCL mRNA CTD PMID:17785943 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA
Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]
CTD PMID:28273962 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NQO1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO alpha-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
alpha-hexachlorocyclohexane results in increased activity of NR1I2 protein
CTD PMID:21115097 PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of OGG1 mRNA CTD PMID:16246485 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Onecut1 one cut homeobox 1 affects expression EXP alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNA CTD PMID:17785943 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of PCNA protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of PCNA protein CTD PMID:16246485 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA CTD PMID:17785943 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Prss8 serine protease 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA CTD PMID:17785943 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNA CTD PMID:17785943 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNA CTD PMID:16940010 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
JBrowse link
G Psme1 proteasome activator subunit 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNA CTD PMID:16940010 NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890
JBrowse link
G Rab7a RAB7A, member RAS oncogene family increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RAB7 mRNA CTD PMID:17785943 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of RB1 mRNA
alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA
CTD PMID:16940010 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rnpep arginyl aminopeptidase decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA
alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA
alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA
CTD PMID:16940010 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RPLP0 mRNA CTD PMID:16940010 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SCD1 mRNA CTD PMID:17785943 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc16a1 solute carrier family 16 member 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in increased expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of SLC16A1 mRNA
CTD PMID:16940010 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SLC17A1 mRNA CTD PMID:17785943 NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304
JBrowse link
G Smpx small muscle protein, X-linked decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SMPX mRNA CTD PMID:17785943 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snx4 sorting nexin 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SNX4 mRNA CTD PMID:17785943 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein] CTD PMID:10993823 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA CTD PMID:16940010 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA CTD PMID:16940010 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tp53 tumor protein p53 increases expression
affects expression
decreases expression
EXP alpha-hexachlorocyclohexane results in increased expression of TP53 mRNA
alpha-hexachlorocyclohexane affects the expression of TRP53 mRNA
alpha-hexachlorocyclohexane results in decreased expression of TP53 mRNA
CTD PMID:16940010 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ubc ubiquitin C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UBC mRNA CTD PMID:16940010 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A5 mRNA CTD PMID:17785943 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA CTD PMID:17785943 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA CTD PMID:16940010 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNA CTD PMID:16940010 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B mRNA CTD PMID:16940010 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      chemical role 19589
        environmental contaminant 18862
          persistent organic pollutant 16548
            alpha-hexachlorocyclohexane 109
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  cyclic hydrocarbon 17206
                                    monocyclic hydrocarbon 6061
                                      cycloalkane 513
                                        cyclohexane 508
                                          chlorocyclohexane 508
                                            hexachlorocyclohexane 508
                                              alpha-hexachlorocyclohexane 109
paths to the root